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List of works by Nabil Seidah

5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation

scientific article

A betaLPH precursor model: recent developments concerning morphine-like substances

scientific article published on October 1977

A case of hypocholesterolemia and steatosis in a carrier of a PCSK9 loss-of-function mutation and polymorphisms predisposing to nonalcoholic fatty liver disease

scientific article published on 13 June 2017

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

scientific article

A new method for measurement of total plasma PCSK9: clinical applications

scientific article published on January 2010

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.

scientific article

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

scientific article published on 24 July 2019

A novel human pituitary peptide containing the γ-MSH sequence

scientific article published in Nature

A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy

scientific article

A novel pituitary protein (7B2)-like immunoreactivity is secreted by a rat phaeochromocytoma cell line (PC12)

scientific article published on 01 January 1986

A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway

scientific article published on December 2000

A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus

scientific article

A rapid high-performance liquid chromatography purification method of lodinated polypeptide hormones

scientific article published on 01 November 1980

A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts

scientific article published on 11 March 2015

A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

scientific article

A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice

scientific article published on 01 November 2018

A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

scientific article published in April 2007

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

scientific article

ANF (Arg 101--Tyr 126) is the peptide secreted by rat atrial cardiocytes in culture

scientific article

APOE p.Leu167del mutation in familial hypercholesterolemia.

scientific article

Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases

scientific article

Abstract 135: Phosphorylation and furin-mediated processing are critical posttranslational modifications of the KISS1 metastasis suppressor

Affinity purification of proteinases by a combination of immobilized peptidyl aldehyde and semicarbazone

scientific article published on 01 October 1992

Age-related alterations in the expression of prohormone convertase messenger ribonucleic acid (mRNA) levels in hypothalamic proopiomelanocortin mRNA neurons in the female C57BL/6J mouse.

scientific article

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

scientific article published on October 1997

Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study

scientific article published in August 2002

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

scientific journal article

Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms.

scientific article

Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases

scientific article published in Nature

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other

scientific article published on 17 June 2015

An Unbiased Mass Spectrometry Approach Identifies Glypican-3 as an Interactor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR) in Hepatocellular Carcinoma Cells

scientific article

Angiopoietin1 Deficiency in Hepatocytes Affects the Growth of Colorectal Cancer Liver Metastases (CRCLM)

scientific article published on 20 December 2019

Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels

scientific article

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

scientific article

Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.

scientific article published on 7 May 2014

Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor

scientific article published on 18 September 2012

Application of the multiple antigenic peptides (MAP) strategy to the production of prophormone convertases antibodies: Synthesis, characterization and use of 8-branched immunogenic peptides

article

Approaches in the study of the posttranslational processing of opioid peptide peptide precursors: Focus on prodynorphin

article published in 1994

Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease

scientific article published on 25 May 2011

Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin

scientific article published on 08 September 2021

Assignment of the gene for neuroendocrine protein 7B2 (SGNE1 locus) to mouse chromosome region 2[E3–F3] and to human chromosome region 15q11-q15

article

Association Between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population

scientific article published on 27 July 2017

Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men

scientific article

Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin

scientific article published on 01 June 1984

Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect

scientific article published in February 1998

Automated design of ligands to polypharmacological profiles.

scientific article

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

scientific article

Beta-endorphin and beta-lipotropin secretion by an ACTH-secreting mouse pituitary tumor

scientific article published on June 1978

Beta-endorphin induced akinesia in rats: a pharmacological study (author's transl)

scientific article published on October 1, 1979

Beta-endorphin induced akinesia in rats: effect of apomorhine and alpha-methyl-p-tyrosine and related modifications of dopamine turnover in the basal ganglia

scientific article

Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency

scientific article published on 6 April 2013

Binding inhibition by monoclonal antibodies of ovine placental lactogen to growth hormone receptors in human liver

scientific article published on 01 May 1986

Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity

scientific article

Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor

scientific article

Biosynthesis of a ubiquitin-related peptide in rat brain and in human and mouse pituitary tumors

scientific article

Biosynthesis of beta-endorphin by the neurointermediate lobes from rats treated with morphine or alcohol

scientific article published in November 1981

Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia ⬇️

scientific article published on October 1, 1978

Biosynthesis of beta-endorphin, beta-lipotropin and the putative ACTH-LPH precursor in the frog pars intermedia

scientific article published on December 1978

Bovine adrenal chromaffin granules are a site of synthesis of atrial natriuretic factor

scientific article published on 01 September 1987

CHEMICAL CHARACTERIZATION OF RAT ?MSH/�-ENDORPHIN PRECURSOR FROM PARS INTERMEDIA

scientific article published on 01 January 1980

CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles

scientific article

Can iPCSK9-induced hypocholesterolemia starve cancer cells?

