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List of works by Philippe Froguel

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

article

8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3–5 October 2016

article

A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes

scientific article published on July 2004

A Genetic Study of the Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) Genes and Stature

article

A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity

article

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

scientific article published on 24 March 2017

A Novel Rare Missense Variation of the Gene: Evidencesof Implication in Crohn's Disease

article

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

scientific article published in February 2006

A Rare Variant in the Visfatin Gene (NAMPT/PBEF1) Is Associated With Protection From Obesity

article

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A central role for GRB10 in regulation of islet function in man.

scientific article published on 3 April 2014

A de novo synonymous variant in EFTUD2 disrupts normal splicing and causes mandibulofacial dysostosis with microcephaly: case report

scientific article published on 17 September 2020

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism

scientific article

A frameshift mutation in human MC4R is associated with a dominant form of obesity ⬇️

scientific article published on October 1, 1998

A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q

scientific article

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

article

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A genome-wide association meta-analysis identifies new childhood obesity loci

scientific article

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A genome-wide association study identifies novel risk loci for type 2 diabetes

scientific article

A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels

scientific article (publication date: 2012)

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

scientific article published on 05 September 2010

A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2.

scientific article

A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27 ⬇️

scientific article published on November 15, 2001

A girl with incomplete Prader-Willi syndrome and negative MS-PCR, found to have mosaic maternal UPD-15 at SNP array.

scientific article

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes.

scientific article

A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes

scientific article

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus

scientific article published on February 1998

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction ⬇️

scientific article published on March 26, 1998

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

scientific article

A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity

scientific article published on 03 June 2014

A novel NEUROG3 mutation in neonatal diabetes associated with a neuro-intestinal syndrome.

scientific article

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

scientific article published in May 2008

A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population

scientific article published in April 2004

A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family

scientific article published in December 2002

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults

scientific article

A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q.

scientific article published in February 1999

A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents

scientific article published on 30 October 2007

A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians

scientific article published on 01 August 2005

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

scientific article published on 01 October 2019

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

scientific article

A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children

scientific article published in August 2002

ACDC/Adiponectin Polymorphisms Are Associated With Severe Childhood and Adult Obesity

scientific article published on 01 February 2006

ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity

scientific article published on 01 December 2005

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

scientific article

Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry

scientific article

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

scientific article

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits

scientific article published on March 2007

Adipocytokins, obesity and development of type 2 diabetes

scientific article published in December 2005

Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study

scientific article

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

scientific article

Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies

scientific article

Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines

scientific article

Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men.

scientific article published on 21 December 2012

Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study

scientific article published on 8 May 2012

Allelic variation in exon 18 of the sulfonylurea receptor 1 (SUR1) gene, insulin secretion and insulin sensitivity in nondiabetic relatives of type 2 diabetic subjects.

scientific article published in June 2002

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

scientific article

Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level

scientific article published on 26 January 2014

An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort

scientific article published in November 2000

Analysis of KLF transcription factor family gene variants in type 2 diabetes

scientific article

Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population

scientific article published on 5 May 2006

Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study

scientific article

Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population

scientific article

Analysis of the SIM1 contribution to polygenic obesity in the French population

scientific article

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.

scientific article

Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?

scientific article published on 02 July 2013

Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases

article

Assessment of insulin sensitivity in glucokinase-deficient subjects.

scientific article

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

scientific article (publication date: November 2010)

Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children

scientific article published on 31 October 2007

Association between high von Willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes

article

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

scientific article published on 14 July 2013

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of Melanin-Concentrating Hormone Receptor 1 5' Polymorphism With Early-Onset Extreme Obesity

scientific article published on 26 September 2005

Association of gene variants with susceptibility to type 2 diabetes among Omanis

scientific article

Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children ⬇️

scientific article published on 22 April 2011

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity

scientific article published on 14 July 2011

Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population

scientific article

Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses

article

Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity

scientific article published on 22 January 2009

Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths.

scientific article

Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians

scientific article published in October 2006

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.

