List of works - Judith Allen

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

scientific article published on 24 April 2015

APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production

article

Alternative activation of macrophages by filarial nematodes is MyD88-independent.

scientific article published on 21 July 2012

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo

scientific article

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

scientific article

Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing

scientific article published in March 2009

Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor

scientific article

Animal models of airway inflammation and airway smooth muscle remodelling in asthma

scientific article published on 23 April 2009

Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity

scientific article

Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naïve CD4(+) T cells

scientific article published in April 2000

Beyond stem cells: self-renewal of differentiated macrophages

scientific article

Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection

scientific article published on 23 December 2007

Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans

scientific article

Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes

scientific article published on 18 October 2015

CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo

scientific article published on 01 October 2007

Candidate innate immune system gene expression in the ecological model Daphnia

scientific article

Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children

scientific article

Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells

scientific article

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage ⬇️

scientific article

Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies.

scientific article published on 17 April 2009

Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered

article

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

scientific article

Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post‐lactational regression ⬇️

scientific article published on January 27, 2012

Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes

scientific article

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

scientific article published on January 2013

Divergent roles for macrophages in lymphatic filariasis.

scientific article

Diversity and dialogue in immunity to helminths.

scientific article published on June 2011

Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline?

scientific article published on 25 September 2007

Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation

scientific article

Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection

scientific article published in January 2009

Enhanced monocyte recruitment and delayed alternative macrophage polarization accompanies impaired repair following myocardial infarction in C57BL/6 compared to BALB/c mice

scientific article published on 17 June 2019

Eosinophils Forestall Obesity

scientific article published in Science

Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.

scientific article

Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites

scientific article published on 30 April 2008

F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection

scientific article published on 01 June 2006

Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy

scientific article

Future prospects and challenges of vaccines against filariasis.

scientific article published on May 2012

Harnessing evolutionary biology to combat infectious disease

scientific article published on 6 February 2012

Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.

scientific article published on 11 July 2014

Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

scientific article published on 15 December 2023

IL-17 and neutrophils: unexpected players in the type 2 immune response.

scientific article published on 18 March 2015

IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection

scientific article published on 07 July 2020

IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype

scientific article

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

scientific article published on 07 October 2013

IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice

scientific article published in September 2002

Immunisation of mice against neosporosis

scientific article

Increased exposure to Plasmodium chabaudi antigens sustains cross-reactivity and avidity of antibodies binding Nippostrongylus brasiliensis: dissecting cross-phylum cross-reactivity in a rodent model

scientific article published on 22 October 2015

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection

scientific article

Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.

scientific article

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung

scientific article published on 04 October 2019

Inflammation-induced formation of fat-associated lymphoid clusters

scientific article published on 29 June 2015

Interactive effects of protein nutrition, genetic growth potential and Heligmosomoides bakeri infection pressure on resilience and resistance in mice.

scientific article published on 18 July 2011

Interferon gamma suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells.

scientific article published in June 2004

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths

scientific article

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

scientific article

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.

scientific article

Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite.

scientific article

Litomosoides sigmodontis: vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection

scientific article

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

scientific article published on 11 May 2017

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

scientific article

MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages

scientific article published on 29 January 2009

Macrophage activation and polarization: nomenclature and experimental guidelines

scientific article (publication date: 17 July 2014)

Macrophage origin limits functional plasticity in helminth-bacterial co-infection

scientific article

Macrophage proliferation, provenance, and plasticity in macroparasite infection

scientific article

Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro.

scientific article published on January 2003

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency

scientific article published on 21 December 2004

Mapping immune response profiles: the emerging scenario from helminth immunology.

scientific article published on December 2007

Microbiota, parasites and immunity.

scientific article

Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid.

scientific article

Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage

scientific article

Murine gammaherpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages

article

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection.

scientific article published on 4 January 2018

Of mice, cattle, and humans: the immunology and treatment of river blindness

scientific article

Over expression of IL-10 by macrophages overcomes resistance to murine filariasis

scientific article published on 19 September 2011

Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections

scientific article published on 18 September 2006

Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice

scientific article

Profound suppression of cellular proliferation mediated by the secretions of nematodes ⬇️

scientific article published on May 1, 1998

Quantifying variation in the potential for antibody-mediated apparent competition among nine genotypes of the rodent malaria parasite Plasmodium chabaudi

scientific article published on 18 September 2013

Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis.

scientific article

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

scientific article published on 05 November 2021

Requirements for in vivo IFN-gamma induction by live microfilariae of the parasitic nematode, Brugia malayi.

scientific article published on June 2000

Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.

scientific article

Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells

scholarly article

Sources of heterogeneity in human monocyte subsets

scientific article published on April 2013

Suppressive antigen-presenting cells in Helminth infection

scientific article published on 01 January 1999

Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function

scientific article published on 31 May 2011

Th1-Th2: Reliable paradigm or dangerous dogma? ⬇️

scientific article published on August 1, 1997

Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo

scientific article

The FAR proteins of filarial nematodes: secretion, glycosylation and lipid binding characteristics

scientific article

The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis

scientific article

The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an 'M2' phenotype in response to Th2 immunologic challenge.

scientific article published on 7 February 2015

The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics.

scientific article

The economy of inflammation: when is less more?

scientific article published on 15 June 2011

The gp15/400 polyprotein antigen of Brugia malayi binds fatty acids and retinoids

scientific article published in April 1995

The immune response of inbred laboratory mice to Litomosoides sigmodontis: A route to discovery in myeloid cell biology

scientific article published on 07 March 2020

The laminated layer: Recent advances and insights into Echinococcus biology and evolution

scientific article

The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo

scientific article (publication date: February 2014)

Tissue-resident macrophages

scientific article

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression.

scientific article

Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages

scientific article published on 30 July 2021

Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

scientific article published on 05 July 2013

Unconventional maturation of dendritic cells induced by particles from the laminated layer of larval Echinococcus granulosus

scientific article

Understanding the laminated layer of larval Echinococcus II: immunology.

scientific article published on 02 March 2011

Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages

scientific article

Wild immunology: converging on the real world.

scientific article published in October 2011

Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection

scientific article published on 30 November 2018

Zebrafish IL-4-like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis

scientific article published on 08 July 2020

List of works by Judith Allen

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production

Alternative activation of macrophages by filarial nematodes is MyD88-independent.

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing

Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor

Animal models of airway inflammation and airway smooth muscle remodelling in asthma

Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity

Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naïve CD4(+) T cells

Beyond stem cells: self-renewal of differentiated macrophages

Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection

Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans

Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes

CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo

Candidate innate immune system gene expression in the ecological model Daphnia

Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children

Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage ⬇️

Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies.

Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post‐lactational regression ⬇️

Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

Divergent roles for macrophages in lymphatic filariasis.

Diversity and dialogue in immunity to helminths.

Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline?

Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation

Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection

Enhanced monocyte recruitment and delayed alternative macrophage polarization accompanies impaired repair following myocardial infarction in C57BL/6 compared to BALB/c mice

Eosinophils Forestall Obesity

Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.

Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites

F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection

Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy

Future prospects and challenges of vaccines against filariasis.

Harnessing evolutionary biology to combat infectious disease

Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.

Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

IL-17 and neutrophils: unexpected players in the type 2 immune response.

IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection

IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice

Immunisation of mice against neosporosis

Increased exposure to Plasmodium chabaudi antigens sustains cross-reactivity and avidity of antibodies binding Nippostrongylus brasiliensis: dissecting cross-phylum cross-reactivity in a rodent model

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection

Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung

Inflammation-induced formation of fat-associated lymphoid clusters

Interactive effects of protein nutrition, genetic growth potential and Heligmosomoides bakeri infection pressure on resilience and resistance in mice.

Interferon gamma suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells.

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.

Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite.

Litomosoides sigmodontis: vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages

Macrophage activation and polarization: nomenclature and experimental guidelines

Macrophage origin limits functional plasticity in helminth-bacterial co-infection

Macrophage proliferation, provenance, and plasticity in macroparasite infection

Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro.

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency

Mapping immune response profiles: the emerging scenario from helminth immunology.

Microbiota, parasites and immunity.

Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid.

Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage

Murine gammaherpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection.

Of mice, cattle, and humans: the immunology and treatment of river blindness

Over expression of IL-10 by macrophages overcomes resistance to murine filariasis

Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections

Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice

Profound suppression of cellular proliferation mediated by the secretions of nematodes ⬇️

Quantifying variation in the potential for antibody-mediated apparent competition among nine genotypes of the rodent malaria parasite Plasmodium chabaudi

Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis.