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List of works by Tessa Holyoake

A comparison of normal and leukemic stem cell biology in Chronic Myeloid Leukemia.

scientific article

A consensus on fungal polymerase chain reaction diagnosis?: a United Kingdom-Ireland evaluation of polymerase chain reaction methods for detection of systemic fungal infections

scientific article published on July 2006

A multinational study of health state preference values associated with chronic myelogenous leukemia

scientific article published on 29 July 2009

A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

scientific article

A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response.

scientific article published on 5 March 2009

A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility

scientific article published on September 2013

ACCELERATED RECOVERY FROM DRUG-INDUCED AGRANULOCYTOSIS FOLLOWING G-CSF THERAPY

scientific article published on 01 April 1992

Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor Danusertib in BCR-ABL-positive cells in vitro

scientific article

Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib

scientific article published on February 2012

Adult hematopoietic stem cells lacking Hif-1α self-renew normally.

scientific article published on 8 April 2016

Alpha1-acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571.

scientific article published in January 2002

Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia

scientific article published in April 2012

Analysis of imatinib in bone marrow and plasma samples of chronic myeloid leukaemia patients using solid phase extraction LC-ESI-MS

scientific article published on 01 July 2011

Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines

scientific article

Aplastic anaemia associated with fenbufen: a report of two cases

scientific article published on 01 April 1994

Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival

scientific article

Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks

scientific article published on October 2011

Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation

scientific article published on 16 September 2013

Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia.

scientific article published on October 1999

Autonomous multi-lineage differentiation in vitro of primitive CD34+ cells from patients with chronic myeloid leukemia

scientific article published on 01 June 2000

Autophagy in blood cancers: biological role and therapeutic implications.

scientific article published on September 2013

Autophagy in chronic myeloid leukaemia: stem cell survival and implication in therapy

scientific article published on September 2013

BCR-ABL FISH monitoring of CML: a survey of current UK practice

scientific article published on 01 October 2002

BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry.

scientific article published on June 2006

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

scientific article

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia

scientific article

BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta.

scientific article published on 8 September 2009

BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors

scientific article published on 21 December 2007

Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.

scientific article

CD34 positive PBPC expanded ex vivo may not provide durable engraftment following myeloablative chemoradiotherapy regimens

scientific article published on 01 June 1997

CD34+ cells can be selected efficiently from cryopreserved peripheral blood progenitor cells and can retain their proliferative potential

scientific article published on 01 October 1997

CD34+ positive haemopoietic cells: biology and clinical applications.

scientific article

CD34-positive cells isolated from cryopreserved peripheral-blood progenitor cells can be expanded ex vivo and used for transplantation with little or no toxicity

scientific article published on 01 June 1996

CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.

scientific article published on 28 October 2016

CML leukapheresis products can be enriched for CD34+ cells and simultaneously depleted of CD15+ cells using a simple Ab cocktail

scientific article published on 01 January 2002

Can we afford to let sleeping dogs lie?

scientific article

Cell separation improves the sensitivity of detecting rare human normal and leukemic hematopoietic cells in vivo in NOD/SCID mice

scientific article published on 01 January 2000

Characterization of cancer stem cells in chronic myeloid leukaemia.

scientific article

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

scientific article published on 19 December 2011

Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues.

scientific article published on 30 July 2009

Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells

scientific article

Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML).

scientific article published on 13 January 2010

Complete molecular responses are achieved after reduced intensity stem cell transplantation and donor lymphocyte infusion in chronic myeloid leukemia

scientific article published on 31 March 2008

Concise review: Telomere biology in normal and leukemic hematopoietic stem cells

scientific article published on 17 May 2007

Concise review: cancer cells escape from oncogene addiction: understanding the mechanisms behind treatment failure for more effective targeting

scientific article published on June 2014

Contrasting effects of rh‐MIP‐1α and TGF‐β1 on chronic myeloid leukemia progenitors in vitro

scientific article published on 01 October 1993

Correction: Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny.

scientific article published on 31 May 2013

Cytokines at the research-clinical interface: potential applications.

scientific article published on September 1996

DPPIV (CD26) as a novel stem cell marker in Ph+ chronic myeloid leukaemia

scientific article

Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

scientific article published on 9 February 2006

Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease.

scientific article published on March 2005

Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia

scientific article published on 28 April 2014

Do we need more drugs for chronic myeloid leukemia?

scientific article

Dual glutathione-S-transferase-θ1 and -μ1 gene deletions determine imatinib failure in chronic myeloid leukemia

scientific article published on 4 September 2014

Dysregulated expression of the major telomerase components in leukaemic stem cells.

scientific article published on March 2005

Early prediction of success or failure of treatment with second-generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia

scientific article

Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606.

