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List of works by Silvana Pilotti

30 years' follow up of randomised studies of adjuvant CMF in operable breast cancer: cohort study

scientific article

9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations.

scientific article

A Sporadic Multiple GIST With Unusual Pathologic, Molecular, and Genetic Features

scientific article published on 01 February 2008

A functional gene expression analysis in epithelial sinonasal cancer: Biology and clinical relevance behind three histological subtypes

article

A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

scientific article

A quality control program for mutation detection in KIT and PDGFRA in gastrointestinal stromal tumours.

scientific article

A randomized trial comparing axillary dissection to no axillary dissection in older patients with T1N0 breast cancer: results after 5 years of follow-up.

scientific article published in July 2005

AKT1 and BRAF mutations in pediatric aggressive fibromatosis

scientific article published on 08 April 2016

Absence of microsatellite instability in breast carcinomas with both p53 and c-erbB-2 alterations

scientific article published in March 1999

Activate and resist: L576P-KIT in GIST.

scientific article published in September 2009

Activated leukocyte cell adhesion molecule expression and shedding in thyroid tumors

scientific article

Activity of abiraterone in rechallenging two AR-expressing salivary gland adenocarcinomas, resistant to androgen-deprivation therapy.

scientific article published on 11 March 2014

Adaptive Immunity in Fibrosarcomatous Dermatofibrosarcoma Protuberans and Response to Imatinib Treatment.

scientific article published on 5 September 2016

Afatinib is a new therapeutic approach in chordoma with a unique ability to target EGFR and Brachyury

scientific article published on 13 December 2017

Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.

scientific article published in September 2004

Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomas

scientific article

Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study

scientific article published on 18 December 2013

Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1

scientific article published on 19 June 2014

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

scientific article

Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases

scientific article published on 25 June 2016

Are Fusion Transcripts in Relapsed/Metastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?

scientific article published on 12 November 2017

Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib

scientific article published on 21 March 2013

BRAF alterations are associated with complex mutational profiles in malignant melanoma

scientific article published in August 2004

CD95-mediated apoptosis is impaired at receptor level by cellular FLICE-inhibitory protein (long form) in wild-type p53 human ovarian carcinoma

scientific article published on August 2004

Cancer Associated Fibroblasts and Senescent Thyroid Cells in the Invasive Front of Thyroid Carcinoma

scientific article published on 01 January 2020

Chordoma of the mobile spine and sacrum: a retrospective analysis of a series of patients surgically treated at two referral centers

scientific article

Chromosome band 17q21 in breast cancer: Significant association between beclin 1 loss and HER2/NEU amplification

scientific article published on 01 October 2010

Circulating free DNA in a screening program for early colorectal cancer detection.

scientific article

Clinical activity of androgen deprivation therapy in patients with metastatic/relapsed androgen receptor-positive salivary gland cancers.

scientific article

Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma

scientific article published on 19 August 2013

Coexpression of survivin and TERT in soft-tissue sarcoma.

scientific article

Combination of PPARγ Agonist Pioglitazone and Trabectedin Induce Adipocyte Differentiation to Overcome Trabectedin Resistance in Myxoid Liposarcomas

scientific article published on 03 September 2019

Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types

scientific article published on 29 October 2018

Correction: Combination of PPARγ Agonist Pioglitazone and Trabectedin Induce Adipocyte Differentiation to Overcome Trabectedin Resistance in Myxoid Liposarcomas

scientific article published on 01 March 2020

Correction: Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin

scientific article published on 01 March 2020

Correction: miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.

scientific article

Cutaneous Melanoma in Childhood and Adolescence Shows Frequent Loss of INK4A and Gain of KIT

article

Cyclin D1 expression analysis in familial breast cancers may discriminate BRCAX from BRCA2-linked cases

scientific article published on 7 March 2008

Cyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis

scientific article

Cyclooxygenase-2 expression in FAP patients carrying germ line MYH mutations.

scientific article

DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells.

scientific article published on 21 January 2013

Dermatofibrosarcoma protuberans-derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib.

scientific article

Detection of overexpressed and phosphorylated wild-type kit receptor in surgical specimens of small cell lung cancer

scientific article published in December 2004

Development of transplantable human chordoma xenograft for preclinical assessment of novel therapeutic strategies

scientific article

Different genetic features associated with colon and rectal carcinogenesis.

scientific article

Differential expression of telomerase activity in neuroendocrine lung tumours: correlation with gene product immunophenotyping.

scientific article published in September 2003

Does immunohistochemistry affect response to therapy and survival of inoperable non-small cell lung carcinoma patients? A survey of 145 stage III-IV consecutive cases.

