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List of works by William M Pardridge

A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease

scientific article published on 05 December 2019

A Direct In Vitro Demonstration of Insulin Binding to Isolated Brain Microvessels

scientific article published on 01 September 1981

AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys

scientific article published on 06 September 2009

Abeta(1-40) peptide radiopharmaceuticals for brain amyloid imaging: (111)In chelation, conjugation to poly(ethylene glycol)-biotin linkers, and autoradiography with Alzheimer's disease brain sections.

scientific article

Absence of albumin receptor on brain capillaries in vivo or in vitro

scientific article

Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes

scientific article

Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport

scientific article published in November 1987

Advances in cell biology of blood-brain barrier transport

scientific article published on December 1, 1991

Alanine metabolism in skeletal muscle in tissue culture

scientific article published on June 1979

Alzheimer's disease drug development and the problem of the blood-brain barrier

scientific article published on September 2009

Alzheimer's disease: future drug development and the blood-brain barrier

scientific article published on 04 June 2019

Amplification of gene expression using both 5'- and 3'-untranslated regions of GLUT1 glucose transporter mRNA.

scientific article published in January 1999

Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels

scientific article

An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain.

scientific article published on October 1999

An electron microscopic immunogold analysis of developmental up-regulation of the blood-brain barrier GLUT1 glucose transporter

scientific article published in September 1993

Androgens and sexual behavior

scientific article

Antibodies to blood-brain barrier bind selectively to brain capillary endothelial lateral membranes and to a 46K protein

scientific article published in April 1986

Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology

scientific article

Antisense gene therapy of brain cancer with an artificial virus gene delivery system

scientific article published in July 2002

Antisense imaging of gene expression in the brain in vivo

scientific article published in December 2000

Antisense radiopharmaceuticals – agents for imaging gene expression

article

Antisense-mediated down-regulation of the human huntingtin gene

scientific article published on October 2000

Arginine metabolism and urea synthesis in cultured rat skeletal muscle cells

scientific article published on 01 February 1982

Astrocyte growth stimulation by a soluble factor produced by cerebral endothelial cells in vitro

scientific article published in November 1990

Augmented transport and metabolism of sex steroids in lymphoid neoplasia in the rat.

scientific article published in March 1987

BBB-Genomics: creating new openings for brain-drug targeting

scientific article published in April 2001

Beta-endorphin chimeric peptides: transport through the blood-brain barrier in vivo and cleavage of disulfide linkage by brain

scientific article published on February 1990

Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery

scientific article published on 09 December 2019

Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels

scientific article published in June 1986

Bioavailability of albumin-bound testosterone

scientific article

Bioavailable testosterone in salivary glands ⬇️

scientific article published on February 1, 1991

Biologic TNFα-inhibitors that cross the human blood-brain barrier ⬇️

scientific article published on April 14, 2010

Biopharmaceutical drug targeting to the brain

scientific article published on April 2010

Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor

scientific article published in November 1992

Blood flow rate and cellular influx of glucose and arginine in mouse liver in vivo

scientific article published in April 1980

Blood-Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer's Disease.

scientific article published on 17 May 2017

Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor

scientific article published on 27 September 2018

Blood-brain barrier and new approaches to brain drug delivery

scientific article

Blood-brain barrier biology and methodology

scientific article

Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids

scientific article published on May 1, 1998

Blood-brain barrier delivery

scientific article

Blood-brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses

scientific article published on 6 April 2007

Blood-brain barrier disruption following the internal carotid arterial perfusion of alkyl glycerols

scientific article

Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

scientific article

Blood-brain barrier drug targeting enables neuroprotection in brain ischemia following delayed intravenous administration of neurotrophins

scientific article

Blood-brain barrier drug targeting: the future of brain drug development

scientific article

Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

scientific article published on 2 May 2015

Blood-brain barrier genomics

scientific article

Blood-brain barrier genomics and cloning of a novel organic anion transporter

scientific article

Blood-brain barrier genomics and the use of endogenous transporters to cause drug penetration into the brain

scientific article published on September 1, 2003

Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study

scientific article published on July 1991

Blood-brain barrier glucose transporter mRNA is increased in experimental diabetes mellitus

scientific article published in October 1989

Blood-brain barrier molecular trojan horse enables imaging of brain uptake of radioiodinated recombinant protein in the rhesus monkey.

scientific article published on 3 October 2013

Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine

scientific article published in June 1997

Blood-brain barrier protein phosphorylation and dephosphorylation

scientific article published in October 1985

Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion

scientific article published in August 2006

Blood-brain barrier transcytosis of insulin in developing rabbits

scientific article

Blood-brain barrier transport and brain metabolism of adenosine and adenosine analogs.