scientific article

Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate

scientific article

Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells

scientific article published on December 2008

Effects of the novel aurora kinase/JAK inhibitor, AT9283 and imatinib on Philadelphia positive cells in vitro

scientific article published on 09 February 2012

Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia.

scientific article

Enhanced CML stem cell elimination in vitro by bryostatin priming with imatinib mesylate

scientific article published on October 2005

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia.

scientific article

Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib

scientific article

Evolution of bone marrow transplantation--the original immunotherapy.

scientific article

Evolving molecular therapy for chronic myeloid leukaemia--are we on target?

scientific article

Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery posttransplant and the ability to serially transplant marrow

scientific article published on 01 June 1996

Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cells

scientific article

FOXO transcription factor activity is partially retained in quiescent CML stem cells and induced by tyrosine kinase inhibitors in CML progenitor cells

scientific article published in December 2009

Fluorescence in situ hybridization for BCR-ABL.

scientific article published in January 2004

Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate

scientific article published on 20 April 2006

Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow

scientific article published on 01 September 1999

GATA1 mutational analysis in chronic myeloid leukaemia

scientific article published on 04 April 2007

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

scientific article published on 29 March 2013

Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1.

scientific article

Granulocyte--colony-stimulating factor (Filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase myelogenous leukemia

scientific article published in January 2005

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HOXA5 is targeted by cell-type-specific CpG island methylation in normal cells and during the development of acute myeloid leukaemia

scientific article

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

scientific article published on 7 December 2015

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance

scientific article published on 26 July 2013

High loading dose AmBisome(R) is efficacious and well tolerated in the management of invasive fungal infection in hematology patients

scientific article published on 01 April 2007

Human neutrophil elastase is not a target for therapy in chronic myeloid leukaemia

scientific article published on 28 September 2006

Hurdles Toward a Cure for CML: The CML Stem Cell ⬇️

scientific article published on October 19, 2011

Hydroxychloroquine for chronic myeloid leukemia: complete cure on the horizon?

scientific article

Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach

scientific article published on 15 February 2007

Imatinib mesylate-induced molecular remission of Philadelphia chromosome-positive myelodysplastic syndrome.

scientific article published in February 2003

Immature monocytes from G-CSF-mobilized peripheral blood stem cell collections carry surface-bound IL-10 and have the potential to modulate alloreactivity

scientific article published on 08 August 2006

In search of CML stem cells' deadly weakness

scientific article published on June 2011

In vivo expansion of the endogenous B-cell compartment stimulated by radiation and serial bone marrow transplantation induces B-cell leukaemia in mice

scientific article published on 01 July 2001

Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis.

scientific article published on September 2007

Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib.

scientific article published on 25 April 2009

Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate

scientific article published in January 2006

Investigation into omacetaxine solution stability for in vitro study

scientific article

Isolation and therapeutic potential of human haemopoietic stem cells

scientific article published on March 2003

Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.

scientific article published in September 1999

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.

scientific article

Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML.

scientific article published on 21 June 2011

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny

scientific article

Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia

scientific article published on June 2011

Management of chronic myeloid leukaemia in relapse following donor lymphocyte infusion induced remission: a retrospective study of the Clinical Trials Committee of the British Society of Blood & Marrow Transplantation (BSBMT).

scientific article

Mechanisms and novel approaches in overriding tyrosine kinase inhibitor resistance in chronic myeloid leukemia

scientific article published on March 2012

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

scientific article published on 10 January 2013

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling

scientific article published on 8 January 2013

Mixed colony formation in vitro by the heterogeneous compartment of multipotential progenitors in human bone marrow

scientific article published on 01 February 1993

Mobilization of Ph chromosome-negative peripheral blood stem cells in chronic myeloid leukaemia patients with imatinib mesylate-induced complete cytogenetic remission

scientific article published in November 2003

Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.

scientific article

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

scientific article published on 09 January 2007

No strong relationship between mannan binding lectin or plasma ficolins and chemotherapy-related infections ⬇️

scientific article published on November 1, 2003

Not so NICE for CML.

scientific article

Nuclear entrapment of BCR-ABL by combining imatinib mesylate with leptomycin B does not eliminate CD34+ chronic myeloid leukaemia cells.

scientific article published on 8 January 2009

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells

scientific article published on 05 April 2011

On the use of lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia.

scientific article published on 12 June 2008

Optimising chronic myeloid leukaemia therapy in the face of resistance to tyrosine kinase inhibitors--a synthesis of clinical and laboratory data

scientific article

Optimization of methods for the detection of BCR-ABL activity in Philadelphia-positive cells

scientific article published on 9 January 2009

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

scientific article published on 03 September 2013

Poor performance of galactomannan and mannan sandwich enzyme-linked immunosorbent assays in the diagnosis of invasive fungal infection

scientific article published in February 2005

Prediction of initial cytogenetic response for subsequent major and complete cytogenetic response to imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia

scientific article published in October 2003

Predictive response-relevant clustering of expression data provides insights into disease processes

scientific article

Prevalence and haemopoietic effects of low serum vitamin B12 levels in geriatric medical patients

scientific article published on 01 July 1997

Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.