scientific article published on 21 April 2017

Cataleptic effect of 61-91 beta-lipotropic hormone in rat.

scientific article published on February 1977

Cathepsin-B Fusion Proteins Misroute Secretory Protein Partners Such as the Proprotein Convertase PC2-7B2 Complex toward the Lysosomal Degradation Pathways

scientific article published on 01 September 2000

Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases

scientific article published on 03 December 2007

Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals

scientific article (publication date: 5 March 1999)

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

scientific article published on February 1996

Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene

scientific article published in June 2002

Characterization of multiple forms of porcine anterior pituitary proopiomelanocortin amino-terminal glycopeptide

scientific article

Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases

scientific journal article

Characterization of β-endorphin immunoreactive peptides in rat pituitary and brain by coupled gel and reversed-phase high-performance liquid chromatography

scientific article published on 01 August 1983

Chemistry and biosynthesis of pro-opiomelanocortin. ACTH, MSH's, endorphins and their related peptides

scientific article published on January 1981

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

scientific article

Chromogranin A can act as a reversible processing enzyme inhibitor

scientific article published on 01 January 1987

Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues

scientific article

Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human

scientific article

Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15–21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1–11.2, and furin (mouse 7[D1-E2] region) ⬇️

scientific article (publication date: September 1991)

Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis

scientific article published on 20 January 2020

Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice

scientific article published on 16 July 2020

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue

scientific article published on 27 January 2011

Clearance of Plasma Proprotein Convertase Subtilisin/Kexin 9 by Low-Density Lipoprotein Apheresis

scientific article published on 01 June 2014

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

scientific article published on 6 November 2015

Co-expression of PC2 and proenkephalin in human tumoral adrenal medullary tissues

scientific article published on 01 January 1994

Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours

scientific article

Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160

scientific article

Comparative processing of bovine leukemia virus envelope glycoprotein gp72 by subtilisin/kexin-like mammalian convertases.

scientific article published on April 1997

Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways

scientific article published on April 1995

Complete amino acid sequence of a human pituitary glycopeptide: an important maturation product of pro-opiomelanocortin

scientific article

Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site

scientific article

Complete amino acid sequence of human seminal plasma β-inhibin

scientific article (publication date: October 1984)

Concomitant changes of ACTH, beta-endorphin and N-terminal portion of pro-opiomelanocortin in rats

scientific article published in April 1982

Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia ⬇️

scientific article published on October 1, 1979

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

scientific article

Content of beta-LPH and its fragments (including endorphins) in anterior and intermediate lobes of the bovine pituitary gland

scientific article

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

scientific article published on 01 November 2000

Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.

scientific article published on 20 February 2003

Correct processing and secretion of a human prostatic secretory protein (PSP94) in Escherichia coli

scientific article published on 01 December 1988

Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.

scientific article published on August 2003

Decreased PCSK9 expression in human hepatocellular carcinoma.

scientific article published on 16 December 2015

Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells

scientific article published on 9 December 2015

Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age.

scientific article published on 30 December 2015

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

scientific article

Demonstration of the vasopressin associated glycopeptide in the brain and peripheral tissues of the Brattleboro rat.

scientific article published in January 1986

Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes

scientific article published on 09 July 2020

Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein

scientific article published on 16 February 2004

Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets

scientific article published in October 1994

Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice

scientific article published on 19 April 2019

Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis

scientific article published on 11 July 2016

Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66

article

Differential expression of the neuroendocrine polypeptide 7B2 in hypothalami of Prader-(Labhart)-Willi syndrome patients

scientific article published on 01 September 1994

Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).

scientific article published on 27 March 2013

Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion

scientific article published on 6 March 2012

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

scientific article

Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

scientific article published on 27 July 2009

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Distribution and regulation of proconvertases PC1 and PC2 in human pituitary adenomas

scientific article

Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary

scientific article published in March 1992

Distribution of a novel pituitary protein (7B2) in mammalian gastrointestinal tract and pancreas

scientific article published on 01 June 1988

Distribution pattern in the human pituitary and hypothalamus of a new neuropeptide: the C-terminal glycoprotein-fragment of human pro-pressophysin (CPP).

scientific article published in January 1982

Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein

scientific article published on March 2003

Dual regulation of the LDL receptor--some clarity and new questions

scientific article

Dynamics of 7B2 and galanin expression in solitary magnocellular hypothalamic vasopressin neurons of the homozygous Brattleboro rat.

scientific article published in July 1992

Dysregulation of dynorphins in Alzheimer disease

scientific article published on 17 August 2006

Effect of alpha-1 antitrypsin Portland variant (alpha 1-PDX) on HIV-1 replication

scientific article

Effect of chronic morphine treatment on β-endorphine biosynthesis by the rat neurointermediate lobe

scientific article published on 01 July 1981

Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome.

scientific article published on 26 July 2011

Effect of the p.Arg357His mutation of PCSK9 on basal and postprandial lipoprotein metabolism