scientific article published in January 1994

Blood-brain barrier transport and brain sequestration of propranolol and lidocaine

scientific article published in September 1984

Blood-brain barrier transport and brain sequestration of steroid hormones

scientific article published in July 1980

Blood-brain barrier transport of 125I-labeled basic fibroblast growth factor

article

Blood-brain barrier transport of butanol and water relative to N-isopropyl-p-iodoamphetamine as the internal reference

scientific article published in June 1985

Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein

scientific article

Blood-brain barrier transport of glucose, free fatty acids, and ketone bodies.

scientific article published on January 1991

Blood-brain barrier transport of neuropeptides: analysis with a metabolically stable dermorphin analogue

scientific article published in July 1994

Blood-brain barrier transport of nutrients.

scientific article

Blood-brain barrier transport of reduced folic acid

scientific article published on March 1999

Blood-brain barrier transport of valproic acid

scientific article published in May 1985

Blood-brain barrier: interface between internal medicine and the brain

scientific article

Blood-brain transport of nutrients. Introduction

scientific article

Blood—Brain Barrier Genomics

article

Brain Drug Targeting and Gene Technologies ⬇️

scientific article published on October 1, 2001

Brain amyloid and Alzheimer disease

scientific article published on July 1988

Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein

scientific article published on 9 March 2017

Brain delivery of biotin bound to a conjugate of neutral avidin and cationized human albumin

article

Brain drug delivery of small molecules using immunoliposomes

scientific article

Brain drug development and brain drug targeting

scientific article

Brain metabolism: a perspective from the blood-brain barrier ⬇️

scientific article published on October 1, 1983

Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain

scientific article

Brain microvascular and astrocyte localization of P-glycoprotein

scientific article

Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse

scientific article published on 26 January 2011

Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein

scientific article

Brain-penetrating IgG-iduronate 2-sulfatase fusion protein for the mouse

scientific article

Brain-penetrating tumor necrosis factor decoy receptor in the mouse

scientific article

Brain-specific expression of an exogenous gene after i.v. administration

scientific article

Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization

scientific article published on October 1990

Branched chain amino acid oxidation in cultured rat skeletal muscle cells. Selective inhibition by clofibric acid

scientific article published on July 1980

CBG does not restrict blood-brain barrier corticosterone transport in rabbits

scientific article published on August 1986

CHO cell expression, long-term stability, and primate pharmacokinetics and brain uptake of an IgG-paroxonase-1 fusion protein

scientific article published in January 2011

CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport ⬇️

scientific article published on May 1, 1998

CSF, blood-brain barrier, and brain drug delivery

scientific article published on 29 March 2016

Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins

scientific article

Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity

scientific article published on August 1997

Carotid artery injection technique: bounds for bolus mixing by plasma and by brain

scientific article published in December 1985

Carrier-Mediated Transport of Thyroid Hormones through the Rat Blood-Brain Barrier: Primary Role of Albumin-Bound Hormone* ⬇️

scientific article published on September 1, 1979

Cationization of a monoclonal antibody to the human immunodeficiency virus REV protein enhances cellular uptake but does not impair antigen binding of the antibody.

scientific article

Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate

scientific article published on July 1991

Cationized hyperimmune immunoglobulins: pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice.

scientific article published in January 1996

Cellular location of rat muscle ferritins and their preferential loss during cell isolation

scientific article published on 01 April 1984

Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system.

scientific article published in October 1996

Chimeric peptides as a vehicle for peptide pharmaceutical delivery through the blood-brain barrier

article

Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes

scientific article published on November 1998

Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein

scientific article

Cis-element/cytoplasmic protein interaction within the 3'-untranslated region of the GLUT1 glucose transporter mRNA.

scientific article published in February 1996

Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2.

scientific article

Cloning and expression in Pichia pastoris of a genetically engineered single chain antibody against the rat transferrin receptor

scientific article published in January 2000

Colocalization of GLUT2 glucose transporter, sodium/glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocytochemistry

scientific article published in June 1992

Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins

scientific article published on 18 February 2013

Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration

scientific article published in April 1998

Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey

scientific article published on 09 September 2009

Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes

scientific article published in July 2007

Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier

scientific article published in May 1990

Complete Inactivation of Target mRNA by Biotinylated Antisense Oligodeoxynucleotide-Avidin Conjugates

article

Complete protection of antisense oligonucleotides against serum nuclease degradation by an avidin-biotin system

article

Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin

scientific article published in January 2001

Critical Illness and Low Testosterone: Effects of Human Serum on Testosterone Transport into Rat Brain and Liver*

article

Crossing the blood-brain barrier: are we getting it right?

scientific article published in January 2001

Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation

scientific article published on 21 June 2006

Decreases in brain protein synthesis elicited by moderate increases in plasma phenylalanine

scientific article published on May 1990

Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology

scientific article

Delivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein

scientific article

Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor

scientific article published on 17 February 2005

Delivery of peptides and proteins through the blood-brain barrier

scientific article

Demonstration and structural comparison of receptors for insulin-like growth factor-I and -II (IGF-I and -II) in brain and blood-brain barrier

scientific article

Development and in vitro characterization of a cationized monoclonal antibody against beta A4 protein: a potential probe for Alzheimer's disease

scientific article

Developmental changes in brain and serum binding of testosterone and in brain capillary uptake of testosterone-binding serum proteins in the rabbit

scientific article

Developmental modulation of blood-brain barrier and choroid plexus GLUT1 glucose transporter messenger ribonucleic acid and immunoreactive protein in rabbits.

scientific article published in February 1993

Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein

scientific article published on 5 February 2004

Differential Permeability of Uterine and Liver Vascular Beds to Estrogens and Estrogen Conjugates*

article

Differential binding of testosterone and estradiol to isoforms of sex hormone-binding globulin: selective alteration of estradiol binding in cirrhosis

scientific article published on October 1988

Differential binding of thyroxine and triiodothyronine to acidic isoforms of thyroid hormone binding globulin in human serum

scientific article

Differential effect of plasma protein binding of bupivacaine on its in vivo transfer into the brain and salivary gland of rats.

scientific article published in December 1986

Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA.

scientific article published on June 1996

Differential expression of 53- and 45-kDa brain capillary-specific proteins by brain capillary endothelium and choroid plexus in vivo and by brain capillary endothelium in tissue culture

scientific article published on August 1990

Differential expression of alpha-actin mRNA and immunoreactive protein in brain microvascular pericytes and smooth muscle cells

scientific article published on November 1994

Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family

scientific article published on October 1992

Differential glycosylation of the GLUT1 glucose transporter in brain capillaries and choroid plexus

scientific article published in July 1994

Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme

scientific article

Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide

scientific article published on 20 August 2013

Does the brain's gatekeeper falter in aging?

scientific article published in January 1988

Downregulation of blood-brain barrier glucose transporter in experimental diabetes

scientific article published in September 1990

Drug Delivery to the Brain ⬇️

scientific article published on July 1, 1997

Drug Transport across the Blood–Brain Barrier ⬇️

scientific article published on August 29, 2012

Drug and gene delivery to the brain: the vascular route

scientific article

Drug and gene targeting to the brain with molecular Trojan horses

scientific article

Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS.

scientific article

Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor

scientific article published on October 1997

Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse

scientific article published on 16 March 2010

Drug targeting to the brain

scientific article

Drug targeting to the brain using avidin-biotin technology in the mouse; (blood-brain barrier, monoclonal antibody, transferrin receptor, Alzheimer's disease).

scientific article published on January 2000

Drug transport in brain via the cerebrospinal fluid ⬇️

scientific article published on January 18, 2011

Effects of Progesterone-Binding Globulin Versus a Progesterone Antiserum on Steroid Hormone Transport through the Blood-Brain Barrier*

article

Effects of clofibric acid on amino acid metabolism in cultured rat skeletal muscle

scientific article published on 01 February 1981

Effects of dichloroacetate on the lactate/ pyruvate ratio and on aspartate and leucine metabolism in cultured rat skeletal muscle cells

article

Effects of glutamine deprivation on glucose and amino acid metabolism in tissue culture

scientific article published on March 1979

Effects of human cirrhotic serum on estradiol and testosterone transport into rat brain

scientific article published in June 1982

Effects of human serum on transport of testosterone and estradiol into rat brain

scientific article published on 01 July 1980

Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

scientific article published on March 2009

Enhanced GLUT1 glucose transporter and cytoskeleton gene expression in cultured bovine brain capillary endothelial cells after treatment with phorbol esters and serum

scientific article published in October 1992

Enhanced cellular uptake and in vivo biodistribution of a monoclonal antibody following cationization

article

Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein

scientific article published in August 1991

Enhanced endocytosis and anti-human immunodeficiency virus type 1 activity of anti-rev antibodies after cationization.

scientific article published in January 1994

Enhanced endocytosis in cultured human breast carcinoma cells and in vivo biodistribution in rats of a humanized monoclonal antibody after cationization of the protein.

scientific article published in July 1998

Enhanced expression of the blood-brain barrier GLUT1 glucose transporter gene by brain-derived factors

scientific article published on March 1994

Enhanced hepatic extraction of estrogens used for replacement therapy

scientific article published in April 1986

Enhanced insulin binding to blood-brain barrier in vivo and to brain microvessels in vitro in newborn rabbits

scientific article

Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector

scientific article published in May 2002

Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies

scientific article

Enkephalin and Blood-Brain Barrier: Studies of Binding and Degradation in Isolated Brain Micro vessels*

article

Enzymatic barrier protects brain capillaries from leukotriene C4.

scientific article

Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors

scientific article published on May 1999

Evaluation of cationized rat albumin as a potential blood-brain barrier drug transport vector

scientific article published on November 1990

Evidence for translational control elements within the 5'-untranslated region of GLUT1 glucose transporter mRNA.

scientific article published on October 1996

Examination of blood-brain barrier transferrin receptor by confocal fluorescent microscopy of unfixed isolated rat brain capillaries

scientific article

Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein

scientific article

Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier

scientific article published on April 2002

Formulation of therapeutic synthetic polymers for drug and gene delivery ▾

article

Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation

scientific article published on 22 February 2007

GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier

scientific article published on June 2008

GLUT-1 glucose transporter is present within apical and basolateral membranes of brain epithelial interfaces and in microvascular endothelia with and without tight junctions

scientific article published in February 1992

GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye.

scientific article

GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues

scientific article

Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors.

scientific article published in November 1994

Gene targeting in vivo with pegylated immunoliposomes

scientific article published in January 2003

Gene targeting technology and gene therapy of the brain

scientific article published in February 2001

Gene therapy of the brain: the trans-vascular approach

scientific article published on April 2004

Genetic engineering of IgG-glucuronidase fusion proteins

scientific article published on April 2010

Genetic engineering of a bifunctional IgG fusion protein with iduronate-2-sulfatase

scientific article published in January 2010

Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier

scientific article published in February 2008

Genetic engineering, expression, and activity of a chimeric monoclonal antibody-avidin fusion protein for receptor-mediated delivery of biotinylated drugs in humans

scientific article published on 16 February 2008

Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier

scientific article published on August 2007

Genetically engineered brain drug delivery vectors: cloning, expression and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein

scientific article published in September 1999

Global non-viral gene transfer to the primate brain following intravenous administration

scientific article published in January 2003

Glucose and amino acid metabolism in an established line of skeletal muscle cells.

scientific article

Glucose and amino acid metabolism in neonatal rat skeletal muscle in tissue culture

article

Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element

scientific article published on February 2002

Glucose deprivation causes posttranscriptional enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization

scientific article published in June 1993

Glucose transport and phosphorylation: which is rate limiting for brain glucose utilization?

scientific article published in May 1994

Glycemic control and chronic dosing of rhesus monkeys with a fusion protein of iduronidase and a monoclonal antibody against the human insulin receptor

scientific article

Hepatic Bioavailability of Serum Thyroid Hormones in Nonthyroidal Illness*

article

Hepatic bioavailability of thyroxine and testosterone in familial dysalbuminemic hyperthyroxinemia.

scientific article

High expression of the Glut1 glucose transporter in human brain hemangioblastoma endothelium

scientific article published on 01 November 1995

High molecular weight Alzheimer's disease amyloid peptide immunoreactivity in human serum and CSF is an immunoglobulin G.

scientific article published in May 1987

Holy grails and in vitro blood–brain barrier models

scientific article published on 01 March 2004

Hormonal effects of danazol and medical oophorectomy in endometriosis

scientific article published on 01 October 1983

Human LAT1 single nucleotide polymorphism N230K does not alter phenylalanine transport

scientific article published in December 2004

Human blood-brain barrier insulin receptor

scientific article published on June 1985

Human blood-brain barrier insulin-like growth factor receptor

scientific article

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels

scientific article published on January 1997

Human blood-brain barrier transferrin receptor

scientific article published on September 1987

Human brain microvascular DR-antigen

scientific article published on July 1989

Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate

scientific article

Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier

scientific article published on February 2007

Hypoxia induces de-stabilization of the LAT1 large neutral amino acid transporter mRNA in brain capillary endothelial cells

scientific article published on May 2003

IgG-enzyme fusion protein: pharmacokinetics and anti-drug antibody response in rhesus monkeys

scientific article published on 31 December 2012

IgG-paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier

scientific article

IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

scientific article

Imaging amyloid plaque in Alzheimer's disease brain with a biotinylated Aβ peptide radiopharmaceutical conjugated to an IgG-avidin fusion protein

scientific article

Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical

scientific article published in February 2002

Imaging brain tumors by targeting peptide radiopharmaceuticals through the blood-brain barrier.

scientific article published on December 1999

Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology.

scientific article

Imaging gene expression in regional brain ischemia in vivo with a targeted [111in]-antisense radiopharmaceutical

scientific article published in October 2004

Imaging gene expression in the brain in vivo in a transgenic mouse model of Huntington's disease with an antisense radiopharmaceutical and drug-targeting technology.

scientific article published in July 2002

Immunohistochemical study of cerebral amyloid angiopathy. II. Enhancement of immunostaining using formic acid pretreatment of tissue sections

scientific article published in October 1988

Immunohistochemical study of cerebral amyloid angiopathy. III. Widespread Alzheimer A4 peptide in cerebral microvessel walls colocalizes with gamma trace in patients with leukoencephalopathy

scientific article published in July 1990

Immunohistochemical study of cerebral amyloid angiopathy: use of an antiserum to a synthetic 28-amino-acid peptide fragment of the Alzheimer's disease amyloid precursor

scientific article published in February 1988

Immunoreactive A4 and gamma-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease

scientific article published on August 1990

Impermeability of the rat blood-brain barrier to exogenously administered gonadotropin-releasing hormone

scientific article published on 01 February 1983

In vivo availability of circulating estradiol in postmenopausal women with and without endometrial cancer

scientific article published in April 1982

In vivo cleavability of a disulfide-based chimeric opioid peptide in rat brain.

scientific article

In vivo demonstration of subcellular localization of anti-transferrin receptor monoclonal antibody-colloidal gold conjugate in brain capillary endothelium

scientific article published on 01 November 1994

In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats

scientific article published in December 2003

In vivo quantification of receptor-mediated uptake of asialoglycoproteins by rat liver

scientific article published in January 1983

Increased blood--brain barrier transport of protein-bound anticonvulsant drugs in the newborn

scientific article

Influence of blood components on the tissue uptake indices of cyclosporin in rats

scientific article

Influx of testosterone-binding globulin (TeBG) and TeBG-bound sex steroid hormones into rat testis and prostate

scientific article published in July 1988

Influx of thyroid hormones into rat liver in vivo. Differential availability of thyroxine and triiodothyronine bound by plasma proteins

scientific article published on August 1980

Inhibition by indomethacin of increased estradiol extraction by the IUD-containing rat uterine horn

Inorganic mercury: selective effects on blood-brain barrier transport systems

scientific article published in July 1976

Insulin Receptor Antibody-α-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts

scientific article published on 24 February 2016

Insulin binding to brain microvessels.

scientific article published on January 1983

Insulin binding to the blood-brain barrier in the streptozotocin diabetic rat.

scientific article published in August 1986

Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys

scientific article published on 5 August 2014

Insulin receptor antibody-sulfamidase fusion protein penetrates the primate blood-brain barrier and reduces glycosoaminoglycans in Sanfilippo type A cells

scientific article

Insulin therapy normalizes GLUT1 glucose transporter mRNA but not immunoreactive transporter protein in streptozocin-diabetic rats

scientific article published in August 1993

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

scientific article published on June 2004

Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

scientific article published on March 2008

Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

scientific article

Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology

scientific article

Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier

scientific article published on 30 June 2010

Intravenous, non-viral RNAi gene therapy of brain cancer

scientific article published in July 2004

Isolation of intact capillaries and capillary plasma membranes from frozen human brain

scientific article

Kinetic analysis of blood-brain barrier transport of amino acids

scientific article

Kinetic constants for blood-brain barrier amino acid transport in conscious rats

scientific article published in November 1985

Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats

scientific article published on August 1979

Kinetics of blood-brain transport of hexoses

scientific article published in March 1975

Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier

scientific article published in January 1977

Kinetics of lactate transport into rat liver in vivo

article

Kinetics of neutral amino acid transport through the blood-brain barrier of the newborn rabbit

scientific article published in April 1982

Kinetics of regional blood-brain barrier glucose transport and cerebral blood flow determined with the carotid injection technique in conscious rats

scientific article

Kinetics of regional blood-brain barrier transport and brain phosphorylation of glucose and 2-deoxyglucose the barbiturate-anesthetized rat.

scientific article published in February 1982

Kinetics of transport and phosphorylation of 2-fluoro-2-deoxy-D-glucose in rat brain

scientific article published in January 1983

Letter: Tryptophan and hepatic encephalopathy ⬇️

scientific article published on May 3, 1975

Letter: Water and solute movement through cell membranes

scientific article published on 01 August 1974

Liver uptake of amino acids and carbohydrates during a single circulatory passage

scientific article

Log(BB), PS products and in silico models of drug brain penetration

article

Low Serum Thyroxine and High Serum Triiodothyronine in Nephrotic Rats: Etiology Implications for Unavailability of Protein-Bound Hormone*

article

Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat.

scientific article published in April 1998

Lysine supplementation in hyperargininemia

article

Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer

scientific article published on 30 June 2007

Marked enhancement in gene expression by targeting the human insulin receptor

scientific article published on February 2003

Measurement of amyloid peptide precursor of Alzheimer disease in human blood by double antibody immunoradiometric assay.

scientific article published in January 1991

Measurement of blood-brain barrier GLUT1 glucose transporter and actin mRNA by a quantitative polymerase chain reaction assay

scientific article published on June 1994

Measurement of cerebral glucose utilization using washout after carotid injection in the rat.

scientific article

Measurement of free intracellular and transfer RNA amino acid specific activity and protein synthesis in rat brain in vivo

scientific article published in March 1990

Mechanisms of neuropeptide interaction with the blood-brain barrier

scientific article published on January 1986

Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

scientific article

Melphalan penetration of the blood-brain barrier via the neutral amino acid transporter in tumor-bearing brain.

scientific article published in January 1992

Molecular Trojan horses for blood-brain barrier drug delivery

scientific article published on 12 July 2006

Molecular Trojan horses for blood-brain barrier drug delivery.

scientific article

Molecular biology of the blood-brain barrier

scientific article

Molecular biology of the blood-brain barrier

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Molecular cloning of the bovine blood-brain barrier glucose transporter cDNA and demonstration of phylogenetic conservation of the 5'-untranslated region.