scientific article

Dotlike or Golgi-like KIT and PDGFRA Staining in GIST

Efficacy and Biological Activity of Imatinib in Metastatic Dermatofibrosarcoma Protuberans (DFSP).

scientific article

Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study

scientific article published on July 2007

Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework

scientific article published on 26 September 2016

Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin

scientific article published on 14 August 2019

Evidence for activation of KIT, PDGFRα, and PDGFRβ receptors in the Ewing sarcoma family of tumors

article

Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone.

scientific article published in August 2003

Evidence of oncogene-induced senescence in thyroid carcinogenesis.

scientific article published in December 2011

Evolution of Dermatofibrosarcoma Protuberans to DFSP-Derived Fibrosarcoma: An Event Marked by Epithelial-Mesenchymal Transition-like Process and 22q Loss

article

Ewing sarcoma of the small bowel: a study of seven cases, including one with the uncommonly reported EWSR1-FEV translocation

scientific article

Experience with peritoneal mesothelioma at the Milan National Cancer Institute.

scientific article

Expression of ligand-activated KIT and platelet-derived growth factor receptor beta tyrosine kinase receptors in synovial sarcoma

scientific article published on February 2004

Expression of protein tyrosine kinases in head and neck squamous cell carcinomas

scientific article published on 01 October 2006

Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib

scientific article

FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer

scientific article published in August 2005

Fixation Time and Microwave Oven Irradiation Affect Immunocytochemical p53 Detection in Formalin-Fixed Paraffin Sections

Fluorescence in situ hybridization (FISH) provides estimates of minute and interstitial BAP1, CDKN2A, and NF2 gene deletions in peritoneal mesothelioma

scientific article published on 30 September 2019

Fluorescence in situ hybridization analysis and immunophenotyping of c-Kit/PDGFRA and Bcl-2 expression in gastrointestinal stromal tumors.

scientific article

Functional Genomics Uncover the Biology behind the Responsiveness of Head and Neck Squamous Cell Cancer Patients to Cetuximab.

scientific article

Functional analysis and molecular modeling show a preserved wild-type activity of p53(C238Y).

scientific article published in June 2006

Functional mapping of receptor tyrosine kinases in myxoid liposarcoma.

scientific article published on 3 June 2010

Gene expression profiling of advanced ovarian cancer: characterization of a molecular signature involving fibroblast growth factor 2.

scientific article published on October 2004

Genetic Markers in Sporadic Tumors

Genetic changes in lung cancer

article

HER-2/neu Assessment in Primary Chemotherapy Treated Breast Carcinoma: No Evidence of Gene Profile Changing

article

HER2 overexpression and doxorubicin in adjuvant chemotherapy for resectable breast cancer.

scientific article published on February 2003

HMGA1 protein expression in familial breast carcinoma patients

scientific article published on 05 November 2009

HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma

scientific article published on 6 April 2017

High CD133 expression levels in gastrointestinal stromal tumors

scientific article published on April 2011

High-Risk Human Papillomavirus Affects Prognosis in Patients With Surgically Treated Oropharyngeal Squamous Cell Carcinoma

scientific article published on 01 December 2006

High-dose continuous-infusion ifosfamide in advanced well-differentiated/dedifferentiated liposarcoma

scientific article

High-grade sarcomatous overgrowth in solitary fibrous tumors: a clinicopathologic study of 10 cases

scientific article

ICON3 and chemotherapy for ovarian cancer

Identification of SRF-E2F1 fusion transcript in EWSR-negative myoepithelioma of the soft tissue

scientific article published on 17 May 2017

Identification of a gene expression driven progression pathway in myxoid liposarcoma

scientific article

Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma

scientific article published on 23 June 2018

Imatinib and everolimus in patients with progressing advanced chordoma: A phase 2 clinical study

scientific article published on 14 September 2018

Imatinib in advanced chordoma: A retrospective case series analysis

scientific article

Imatinib mesylate in chordoma

scientific article

Imatinib response in two GIST patients carrying two hitherto functionally uncharacterized PDGFRA mutations: an imaging, biochemical and molecular modeling study

scientific article published in February 2011

In Response

In situ hybridization detection methods for HPV16 E6/E7 mRNA in identifying transcriptionally active HPV infection of oropharyngeal carcinoma: an updating

scientific article published on 6 October 2017

In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas.

scientific article published on 9 September 2013

Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene

scientific article

Integrative approach for prioritizing cancer genes in sporadic colon cancer.

scientific article published in November 2009

Integrative miRNA-Gene Expression Analysis Enables Refinement of Associated Biology and Prediction of Response to Cetuximab in Head and Neck Squamous Cell Cancer.

scientific article published on 14 January 2017

Is autophagy rather than apoptosis the regression driver in imatinib-treated gastrointestinal stromal tumors?

scientific article published on December 2008

Isolating p16-positive/HPV-negative oropharyngeal cancer: an effort worth making.

scientific article

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

scientific article (publication date: July 2005)

KIT activation in soft tissue sarcomas

scientific article published on 01 September 2002

KIT/Val654 Ala receptor detected in one imatinib-resistant GIST patient.

scientific article published in February 2005

KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors

scientific article published on 26 January 2012

Lack of SYT-SSX fusion transcripts in malignant peripheral nerve sheath tumors on RT-PCR analysis of 34 archival cases

scientific article published on May 2002

Lack of telomerase activity in lung carcinoids is dependent on human telomerase reverse transcriptase transcription and alternative splicing and is associated with long telomeres.

scientific article

MIF/CD74 axis is a target for novel therapies in colon carcinomatosis

scientific article

Malignant peripheral nerve sheath tumors

scientific article published on 01 September 2006

Melan-A/MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report

scientific article

Metallothionein 1G acts as an oncosupressor in papillary thyroid carcinoma

scientific article

Minimally invasive (encapsulated) follicular carcinoma of the thyroid gland is the low-risk counterpart of widely invasive follicular carcinoma but not of insular carcinoma

scientific article published on 02 October 2002

Molecular Signatures for Combined Targeted Treatments in Diffuse Malignant Peritoneal Mesothelioma

scientific article published on 19 November 2019

Molecular and Cytogenetic Subgroups of Oropharyngeal Squamous Cell Carcinoma

scientific article published on 01 November 2006

Molecular and biochemical analyses of platelet-derived growth factor receptor (PDGFR) B, PDGFRA, and KIT receptors in chordomas

scientific article

Molecular changes track recurrence and progression of bronchial precancerous lesions

scientific article

Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation

scientific article

Molecular cytogenetic characterization of proximal-type epithelioid sarcoma

scientific article published in November 2004

Myogenic Differentiation and Histologic Grading Are Major Prognostic Determinants in Retroperitoneal Liposarcoma

scientific article published on 01 March 2015

NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas

scientific article published on 14 May 2019

Neoplastic Lymphangiosis of the Upper Aerodigestive Tract Simulating Field Cancerization: Histopathological Analysis, Surgical Limits and Literature Review ⬇️

scientific article published on July 1, 2012

Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report

scientific article published on 01 July 2007

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

scientific article published on 27 June 2019

New transcriptional-based insights into the pathogenesis of desmoplastic small round cell tumors (DSRCTs)

scientific article published on 22 March 2017

Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacologic features of human tumors.

scientific article published on 20 August 2010

Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved.

scientific article published on September 2014

Oropharyngeal squamous cell carcinoma treated with radiotherapy or radiochemotherapy: prognostic role of TP53 and HPV status

scientific article published on 04 July 2009

Other targetable sarcomas

scientific article

PDGFRA Immunostaining Can Help in the Diagnosis of Gastrointestinal Stromal Tumors

scientific article published on 01 May 2008

PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor

scientific article published on December 2009

PIK3CA cancer mutations display gender and tissue specificity patterns

scientific article published in February 2008

PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells

scientific article

Pathology of ovarian cancers in BRCA1 and BRCA2 carriers

scientific article published on April 2004

Phase II study of imatinib in advanced chordoma

scientific article

Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.

scientific article

Phosphatase Protein Homologue to Tensin Expression and Phosphatidylinositol-3 Phosphate Kinase Mutations in Colorectal Cancer

Platelet-derived growth factor receptor alpha expression improves the diagnostic assessment of gastrointestinal stromal tumours.

scientific article

Polymorphisms of Metabolizing Enzymes and Susceptibility to Ethmoid Intestinal-type Adenocarcinoma in Professionally Exposed Patients

scientific article published on May 2009

Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype

scientific article published on July 2005

Primary primitive peripheral neuroectodermal tumor of the prostate. Immunophenotypic and molecular study of a case.

scientific article

Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma

scientific article

Prognostic determinants in epithelioid sarcoma.

scientific article published in January 2011

Prolonged response using gefitinib followed by sirolimus for advanced cutaneous squamous cell carcinoma

scientific article published on 01 November 2012

Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification

scientific article published on June 2007

Proteomic detection of a large amount of SCGFα in the stroma of GISTs after imatinib therapy

scientific article

Quadruple-Negative GIST Is a Sentinel for Unrecognized Neurofibromatosis Type 1 Syndrome

scientific article published on 7 July 2016

Quantitative analysis of plasma DNA in colorectal cancer patients: a novel prognostic tool

scientific article published in September 2006

Re: Potential use of imatinib in Ewing's sarcoma: evidence for in vitro and in vivo activity

scientific article

Re: Response of a KIT-Positive Extra-abdominal Fibromatosis to Imatinib Mesylate and KIT Genetic Analysis

article

Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma.