Effects of L- and D-REKR amino acid-containing peptides on HIV and SIV envelope glycoprotein precursor maturation and HIV and SIV replication

scientific article published on September 2002

Effects of peptides of pituitary origin on the formation of C21 steroid by fetal calf adrenal cells in culture ⬇️

scientific article published on November 21, 1977

Effects of pro-opiomelanocortin fragments on release of catecholamines from adrenal chromaffin cells

scientific article

Effects of proopiomelanocortin-derived peptides, methionine-enkephalin and forskolin on the maturation of ovine fetal adrenal cells in culture

scientific article published on November 1984

Effects of several pro-opiomelanocortin derived peptides on steroidogenesis in ovine and bovine adrenal cells

scientific article published on 01 August 1985

Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events

scientific article published on 11 October 2010

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors

scientific article published in 2022

Elevated expression of proprotein convertases alters breast cancer cell growth in response to estrogen and tamoxifen

scientific article

Elevation of plasma 7B2 (a novel pituitary protein) in cord blood at obstetrical delivery and the possible correlation with GH

scientific article published on 01 October 1987

Emerging viruses: risk of pandemic

scientific article published in 2008

Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

scientific article

Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling

scientific journal article

Endoproteolytic processing of integrin pro-α subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

scientific article (publication date: 15 February 2000)

Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction

scientific article published on 4 October 2004

Enzymatic cleavage of pro-opiomelanocortin by anterior pituitary granules. Evidence for a chymotryptic-like enzyme

scientific article published in August 1983

Enzymatic maturation of pro-opiomelanocortin by anterior pituitary granules

scientific article published on 01 August 1983

Enzymic characterization in vitro of recombinant proprotein convertase PC4.

scientific article published on October 1999

Eukaryotic protein processing: endoproteolysis of precursor proteins

scientific article published on October 1997

Evidence for a Signal Sequence at the N Terminus of the Common Precursor to Adrenocorticothrophin and beta-Lipotropin in Mouse Pituitary Cells

scientific article published on 01 May 1981

Evidence for a novel pituitary protein (7B2) in human brain, cerebrospinal fluid and plasma: Brain concentrations in controls and patients with Alzheimer's disease

article

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.

scientific article published on 28 September 2005

Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels

scientific article published on 27 March 2013

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme

scientific article

Expression and Processing of the Neuroendocrine Protein Secretogranin II in Benign and Malignant Pheochromocytomas

scientific article published on 01 August 2006

Expression of PC2 and PC1/PC3 in human pheochromocytomas

scientific article published on 01 March 1994

Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line.

scientific article published on August 1995

Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors

scientific article published on November 1994

Expression of the proprotein convertases PC1 and PC2 mRNAs in thyrotropin releasing hormone neurons of the rat paraventricular nucleus of hypothalamus

scientific article published in June 1997

Expression of variant forms of proopiomelanocortin, the common precursor to corticotropin and .beta.-lipotropin in the rat pars intermedia

scientific article published on 01 April 1981

Familial hypercholesterolemia mutations in the Middle Eastern and North African region: a need for a national registry

scientific article

Fragmentation of bovine chromogranin A by plasma kallikrein

scientific article published on 01 January 1990

From proopiomelanocortin to cancer. Possible role of convertases in neoplasia

scientific article published on May 1993

Functional Analysis of Novel PCSK9 Mutants from Sapiens (R96L, R105W and P174S) and Denisovan (H449L)

Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform

scientific article

Functional analysis of natural PCSK9 mutants in modern and archaic humans

scientific article published on 22 August 2019

Functional aspects of multitransmitter neurons. Studies of interactions among pro-opiomelanocortin products.

scientific article published on January 1987

Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

scientific article

Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing

scientific article published on 13 January 2014

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes

scientific article

Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis

scientific article published on 23 May 2005

GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence

scientific article published in January 1985

Gamma-melanotropin response to ovine corticotropin releasing factor in normal humans

scientific article published on 01 May 1987

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

article

Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells

scientific article

Gene structure and chromosomal localization of plasma kallikrein

scientific article

Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.

scientific article published in April 2002

Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels

scientific article

HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin

article

Heparin enhances the furin cleavage of HIV-1 gp160 peptides.

scientific article published on 26 November 2007

High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels

scientific article published on 30 January 2015

Homologous IRCM-serine protease 1 from pituitary, heart atrium and ventricle: a common pro-hormone maturation enzyme?

scientific article

How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?

scientific article published in 2021

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin

scientific article

Hypolipidaemia among patients with PMM2-CDG is associated with low circulating PCSK9 levels: a case report followed by observational and experimental studies

scientific article published on 07 August 2019

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia

scientific article published on 17 May 2012

Identification of a biologically active circulating form of rat atrial natriuretic factor

scientific article

Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus

scientific article published on 01 August 1995

Immunocytochemistry of the C-terminal peptide of propressophysin (CPP): relationship to vasopressin, oxytocin and neurophysin

scientific article

Immunohistochemical distribution of the prohormone convertase PC5-A in rat brain

scientific journal article

Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain

scientific journal article

Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.

scientific article

Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal

scientific article published on January 1997

Immunohistochemical localization of γ-melanocyte-stimulating hormone in the rat pituitary gland

scientific article published on 01 May 1981

Immunological characterization of beta-lipotropin fragments (endorphin, beta-MSH, and N-fragment) from fish pituitaries

scientific article

Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2.

scientific article published on December 1991

Immunoreactivity of vasopressin and a novel pituitary protein '7B2' in Long-Evans and Brattleboro rat hypothalamus and hypophysis

scientific article published in September 1985

Impaired fertility in mice deficient for the testicular germ-cell protease PC4

scientific journal article

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

scientific article published in January 2005

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

scientific journal article

Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides

scientific article

Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin

scientific article

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2’ by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

retracted scholarly article by Rachid Essalmani published in July 2021

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2’ by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

scientific article

Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model.

scientific article

In utero measurement of heart rate in mouse by noninvasive M-mode echocardiography

scientific article

In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia ⬇️

scientific article published on July 1, 1978

In vitro biosynthesis of beta-endorphin in pituitary glands ⬇️

scientific article published on April 1, 1977

In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands ⬇️

scientific article published on October 1, 1977

In vitro characterization of the novel proprotein convertase PC7.

scientific article published in August 1997

In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor

scientific article published on April 1998

In vivo evidence that furin from hepatocytes inactivates PCSK9

scientific journal article

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate

scholarly article

Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy

scientific article published on 17 June 2011

Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.

scientific article

Inhibition by beta-endorphin of dopamine-sensitive adenylate cyclase in rat striatum

scientific article published in July 1977

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

scientific article

Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI).

scientific article

Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization

scientific article

Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model

scientific article

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions

scientific article published on 11 June 2001

Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters

scientific article published on February 1999

Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C

scientific article published in 2024

Insights into a PCSK9 structural groove: a harbinger of new drugs to reduce LDL-cholesterol

scientific article published in October 2017

Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus

scientific article published on 3 February 2010

Is there a link between proprotein convertase PC7 activity and human lipid homeostasis?

scientific article

Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily

article

Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.

scientific article

Isolation and characterization of four proteases from porcine pituitary neurointermediate lobes: relationship to the maturation enzyme of prohormones

scientific article published in February 1985

Isolation and partial characterization of a biosynthetic N-terminal methionyl peptide of bovine pars intermedia: relationship to ubiquitin

scientific article

Isolation and primary structure of novel neurointermediate pituitary peptides derived from the C-terminal of the rat vasopressin-neurophysin precursor (propressophysin).

scientific article published in April 1986

Isolation and purification of Escherichia coli heat-stable enterotoxin of porcine origin

scientific article published on 01 December 1982

Isolation from human seminal plasma of an abundant 16-kDa protein originating from the prostate, its identification with a 94-residue peptide originally described as beta-inhibin

scientific article published on 01 May 1987

Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin

scientific article published in September 1976

L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection

scientific article

LDLR Activity and Subcellular Distribution is Sensitive to Estrogen in Mice Lacking PCSK9

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

scientific article

Light and electron microscopic localization of the N-terminal fragment of human pro-opiomelanocortin in the human pituitary gland and in neoplasms

scientific article

Linkage mapping of the gene for the LIM-homeoprotein LIM3 (locus Lhx3) to mouse Chromosome 2

article

Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor

scientific article

Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

scientific article published on 8 June 2015

Loss of endothelial furin leads to cardiac malformation and early postnatal death

scientific article

Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation

scientific article published on 8 August 2012

Loss-of-function PCSK9 Mutants Evade the Unfolded Protein Response Sensor, GRP78, and Fail to Induce Endoplasmic Reticulum Stress when Retained

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor, GRP78, and fail to induce endoplasmic reticulum stress when retained

scientific article published on 28 March 2018

Low density lipoprotein receptor class A repeats are O-glycosylated in linker regions

scientific article

Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor.

scientific article published on 12 July 2018

MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development†.

scientific article published on 4 February 2015

Maintained PC1 and PC2 expression in the AtT-20 variant cell line 6T3 lacking regulated secretion and POMC: restored POMC expression and regulated secretion after cAMP treatment

scientific article published on February 1995

Mammalian paired basic amino acid convertases of prohormones and proproteins

scientific article

Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P).

scientific article published on 8 December 2015

Metabolic clearance rate and half-time disappearance rate of human N-terminal and adrenocorticotropin of pro-opiomelanocortin in the rat: a comparative study.