scientific article published on 14 November 2014

Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice

scientific article

Bio-Repository of DNA in stroke (BRAINS): a study protocol

scientific article

Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes

scientific article published on March 2009

C-Jun amino terminal kinase 3 (JNK3) contrôle la masse fonctionnelle de la cellule bêta en réponse à l’obésité

scientific article published in March 2017

CA repeat polymorphism in the glucose transporter GLUT 2 gene ⬇️

scientific article published on July 11, 1991

CDKN2B expression and subcutaneous adipose tissue expandability: possible influence of the 9p21 atherosclerosis locus

scientific article published on 25 March 2014

CO-68: L'étude génomique et fonctionnelle des gènes du diabète de type 2 confirme leur rôle dans les cellules beta-pancréatiques

scientific article published in March 2016

Cdkn2a deficiency promotes adipose tissue browning

scientific article published in December 2017

Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects

scientific article published on 4 July 2013

Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis

scientific article

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

scientific article published in August 2014

Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM

scientific article

Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM

article

Characterization of the human SLC30A8 promoter and intronic enhancer

scientific article published on 30 September 2011

Childhood obesity is associated with shorter leukocyte telomere length

scientific article

Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems

Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study

scientific article published on 09 October 2020

Clinical and metabolic features of adult-onset diabetes caused by ABCC8 mutations

scientific article published on 30 December 2011

Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).

scientific article

Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation

scientific article

Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes

scientific journal article

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

scientific article

Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

scientific article published in October 1995

Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

scientific article (publication date: October 1995)

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

scientific article published on March 12, 1992

CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability.

scientific article published on 16 May 2018

Coexistence in the Same Family of Both Focal and Diffuse Forms of Hyperinsulinism

article

Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease

scientific article published on 3 November 2017

Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.

scientific article

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations

scientific article published on 3 March 2009

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

scientific article published in Science

Comment on Beltrand et al. Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations. Diabetes Care 2015;38:2033-2041.

scientific article published in September 2016

Comment on: Valette et al. Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery. PLOS ONE 2012; 7(11):E48221.

scientific article

Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians

scientific article published in January 2005

Common genetic variants and risk of brain injury after preterm birth.

scientific article

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

scientific article

Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians

scientific article published on 03 August 2009

Common nonsynonymous variants in PCSK1 confer risk of obesity

article

Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians

scientific article published in October 2005

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scientific article

Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population

scientific article

Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations

scientific article published on 3 May 2013

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

scientific article (publication date: 12 February 2012)

Common variation in SIM1 is reproducibly associated with BMI in Pima Indians

scientific article published on 28 April 2009

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects

scientific article (publication date: March 2007)

Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population

scientific article

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

scientific article published on 23 October 2012

Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications

scientific article published on 20 November 2019

Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels

scientific article published on 29 May 2015

Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study

scientific article

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children

scientific article published on 27 March 2017

Correction: Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets.

scientific article

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 23 August 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Corrigendum to “High prevalence of leptin and melanocotin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families” [Mol. Genet. Metab. 106/1 (2012) 121–126]

article

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scholarly article published in Nature Genetics

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

scientific article published on 7 July 2016

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

scientific article

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice ⬇️

scientific article published on May 15, 1998

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

scientific article

Detection of human adaptation during the past 2000 years

scientific article

Determination of peritoneal glucose kinetics in rats: implications for the peritoneal implantation of closed-loop insulin delivery systems

scientific article

Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q.

scientific article published in September 1996

Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.

scientific article published in January 2007

Diabète néonatal (monogénique de la très petite enfance). État des travaux du Réseau Français d’étude du diabète néonatal

scientific article published in March 2012

Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study.

scientific article published on 3 May 2011

Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue.

scientific article

Direct estimates of natural selection in Iberia indicate calcium absorption was not the only driver of lactase persistence in Europe

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

scientific article published on 15 June 2019

Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?

scientific article published on 23 October 2017

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

scientific article

Disruption of adiponectin causes insulin resistance and neointimal formation

scientific journal article

Dissection of an inverted X(p21.3q27.1) chromosome associated with mental retardation.

scientific article published in January 2003

Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women

scientific article published on 24 July 2006

Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS

scientific article published in PLoS ONE

Does Type 2 diabetes increase the risk of developing cancer?

scientific article published in November 2013

Does the −11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families?

article

Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine

scientific article published on December 2003

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

scientific article

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

scientific journal article

EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families

scientific article

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study

article by D. Meyre et al published 18 August 2007 in Diabetologia

ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes

scientific article published in March 2006

Early detrimental metabolic outcomes of rs17300539-A allele of ADIPOQ gene despite higher adiponectinemia

scientific article published on 5 November 2009

Early metabolic markers identify potential targets for the prevention of type 2 diabetes

scientific article published on 08 June 2017

Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A 6-Year Prospective Study

scientific article

Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population

scientific article

Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death

scientific article published on 21 November 2019

Effect of common polymorphisms in the HNF4? promoter on susceptibility to type 2 diabetes in the French Caucasian population

article

Effects of TCF7L2 polymorphisms on obesity in European populations

scientific article published on February 2008

Effects of genetic susceptibility for type 2 diabetes on the evolution of glucose homeostasis traits before and after diabetes diagnosis: data from the D.E.S.I.R. Study

scientific article

Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes

scientific article published on 22 September 2020

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations

scientific article published on 28 March 2008

Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL

scientific article

Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway

scientific article

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

scientific article published on 11 June 2021

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

scientific article

Epigenome-wide association study of adiposity and future risk of obesity-related diseases

article by Gianluca Campanella et al published 1 May 2018 in International Journal of Obesity

Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans

scientific article published on 01 November 2006

Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scholarly article published in Nature Genetics

Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

scholarly article by Johan Rung et al published October 2009 in Nature Genetics

Erratum: Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population.

scientific article

Erratum: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

article

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

scholarly article published in Obesity

Erratum: corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

scientific article published in Nature

Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts

scientific article

Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose

scientific article published in November 2008

European genetic variants associated with type 2 diabetes in North African Arabs

scientific article

Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population

article

Evaluating the association of common APOA2 variants with type 2 diabetes

scientific article

Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids

scientific article published on 10 November 2007

Evaluating the association of common PBX1 variants with type 2 diabetes

scientific article

Evaluation of A2BP1 as an obesity gene ⬇️

scientific article

Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians

scientific article published on 22 April 2008

Evidence for leptin receptor isoforms heteromerization at the cell surface

scientific article

Evidence for tuning adipocytes ICER levels for obesity care

scientific article published on July 2012

Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.

scientific article

Examining the Candidacy of Ghrelin as a Gene Responsible for Variation in Adult Stature in a United Kingdom Population with Type 2 Diabetes

article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

scientific article published on 19 November 2012

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

scientific article

Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors

scientific article

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

scientific article published on 21 May 2007

Familial early-onset diabetes is not a typical MODY in several Tunisian patients

scientific article published on December 1, 2012

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus

scientific article

Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations

scientific article published on 9 January 2011

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

Fine-scale human genetic structure in Western France

scientific article published on 3 September 2014

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

scientific article published on 25 September 2018

Fostering improved human islet research: a European perspective

scientific article published on 13 June 2019

From obesity genetics to the future of personalized obesity therapy

scientific article

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study

scientific article

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans

scientific article published on 26 March 2009

GAD2 on chromosome 10p12 is a candidate gene for human obesity

scientific article

GAD2: A polygenic contribution to genetic susceptibility for common obesity?

GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes

scientific article published on 18 July 2012

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

scientific article

Gender effect of the Trp64Arg mutation in the beta 3 adrenergic receptor gene on weight gain in morbid obesity

scientific article published on November 1, 1997

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

scientific article

General regression model: A "model-free" association test for quantitative traits allowing to test for the underlying genetic model

scientific article published on 13 December 2019

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation.

scientific article published on 25 July 2017

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation.

scientific article published on 7 March 2018

Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence (≥49%) in an Inbred Population of Pakistan

scientific article published on 29 April 2020

Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

scientific article published on 16 December 2019

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease

scientific article

Genetic Study of the Melanin-Concentrating Hormone Receptor 2 in Childhood and Adulthood Severe Obesity

article by Maya Ghoussaini et al published November 2007 in The Journal of Clinical Endocrinology and Metabolism

Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population

scientific article published on 01 March 2006

Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C.

scientific article published on 27 May 2008

Genetic and clinical characterisation of maturity-onset diabetes of the young in Spanish families

scientific article

Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

scientific article published on 9 July 2010

Genetic approaches to the molecular understanding of type 2 diabetes

scientific article

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

scientific article published on 24 August 2015

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic associations with human longevity at the APOE and ACE loci

scientific article published in January 1994

Genetic basis of maturity-onset diabetes of the young

scientific article

Genetic determinants of leucocyte telomere length in children: a neglected and challenging field

scientific article published on February 2015

Genetic determinants of non-insulin-dependent diabetes mellitus: strategies and recent results

scientific article published on February 1997

Genetic determinants of type 2 diabetes

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Genetic determinants of type 2 diabetes mellitus: lessons learned from family studies.

