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List of works by Giorgio Scita

16 Stability of β-carotene under different laboratory conditions

scientific article published on January 1, 1992

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

scientific article published on 30 July 2018

A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

scientific article published on 16 April 2018

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

scientific article

A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans

scientific article published on 21 November 2004

A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

scientific article published on 15 June 2020

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

scientific article published on 24 September 2020

ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress

scientific article

Abi1 is essential for the formation and activation of a WAVE2 signalling complex

scientific article

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

article

Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

scientific article published on 22 February 2004

Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing

scientific article

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

scientific article

Antioxidant radical-scavenging activity of carotenoids and retinoids compared to alpha-tocopherol

scientific article published in January 1992

Arthroscopic treatment for cuff tear: strength recovery at 12 months of follow-up.

scientific article published on 29 January 2013

Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

scientific article

Bidirectional Crosstalk between Actin Dynamics and Endocytosis

article

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

scientific article

CIP4 controls CCL19-driven cell steering and chemotaxis in chronic lymphocytic leukemia.

scientific article published on 3 May 2013

Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways

scientific article

Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination

scientific article published on November 2009

Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells

scientific article (publication date: 2015)

Collagen Prolyl Hydroxylation-Dependent Metabolic Perturbation Governs Epigenetic Remodeling and Mesenchymal Transition in Pluripotent and Cancer Cells

scientific article published on 06 May 2019

Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion

scientific article

Complementary mesoscale dynamics of spectrin and acto-myosin shape membrane territories during mechanoresponse

scientific article published on 09 October 2020

Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion

scientific article

Cytoskeletal Regulation: Coordinating Actin and Microtubule Dynamics in Membrane Trafficking

article

EPS8 and E3B1 transduce signals from Ras to Rac

scientific article (publication date: 16 September 1999)

Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration

scientific article

Endocytosis and Cytoskeleton

Endocytosis and signaling: cell logistics shape the eukaryotic cell plan

scientific article published on January 2012

Endocytosis and spatial restriction of cell signaling

scientific article published on 06 June 2009

Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries

scientific article published on 26 February 2015

Eps8

Eps8 and E3b1 mediate transduction of signals from Ras to Rac

article

Eps8 controls actin-based motility by capping the barbed ends of actin filaments

scientific journal article

Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity

scientific article published on 17 May 2013

Eps8 in the midst of GTPases

scientific article (publication date: October 2002)

Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells

scientific article

Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)

scientific article

Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH-3T3 cell growth

scientific article published on October 1997

F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation.

scientific article

From filopodia to synapses: the role of actin-capping and anti-capping proteins.

scientific article

From jamming to collective cell migration through a boundary induced transition

scientific article published on 01 May 2018

Frustration-induced phases in migrating cell clusters

scientific article published on 12 September 2018

Ha-ras oncogene transformation abolishes retinoic acid-induced reduction of intracellular fibronectin.

scientific article published on September 1996

Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A.

scientific article

IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

scientific article published on 14 July 2020

IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.

scientific article published on March 2009

IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions

scientific article published on 22 January 2008

In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.

scientific article

Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics

scientific journal article

Increasing both the public health potential of basic research and the scientist satisfaction. An international survey of bio-scientists.

scientific article published on 12 January 2016

Induction of HoxB transcription by retinoic acid requires actin polymerization.

scientific article

L-Proline induces a mesenchymal-like invasive program in embryonic stem cells by remodeling H3K9 and H3K36 methylation

scientific article published on 10 October 2013

LIN7 regulates the filopodium- and neurite-promoting activity of IRSp53.

scientific article

LIN7-IRSp53: A novel pathway for filopodia and neurite formation?

scientific article published on November 2012

Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis.

scientific article

Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression.

scientific article published on November 1996

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice

scientific article (publication date: 2 March 2010)

Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors

scientific article

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

scientific article

Mechano-biological model of glioblastoma cells in response to osmotic stress

scientific article published on 1 April 2019

Membrane and actin dynamics interplay at lamellipodia leading edge

scientific article published on 29 April 2013

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping

scientific article

Non-invasive measurement of nuclear relative stiffness from quantitative analysis of microscopy data

scientific article published in 2022

Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells

scientific article

Nuclear and cellular plasticity: nuclear RAC1 takes center stage

scientific article published in February 2015

Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification

scientific article

Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells

scientific journal article

Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms

scientific article published on 14 June 2006

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

scientific article

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

scientific article published on 18 August 2017

Propagating cell-membrane waves driven by curved activators of actin polymerization

scientific article

Protein complexes regulating Arp2/3-mediated actin assembly.

scientific article

Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

scientific article

Recycling of vitamin E in human low density lipoproteins

scientific article published on March 1992

Regulation of actin dynamics by WASP and WAVE family proteins.

scientific article published on June 2004

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex

scientific journal article

Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8

scientific journal article

Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis

scientific article (publication date: October 2009)

Retinoic acid and beta-carotene inhibit fibronectin synthesis and release by fibroblasts; antagonism to phorbol ester

scientific article

Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation

scientific article published on March 1996

Retinoic acid downregulates growth, fibronectin and RAR alpha in 3T3 cells: Ha-ras blocks this response and RA metabolism

scientific article published on November 1997

Retinol bound to cellular retinol-binding protein is a substrate for cytosolic retinoic acid synthesis

scientific article published in Journal of Biological Chemistry

SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression

scientific article

Secretory and endo/exocytic trafficking in invadopodia formation: the MT1-MMP paradigm

scientific article published on February 2011

Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis.

scientific article published on 9 May 2018

Somatostatin inhibits PDGF-stimulated Ras activation in human neuroblastoma cells

scientific article published on October 1999

Sos-mediated activation of rac1 by p66shc

scientific article

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.

scientific article

Strength recovery after proximal humeral fractures treated with locking plate.

scientific article

The 'endocytic matrix reloaded' and its impact on the plasticity of migratory strategies.

scientific article published on 12 March 2018

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

scientific article published on September 2014

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

scientific article (publication date: 16 November 2000)

The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation

scientific article

The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration

scientific article

The SH3 domain of Eps8 exists as a novel intertwined dimer

scientific article

The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.

scientific article

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

scientific article published on 5 November 2010

The effect of diacylglycerols on fibronectin release and its reversal by retinoic acid in cell culture

scientific article published in October 1991

The effect of sphingosine and phorbol ester on the signal transduction enzymes and fibronectin release in cell culture

scientific article published on June 1992

The effect of sphingosine on the release of fibronectin from human lung fibroblasts

scientific article published in August 1994

The endocytic matrix

scientific article published on January 2010

The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway

scientific article

The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity

scientific journal article

The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway

scientific article published on 16 January 2008

The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration

scientific article

Time to tackle the incumbency advantage in science: A survey of scientists shows strong support for funding policies that would distribute funds more evenly among laboratories and thereby benefit new and smaller research groups

scientific article published on 4 August 2016

Ultraviolet light-induced generation of vitamin E radicals and their recycling. A possible photosensitizing effect of vitamin E in skin

scientific article published on January 1992

Understanding biological dynamics: following cells and molecules to track functions and mechanisms

scientific article published on 20 May 2009

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma

scientific article published on 22 July 2019

Uptake and cleavage of beta-carotene by cultures of rat small intestinal cells and human lung fibroblasts

scientific article published on January 1993

Vaccination of Metastatic Melanoma Patients With Autologous Tumor-Derived Heat Shock Protein gp96-Peptide Complexes: Clinical and Immunologic Findings

scientific article published on 01 October 2002

WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor

scientific article published on 15 March 2005

WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium

scientific article

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