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Monoclonal antibody radiopharmaceuticals: cationization, pegylation, radiometal chelation, pharmacokinetics, and tumor imaging

scientific article published on May 2003

Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse

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Near complete rescue of experimental Parkinson's disease with intravenous, non-viral GDNF gene therapy

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Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 t

Neuropeptides and the Blood-Brain Barrier ⬇️

scientific article published on January 1, 1983

Neuropeptides and the blood-brain barrier.

scientific article published on January 1981

Neuroprotection in experimental stroke in the rat with an IgG–erythropoietin fusion protein

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Neuroprotection in stroke in the mouse with intravenous erythropoietin–Trojan horse fusion protein

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Neuroprotection in stroke: is it time to consider large-molecule drugs?

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Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system

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Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor

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Neuroprotection with noninvasive neurotrophin delivery to the brain

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Neurotrophins, neuroprotection and the blood-brain barrier

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Neutral amino acid transport at the human blood-brain barrier

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Neutral amino acid transport at the human blood-brain barrier

scientific article published in Journal of Biological Chemistry

New approaches to drug delivery through the blood-brain barrier

scientific article published on June 1994

New directions in blood-brain barrier research. Studies with isolated human brain capillaries

scientific article published on January 1988

Nomogram for 2-deoxyglucose lumped constant for rat brain cortex

scientific article published in January 1982

Non-invasive drug delivery to the human brain using endogenous blood-brain barrier transport systems

scientific article

Non-invasive gene targeting to the fetal brain after intravenous administration and transplacental transfer of plasmid DNA using PEGylated immunoliposomes.

scientific article

Noninvasive gene targeting to the brain

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Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter

scientific article published in April 2004

Opioid peptide drug development: transport of opioid chimeric peptides through the blood-brain barrier

scientific article published on January 1, 1992

Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice

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Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer

scientific article published on 3 October 2003

P-Glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries

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P-glycoprotein and caveolin-1alpha in endothelium and astrocytes of primate brain

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Palmitate and Cholesterol Transport Through the Blood-Brain Barrier

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Pathological upregulation of inner blood-retinal barrier Glut1 glucose transporter expression in diabetes mellitus

scientific article published in January 1996

Permeability changes in the blood-brain barrier induced by nortriptyline and chlorpromazine

scientific article published in September 1973

Permeability changes in the blood-brain barrier: causes and consequences

scientific article

Pharmacokinetics and blood-brain barrier transport of [3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system

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Pharmacokinetics and blood-brain barrier transport of an anti-transferrin receptor monoclonal antibody (OX26) in rats after chronic treatment with the antibody.

scientific article published in September 1998

Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

scientific article published on 25 December 2012

Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor

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Pharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in mice

scientific article published on 28 February 2013

Pharmacokinetics and brain uptake of biotinylated basic fibroblast growth factor conjugated to a blood-brain barrier drug delivery system

scientific article

Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo

scientific article published in November 2001

Pharmacokinetics and organ clearance of a 3'-biotinylated, internally [32P]-labeled phosphodiester oligodeoxynucleotide coupled to a neutral avidin/monoclonal antibody conjugate.

scientific article

Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery

scientific article published on 17 July 2009

Pharmacokinetics and saturable blood-brain barrier transport of biotin bound to a conjugate of avidin and a monoclonal antibody to the transferrin receptor

scientific article published in January 1994

Pharmacokinetics of [3H]Biotin Bound to Different Avidin Analogues

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Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.

scientific article

Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries.

scientific article published on May 1986

Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice

scientific article published on 27 June 2019

Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I.

scientific article published on 13 February 2018

Plasma protein-mediated transport of steroid and thyroid hormones

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Predominant low-molecular-weight proteins in isolated brain capillaries are histones

scientific article published in October 1989

Preferential Release of Triiodothyronine: An Intrathyroidal Adaptation to Reduced Serum Thyroxine in Aging Rats

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Preparation of Trojan horse liposomes (THLs) for gene transfer across the blood-brain barrier

scientific article published in April 2010

Protamine-mediated transport of albumin into brain and other organs of the rat. Binding and endocytosis of protamine-albumin complex by microvascular endothelium

scientific article

Protein-bound corticosteroid in human serum is selectively transported into rat brain and liver in vivo

scientific article published on July 1983

Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond

scientific article published on 01 November 1995

Rapid sequestration and degradation of somatostatin analogues by isolated brain microvessels

scientific article published in April 1985

Rapid transferrin efflux from brain to blood across the blood-brain barrier

scientific article published in March 2001

Rat blood-brain barrier genomics. II.