scientific article

Microsequencing evidence for the maturation of human proopiomelanocortin into an 18 amino acid β-melanocyte stimulating hormone [hβMSH(5–22)] in nonpituitary tissue

scientific article published on 01 January 1989

Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model

scientific article

Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease

scientific article

Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells

scientific article published on December 1998

Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family

scientific article

Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors.

scientific article published on October 1984

Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development

scientific article published on November 2010

Molecular cloning and expression of the ovine testicular follicle stimulating hormone receptor

scientific article published on June 1993

Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2.

scientific article published on July 2000

Molecular evolution of the proopiomelanocortin system in Barn owl species

scientific article published on 05 May 2020

Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels

scientific article published in 2023

Mouse insulinoma beta TC3 cells express prodynorphin messenger ribonucleic acid and derived peptides: a unique cellular model for the study of prodynorphin biosynthesis and processing

scientific article published on March 1995

Mouse model of intraluminal MCAO: cerebral infarct evaluation by cresyl violet staining

scientific article

Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species.

scientific article

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

scientific article (publication date: June 2003)

N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface

scientific article published in July 2000

N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1.

scientific article published on 28 April 2011

N-linked glycosylation affects the processing of mouse submaxillary gland prorenin in transfected AtT20 cells

scientific article published on June 1991

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

scientific article

NH2-terminal fragment of rat pro-atrial natriuretic factor in the circulation: Identification, radioimmunoassay and half-life

scientific article published on 01 January 1988

Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons

scientific article published on June 1996

Neuroendocrine secretory protein 7B2: structure, expression and functions

scientific article published in 2001

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder

scientific article

Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway

scientific article published on 11 September 2003

New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia.

scientific article published on 31 January 2018

New developments in proprotein convertase subtilisin-kexin 9's biology and clinical implications

scientific article published on 30 March 2016

New insights of altered lipid profile in Fragile X Syndrome

scientific article

Novel approach to rapid and sensitive localization of protein disulfide bridges by high-performance liquid chromatography and electrochemical detection

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture

scientific article published on 3 August 2011

Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies

scientific article published on 01 March 2019

Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms

scientific article published on 14 May 2007

Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine

scientific article published in November 1985

Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin

scientific article

Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.

scientific article

Opposite roles of furin and PC5A in N-cadherin processing

scientific article

Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone

scientific article published on 7 November 2017

PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?

scientific article published on September 2015

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

scientific article published on May 1991

PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism

scientific article

PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfected PC12 cells

scientific article published on September 1998

PCSK9 as a therapeutic target of dyslipidemia

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice

scientific article

PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression

scientific article published in July 2009

PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor's role

scientific article published on 21 April 2016

PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans

scientific article

PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells.

scientific article published on 4 February 2013

PCSK9 prosegment chimera as novel inhibitors of LDLR degradation

scientific article

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

scientific article

PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs

scientific article published on 04 November 2021

PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: evidence for genotype-specific regulation of lipoprotein metabolism.

scientific article published on 21 November 2014

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

scientific article published on 16 December 2009

PCSK9: a key modulator of cardiovascular health

scientific article

Partial N-terminal amino acid sequence of pro-opio-melanocortin (ACTH/beta-LPH precursor) from rat pars intermedia

scientific article published on 01 February 1980

Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity

scientific article

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development

scientific article published on 26 April 2017

Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice

scientific article published on 05 November 2019

Peptide mapping of 125I-labelled membrane protein of influenza viruses by reverse-phase high-performance liquid chromatography

scientific article published on 01 March 1982

Peptides of the neurointermediary lobe of rat pituitary stimulate GH secretion in vitro

scientific article published in September 1983

Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression

scientific article published on January 1997

Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9.

scientific article

Plasma PCSK9 levels correlate with cholesterol in men but not in women

scientific article published on 18 July 2007

Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224.

scientific article published on 27 November 2017

Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics

scientific article published on 3 April 2018

Potential role of proprotein convertase SKI-1 in the mineralization of primary bone

scientific article

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

scientific article

Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins

scientific article

Presence of a pre-sequence (signal sequence) in the common precursor to ACTH and endorphin and the role of glycosylation in processing of the precursor and secretion of ACTH and endorphin

scientific article published in January 1980

Presence of the novel pituitary protein "7B2" in bovine chromaffin granules: possible co-release of 7B2 and catecholamine as induced by nicotine

scientific article

Presence of vasopressin, oxytocin and neurophysin in the retina of mammals, effect of light and darkness, comparison with the neuropeptide content of the neurohypophysis and the pineal gland

scientific article

Primary structure of a high M r form of rat atrial natriuretic factor

scientific article published on 01 February 1984

Primary structure of mouse chromogranin B deduced from cDNA sequence

scientific article published on March 1990

Pro-opiomelanocortin-Related Peptides, Prohormone Convertases 1 and 2 and the Regulatory Peptide 7B2 are Present in Melanosomes of Human Melanocytes

scientific article published on 01 March 2000

Pro-opiomelanocortin-related peptides in cerebrospinal fluid: A study of manic-depressive disorder

scientific article published on 01 December 1985

Pro-protein convertase gene expression in human breast cancer

scientific article published in June 1997

Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases ⬇️

scientific article published on August 8, 1997

Processing of Two Forms of the Common Precursor to alpha-Melanotropin and beta-Endorphin in the Rat Pars Intermedia. Evidence for and Partial Characterization of New Pituitary Peptides

scientific article published on 01 September 1980

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage

scientific article published in July 2003

Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes

scientific article published on October 2013

Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue

scientific article published on January 1994

Processing of secretogranin II by prohormone convertases: importance of PC1 in generation of secretoneurin

scientific article published in March 1995

Processing, release and metabolism of cholecystokinin in SK-N-MCIXC cells

scientific article published on July 1993

Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis

scientific article published on 14 October 2013

Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain

scientific article published on 3 December 2016

Proparathyroid Hormone Is Preferentially Cleaved to Parathyroid Hormone by the Prohormone Convertase Furin

scientific article published in Journal of Biological Chemistry

Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain

scientific article published in July 1986

Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies ⬇️

scientific article published on January 1, 2013

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation

scientific article published on 8 June 2016

Proprotein Convertase Subtilisin/Kexin type 9 affects insulin but not lipid metabolism in cystic fibrosis.

scientific article

Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives

scientific article published on May 1992

Proprotein convertase 7 (PCSK7) reduces apoA-V levels

scientific article published on 16 January 2020

Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor

scientific article published on 5 January 2011

Proprotein convertase furin regulates osteocalcin and bone endocrine function

scientific article published on 3 October 2017

Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015).

scientific article published on 30 June 2016

Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of low density lipoprotein receptor degradation

scientific article published on December 2016

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)

scientific article

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

scientific article

Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver

scientific article published on December 2012

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase

scientific journal article

Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells.

scientific article published on March 2002

Proprotein convertases as therapeutic targets

scientific article published on 01 October 2008

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

scientific article

Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor

scientific article published in August 2004

Proprotein convertases: lessons from knockouts

scientific article published on October 2006

Prorenin activation and prohormone convertases in the mouse As4.1 cell line

scientific article published on January 1997

Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.

scientific article

Protease inhibitors suppress in vitro growth of human small cell lung cancer

article

Proteolytic processing of chromogranin A by the prohormone convertase PC2

scientific article published on 01 March 2003

Proteolytic processing of human prorenin in renal and non-renal tissues

scientific article published on December 1994

Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors

correction of a scholarly article

Purification and characterization of the N-terminal fragment of pro-opiomelanocortin from human pituitaries: Homology to the bovine sequence

scientific article published on 01 August 1980

Purification and partial chemical characterization of human pituitary lipolytic hormone ⬇️

scientific article published on September 1, 1976

Purification and sequence determination of bovine atrial natriuretic factor

scientific article published on 01 April 1986

Purification of ovine placental lactogen (oPL) using high-performance liquid chromatography

scientific article published on 01 April 1986

Purification of radiolabeled and native polypeptides by gel permeation high-performance liquid chromatography

scientific article published in September 1982

Purification of three rat atrial natriuretic factors and their amino acid composition

article

Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells

scientific article published on 10 March 2011

Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum

scientific article published on 08 January 2013

Rat plasma kallikrein: purification, NH2-terminal sequencing and development of a specific radioimmunoassay

article

Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia

scientific article published on 22 April 2015

Region specific expression of furin mRNA in the rat brain

scientific article published in January 1993

Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype

scientific article published on 3 June 2013

Regional distribution of a novel pituitary protein (7B2) in the rat brain

scientific article published in July 1985

Regional distribution of a novel pituitary protein (7B2) in the rat spinal cord: effect of neonatal capsaicin treatment and thoracic cord transection

scientific article published in April 1985

Regional heterogeneity in the processing of pro-opiomelanocortin in rat brain

scientific article published in January 1983

Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes

scientific article

Regional processing of the N- and C-terminal domains of proopiomelanocortin in monkey pituitary and brain

scientific article

Regulation by gastric acid of the processing of progastrin-derived peptides in rat antral mucosa

scientific article published on 01 July 1997

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase

scientific journal article

Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells

scientific article published on 29 January 2009

Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases

scientific article published on October 2005

Reinvestigation of the N-terminal amino acid sequence of beta-lipotropin from human pituitary glands

scientific article published in December 1981

Replication of HIV-1 viruses in the presence of the Portland alpha1-antitrypsin variant (alpha1-PDX) inhibitor

scientific article published in November 2001

Reply: To PMID 23390091.