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Genetic evidence of assortative mating in humans

scholarly article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

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Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome

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Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

scientific article published in Nature

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

scientific article published on 30 June 2006

Genetic studies of body mass index yield new insights for obesity biology

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Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity ⬇️

scientific article published on June 1, 1997

Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery

scientific article published on June 1, 1998

Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families ⬇️

scientific article published on October 1, 1997

Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians

scientific article published in April 1997

Genetic study of the CD36 gene in a French diabetic population

scientific article published in November 2004

Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10.

scientific article published in November 1997

Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits

scientific article published on 03 August 2009

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

scientific article published on 6 September 2009

Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population.

scientific article published on 14 July 2015

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity

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Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population

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Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients ⬇️

scientific article published on January 1, 2002

Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs

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Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs

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Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes

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Genetics of Pathways Regulating Body Weight in the Development of Obesity in Humans ⬇️

scientific article published on December 1, 2001

Genetics of human obesity

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Genetics of obesity

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Genetics of obesity and the prediction of risk for health

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Genetics of obesity: towards the understanding of a complex syndrome.

scientific article published in March 2000

Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians

scientific article published on 01 November 2004

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

scientific article published on 01 July 2019

Genome-wide Linkage Analysis for Severe Obesity in French Caucasians Finds Significant Susceptibility Locus on Chromosome 19q

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Genome-wide analysis identifies 12 loci influencing human reproductive behavior

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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

scientific article published on 24 November 2015

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

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Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

scientific article

Genome-wide association study identifies five loci associated with lung function

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Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

scientific article published on 16 October 2011

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

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Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 27 April 2017

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p

scientific article published on 01 April 2002

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

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Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)

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Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).

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Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

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Genomic insights into the origin of farming in the ancient Near East

scientific article (publication date: 25 August 2016)

Genotype-by-nutrient interactions assessed in European obese women

scientific article published on 01 November 2006

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

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Glucokinase as pancreatic beta cell glucose sensor and diabetes gene

scientific article published on November 1993

Glucokinase gene mutations are not a common cause of permanent neonatal diabetes in France

scientific article published in March 2002

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships

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Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene

scientific article published on September 1998

Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity

scientific article (publication date: 2012)

Hepatic DPP4 DNA Methylation Associates With Fatty Liver.

scientific article published on 10 October 2016

Hepatocyte Nuclear Factor-4 P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population

scientific article published on 01 May 2006

Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group

scientific article published on 2 January 2008

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

scientific article published on 30 December 2011

High Prevalence of Rare Monogenic Forms of Obesity in Obese Guadeloupean Afro-Caribbean Children

scientific article published on 5 December 2017

High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families.

scientific article published on 10 March 2012

Highly sensitive diagnosis of 43 monogenic forms of diabetes or obesity through one-step PCR-based enrichment in combination with next-generation sequencing

scientific article published on 16 September 2013

Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect

scientific article published on 14 May 2020

Historical Overview of Gene Discovery Methodologies in Type 2 Diabetes

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How Recent Advances in Genomics Improve Precision Diagnosis and Personalized Care of Maturity-Onset Diabetes of the Young

scientific article published on 05 August 2019

Human diabetes and obesity: tracking down the genes

scientific article published in February 1995

Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease.

scientific article

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus ⬇️

scientific article published on August 15, 1992

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

scientific article published on 7 November 2011

Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity

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INS VNTR is not associated with childhood obesity in 1,023 families: a family-based study

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ITIH-5 expression in human adipose tissue is increased in obesity.

scientific article

Identification de 4 nouveaux gènes à risque de diabète de type 2 modulant la fonction β pancréatique et l’insulino-sécrétion

scientific article published in March 2017

Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1.