scientific article

Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3

scientific article published on 01 February 2001

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

scientific article published in January 2002

Proceedings of the Third Global Workshop on Chronic Myeloid Leukemia

scientific article published on December 2010

Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate

scientific article

Published rather than proposed definitions for invasive fungal infection must be applied to allow standardization in clinical trials

scientific article

Punish the parent not the progeny.

scientific article

Quantitative proteomics analysis of BMS-214662 effects on CD34 positive cells from chronic myeloid leukaemia patients.

scientific article

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

scientific article

Redirecting traffic using the XPO1 police.

scientific article published in October 2013

Restricted access to second generation tyrosine kinase inhibitors in the UK could result in suboptimal treatment for almost half of chronic myeloid leukaemia patients: results from a West of Scotland and Lothian population study

article

Role of autophagy in cancer prevention, development and therapy

scientific article published on January 2013

Safety and efficacy of pulsed imatinib with or without G-CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up

scientific article published on 19 August 2013

Second-generation tyrosine kinase inhibitors improve the survival of patients with chronic myeloid leukemia in whom imatinib therapy has failed

scientific article published on 22 August 2011

Smouldering Systemic Mastocytosis Presenting with Cryptic Life-threatening Crises: Case Report and Literature Review ⬇️

scientific article published on February 1, 2012

Stage-specific alterations in serum levels of G-CSF in chronic myeloid leukaemia

scientific article published on 01 July 2003

Stem cells in chronic myeloid leukaemia.

scientific article published on January 2007

Successful haemopoietic stem cell transplantation does not correct mannan-binding lectin deficiency

scientific article published on 01 January 2005

Successful use of National Cancer Registry data to monitor the effective use of imatinib for treating chronic myeloid leukaemia.

scientific article

Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models

scientific article published on 03 March 2014

Targeted therapy in haematological malignancies

scientific article published on March 2010

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

scientific article published on 13 April 2009

Targeting autophagy potentiates tyrosine kinaseinhibitor–induced cell death in Philadelphia chromosome–positivecells, including primary CML stem cells.

scientific article

Targeting chronic myeloid leukemia stem cells

scientific article published on April 2010

Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex

scientific article published on 27 February 2013

Targeting survival pathways in chronic myeloid leukaemia stem cells

scientific article published on August 2013

Targeting the silent minority: emerging immunotherapeutic strategies for eradication of malignant stem cells in chronic myeloid leukaemia.

scientific article

Telomere shortening correlates with prognostic score at diagnosis and proceeds rapidly during progression of chronic myeloid leukemia

scientific article

The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells ⬇️

scientific article published on 12 April 2011

The Number of CD34+ Cells Mobilized into the Peripheral Blood Can Predict the Quality of Subsequent Collections

scientific article published on 01 February 2000

The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues

scientific article

The Scotland Leukaemia Registry audit of incidence, diagnosis and clinical management of new patients with chronic myeloid leukaemia in 1999 and 2000.

scientific article published in August 2004

The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors

scientific article

The chronic myeloid leukemia stem cell

scientific article published on January 2009

The chronic myeloid leukemia stem cell: stemming the tide of persistence

scientific article published on 3 February 2017

The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia

scientific article published on 5 December 2012

The storage and re-infusion of autologous blood and BM as back-up following failed primary hematopoietic stem-cell transplantation: A survey of European practice

scientific article published on 01 January 2002

The use of a risk group stratification in the management of invasive fungal infection: a prospective validation

scientific article published in February 2004

The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia

scientific article published in June 2007

Therapeutic targets in chronic myeloid leukaemia

scientific article published on June 2007

Transcriptional analysis of quiescent and proliferating CD34+ human hemopoietic cells from normal and chronic myeloid leukemia sources

scientific article published on 23 August 2007

Tyrosine kinase inhibitor independent gene expression signature in CML offers new targets for LSPC eradication therapy

Tyrosine kinase inhibitors in the treatment of chronic myeloid leukaemia: so far so good?

scientific article published in June 2001

Unique differentiation programs of human fetal liver stem cells shown both in vitro and in vivo in NOD/SCID mice.

scientific article published on October 1999

Uptake of synthetic Low Density Lipoprotein by leukemic stem cells--a potential stem cell targeted drug delivery strategy

scientific article published on 22 September 2010

Use of plasma ferritin concentration to diagnose iron deficiency in elderly patients.

scientific article published on September 1993

Use of the erythrogram in the diagnosis of iron deficiency in elderly patients

scientific article published on 01 January 1993

What is new in chronic myeloid leukaemia?

scientific article published on February 2007

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