scientific article published on 12 September 2013

Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

scientific article published on May 1998

Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation

scientific journal article

Response of Human Aldosteronoma Cells in Culture to the N-Terminal Glycopeptide of Pro-Opiomelanocortin and γ3-MSH

article

Reversed-phase high-performance liquid chromatographic purification and characterization of the adrenocorticotropin/lipotropin precursor and its fragments

scientific article published on 01 May 1980

Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.

scientific article

Role of prohormone convertases in the tissue-specific processing of proglucagon

scientific article

Role of proprotein convertases in the pathogenic processing of the amyloidosis-associated form of secretory gelsolin

scientific article published on June 2002

Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9.

scientific article published on 27 July 2017

Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial

scientific article

SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.

scientific article published in February 2012

SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication

scientific article published on 22 May 2012

SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection

scientific article

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells

scientific article

STATINS AND EZETIMIBE UPREGULATE PLASMA PCSK9

Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro

scientific journal article

Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells

scientific article

Sequence homologies between tonin, nerve growth factor γ-subunit, epidermal growth factor-binding protein and serine proteases

scientific article published in Nature

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor)

scientific article published on 05 September 2019

Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression

scientific article published on 20 August 2020

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

scientific article published on 20 March 2018

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

scientific article published on 01 May 2019

Specific cleavage of beta-LPH and ACTH by tonin: release of an opiate-like peptide beta-LPH (61-78).

scientific article published on February 1979

Specific release of a novel pituitary polypeptide, 7B2, from rat anterior pituitary cells in vitro by luteinizing hormone-releasing hormone

scientific article

Sta!le and transient expression of mouse submaxillary gland renin cDNA in AtT20 cells: proteolytic processing and secretory pathways.

scientific article published in March 1989

Statins can exert dual, concentration dependent effects on HCV entry in vitro

scientific article

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

scientific article

Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1.

scientific article

Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters

scientific article

Structural Investigation and Kinetic Characterization of Potential Cleavage Sites of HIV Gp160 by Human Furin and Pc1 ⬇️

scientific article published on August 4, 1995

Structural and immunological homology of human and porcine pituitary and plasma IRCM-serine protease 1 to plasma kallikrein: marked selectivity for pairs of basic residues suggests a widespread role in pro-hormone and pro-enzyme processing

scientific article

Structure of the carboxyl propeptide of chicken type II procollagen determined by DNA and protein sequence analysis

scientific article published in 1984

Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms

scientific article published in March 1994

Structure-activity relationships of atrial natriuretic factor (ANF) III correlation of receptor affinity with relative potency on aldosterone production in zona glomerulosa cells

scientific article published on 01 October 1985

Structure-activity relationships of atrial natriuretic factor (ANF). I. Natriuretic activity and relaxation of intestinal smooth muscle

scientific article published on 01 December 1984

Structure-activity relationships of atrial natriuretic factor (ANF). II. Effect of chain-length modifications on vascular reactivity

scientific article published in 1985

Structure-function analysis of the prosegment of the proprotein convertase PC5A.

scientific article

Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex

scientific article published on April 1995

Substrate phosphorylation can inhibit proteolysis by trypsin-like enzymes

scientific article published on 01 August 1989

Substrate specificity of the enzyme tonin: cleavage of substance P

scientific article published on 01 May 1980

Surface expression of precursor N-cadherin promotes tumor cell invasion

scientific article

Synthesis of the segment (11–23) located in the first tandem repeat of plasma kallikrein: comparative binding studies of this and another segment (328–343) to high-molecular-mass kininogen

scientific article published on 01 June 1993

Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice

scientific article published in October 2009

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase

scientific article published on October 1992

Tetraphenylborate adsorption onto an artificial ultrathin membrane

The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1

scientific article published in Journal of Biological Chemistry

The Cellular Trafficking of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the LDLR

The Elusive Inhibitory Function of the Acidic N-Terminal Segment of the Prodomain of PCSK9: The Plot Thickens

scientific article published on 15 January 2019

The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains.

scientific article published on 28 February 2008

The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography

scientific article published on 26 August 2011

The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit‐1/GHF‐1‐independent pathway in corticotroph AtT20 cells ⬇️

scientific article published on July 24, 1998

The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway

scientific article published on 26 October 2012

The Multifaceted Biology of PCSK9 ⬇️

journal article from 'Endocrine Reviews' published in 2022

The Notch1 receptor is cleaved constitutively by a furin-like convertase ⬇️

scientific article published on July 7, 1998

The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol

scientific article published on 31 March 2017

The Pore-forming Toxin Proaerolysin Is Activated by Furin ⬇️

scientific article published in Journal of Biological Chemistry

The Proprotein Convertase 7 Regulates Triglyceride Levels via Enhanced ApoA5 Degradation