scientific article published on 6 August 2010

Receptor tyrosine kinase pathway analysis sheds light on similarities between clear-cell sarcoma and metastatic melanoma.

scientific article

Receptor tyrosine kinase profiles and human papillomavirus status in oropharyngeal squamous cell carcinoma

scientific article published on 14 December 2014

Reproducibility between messenger RNA real-time polymerase chain reaction and messenger RNA in situ hybridization in oropharyngeal squamous cell carcinoma patients

scientific article published on 3 October 2015

Response to Griewank and Bastian

Response to imatinib in villonodular pigmented synovitis (PVNS) resistant to nilotinib

scientific article published on 13 May 2013

Response to sunitinib malate in advanced alveolar soft part sarcoma

scientific article

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

scientific article published on 01 February 2013

SCCA2-like serpins mediate genetic predisposition to skin tumors

scientific article (publication date: 15 April 2003)

SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas

scientific article

Self-Assembled Nanomicelles as Curcumin Drug Delivery Vehicles: Impact on Solitary Fibrous Tumor Cell Protein Expression and Viability

scientific article published on 17 September 2018

Sirolimus in Advanced Epithelioid Hemangioendothelioma: A Retrospective Case-Series Analysis from the Italian Rare Cancer Network Database.

scientific article published on 22 June 2016

Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma.

scientific article published on 26 September 2014

Solitary fibrous tumor of all sites: outcome of late recurrences in 14 patients.

scientific article published on 3 April 2013

Solitary fibrous tumors: loss of chimeric protein expression and genomic instability mark dedifferentiation

scientific article

Structured myeloid cells and anti-angiogenic therapy in alveolar soft part sarcoma.

scientific article published on 27 September 2013

Subcellular Localization of Activated Leukocyte Cell Adhesion Molecule Is a Molecular Predictor of Survival in Ovarian Carcinoma Patients

scientific article published on 01 March 2008

Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response

scientific article

Sunitinib-induced morpho-functional changes and drug effectiveness in malignant solitary fibrous tumours

scientific article

Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/metastatic GIST.

scientific article published in March 2007

T670X KIT mutations in gastrointestinal stromal tumors: making sense of missense

scientific article published on 27 January 2009

TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma.

scientific article published on 4 January 2010

TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses

article

TRK-A, HER-2/neu, and KIT Expression/Activation Profiles in Salivary Gland Carcinoma

scientific article published on September 2008

Targeted therapies: the rare cancer paradigm

scientific article published on 28 October 2009

Targeted therapy in GIST: in silico modeling for prediction of resistance

scientific article published on March 2011

Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression

scientific article published on 01 September 2006

The CD133 expression levels and its role as potential cancer stem cells marker in gastrointestinal stromal tumor

scientific article published on 18 February 2012

The familial medullary thyroid carcinoma-associated RET E768D mutation in a multiple endocrine neoplasia type 2A case

scientific article published on 01 May 2005

The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response

article

Tp53 status as guide for the management of ethmoid sinus intestinal-type adenocarcinoma.

scientific article published on 29 January 2013

Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors

scientific article

Trabectedin in advanced uterine leiomyosarcomas: A retrospective case series analysis from two reference centers

scientific article published on 13 September 2011

Tumor location and detection of k-ras mutations in stool from colorectal cancer patients.

scientific article

UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines

scientific article

Unusual myogenic and melanocytic differentiation of soft tissue pPNETs: an immunohistochemical and molecular study of 3 cases.

scientific article published in July 2010

Well-differentiated liposarcoma with leiomyomatous differentiation

scientific article published on 01 December 2002

c-FLIPL expression defines two ovarian cancer patient subsets and is a prognostic factor of adverse outcome

scientific article published on 25 March 2009

c-Kit/PDGFRA gene status alterations possibly related to primary imatinib resistance in gastrointestinal stromal tumors.

scientific article published in April 2007

miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma.

scientific article published on May 2014

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.

scientific article published on 08 February 2016

miRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation.

scientific article

p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors

scientific article published on 01 September 2003

p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx

scientific article published on 01 June 2007

β-Catenin in desmoid-type fibromatosis: deep insights into the role of T41A and S45F mutations on protein structure and gene expression.

scientific article published on 19 June 2017

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