scientific article

Re-engineering biopharmaceuticals for delivery to brain with molecular Trojan horses

scientific article published on 12 June 2008

Re-engineering erythropoietin as an IgG fusion protein that penetrates the blood-brain barrier in the mouse

scientific article

Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies

scientific article published on 30 August 2016

Recent advances in blood-brain barrier transport

scientific article published on January 1988

Recent developments in peptide drug delivery to the brain

scientific article published in July 1992

Receptor mediated delivery of daunomycin using immunoliposomes: pharmacokinetics and tissue distribution in the rat.

scientific article published in September 1997

Receptor-mediated abeta amyloid antibody targeting to Alzheimer's disease mouse brain

scientific article published on 21 December 2010

Receptor-mediated delivery of an antisense gene to human brain cancer cells

scientific article

Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes

scientific article

Red cell phenylalanine is not available for transport through the blood-brain barrier

scientific article published in August 1990

Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse-Sulfamidase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse

scientific article published on 18 December 2017

Reduction of testosterone availability to 5α-reductase by human sex hormone-binding globulin in the rat ventral prostate gland in vivo

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Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier

scientific article

Regional blood-brain barrier transport of the steroid hormones

scientific article published on August 1979

Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier

scientific article published in September 1988

Restricted transport of vitamin D and A derivatives through the rat blood-brain barrier

scientific article published in April 1985

Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrier

scientific article published in December 1985

Retention of biologic activity of human epidermal growth factor following conjugation to a blood-brain barrier drug delivery vector via an extended poly(ethylene glycol) linker

scientific article published in January 1999

Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein

scientific article published on 17 June 2011

Sarcolemmal protein profiles from cultured myotubes and myoblasts

scientific article published on 01 September 1981

Saturable transport of amphetamine across the blood-brain barrier

scientific article published in March 1973

Selective delivery of sex steroid hormones to tissues by albumin and by sex hormone-binding globulin

scientific article published on January 1988

Selective delivery of sex steroid hormones to tissues in vivo by albumin and by sex hormone-binding globulin

scientific article published on January 1988

Selective expression of the large neutral amino acid transporter at the blood-brain barrier

scientific article

Selective plasma pharmacokinetics and brain uptake in the mouse of enzyme fusion proteins derived from species-specific receptor-targeted antibodies

scientific article published in September 2012

Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein

scientific article

Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo

scientific article published in October 1991

Serum Bioavailability and Tissue Metabolism of Testosterone and Estradiol in Rat Salivary Gland*

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Serum bioavailability of sex steroid hormones

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Site-directed deletion of a 10-nucleotide domain of the 3'-untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain tumors and induction of reporter gene expression

scientific article published in June 1997

Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1.

scientific article published in September 2005

Site-directed mutagenesis of rabbit LAT1 at amino acids 219 and 234.

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Steady state model of 3,5,3'-triiodothyronine transport in liver predicts high cellular exchangeable hormone concentration relative to in vitro free hormone concentration

scientific article published in March 1987

Stereospecificity of triiodothyronine transport into brain, liver, and salivary gland: role of carrier- and plasma protein-mediated transport

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Strategies for drug delivery through the blood-brain barrier

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Strategies to advance translational research into brain barriers

scientific article published on January 2008

Subtractive expression cloning reveals high expression of CD46 at the blood-brain barrier

scientific article

Summary: circulating tryptophan, brain tryptophan, and psychiatric disease

scientific article published on January 1979

Synthesis and bioactivity of monobiotinylated DALDA: a mu-specific opioid peptide designed for targeted brain delivery.

scientific article

Synthesis of pegylated immunonanoparticles

scientific article published in August 2002

Targeted delivery of protein and gene medicines through the blood-brain barrier

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Targeted drug delivery to the brain; (blood-brain barrier, efflux, endothelium, biological transport).

scientific article published in January 2000

Targeting Neurotherapeutic Agents Through the Blood-Brain Barrier ⬇️

scientific article published on January 1, 2002

Targeting of an anti-CR3 (CD11b/CD18) monoclonal antibody to spleen but not brain, in vivo in mice.

scientific article

Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse.

scientific article published on March 2000

TeBG- and CBG-bound steroid hormones in rabbits are available for influx into uterus in vivo

scientific article published in January 1988

Ten nucleotide cis element in the 3'-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization

scientific article published in August 1998

Testosterone transport in brain: primary role of plasma protein-bound hormone

scientific article published on November 1985

The 5'-untranslated region of GLUT1 glucose transporter mRNA causes differential regulation of the translational rate in plant and animal systems

scientific article published in October 1997

The Interaction of Transport and Metabolism on Brain Glucose Utilization: A Reevaluation of the Lumped Constant

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The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature

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The Role of Blood-Brain Barrier Transport of Tryptophan and Other Neutral Amino Acids in the Regulation of Substrate-Limited Pathways of Brain Amino Acid Metabolism ⬇️

scientific article published on January 1, 1979

The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier

scientific article published on 16 November 2011

The blood-brain barrier and neurotherapeutics

scientific article published on January 2005

The blood-brain barrier: bottleneck in brain drug development

scientific article

The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier

scientific article published in January 1990

The effect of membrane permeability and binding by human serum proteins on sex steroid influx into the uterus

scientific article published in June 1983

The effects of membrane permeability and binding by human serum proteins on steroid influx into the rabbit uterus

scientific article published in December 1987

The safety of aspartame

scientific article published in November 1986

Theory and methods for measuring the unidirectional clearance constant for the blood-brain barrier transport of alpha-aminoisobutyric acid

scientific article

Thyroid function in nonthyroidal illnesses

scientific article published on June 1983

Tracer kinetic model of blood-brain barrier transport of plasma protein-bound ligands. Empiric testing of the free hormone hypothesis

scientific article

Transferrin-antibody fusion proteins are effective in brain targeting

scientific article

Translational science: what is it and why is it so important?

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Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor

scientific article

Transport of Albumin-bound Melatonin Through the Blood-Brain Barrier

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Transport of Thyroid and Steroid Hormones through the Blood-Brain Barrier of the Newborn Rabbit: Primary Role of Protein-Bound Hormone*

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Transport of [125I]transferrin through the rat blood-brain barrier

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Transport of histone through the blood-brain barrier

scientific article published in December 1989

Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery

scientific article

Transport of insulin-related peptides and glucose across the blood-brain barrier

scientific article

Transport of metabolic substrates through the blood-brain barrier

scientific article published in January 1977

Transport of nutrients and hormones through the blood-brain barrier

scientific article published on March 1981

Transport of propranolol and lidocaine through the rat blood-brain barrier. Primary role of globulin-bound drug

scientific article

Transport of protein-bound hormones into tissues in vivo

scientific article published on January 1981

Transport of protein-bound steroid hormones into liver in vivo.

scientific article published in October 1979

Transport of recombinant CD4 through the rat blood-brain barrier in vivo.

scientific article

Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone ⬇️

scientific article published on July 1, 1979

Transport of tryptophan into brain from the circulating, albumin-bound pool in rats and in rabbits

scientific article published on March 1990

Treatment of Alzheimer's Disease and Blood-Brain Barrier Drug Delivery

scientific article published on 16 November 2020

Treatment of human immunodeficiency virus-infected lymphocytes with cationized human immunoglobulins

scientific article published in September 1994

Treatment of large solid tumors in mice with daunomycin-loaded sterically stabilized liposomes

scientific article published on January 1998

Triiodothyronine bound to red blood cells is not available for transport through the blood-brain barrier

scientific article published on 01 July 1989

Tryptophan transport through the blood-brain barrier: In vivo measurement of free and albumin-bound amino acid ⬇️

scientific article published on October 22, 1979

Tumor necrosis factor receptor-IgG fusion protein for targeted drug delivery across the human blood-brain barrier

scientific article

Two-day starvation does not alter the kinetics of blood--brain barrier transport and phosphorylation of glucose in rat brain

scientific article

Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy

scientific article

Ultrastructural localization of blood-brain barrier-specific antibodies using immunogold-silver enhancement techniques

scientific article published in April 1991

Unidirectional influx of glutamine and other neutral amino acids into liver of fed and fasted rat in vivo

scientific article published in May 1977

Upregulation of blood-brain barrier GLUT1 glucose transporter protein and mRNA in experimental chronic hypoglycemia

scientific article published in December 1995

Up‐Regulation of Blood‐Brain Barrier Short‐Form Leptin Receptor Gene Products in Rats Fed a High Fat Diet ⬇️

scientific article published on October 1, 1998

Use of neutral avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate

scientific article

Vascular genomics of the human brain

scientific article published in March 2002

Vascular proteomics and subtractive antibody expression cloning

scientific article

Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex

scientific article

Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo

scientific article

Vector-mediated delivery of opioid peptides to the brain

scientific article published on January 1995

Vector-mediated drug delivery to the brain

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Very High Plasma Concentrations of a Monoclonal Antibody against the Human Insulin Receptor Are Produced by Subcutaneous Injection in the Rhesus Monkey

scientific article published on 11 August 2016

Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters ⬇️

scientific article published on December 1, 1997

Why is the global CNS pharmaceutical market so under-penetrated? ⬇️

scientific article published on January 1, 2002

Widespread expression of an exogenous gene in the eye after intravenous administration.

scientific article published in September 2002

William M. Pardridge, Recipient of the AAPS Meritorious Manuscript Award

scientific article published on December 1, 1997

William Pardridge discusses the lack of BBB research. Interview by Rebecca N. Lawrence

scientific article

hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo

scientific article (publication date: 11 August 1999)

shRNA and siRNA delivery to the brain

scientific article published on 16 March 2007

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