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List of works by Harri Lähdesmäki

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The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes

scientific article published on 5 February 2015
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

scientific article
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

scientific article published on 7 April 2013
Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis

scientific article published on March 2004
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

scientific journal article
Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility

scientific article published on 18 February 2014
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming

scientific article
The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

scientific article published in Nature
Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation

scientific article published on July 28, 2014
Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex

scientific article
Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

scientific article published on 28 October 2014
In silico microdissection of microarray data from heterogeneous cell populations

scientific article
Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization

scientific article
The role of certain Post classes in Boolean network models of genetic networks

scientific article
On Learning Gene Regulatory Networks Under the Boolean Network Model

RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation

scientific article
Probabilistic analysis of gene expression measurements from heterogeneous tissues

scientific article
TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

scientific article published on 21 November 2016
Methods for time series analysis of RNA-seq data with application to human Th17 cell differentiation

scientific article
Robust detection of periodic time series measured from biological systems

scientific article
Learning gene regulatory networks from gene expression measurements using non-parametric molecular kinetics

scientific article
Relationships between probabilistic Boolean networks and dynamic Bayesian networks as models of gene regulatory networks

scientific article published on April 2006
BinDNase: a discriminatory approach for transcription factor binding prediction using DNase I hypersensitivity data

scientific article published on May 7, 2015
Genome-wide copy number variation analysis in extended families and unrelated individuals characterized for musical aptitude and creativity in music

scientific article
Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels

scientific article published on 4 September 2014
A linear model for transcription factor binding affinity prediction in protein binding microarrays

scientific article
The miR-15a-miR-16-1 locus is homozygously deleted in a subset of prostate cancers

scientific article published on 31 March 2011
Identification of early gene expression changes during human Th17 cell differentiation

scientific article published on 27 April 2012
Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells

scientific article published on 25 February 2014
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells

scientific article
Robust regression for periodicity detection in non-uniformly sampled time-course gene expression data

scientific article
Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels

scientific article
The effect of music performance on the transcriptome of professional musicians

scientific article
Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility

scientific article published on 23 January 2015
Identification of global regulators of T-helper cell lineage specification

scientific article
Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

scientific article published on 17 December 2018
Standard of hygiene and immune adaptation in newborn infants

article
An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation

scientific article published in 2012
The effect of listening to music on human transcriptome

scientific article
Comparative analysis of human and mouse transcriptomes of Th17 cell priming

scientific article published on 07 March 2016
Synthetic Transcription Amplifier System for Orthogonal Control of Gene Expression in Saccharomyces cerevisiae

scientific article
Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation

scientific article
Inference of Boolean networks using sensitivity regularization

scientific article published on January 2008
The genome-wide landscape of copy number variations in the MUSGEN study provides evidence for a founder effect in the isolated Finnish population

scientific article
Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells

scientific article
The landscape of copy number variations in Finnish families with autism spectrum disorders

scientific article published on 6 June 2015
A data integration framework for prediction of transcription factor targets

scientific article
Sorad: a systems biology approach to predict and modulate dynamic signaling pathway response from phosphoproteome time-course measurements

scientific article published on 16 March 2013
Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells.

scientific article published on 24 September 2016
A joint finite mixture model for clustering genes from independent Gaussian and beta distributed data

scientific article

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