List of works by Klemens Rottner

A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion

scientific article

A novel contractility pathway operating in Salmonella invasion.

scientific article published in January 2012

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

article

Actin Networks: Adapting to Load through Geometry

scientific article published in December 2017

Actin and the coordination of protrusion, attachment and retraction in cell crawling.

scientific article published on October 1996

Actin assembly mechanisms at a glance.

scientific article

Actin branching in the initiation and maintenance of lamellipodia

scientific article published on 19 March 2012

Actin dynamics and turnover in cell motility.

scientific article

Actin dynamics in cell migration

scientific article published on 01 October 2019

Actin-based motility of Burkholderia pseudomallei involves the Arp 2/3 complex, but not N-WASP and Ena/VASP proteins

scientific article published on 01 June 2003

Activation of a RhoA/myosin II-dependent but Arp2/3 complex-independent pathway facilitates Salmonella invasion.

scientific article published on April 2011

Arp2/3 complex interactions and actin network turnover in lamellipodia.

scientific article

Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin

scientific article

Assembling actin filaments for protrusion

scientific article published on 01 October 2018

Assembling an actin cytoskeleton for cell attachment and movement

scientific article published on 01 September 1998

Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42

scientific article published on 26 November 2019

Bacteria-host-cell interactions at the plasma membrane: stories on actin cytoskeleton subversion.

scientific article

Biomedical Research Publication System

scientific article published in Science

CELL BIOLOGY. Formin' filaments at a faster CLIP.

scientific article published on May 2016

Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways

scientific article

Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells

scientific article

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

scientific article published on 03 August 2020

Cofilin cooperates with fascin to disassemble filopodial actin filaments

scientific article

Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.

scientific article published on 11 March 2009

Cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe DSS-induced colitis

scientific article published on 25 January 2017

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo

scientific article

Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases.

scientific article

Cortactin regulates the activity of small GTPases and ICAM-1 clustering in endothelium: Implications for the formation of docking structures

scientific article published on January 2013

Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein

scientific article published on 18 November 2017

Cytoskeleton cross-talk during cell motility.

scientific article

Cytotoxic necrotizing factor-Y boosts Yersinia effector translocation by activating Rac protein

scientific article

Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes

scientific article published on 4 September 2017

Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

scientific article published on 01 November 2018

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain

scientific article published on 07 March 2016

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes

scientific article

Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate

scientific article published on 28 June 2018

Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly

scientific article published on 22 March 2017

Elementary Cellular Processes Driven by Actin Assembly: Lamellipodia and Filopodia

Enterohaemorrhagic and enteropathogenic Escherichia coli use different mechanisms for actin pedestal formation that converge on N-WASP.

scientific article published on March 2004

Essential role for Abi1 in embryonic survival and WAVE2 complex integrity

scientific article

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

scientific article published on 31 May 2013

F- and G-actin concentrations in lamellipodia of moving cells

scientific article

FMNL formins boost lamellipodial force generation

scientific article

FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.

scientific article published on 29 August 2017

FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

scientific article

Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes

scientific article

Filopodia formation induced by active mDia2/Drf3.

scientific article published on September 2008

Filopodia: Complex models for simple rods.

scientific article published on 23 February 2009

ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cells

scientific article published in June 2013

Functional design in the actin cytoskeleton

scientific article

Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins

scientific article published on 11 February 2019

High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse

scientific article published on 20 December 2018

Host-Pathogen Interactions and Cell Motility: Learning from Bacteria

How distinct Arp2/3 complex variants regulate actin filament assembly

scientific article published on December 2015

IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.

scientific article published on March 2009

Imaging the Molecular Machines That Power Cell Migration.

scientific article published in January 2018

Inhibitory signalling to the Arp2/3 complex steers cell migration

scientific article

Interplay between Rac and Rho in the control of substrate contact dynamics

scientific article published on June 1999

Intima-like smooth muscle cells: developmental link between endothelium and media?

scientific article published on September 1999

Introduction to Small GTPases

scientific article

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.

scientific article published on 14 September 2017

Lamellipodia-like actin networks in cells lacking WAVE Regulatory Complex

scientific article published on 18 June 2021

Live imaging of glioblastoma cells in brain tissue shows requirement of actin bundles for migration

scientific article

Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

scientific article published on 11 May 2020

Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility

scientific article published on 30 June 2016

MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.

scientific article

Metavinculin: New insights into functional properties of a muscle adhesion protein

scientific article published on 14 November 2012

Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators

scientific article published on 12 May 2018

Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.

scientific article

Microtubules as platforms for assaying actin polymerization in vivo

scientific article (publication date: 2011)

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping

scientific article

Molecular dissection of Salmonella-induced membrane ruffling versus invasion

scientific article

Monomeric red fluorescent protein variants used for imaging studies in different species

scientific article published on 21 June 2006

N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits

scientific article published on 28 June 2005

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.

scientific article published on 7 October 2014

On the Rho'd: the regulation of membrane protrusions by Rho-GTPases

scientific article published on 28 April 2008

On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility.

scientific article

Pathogen-induced actin filament rearrangement in infectious diseases.

scientific article published in November 2004

Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2

scientific article (publication date: 4 October 2002)

Poxviruses Taking a Ride on Actin: New Users of Known Hardware

scientific article published in 2009

Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1.

scientific article published on 9 October 2008

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

scientific article

Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry

scientific article published on 19 May 2014

Regulation of actin dynamics by WASP and WAVE family proteins.

scientific article published on June 2004

Requirements for and consequences of Rac-dependent protrusion

scientific article published on 11 February 2014

Retraction: The association between the microtubule plus end protein EB1 and cortactin controls podosomes and bone resorption

RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

scientific article

RhoA, Rac1 and Cdc42 differentially regulate aSMA and collagen I expression in mesenchymal stem cells.

scientific article published on 26 April 2018

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding

scientific article published on 26 August 2019

Role of the WASP family proteins for Mycobacterium marinum actin tail formation

scientific article

Serine-71 phosphorylation of Rac1 modulates downstream signaling

scientific article

Sex steroid-opioid interactions associated with the temporal component of avian calling patterns

scientific article

Signalling Pathways Controlling Cellular Actin Organization

scientific article

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.

scientific article

Structure of Shigella IpgB2 in Complex with Human RhoA: IMPLICATIONS FOR THE MECHANISM OF BACTERIAL GUANINE NUCLEOTIDE EXCHANGE FACTOR MIMICRY

scientific article

Targeting, capture, and stabilization of microtubules at early focal adhesions

scientific article

The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia

scientific article

The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts

scientific article published on 07 October 2020

The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

scientific article published on 22 May 2019

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

scientific article published on 01 July 2020

The lamellipodium: where motility begins

scientific article (publication date: March 2002)

The making of filopodia

scientific article

The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.

scientific article published on 12 May 2015

The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin

scientific article (publication date: 2010)

Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion

scientific article published on 15 August 2019

VASP dynamics during lamellipodia protrusion

article

Visualising the actin cytoskeleton

scientific article

WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond

scientific article published on October 2010

Xin repeats define a novel actin-binding motif.

scientific article

Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions

scientific article

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