The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA.

scientific article published on 20 December 2016

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.

scientific article published on January 2017

The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1.

scientific article

The activation and physiological functions of the proprotein convertases

scientific article published on 08 February 2008

The biology and therapeutic targeting of the proprotein convertases ⬇️

scientific article published on May 1, 2012

The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC.

scientific article

The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain

scientific article

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

scientific article

The complete sequence of a novel human pituitary glycopeptide homologous to pig posterior pituitary glycopeptide

scientific article published on 01 May 1981

The complete sequence of sheep beta-endorphin

scientific article published in February 1977

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases

scientific article published on 31 August 2005

The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins

scientific article published on 20 February 2013

The developmental expression in the rat CNS and peripheral tissues of proteases PC5 and PACE4 mRNAs: comparison with other proprotein processing enzymes

scientific article published in January 1997

The effect of insulin on circulating PCSK9 in postmenopausal obese women

scientific article published on 8 April 2014

The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation

scientific article published on 15 January 2018

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions

scientific article

The high-molecular-mass kininogen deficient rat expresses all kininogen mRNA species, but does not export the high-molecular-mass kininogen synthesized

scientific article published on October 1988

The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis

scientific article published on September 2010

The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments

scientific article

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

scientific article published on 19 November 2020

The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid sequencing

scientific article published on 01 September 1984

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

scientific article

The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)

scientific article

The missing fragment of the pro-sequence of human pro-opiomelanocortin: Sequence and evidence for C-terminal amidation

article

The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity

scientific article published on 08 January 2020

The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary.

scientific article published on December 1994

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions

scientific article

The pituitary polypeptide "7B2" is associated with LH/FSH and TSH cells and is localized within secretory vesicles

scientific article published in October 1987

The primary structure of human beta-lipotropin. Further peptide sequencing resolves the controversy and suggests the existence of only one human beta-lipotropin

scientific article

The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man

scientific article

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

scientific article

The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease ⬇️

scientific article published on January 1, 2003

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model

scientific article published on 08 September 2009

The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1.

scientific article published on 15 January 2003

The proprotein convertase PC7: unique zymogen activation and trafficking pathways

scientific article published on 12 November 2010

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

scientific article

The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors

scientific article published on 21 June 2006

The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization

scientific article

The proprotein convertases and their implication in sterol and/or lipid metabolism

scientific article

The proprotein convertases are potential targets in the treatment of dyslipidemia

scientific article published on 10 March 2007

The proprotein convertases, 20 years later

scientific article published on January 2011

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

scientific article published on April 2003

The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates

scientific article published on 26 November 2007

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

scientific article

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

scientific article (publication date: June 2003)

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

scientific article published on 10 February 2020

The vasopressin precursor is not processed in the hypothalamus of Wolfram syndrome patients with diabetes insipidus: evidence for the involvement of PC2 and 7B2.

scientific article published in November 1998

Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells

scientific article published on January 2007

Thrombin activation of protein C requires prior processing by a liver proprotein convertase

scientific article published on August 2017

Thrombin activation of protein C requires prior processing by a liver proprotein convertase

scientific article published on 3 May 2017

Tissue distribution and molecular forms of a novel pituitary protein in the rat.

scientific article published in November 1984

Tissue-Specific and Substrate-Specific Endoproteolytic Cleavage of Monkey Pro-Opiomelanocortin in Heterologous Endocrine Cells: Processing at Lys-Lys Dibasic Pairs

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

scientific article published on 01 October 2018

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

scientific journal article

Transport of ions of one kind through thin membranes

article

Transport of ions of one kind through thin membranes. 3. Current-voltage curves for membrane-soluble ions.

scientific article

Two activation states of the prohormone convertase PC1 in the secretory pathway

scientific article published on June 1997

Two glycosylation sites on the N-terminal segment of porcine pars distalis pro-opiomelanocortin

scientific article published on 01 December 1980

Two-dimensional immunoblotting analysis and immunocytochemical localization of the secretory polypeptide 7B2 in adrenal medulla

scientific article published on 01 December 1988

Unexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinases

scientific article

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

scientific article

Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition

scientific article published on 01 January 2019

Viral envelope glycoprotein processing by proprotein convertases

scientific article published on 20 April 2013

What lies ahead for the proprotein convertases? ⬇️

scientific article published on March 1, 2011

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

scientific journal article

YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6

Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration

scientific article

Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease

scientific article

beta 2-Inhibin contains the active core of human seminal plasma beta-inhibin: synthesis and bioactivity

scientific article published in February 1985

cDNA structure and in situ localization of the Aplysia californica pro-hormone convertase PC2.

scientific article published on September 1993

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

scientific article

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

scientific article published on April 1996

pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation.

scientific article published on May 2001

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