scientific article

Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene

scientific article

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

scientific article published in 2023

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients

scientific article

Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans

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Identification of trinucleotide repeat-containing genes in human pancreatic islets

scientific article

Identification of trinucleotide repeat-containing genes in human pancreatic islets

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Identification of two novel loss-of-function SIM1 mutations in two overweight children with developmental delay

scientific article published on 19 September 2014

Impact of a CART promoter genetic variation on plasma lipid profile in a general population

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study

scientific article published on 31 October 2007

Impact of common variation in bone-related genes on type 2 diabetes and related traits

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Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling

scientific article published on 23 August 2016

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

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Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects

scientific article

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function

scientific article published on 05 October 2016

Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

scientific article published on 23 July 2003

Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population

scientific article

Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors

scientific article

Improved protocol for laser microdissection of human pancreatic islets from surgical specimens

scientific article

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

scientific article

Indication for linkage of the human OB gene region with extreme obesity

scientific article

Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity

scientific article published on 21 July 2013

Inferring combined CNV/SNP haplotypes from genotype data

scientific article

Inflammation is associated with a decrease of lipogenic factors in omental fat in women

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Inflammatory role of Toll-like receptors in human and murine adipose tissue

scientific article

Inputs from the genetics of fasting glucose: lessons for diabetes

scientific article published in November 2009

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus

scientific article

Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

scientific article

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

scientific article

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

scientific article published in Nature

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity

scientific article

Integration of clinical data with a genome-scale metabolic model of the human adipocyte

scientific article

Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study

scientific article published on 25 April 2016

Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms

scientific article

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

scientific article published on January 2003

Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine

scientific article published on December 2010

Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants

scientific article published on 14 March 2011

Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?

scientific article published on 25 January 2005

Is obesity our genetic legacy?

scientific article

Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease

scientific article

Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]

scientific article (publication date: July 1994)

Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose.

scientific article published on 14 June 2018

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

scientific article published on 20 April 2016

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

scientific article

Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients

scientific article published in October 2004

Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta-Analysis in 9,973 European Subjects

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Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population

scientific article published on 6 September 2007

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Leptin Receptor Gene in a Large Cohort of Massively Obese Subjects: No Indication of the fa/fa Rat Mutation. Detection of an Intronic Variant with No Association with Obesity ⬇️

scientific article published on March 1, 1998

Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women

scientific article published in April 2007

Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families

scientific article

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q

scientific article (publication date: July 2009)

Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).

scientific article published on 14 April 2008

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

scientific article published on 25 June 2009

Loss-of-function mutations in ADCY3 cause monogenic severe obesity

scientific article published on 8 January 2018

Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population

scientific article published on 26 March 2012

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

scientific article published on 07 November 2019

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features

scientific article published on 17 June 2013

Low copy number of the salivary amylase gene predisposes to obesity.

scientific article published on 30 March 2014

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

scientific article

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk

scientific article published on 30 December 2011

MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue

scientific article published on 25 July 2018

MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells

scientific article published on 20 October 2009

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

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Macrophage gene expression in adipose tissue is associated with insulin sensitivity and serum lipid levels independent of obesity.

scientific article published on 13 June 2013

Maternal diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensitivity

scientific article published in August 2000

Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associates with a single point mutation in the mitochondrial tRNA(Leu(UUR)) gene

scientific article published in June 1994

Maturity-onset diabetes of the young (MODY), MODY genes and non-insulin-dependent diabetes mellitus

scientific article published on March 1997

Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986

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Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes

scientific article published on 13 July 2013

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

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Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

scientific article published on 07 May 2020

Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity*

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Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

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Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle

scientific article published on 30 June 2021

Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

scientific article published on 23 October 2009

Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes

scientific article

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

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Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online

scientific article published in November 2007

Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome.

