List of works - Judith Allen

Macrophage activation and polarization: nomenclature and experimental guidelines

scientific article (publication date: 17 July 2014)

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

scientific article

Tissue-resident macrophages

scientific article published on September 18, 2013

Diversity and dialogue in immunity to helminths.

scientific article published on June 2011

Beyond stem cells: self-renewal of differentiated macrophages

scientific article

Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

scientific article published on 05 July 2013

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

scientific article published on 07 October 2013

IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype

scientific article

Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.

scientific article

Th1-Th2: Reliable paradigm or dangerous dogma?

scientific article published on August 1, 1997

Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro.

scientific article published on January 2003

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

scientific article published on January 2013

Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells

scientific article

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

scientific article

Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function

scientific article published on 31 May 2011

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

scientific article

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency

scientific article published on 21 December 2004

The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis

scientific article

Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection

scientific article published in January 2009

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo

scientific article

Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.

scientific article published on 11 July 2014

Mapping immune response profiles: the emerging scenario from helminth immunology.

scientific article published on December 2007

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

scientific article

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

scientific article

Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing

scientific article published in March 2009

CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo

scientific article published on 01 October 2007

Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells

scholarly article

Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.

scientific article

The economy of inflammation: when is less more?

scientific article published on 15 June 2011

Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans

scientific article

Profound suppression of cellular proliferation mediated by the secretions of nematodes

scientific article published on May 1, 1998

APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production

article

F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection

scientific article published on 01 June 2006

Of mice, cattle, and humans: the immunology and treatment of river blindness

scientific article

Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.

scientific article

Inflammation-induced formation of fat-associated lymphoid clusters

scientific article published on 29 June 2015

Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naïve CD4(+) T cells

scientific article published in April 2000

Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy

scientific article

Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies.

scientific article published on 17 April 2009

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

scientific article published on 11 May 2017

IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice

scientific article published in September 2002

Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post‐lactational regression

scientific article published on January 27, 2012

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

scientific article

Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite.

scientific article

Divergent roles for macrophages in lymphatic filariasis.

scientific article

Understanding the laminated layer of larval Echinococcus II: immunology.

scientific article published on 02 March 2011

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

scientific article published on 24 April 2015

The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics.

scientific article

Macrophage proliferation, provenance, and plasticity in macroparasite infection

scientific article

Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages

scientific article published on 24 May 2006

List of works by Judith Allen

Macrophage activation and polarization: nomenclature and experimental guidelines

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

Tissue-resident macrophages

Diversity and dialogue in immunity to helminths.

Beyond stem cells: self-renewal of differentiated macrophages

Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype

Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.

Th1-Th2: Reliable paradigm or dangerous dogma?

Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro.

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency

The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis

Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo

Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.

Mapping immune response profiles: the emerging scenario from helminth immunology.

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing

CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo

Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells

Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.

The economy of inflammation: when is less more?

Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans

Profound suppression of cellular proliferation mediated by the secretions of nematodes

APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production

F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection

Of mice, cattle, and humans: the immunology and treatment of river blindness

Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.

Inflammation-induced formation of fat-associated lymphoid clusters

Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naïve CD4(+) T cells

Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy

Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies.

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice

Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post‐lactational regression

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite.

Divergent roles for macrophages in lymphatic filariasis.

Understanding the laminated layer of larval Echinococcus II: immunology.

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics.

Macrophage proliferation, provenance, and plasticity in macroparasite infection

Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages