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List of works by Elena Tamborini

9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations.

scientific article

A Sporadic Multiple GIST With Unusual Pathologic, Molecular, and Genetic Features

scientific article published on 01 February 2008

A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

scientific article

A quality control program for mutation detection in KIT and PDGFRA in gastrointestinal stromal tumours

scientific article

Activate and resist: L576P-KIT in GIST.

scientific article published in September 2009

Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation.

scientific article

An immunoglobulin-like fold in a major plant allergen: the solution structure of Phl p 2 from timothy grass pollen

scientific article

Analysis of potential receptor tyrosine kinase targets in intimal and mural sarcomas

article

Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomas

scientific article published on 17 February 2010

Analysis of the molecular species generated by mdm2 gene amplification in liposarcomas

article

Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib

scientific article published on 21 March 2013

BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis

scientific article published on 7 July 2015

Biochemical Uncovering of mdm2/p53 Complexes in Liposarcomas Parallels Their Immunohistochemical Detection

scientific article published on 01 September 1999

Biological insights into BRAF(V600) mutations in melanoma patient: Not mere therapeutic targets

scientific article published on 3 July 2013

Carney triad: case report and molecular analysis of gastric tumor

scientific article

Challenging Lung Carcinoma with Coexistent ΔNp63/p40 and Thyroid Transcription Factor-1 Labeling Within the Same Individual Tumor Cells

scientific article published in October 2015

Clinical, histopathologic, molecular and therapeutic findings in a large kindred with gastrointestinal stromal tumor

scientific article published on February 2008

Cyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis

scientific article

Dacarbazine in solitary fibrous tumor: a case series analysis and preclinical evidence vis-a-vis temozolomide and antiangiogenics

scientific article published on 25 July 2013

Deciphering intra-tumor heterogeneity of lung adenocarcinoma confirms that dominant, branching, and private gene mutations occur within individual tumor nodules

scientific article published on 7 April 2016

Detection of novel mRNA splice variants of human ING4 tumor suppressor gene.

scientific article

Detection of overexpressed and phosphorylated wild-type kit receptor in surgical specimens of small cell lung cancer

scientific article published in December 2004

Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies

scientific article published on 16 December 2013

Different clinical effects upon separate inhibition of coexisting EGFR and PI3KCA mutations in a lung adenocarcinoma patient.

scientific article published on 19 December 2014

Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge

scientific article published on 26 August 2015

Does immunohistochemistry affect response to therapy and survival of inoperable non-small cell lung carcinoma patients? A survey of 145 stage III-IV consecutive cases.

scientific article

Doing more with less: fluorescence in situ hybridization and gene sequencing assays can be reliably performed on archival stained tumor tissue sections

scientific article published on 27 January 2016

Dose-Dense Temozolomide in Patients with MGMT-Silenced Chemorefractory Colorectal Cancer

scientific article published on 4 November 2015

Dotlike or Golgi-like KIT and PDGFRA Staining in GIST

Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study

scientific article published on July 2007

Evidence for PDGFRA, PDGFRB and KIT deregulation in an NSCLC patient.

scientific article published in January 2007

Evidence for activation of KIT, PDGFRα, and PDGFRβ receptors in the Ewing sarcoma family of tumors

article

Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone

scientific article published in August 2003

Ewing sarcoma of the small bowel: a study of seven cases, including one with the uncommonly reported EWSR1-FEV translocation

scientific article

Expression of HER-2/neu gene and protein in salivary duct carcinomas of parotid gland as revealed by fluorescence in-situ hybridization and immunohistochemistry

scientific article published in March 2004

Expression of ligand-activated KIT and platelet-derived growth factor receptor beta tyrosine kinase receptors in synovial sarcoma

scientific article published on February 2004

FOLFOX-4 chemotherapy for patients with unresectable or relapsed peritoneal pseudomyxoma

scientific article

Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients

article

Functional analysis and molecular modeling show a preserved wild-type activity of p53(C238Y).

scientific article published in June 2006

Functional mapping of receptor tyrosine kinases in myxoid liposarcoma.

scientific article published on 3 June 2010

GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: a clinical and translational study

scientific article published on 6 May 2016

Gastrointestinal stromal tumors I: pathology, pathobiology, primary therapy, and surgical issues

scientific article published on August 2009

Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript.

scientific article

Genetic Markers in Sporadic Tumors

Genomics in non-adenoid cystic group of salivary gland cancers: one or more druggable entities?

scientific article published on 04 April 2019

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer.

scientific article published on 25 October 2016

High CD133 expression levels in gastrointestinal stromal tumors

scientific article published on April 2011

Human recombinant antibody fragments specific for a rye-grass pollen allergen: characterization and potential applications.

scientific article

Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma

scientific article

Imatinib in advanced chordoma: A retrospective case series analysis

scientific article published on 14 August 2015

Imatinib mesylate in chordoma

scientific article

Imatinib response in two GIST patients carrying two hitherto functionally uncharacterized PDGFRA mutations: an imaging, biochemical and molecular modeling study

scientific article published in February 2011

Immunohistochemical and molecular profile of salivary gland cancer in children.

scientific article

In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas.

