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Authors whose works are in public domain in at least one jurisdiction

List of works by Harri Lähdesmäki

1-50 of 78 results

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes

scientific article published on 5 February 2015

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

scientific article

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

scientific article published on 7 April 2013

Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis

scientific article published on March 2004

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

scientific journal article

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility

scientific article published on 18 February 2014

Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming

scientific article

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

scientific article published in Nature

Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation

scientific article published on July 28, 2014

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex

scientific article

Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

scientific article published on 28 October 2014

In silico microdissection of microarray data from heterogeneous cell populations

scientific article

Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization

scientific article

The role of certain Post classes in Boolean network models of genetic networks

scientific article

On Learning Gene Regulatory Networks Under the Boolean Network Model

RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation

scientific article

Probabilistic analysis of gene expression measurements from heterogeneous tissues

scientific article

TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

scientific article published on 21 November 2016

Methods for time series analysis of RNA-seq data with application to human Th17 cell differentiation

scientific article

Robust detection of periodic time series measured from biological systems

scientific article

Learning gene regulatory networks from gene expression measurements using non-parametric molecular kinetics

scientific article

Relationships between probabilistic Boolean networks and dynamic Bayesian networks as models of gene regulatory networks

scientific article published on April 2006

BinDNase: a discriminatory approach for transcription factor binding prediction using DNase I hypersensitivity data

scientific article published on May 7, 2015

Genome-wide copy number variation analysis in extended families and unrelated individuals characterized for musical aptitude and creativity in music

scientific article

Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels

scientific article published on 4 September 2014

A linear model for transcription factor binding affinity prediction in protein binding microarrays

scientific article

The miR-15a-miR-16-1 locus is homozygously deleted in a subset of prostate cancers

scientific article published on 31 March 2011

Identification of early gene expression changes during human Th17 cell differentiation

scientific article published on 27 April 2012

Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells

scientific article published on 25 February 2014

Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells

scientific article

Robust regression for periodicity detection in non-uniformly sampled time-course gene expression data

scientific article

Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels

scientific article

The effect of music performance on the transcriptome of professional musicians

scientific article

Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility

scientific article published on 23 January 2015

Identification of global regulators of T-helper cell lineage specification

scientific article

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

scientific article published on 17 December 2018

Standard of hygiene and immune adaptation in newborn infants

article

An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation

scientific article published in 2012

The effect of listening to music on human transcriptome

scientific article

Comparative analysis of human and mouse transcriptomes of Th17 cell priming

scientific article published on 07 March 2016

Synthetic Transcription Amplifier System for Orthogonal Control of Gene Expression in Saccharomyces cerevisiae

scientific article

Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation

scientific article

Inference of Boolean networks using sensitivity regularization

scientific article published on January 2008

The genome-wide landscape of copy number variations in the MUSGEN study provides evidence for a founder effect in the isolated Finnish population

scientific article

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells

scientific article

The landscape of copy number variations in Finnish families with autism spectrum disorders

scientific article published on 6 June 2015

A data integration framework for prediction of transcription factor targets

scientific article

Sorad: a systems biology approach to predict and modulate dynamic signaling pathway response from phosphoproteome time-course measurements

scientific article published on 16 March 2013

Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells.

scientific article published on 24 September 2016

A joint finite mixture model for clustering genes from independent Gaussian and beta distributed data

scientific article