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Molecular genetics of human obesity-associated MC4R mutations

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Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes

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Monogenic diabetes: Implementation of translational genomic research towards precision medicine

scientific article published on 7 July 2016

Monogenic forms of diabetes mellitus: an update

scientific article published on December 2009

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition

scientific article published on 23 February 2012

Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels

scientific article

Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.

scientific article published on September 2010

Mutation screening in 18 Caucasian families suggest the existence of other MODY genes

article

Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease.

scientific article published in November 2000

Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians ⬇️

scientific article published on May 1, 1998

Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children

article

Mutations exomiques rares transmises au sein de familles de type MODY : analyse de corrélation avec la variabilité phénotypique et les défauts métaboliques précoces

scientific article published in March 2017

Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction

scientific article published on 24 February 2009

Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians

scientific article published on 9 May 2003

NACHO: an R package for quality control of NanoString nCounter data

scientific article published on 01 February 2020

Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians

scientific article published in June 2001

Neonatal diabetes: a disease linked to multiple mechanisms

scientific article published on 10 October 2007

Neonatal hyperglycaemia and abnormal development of the pancreas.

scientific article published on February 2008

Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected].

scientific article

New ABCC8 mutations in relapsing neonatal diabetes and clinical features

scientific article

New gene functions in megakaryopoiesis and platelet formation

scientific article published on 30 November 2011

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck ⬇️

scientific article published on July 29, 2013

No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians

scientific article (publication date: April 2002)

No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases

article

No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France

article

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

scientific article published on 13 March 2012

No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects

article

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene

article

Novel LEPR mutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing.

scientific article

Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity

scientific article

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

scientific article published on 12 October 2020

O06 Le mutant perte de fonction p.R46L de PCSK9 n’est pas associé à un risque accru de diabète chez l’homme

scientific article published in March 2015

O2 L’extinction de la biosynthèse d’insuline via l’altération d’un site de fixation du facteur de transcription KLF11 entraîne une forme congénitale de diabète néonatal

scientific article published in March 2011

O31 Deux scores de risque génétique sont fortement associés aux variations de glycémie à jeun et à l’incidence d’hyperglycémie et de diabète de type 2 dans l’étude prospective D.E.S.I.R

scientific article published in March 2014

O5 Des mutations du gène de la préproinsuline altèrent la maturation de l’insuline et entraînent un diabète non auto-immun chez l’enfant et de type Mody

scientific article published in March 2009

O5 La lysine acetyl-transferase P300/CBP-associated factor (PCAF) contrôle la sécrétion d’insuline et la réponse au stress du reticulum

scientific article published in March 2014

O50 La protéine P300/CBP-associated factor (PCAF) est une histone acetyl-transferase qui contrôle la fonction de la cellule ß pancréatique

scientific article published in March 2013

O52 L’activité enzymatique plasmatique de l’amylase pancréatique est associée à une diminution de l’indice de masse corporelle et protège du risque de diabète dans la cohorte D.E.S.I.R

scientific article published in March 2015

O53 L’altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l’Homme et la Souris

scientific article published in March 2012

O57 Des variations du nombre de copies au niveau d’un CNV fréquent contribuent très fortement au risque d’obésité

scientific article published in March 2012

O58 Une nouvelle cause curable de MODY et de DT2 de l’adulte jeune révélée par une mutation de KCNJ11, codant la sous-unité Kir6.2 du canal potassique ATP-dépendant

scientific article published in March 2012

O59 Identification de nouvelles mutations associées au diabète néonatal grâce à l’utilisation de techniques (pan) génomiques incluant le séquençage de nouvelle génération

scientific article published in March 2015

O61 Le diabète de type 2 est responsable d’anomalies chromosomiques somatiques en mosaïques qui sont pré-cancéreuses

scientific article published in March 2013

O9 L’Extinction de l’Activité du Promoteur du Gène de l’Insuline Entraîne une Forme Congénitale de Diabète Néonatal Transitoire

scientific article published in March 2010

O97 Des variants du gène MTNR1B du récepteur 2 à la mélatonine augmentent la glycémie et le risque de DT2 : un lien entre le rythme circadien et le diabète ?

scientific article published in March 2009

O98 Des variants du promoteur du gène G6PC2 pourraient expliquer la contribution de ce locus au contrôle génétique de la glycémie

scientific article published in March 2009

Obesity status modifies the association between rs7556897T>C in the intergenic region SLC19A3-CCL20 and blood pressure in French children

scientific article published on 01 April 2020

Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women

scientific article

Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study

scientific article

P128 Identification de nouveaux polymorphismes génétiques associés au risque de diabète de type 2 chez les obèses et non obèses européens

P202 Utilisation des cellules souches somatiques pour modéliser le diabète monogénique lié aux anomalies du canal potassique de KCNJ11

scientific article published in March 2015

P210 Nouvelles Approches dans l’Étude des Diabètes Monogéniques chez l’Enfant et l’Adulte Jeune, et Distribution des Étiologies Génétiques à partir de la Cohorte du Réseau d’Étude Français

scientific article published in March 2010

P222 Expression différentielle de transcrits alternatifs de TCF7L2 dans le foie humain diabétique, et leur induction par l’insuline dans les cellules hépatiques HepG2

PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population

scientific article

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

scientific article published on 28 November 2016

PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women

scientific article

PO11 Deux nouveaux loci associés au diabète de type 2 dans la population mexicaine identifiés par les puces Metabochip

scientific article published in March 2015

PO13 Identification par séquençage de nouvelle génération de deux nouvelles mutations situées dans LEPR, chez des enfants pakistanais avec une obésité sévère et issus de familles consanguines

scientific article published in March 2014

PO27 Diagnostic moléculaire simultané de 43 formes monogéniques de diabète et d’obésité : un pas vers la médecine métabolique Personnalisée

scientific article published in March 2013

Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes

scientific article published on January 1997

Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts

scientific article

Pathogenic variants in actionable MODY genes are associated with type 2 diabetes

scientific article published on 12 October 2020

Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes.

scientific article published on 27 November 2013

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

scientific article published on 01 December 2020

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

scientific article published on 29 October 2019

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

scientific article

Physiopathologie du diabète

scientific article published in May 2018

Placental antiangiogenic prolactin fragments are increased in human and rat maternal diabetes

article

Pluripotent stem cells as a potential tool for disease modelling and cell therapy in diabetes.

scientific article published on June 2014

Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians

scientific article

Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes

scientific article

Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes

scientific article published in May 2002

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

scientific article published in 2008

Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis

scientific article

Preadipocyte response and impairment of differentiation in an inflammatory environment

scientific article published on 19 March 2007

Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

scientific article

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans

scientific article published on 9 April 2008

Prevalence of loss-of-function FTO mutations in lean and obese individuals

scientific article

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

scientific article published on 16 June 2008

Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetes

scientific article published in February 2002

Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young

scientific article published in August 1992

Promoter polymorphism T(-107)C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients

scientific article

R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population

article

RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells

scientific article

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

scientific article published on 29 January 2012

Rare and common genetic events in type 2 diabetes: what should biologists know?

scientific article

Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity

scientific article

Rare variants identified in the HNF-4α β-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes

article by S. Mitchell et al published 19 July 2002 in Diabetologia

Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.

scientific article published on 6 December 2012

Recherche translationnelle : médecine personnalisée, médecine de précision, thérapies ciblées : marketing ou science ?

article by Pierre Marquet et al published January 2015 in Thérapie

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

scientific article published on 9 April 2018

Reflections on the field of metabolism

scientific article published on 01 April 2015

Regulation of carboxylesterase 1 (CES1) in human adipose tissue

scientific article published on 28 March 2009

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

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Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.

scientific article

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

scientific article

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

Response to comment on: Marquez et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2012;61:524-530.

scientific article published in September 2012

Response to the letter to the editor: “HIF-1α protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity,” by Trayhurn et al

Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions

scientific article published on 06 February 2014

Role of the DGAT Gene C79T Single‐Nucleotide Polymorphism in French Obese Subjects ⬇️

scientific article published on October 1, 2003

Role of the unfolded protein response in β cell compensation and failure during diabetes

scientific article published on 09 April 2014

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function

scientific article

SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts

scientific article published on 01 August 2004

Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS

scientific article

Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity

scientific article

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Seventy-five genetic loci influencing the human red blood cell

scientific article published on 5 December 2012

Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study

scientific article published on 28 April 2009

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

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Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis.

scientific article

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity

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Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects

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Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects

scientific article published on 3 July 2004

Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians

scientific article published in October 2002

Small deletion variants have stable breakpoints commonly associated with alu elements.

scientific article

Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height

scientific article published on 12 January 2009

Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass

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Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

scientific article

Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids

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Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants

scientific journal article

Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population

scientific article

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.