scientific article published on 9 September 2013

Is autophagy rather than apoptosis the regression driver in imatinib-treated gastrointestinal stromal tumors?

scientific article published on December 2008

KIT/Val654 Ala receptor detected in one imatinib-resistant GIST patient.

scientific article published in February 2005

KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors

scientific article published on 26 January 2012

Lack of SYT-SSX fusion transcripts in malignant peripheral nerve sheath tumors on RT-PCR analysis of 34 archival cases

scientific article published on May 2002

Mode of action of trabectedin in myxoid liposarcomas.

scientific article published on 11 November 2013

Molecular and biochemical analyses of platelet-derived growth factor receptor (PDGFR) B, PDGFRA, and KIT receptors in chordomas

scientific article published in December 2006

Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation

scientific article

Neoadjuvant imatinib in a locally advanced gastrointestinal stromal tumour (GIST) of the rectum: a rare case of two GISTs within a family without a familial GIST syndrome

scientific article published on 01 August 2007

Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacologic features of human tumors.

scientific article published on 20 August 2010

Oncogenic and ligand-dependent activation of KIT/PDGFRA in surgical samples of imatinib-treated gastrointestinal stromal tumours (GISTs).

scientific article published in January 2009

Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b

scientific article published on 14 December 2015

PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics

scientific article published on 15 September 2014

PDGFRA Immunostaining Can Help in the Diagnosis of Gastrointestinal Stromal Tumors

scientific article published on 01 May 2008

PDGFRalpha, PDGFRbeta and KIT expression/activation in conventional chondrosarcoma.

scientific article published on April 2006

Pathological response after neoadjuvant bevacizumab- or cetuximab-based chemotherapy in resected colorectal cancer liver metastases

article

Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma

scientific article published on 03 June 2011

Phase II study of imatinib in advanced chordoma

scientific article

Phase II study on lapatinib in advanced EGFR-positive chordoma

scientific article published on 4 April 2013

Phase II trial with axitinib in recurrent and/or metastatic salivary gland cancers of the upper aerodigestive tract

scientific article published on 29 July 2019

Platelet-derived growth factor receptor alpha expression improves the diagnostic assessment of gastrointestinal stromal tumours.

scientific article

Post-imatinib surgery in advanced/metastatic GIST: is it worthwhile in all patients?

scientific article published on 23 July 2009

Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors (GIST).

scientific article

Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib

scientific article

Proteomic detection of a large amount of SCGFα in the stroma of GISTs after imatinib therapy

scientific article

Quadruple-Negative GIST Is a Sentinel for Unrecognized Neurofibromatosis Type 1 Syndrome

scientific article published on 7 July 2016

Re: Odaet al. Frequent alteration ofp16INK4a/p14ARF andp53 pathways in the round cell component of myxoid/round cell liposarcoma:p53 gene alterations and reduced p14ARF expression both correlate with poor prognosis.J Pathol 2005;207:410–421

article

Re: Response of a KIT-Positive Extra-abdominal Fibromatosis to Imatinib Mesylate and KIT Genetic Analysis

article

Response to imatinib plus sirolimus in advanced chordoma.

scientific article published in July 2009

Response to sunitinib malate in advanced alveolar soft part sarcoma

scientific article

Role of EGFR family receptors in proliferation of squamous carcinoma cells induced by wound healing fluids of head and neck cancer patients.

scientific article published on 22 February 2011

SYT-SSX fusion genes and prognosis in synovial sarcoma.

scientific article published on November 2001

Self-Assembled Nanomicelles as Curcumin Drug Delivery Vehicles: Impact on Solitary Fibrous Tumor Cell Protein Expression and Viability

scientific article published on 17 September 2018

Solitary fibrous tumors: loss of chimeric protein expression and genomic instability mark dedifferentiation

scientific article

Synergistic Activation upon MET and ALK Coamplification Sustains Targeted Therapy in Sarcomatoid Carcinoma, a Deadly Subtype of Lung Cancer

scientific article published on 21 January 2016

T315I-mutated Bcr-Abl in chronic myeloid leukemia and imatinib: insights from a computational study

scientific article published in August 2005

T670X KIT mutations in gastrointestinal stromal tumors: making sense of missense

scientific article published on 27 January 2009

TRK-A, HER-2/neu, and KIT Expression/Activation Profiles in Salivary Gland Carcinoma

scientific article published on September 2008

Targeted therapies: the rare cancer paradigm

scientific article published on 28 October 2009

Targeted therapy in GIST: in silico modeling for prediction of resistance

scientific article published on March 2011

The CD133 expression levels and its role as potential cancer stem cells marker in gastrointestinal stromal tumor

scientific article published on 18 February 2012

The Role of the L-Chain in Ferritin Iron Incorporation

scientific article published on 01 May 1994

The status of PD-L1 and tumor-infiltrating immune cells predict resistance and poor prognosis in BRAFi-treated melanoma patients harboring mutant BRAFV600.

scientific article published on 2 June 2015

Toward the molecular dissection of peritoneal pseudomyxoma.

scientific article published in November 2016

Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors

scientific article

Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs).

scientific article published in July 2009

c-Kit/PDGFRA gene status alterations possibly related to primary imatinib resistance in gastrointestinal stromal tumors

scientific article published in April 2007

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