List of works - Stefano Confalonieri

8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes

scientific article published in March 2005

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

scientific article published on 30 July 2018

A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.

scientific article published on 21 December 2017

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

scientific article

A cancer-specific transcriptional signature in human neoplasia

scientific article

A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia.

scientific article published in November 2004

A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode.

scientific article

Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression

scientific article

Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor

scientific article published on 22 June 2009

An atlas of altered expression of deubiquitinating enzymes in human cancer

scientific article

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

scientific article

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

scientific article

CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells.

scientific article published on 10 March 2018

Chromosomal rearrangements in acute myeloid leukemia (AML).

scientific article published on 30 September 2010

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

scientific article

DG-CST (Disease Gene Conserved Sequence Tags), a database of human-mouse conserved elements associated to disease genes

scientific article

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

scientific article

Endocytosis and signaling: cell logistics shape the eukaryotic cell plan

scientific article published on January 2012

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization

scientific article

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization

Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.

scientific article published on February 1999

Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization

scientific journal article

Eps8 controls actin-based motility by capping the barbed ends of actin filaments

scientific journal article

Evolution of Shc functions from nematode to human

scientific article

Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

scientific article published on 07 October 2019

Frequent alterations in the expression of serine/threonine kinases in human cancers

scientific article

Gene expression analysis of early and advanced gastric cancers.

scientific article published on 5 February 2007

IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions

scientific article published on 22 January 2008

In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.

scientific article

Increasing both the public health potential of basic research and the scientist satisfaction. An international survey of bio-scientists.

scientific article published on 12 January 2016

Maspin expression and melanoma progression: a matter of sub-cellular localization.

scientific article

Mining cancer gene expression databases for latent information on intronic microRNAs

scientific article

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

scientific article published on 26 September 2016

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping

scientific article

Molecular mechanisms of coupled monoubiquitination

article published in 2006

NUMB-ing down cancer by more than just a NOTCH.

scientific article

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer

scientific article published on March 2017

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs

scientific article published on 02 June 2016

Regulation of actin dynamics by WASP and WAVE family proteins.

scientific article published on June 2004

Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis

scientific article (publication date: October 2009)

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

scientific article published in May 2017

ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma

scientific article published on 13 November 2020

Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis

scientific article

TTP specifically regulates the internalization of the transferrin receptor

scientific article

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

scientific article published on September 2014

The Eps15 homology (EH) domain

scientific article

The alternative splicing factor Nova2 regulates vascular development and lumen formation

scientific article

The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway

scientific article published on 16 January 2008

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

scientific article published on 22 December 2016

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

scientific article

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

scientific article published on 16 March 2017

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

scientific article published in Nature

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

scientific article

Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

scientific article

UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway

scientific article

Zebrafish numb and numblike are involved in primitive erythrocyte differentiation

scientific article (publication date: 2010)

List of works by Stefano Confalonieri

8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

A cancer-specific transcriptional signature in human neoplasia

A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia.

A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode.

Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression

Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor

An atlas of altered expression of deubiquitinating enzymes in human cancer

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells.

Chromosomal rearrangements in acute myeloid leukemia (AML).

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

DG-CST (Disease Gene Conserved Sequence Tags), a database of human-mouse conserved elements associated to disease genes

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

Endocytosis and signaling: cell logistics shape the eukaryotic cell plan

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization

Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.

Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization

Eps8 controls actin-based motility by capping the barbed ends of actin filaments

Evolution of Shc functions from nematode to human

Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

Frequent alterations in the expression of serine/threonine kinases in human cancers

Gene expression analysis of early and advanced gastric cancers.

IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions

In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.

Increasing both the public health potential of basic research and the scientist satisfaction. An international survey of bio-scientists.

Maspin expression and melanoma progression: a matter of sub-cellular localization.

Mining cancer gene expression databases for latent information on intronic microRNAs

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping

Molecular mechanisms of coupled monoubiquitination

NUMB-ing down cancer by more than just a NOTCH.

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs

Regulation of actin dynamics by WASP and WAVE family proteins.

Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma

Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis

TTP specifically regulates the internalization of the transferrin receptor

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

The Eps15 homology (EH) domain

The alternative splicing factor Nova2 regulates vascular development and lumen formation

The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway

Zebrafish numb and numblike are involved in primitive erythrocyte differentiation