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List of works by Caetano Reis e Sousa

2011 ESCI Award for Excellence in Basic / Translational Research: innate regulation of adaptive immunity by dendritic cells ⬇️

scientific article published on May 26, 2011

A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells

scientific article

Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster

scientific article

Activation of MDA5 requires higher-order RNA structures generated during virus infection

scientific article

Activation of dendritic cells: translating innate into adaptive immunity

scientific article published on February 2004

Adaptive immunity after cell death ⬇️

scientific article published on April 20, 2013

Advantages and limitations of mouse models to deplete dendritic cells

scientific article published in January 2013

Alive but Confused: Heterogeneity of CD11c + MHC Class II + Cells in GM-CSF Mouse Bone Marrow Cultures

article

Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells.

scientific article

An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma

scientific article

Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue

article

Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates

scientific article published on 14 January 2015

Antigen processing

scientific article

Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro.

scientific article

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

scientific article

CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

article

CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells

scientific article published on 01 June 2002

CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal

scientific article published on October 2000

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

scientific article published on 17 October 2012

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

scientific article

CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.

scientific article published on April 2009

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

scientific article published on 17 August 2011

Caetano Reis e Sousa: harnessing DC power. Interview by Hema Bashyam

scientific article published on September 2008

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells

scientific article

Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo.

scientific article published on 16 April 2018

Conditioning of dendritic cells by pathogen-derived stimuli.

scientific article

Correction: Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection

scientific article published on 21 November 2018

Cross-presentation of cell-associated antigens by CD8alpha+ dendritic cells is attributable to their ability to internalize dead cells

scientific article published in October 2002

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

scientific article

Cytoskeletal Exposure in the Regulation of Immunity and Initiation of Tissue Repair

scientific article published on 03 June 2019

Cytosolic sensing of viruses

scientific article

DC activated via dectin-1 convert Treg into IL-17 producers

scientific article published on December 2008

DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues

scientific article

Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

scientific article published on 10 August 2004

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

scientific article published on 24 August 2009

Defining dendritic cells

scientific article published on 03 December 2014

Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors

scientific article published on July 2017

Dendritic cell expression of the Notch ligandjagged2 is not essential for Th2 response inductionin vivo

article

Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo

scientific article

Dendritic cells as sensors of infection.

scientific article

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

scientific article

Dendritic cells in a mature age.

scientific article

Dendritic cells in remodeling of lymph nodes during immune responses

scientific article published on May 2016

Dendritic cells: immunobiology and cancer immunotherapy

scientific article published in January 2004

Differential TCR Signaling Regulates Apoptosis and Immunopathology during Antigen Responses In Vivo

article

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

scientific article (publication date: 4 May 2006)

Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination

scientific article

Direct reprogramming of fibroblasts into antigen-presenting dendritic cells

scientific article published on 01 December 2018

Drosha cuts the tethers of myelopoiesis

scientific article

Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.

scientific article

Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells

scientific journal article

F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.

scientific article

Gene manipulation in the induction of anti-tumour immunity

scientific article published in November 1999

Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage.

scientific article

Harnessing dendritic cells ⬇️

scientific article published on February 1, 2011

Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection.

scientific article published on February 2015

Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells

scientific article published on 11 January 2011

ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro

article

IL-12 Induction by a Th1-Inducing Adjuvant In Vivo: Dendritic Cell Subsets and Regulation by IL-10

scientific article published on 01 August 2001

IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells

scientific article published on 9 January 2014

IMMUNOLOGY: Eating In to Avoid Infection

scientific article published in Science

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

scientific article published on April 2009

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

scientific article published on 18 February 2014

Ignition of the type 1 response to intracellular infection by dendritic cell-derived interleukin-12.

scientific article published in September 1998

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas ⬇️

scientific article published on December 1, 1997

Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.

scientific article

Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function

article by Roman Spörri & Caetano Reis e Sousa published 16 January 2005 in Nature Immunology

Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

scientific article published on January 2009

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

scientific journal article

Innate recognition of viruses

scientific article published on September 2007

Internalization of Dectin-1 terminates induction of inflammatory responses

scientific article published on February 2009

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

scientific article published on 19 May 2015

Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

scientific article published on 17 December 2001

MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells.

scientific article

Microbial and T Cell-Derived Stimuli Regulate Antigen Presentation by Dendritic Cells In Vivo

scientific article published on 01 November 2000

Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering

scientific article

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

scientific article

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

scientific article

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

scientific article published on 10 September 2015

Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense ⬇️

scientific article published on May 27, 2011

Myeloid C-type lectins in innate immunity

scientific article published on December 2006

Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens

scientific article published on 01 July 2018

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

scientific article published on 6 February 2018

Newly activated T cells promote maturation of bystander dendritic cells but not IL-12 production

article

Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides

scientific article published on 01 December 2006

Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice

scientific article

PYHIN proteins: center stage in DNA sensing

Paralysis of Dendritic Cell IL-12 Production by Microbial Products Prevents Infection-Induced Immunopathology

article

Phagocytosis of antigens by Langerhans cells

scientific article

Processing and presentation of endocytically acquired protein antigens by MHC class II and class I molecules

scientific article published on June 1996

Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes

scientific article published on October 2013

Production, specificity, and functionality of monoclonal antibodies to specific peptide–major histocompatibility complex class II complexes formed by processing of exogenous protein ⬇️

scientific article published on December 9, 1997

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity

scientific article

RIG-I detects viral genomic RNA during negative-strand RNA virus infection

scientific article

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

scientific article (publication date: 10 November 2006)

RIGorous detection: exposing virus through RNA sensing.

scientific article published in January 2010

RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.

scientific article

RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency

scientific article published on 14 February 2022

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

scientific article published on 05 November 2021

Reducing prostaglandin E2 production to raise cancer immunogenicity

scientific article published on 4 January 2016

Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns

scientific article published on July 2003

SAMHD1-dependent retroviral control and escape in mice.

scientific article published on 19 July 2013

SAMHD1-dependent retroviral control and escape in mice.

scientific article

Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands.

scientific article

Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen

scientific article published on 01 November 2002

Sensing infection and tissue damage

scientific article published on 24 January 2017

Sensing of cell death by myeloid C-type lectin receptors

scientific article

Signaling by myeloid C-type lectin receptors in immunity and homeostasis

scientific article published on 6 January 2012

Slicing and dicing viruses: antiviral RNA interference in mammals

scientific article published on 14 March 2019

Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses

scientific article published on 25 September 2008

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

scientific article

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

article by Salomé LeibundGut-Landmann et al published 22 April 2007 in Nature Immunology

Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan

scientific article published on June 2007

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

scientific journal article

Targeting the viral Achilles’ heel: recognition of 5′-triphosphate RNA in innate anti-viral defence ⬇️

scientific article published on May 23, 2013

The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice

scientific article published on 16 April 2012

The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes

scientific article published on 27 April 2015

The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells

scientific article published on 19 January 2018

The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity

scientific article published on 29 September 2018

The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals

scientific article published on 01 January 2003

The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

scientific article published on 16 April 2012

The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens

scientific article published on 21 December 2020

The role of dendritic cells in the induction and regulation of immunity to microbial infection.

scientific article

The role of dendritic cells in the initiation of host resistance to Toxoplasma gondii.

scientific article

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

scientific article published on 01 March 2019

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

scientific article

Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.

scientific article published in April 2003

Toll-like receptors and dendritic cells: for whom the bug tolls

scientific article published on February 2004

Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9.

scientific article published on November 2006

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

scientific article

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.

scientific article

Vitamin D regulates microbiome-dependent cancer immunity

scientific article published on 26 April 2024

α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in

article

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