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List of works by Michele Brignole

'The Italian Protocol': a simplified head-up tilt testing potentiated with oral nitroglycerin to assess patients with unexplained syncope

scientific article published in October 2000

2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Associ

scientific article published on 24 June 2013

2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope

scientific article published on 14 May 2015

A new management of syncope: prospective systematic guideline-based evaluation of patients referred urgently to general hospitals

scientific article published on 4 November 2005

A patient with syncopal ventricular tachycardia (noninducible on electrophysiologic study) and coronary artery disease

scientific article published in September 1996

A positive response to head-up tilt testing predicts syncopal recurrence in carotid sinus syndrome patients with permanent pacemakers

scientific article published in October 1995

A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE).

scientific article published in October 2004

A standardized conventional evaluation of the mechanism of syncope in patients with bundle branch block

scientific article published in October 2002

A very prolonged asystolic vasovagal syncope is suspended but not aborted by counterpressure manoeuvre

scientific article published in January 2010

Additional diagnostic value of implantable loop recorder in patients with initial diagnosis of real or apparent transient loss of consciousness of uncertain origin

scientific article published on 25 March 2014

Additional diagnostic value of very prolonged observation by implantable loop recorder in patients with unexplained syncope

scientific article published on 21 July 2011

Adenosine-induced atrioventricular block in patients with unexplained syncope: the diagnostic value of ATP testing

scientific article published in December 1997

An abnormal neural reflex plays a role in causing syncope in sinus bradycardia

scientific article published in October 1993

An update on the diagnosis and treatment of autonomic nervous system dysfunctional syndromes with orthostatic intolerance

scientific article published in March 1999

Analysis of rhythm variation during spontaneous cardioinhibitory neurally-mediated syncope. Implications for RDR pacing optimization: an ISSUE 2 substudy

scientific article published on 30 March 2007

Assessment of VVI diagnostic pacing mode in patients with cardioinhibitory carotid sinus syndrome

scientific article published in November 1988

Assessment of a standardized algorithm for cardiac pacing in older patients affected by severe unpredictable reflex syncopes

scientific article published on 29 March 2015

Assessment of a structured management pathway for patients referred to the Emergency Department for syncope: results in a tertiary hospital

scientific article published on 14 May 2015

Assessment of the vasodepressor reflex in carotid sinus syndrome

scientific article published on 24 April 2014

Association of the carotid sinus syndrome and orthostatic hypotension. Another potential cause of the failure of VVI electrostimulation

scientific article published in October 1985

Benefit of dual-chamber pacing with Closed Loop Stimulation in tilt-induced cardio-inhibitory reflex syncope (BIOSync trial): study protocol for a randomized controlled trial

scientific article published on 4 May 2017

Benefit of pacemaker therapy in patients with presumed neurally mediated syncope and documented asystole is greater when tilt test is negative: an analysis from the third International Study on Syncope of Uncertain Etiology (ISSUE-3).

scientific article published on 12 December 2013

Cardiac output and vasodilation in the vasovagal response: An analysis of the classic papers

scientific article published on 17 November 2015

Cardiac pacing in patients with neurally mediated syncope and documented asystole: effectiveness analysis from the Third International Study on Syncope of Uncertain Etiology (ISSUE-3) Registry

scientific article published on 9 January 2014

Cardioinhibitory carotid sinus hypersensitivity in subjects with symptomatic sinus dysfunction

scientific article published in August 1986

Cardioinhibitory carotid sinus hypersensitivity predicts an asystolic mechanism of spontaneous neurally mediated syncope

scientific article published on 16 May 2007

Cardioinhibitory reflex provoked by stimulation of carotid sinus in normal subjects and those with cardiovascular disease

scientific article published in May 1985

Carotid sinus massage, eyeball compression, and head-up tilt test in patients with syncope of uncertain origin and in healthy control subjects

scientific article published in December 1991

Carotid sinus syncope: the most frequent neurally mediated syncope in the elderly

scientific article published in January 1995

Carotid sinus syndrome: evaluation of the cardioinhibitor and vasodepressive components and of the association with orthostatic hypotension

scientific article published in August 1985

Clinical Characteristics and Outcome of Patients with Situational Syncope Compared to Patients with Vasovagal Syncope

scientific article published on 28 February 2017

Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families

scientific article published in November 2000

Clinical context and outcome of carotid sinus syndrome diagnosed by means of the 'method of symptoms'.

scientific article published on 20 September 2013

Clinical features of adenosine sensitive syncope and tilt induced vasovagal syncope

scientific article published in January 2000

Clinical spectrum of neurally mediated reflex syncopes

scientific article

Comparison of clinical and electrophysiologic characteristics of patients with occult and manifest atrioventricular accessory pathway

scientific article published in August 2001

Comparison of diagnostic accuracy of sublingual nitroglycerin test and low-dose isoproterenol test in patients with unexplained syncope

scientific article published in May 2000

Comparison of permanent cardiac pacing and cardiac pacing on demand in mixed carotid sinus syndrome. Acute- and medium-term follow-up study

scientific article published in January 1988

Detecting incipient vasovagal syncope: intraventricular acceleration

scientific article published in March 1997

Diagnosis and treatment of syncope

scientific article published in January 2007

Diagnosis of neurally mediated syncope at initial evaluation and with tilt table testing compared with that revealed by prolonged ECG monitoring. An analysis from the Third International Study on Syncope of Uncertain Etiology (ISSUE-3).

scientific article published on 23 October 2013

Diagnostic value of history in patients with syncope with or without heart disease

scientific article published in June 2001

Discrepancy between clinical practice and standardized indications for an implantable loop recorder in patients with unexplained syncope

scientific article published in October 2010

Distinguishing syncopal from non-syncopal causes of fall in older people

scientific article published in September 2006

Dual-chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope : pacemaker versus no therapy: a multicenter randomized study. The Vasovagal Syncope International Study (VASIS) Investigators

scientific article published in July 2000

Early and late outcome of treated patients referred for syncope to emergency department: the EGSYS 2 follow-up study

scientific article published on 18 February 2010

Early application of an implantable loop recorder allows effective specific therapy in patients with recurrent suspected neurally mediated syncope

scientific article published on 28 March 2006

Effect of clinical triggers on positive responses to tilt-table testing potentiated with nitroglycerin or clomipramine

scientific article published on 21 March 2011

Effect of etilefrine in preventing syncopal recurrence in patients with vasovagal syncope: a double-blind, randomized, placebo-controlled trial. The Vasovagal Syncope International Study

scientific article published in March 1999

Effectiveness of physical counterpressure maneuvers in preventing vasovagal syncope: the Physical Counterpressure Manoeuvres Trial (PC-Trial).

scientific article published on 26 September 2006

Effectiveness of remote monitoring in the management of syncope and palpitations

scientific article published on 17 January 2011

Effects of chronic vasodilator therapy to enhance susceptibility to vasovagal syncope during upright tilt testing

scientific article published in October 1997

Effects of long-term vasodilator therapy in patients with carotid sinus hypersensitivity

scientific article published in August 1998

Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial

scientific article published in July 1997

Efficacy and feasibility of isometric arm counter-pressure manoeuvres to abort impending vasovagal syncope during real life

scientific article published in July 2004

Efficacy and safety of out-of-hospital self-administered single-dose oral drug treatment in the management of infrequent, well-tolerated paroxysmal supraventricular tachycardia

scientific article

Efficacy of theophylline in patients affected by low adenosine syncope

scientific article published on 9 December 2015

Efficacy of tilt training in the treatment of neurally mediated syncope. A randomized study

scientific article published in May 2004

Empiric pacemaker compared with a monitoring strategy in patients with syncope and bifascicular conduction block--rationale and design of the Syncope: Pacing or Recording in ThE Later Years (SPRITELY) study

scientific article published on 8 February 2012

Evaluation of patients with "faint" in an American teaching hospital: a dire need for a standardized approach

scientific article published on 22 November 2010

Experience with implantable loop recorders for recurrent unexplained syncope

scientific article published in September 2008

Follow-up of asystolic episodes in patients with cardioinhibitory, neurally mediated syncope and VVI pacemaker

scientific article published in November 1993

Guidelines for the diagnosis and management of syncope (version 2009)

scientific article

Guidelines on management (diagnosis and treatment) of syncope--update 2004.

scientific article published in November 2004

Guidelines on management (diagnosis and treatment) of syncope-update 2004. Executive Summary

scientific article published in November 2004

Guidelines on management (diagnosis and treatment) of syncope. Update 2004. Executive summary

scientific article published in February 2005

Guidelines on the diagnostic assessment of patients with syncope

scientific article published in July 1995

Head-up tilt testing potentiated with oral nitroglycerin: a randomized trial of the contribution of a drug-free phase and a nitroglycerin phase in the diagnosis of neurally mediated syncope

scientific article published in July 1999

How is syncope studied in the Italian hospitals?

scientific article published in June 2004

Hyperoxia Improves Hemodynamic Status During Head-up Tilt Testing in Healthy Volunteers: A Randomized Study

scientific article published in February 2016

Incidence, diagnostic yield and safety of the implantable loop-recorder to detect the mechanism of syncope in patients with and without structural heart disease

scientific article published in July 2004

Indications for the use of diagnostic implantable and external ECG loop recorders

scientific article published in May 2009

Influence of beta block and autonomic nerve block on the recovery time of the sinus node in sick sinus syndrome and carotid sinus syndrome

scientific article published in October 1984

Is DDD superior to VVI pacing in mixed carotid sinus syndrome? An acute and medium-term study

scientific article published in November 1988

Is vasovagal syncope a disease?

scientific article published in February 2007

Isometric arm counter-pressure maneuvers to abort impending vasovagal syncope

scientific article published in December 2002

Key challenges in the current management of syncope

scientific article published on 17 July 2012

Lack of correlation between the responses to tilt testing and adenosine triphosphate test and the mechanism of spontaneous neurally mediated syncope

scientific article published on 24 July 2006

Limitations of the stress test in the diagnosis of the sick sinus syndrome

scientific article published in December 1984

Long-Term Outcome of Patients with Bifascicular Block and Unexplained Syncope Following Cardiac Pacing

scientific article published on 26 August 2016

Long-term outcome in symptomatic carotid sinus hypersensitivity

scientific article published in March 1992

Long-term outcome of paced and nonpaced patients with severe carotid sinus syndrome

scientific article published in April 1992

Mechanism of syncope in patients with heart disease and negative electrophysiologic test

scientific article

Mechanism of syncope in patients with positive adenosine triphosphate tests

scientific article published in January 2003

Mechanism of syncope without prodromes with normal heart and normal electrocardiogram

scientific article published on 14 September 2016

Mechanisms of syncope caused by transient bradycardia and the diagnostic value of electrophysiologic testing and cardiovascular reflexivity maneuvers

scientific article published in August 1995

Methods other than tilt testing for diagnosing neurocardiogenic (neurally mediated) syncope

scientific article published in March 1997

Natural and unnatural history of patients with severe carotid sinus hypersensitivity: a preliminary study

scientific article published in November 1988

Neurally mediated syncope detected by carotid sinus massage and head-up tilt test in sick sinus syndrome

scientific article published in October 1991

Neurally-mediated syncope

scientific article published in March 2005

New classification of haemodynamics of vasovagal syncope: beyond the VASIS classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglycerin challenge. Vasovagal Syncope International Study

scientific article published in January 2000

New concepts in the assessment of syncope

scientific article

Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope

scientific article published in January 1994

Nonarrhythmic syncope documented by an implantable loop recorder (an ISSUE substudy).

scientific article

Orthostatic hypotension as cause of syncope in patients older than 65 years admitted to emergency departments for transient loss of consciousness

scientific article published on 6 April 2009

Pacemaker therapy in patients with neurally mediated syncope and documented asystole: Third International Study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial

scientific article published on 7 May 2012

Pacing for Carotid Sinus Syndrome and Sick Sinus Syndrome

scientific article published on December 1, 1990

Pacing for neurally mediated syncope: is placebo powerless?

scientific article published in January 2007

Pacing for neurally-mediated syncope: How to decide?

scientific article published in January 2014

Priorities for emergency department syncope research

scientific article published on 2 June 2014

Progression to 2d and 3d grade atrioventricular block in patients after electrostimulation for bundle-branch block and syncope: a long-term study

scientific article published in April 1994

Proposed electrocardiographic classification of spontaneous syncope documented by an implantable loop recorder

scientific article published in January 2005

Prospective multicentre systematic guideline-based management of patients referred to the Syncope Units of general hospitals

scientific article published in January 2010

Randomized clinical trials of neurally mediated syncope

scientific article published in September 2003

Reappraisal of the vasodepressor reflex in carotid sinus syndrome

scientific article published in March 1995

Recent advances in the treatment of syncopal syndromes

scientific article published in July 2006

Reevaluation of physiopathologic and clinical aspects of syncope in sick sinus syndrome

scientific article published in June 1993

Relation of clinical presentation of syncope to the age of patients

scientific article published on 27 September 2005

Reproducibility of electrocardiographic findings in patients with suspected reflex neurally-mediated syncope

scientific article published on 11 September 2008

Results and complications of the carotid sinus massage performed according to the "method of symptoms".

scientific article

Risk of syncope during work

scientific article published on 9 August 2013

Role of autonomic reflexes in syncope associated with paroxysmal atrial fibrillation

scientific article published in October 1993

Role of body position during the carotid sinus stimulation test in the diagnosis of cardio-inhibitory carotid sinus syndrome

scientific article published in July 1983

Sick sinus syndrome

scientific article

Spontaneous occurrence of the induced cardioinhibitory vasovagal reflex

scientific article published in March 1991

Standardized algorithm for cardiac pacing in older patients affected by severe unpredictable reflex syncope: 3-year insights from the Syncope Unit Project 2 (SUP 2) study

scientific article published on 26 November 2015

Standardized care pathway versus conventional approach in the management of patients presenting with faint at the University of Utah

scientific article published on 25 October 2012

Standardized-care pathway vs. usual management of syncope patients presenting as emergencies at general hospitals

scientific article published in August 2006

Stop vasodepressor drugs in reflex syncope: a randomised controlled trial

scientific article published on 23 September 2016

Syncope Unit: rationale and requirement--the European Heart Rhythm Association position statement endorsed by the Heart Rhythm Society

scientific article

Syncope and Idiopathic (Paroxysmal) AV Block

scientific article

Syncope caused by paroxysmal atrial fibrillation and flutter: diagnostic usefulness of electrophysiological studies in the erect and supine positions

scientific article published in September 1990

Syncope clinical management in the emergency department: a consensus from the first international workshop on syncope risk stratification in the emergency department

scientific article

Syncope due to idiopathic paroxysmal atrioventricular block: long-term follow-up of a distinct form of atrioventricular block

scientific article published on 12 May 2011

Syncope in patients paced for atrioventricular block

scientific article published on 6 February 2016

Syncope in the emergency department: comparison of standardized admission criteria with clinical practice

scientific article published on 14 July 2011

Syncope without prodromes in patients with normal heart and normal electrocardiogram: a distinct entity

scientific article published on 27 June 2013

The application of a standardized strategy of evaluation in patients with syncope referred to three syncope units

scientific article published in October 2002

The choice of stimulation mode in patients with cardioinhibitory or mixed carotid sinus hypersensitivity, with or without associated sinus dysfunction

scientific article published in January 1989

The diagnosis and management of syncope

scientific article published in October 2010

The effect of exogenous adenosine in patients with neurally-mediated syncope and sick sinus syndrome

scientific article published in November 1994

The hidden part of neurally mediated disease

scientific article

The history of diagnosing carotid sinus hypersensitivity: why are the current criteria too sensitive?

scientific article published on 17 November 2010

The natural course of untreated sick sinus syndrome and identification of the variables predictive of unfavorable outcome

scientific article published in November 1998

The pathophysiologic mechanisms associated with hypotensive susceptibility

scientific article published on 20 June 2016

The prevalence and cost of the faint and fall problem in the state of Utah

scientific article published on 4 October 2010

The re-evaluation of the vasodepressive component in the carotid sinus syndrome

scientific article published on March 1, 1995

The usage and diagnostic yield of the implantable loop-recorder in detection of the mechanism of syncope and in guiding effective antiarrhythmic therapy in older people

scientific article published in May 2005

The vasovagal Syncope and pacing (Synpace) trial: rationale and study design

scientific article published in October 2001

Treatment of persistent sinus bradycardia with intermittent symptoms: are guidelines clear?

scientific article published on 12 February 2009

Twenty-eight years of research permit reinterpretation of tilt-testing: hypotensive susceptibility rather than diagnosis

scientific article published on 30 June 2014

Update in the treatment of neurally-mediated syncope.

scientific article published in October 2007

Vagally mediated atrioventricular block: pathophysiology and diagnosis

scientific article published on 2 January 2013

Validation of a method for choice of pacing mode in carotid sinus syndrome with or without sinus bradycardia

scientific article published in February 1991

Value of head-up tilt testing potentiated with sublingual nitroglycerin to assess the origin of unexplained syncope

scientific article published in August 1995

Vasovagal syncope with asystole: the role of cardiac pacing

scientific article published in July 2017

Ventricular and dual chamber pacing for treatment of carotid sinus syndrome

scientific article published in April 1989

Why has the arrhythmia cardiologist become the specialist in syncope?

scientific article published in April 1999

[The tilt test enhanced with oral nitroglycerin in patients with unexplained syncope: the Italian Protocol. The Working Group on Syncope of the Associazione Italiana di Aritmologia e Cardiostimolazione--the Arrhythmia Area of the Associazione Nazion

scientific article published in February 2000