scientific article

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

scientific article published on 28 November 2017

TCF7L2 genetic defect and type 2 diabetes

scientific article published on April 2008

TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia

scientific article

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

scientific article published on 3 May 2007

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

scientific article

TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

scientific article

TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet

scientific article published on 23 December 2009

TCF7L2 splice variants have distinct effects on beta-cell turnover and function

scientific article published on 28 February 2011

TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study

scientific article

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss

scientific article

The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients

scientific article published in January 1997

The Case | Hypokalemia and severe renal loss of sodium

scientific article published on 01 June 2020

The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm

scientific article published in September 2016

The EIF2AK3 gene region and type I diabetes in subjects from South India

scientific article

The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon

scientific article published on June 1996

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development

scientific article published on 18 March 2020

The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resi

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The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population

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The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects

scientific article published on 18 April 2009

The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate

scientific article published on 22 March 2013

The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus

scientific article published in July 2004

The case for too little melatonin signalling in increased diabetes risk

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The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population

scientific article

The emerging genetics of type 2 diabetes

scientific article published on 20 August 2010

The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward

scientific article published on 06 August 2019

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

scientific journal article

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

scientific article

The genetic abnormality in the beta cell determines the response to an oral glucose load

scientific article published in March 2002

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The genetic contribution to non-syndromic human obesity

scientific article

The genetic structure of the world's first farmers

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

scientific article

The genetics of adiponectin ⬇️

scientific article published on April 1, 2003

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The genetics of human obesity

scientific article

The genetics of non-insulin-dependent diabetes mellitus: tools and aims

scientific article published on October 1994

The genetics of non-insulin-dependent diabetes mellitus: tools and aims

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The imprinted gene neuronatin is regulated by metabolic status and associated with obesity.

scientific article

The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size

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The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

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The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis

scientific article published on April 2012

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis

scientific article published on 7 June 2015

The power of the extreme in elucidating obesity

scientific article published in August 2008

The trans-ancestral genomic architecture of glycemic traits

The unique clinical spectrum of maturity onset diabetes of the young type 3.

scientific article published on 28 October 2017

TheFTOGene Is Associated With Adulthood Obesity in the Mexican Population

scientific article published on 31 July 2008

TheINSVNTR Locus Does Not Associate with Smallness for Gestational Age (SGA) but Interacts with SGA to Increase Insulin Resistance in Young Adults

scholarly article by Thuy-Ai Vu-Hong et al published June 2006 in The Journal of Clinical Endocrinology and Metabolism

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

scientific article published on 23 February 2016

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

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Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

scientific article

Transcription profiling in the liver of undernourished male rat offspring reveals altered lipid metabolism pathways and predisposition to hepatic steatosis

scientific article published on 22 October 2019

Translational research: precision medicine, personalized medicine, targeted therapies: marketing or science?

scientific article

Transmission of Type 2 diabetes to sons and daughters: the D.E.S.I.R. cohort.

scientific article published on 9 August 2017

Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scientific article

Two Caucasian Families with the Hepatocyte Nuclear Factor-1Alpha Mutation Tyr218Cys

Two Taql RFLPs at the GLUT2 locus in French Caucasian population ⬇️

scientific article published on October 25, 1991

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups

scientific journal article

Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium

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Type 2 diabetes-associated variants of the MT melatonin receptor affect distinct modes of signaling

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

scientific article published on 4 June 2014

Type 2 diabetes–associated variants of the MT2melatonin receptor affect distinct modes of signaling

Understanding the rising incidence of type 2 diabetes in adolescence

scientific article

VNTR polymorphism of the insulin gene and childhood overweight in a general population

scientific article published in March 2004

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

scientific article

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

scientific article published on 17 July 2005

Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q

article

Variation in FTO contributes to childhood obesity and severe adult obesity

scientific article

Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.

scientific article

Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients

scientific article

What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity?

scientific article published on 23 November 2015

What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?

scientific article

Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene

scientific article

[Adipocytokins, obesity and development of type 2 diabetes]. ⬇️

scientific article published in August 2003

[Obesity genes and their effect on the energy balance]

scientific article published in November 2015

[Something new in the genetics of monogenic obesity and its insights into pathophysiology]

scientific article published on 07 October 2020

beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations

scientific article

cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs

scientific article published on 30 May 2010

famCNV: copy number variant association for quantitative traits in families.

scientific article

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