List of works - Pier Paolo Di Fiore

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

scientific article published on 30 July 2018

A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.

scientific article published on 21 December 2017

A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

scientific article published on 16 April 2018

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

scientific article

A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

scientific article published on 15 June 2020

Abi1 is essential for the formation and activation of a WAVE2 signalling complex

scientific article

Alterations of the Notch pathway in lung cancer.

scientific article

Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

scientific article

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

scientific article

Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development

scientific article

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

scientific article

Endocytic control of signaling at the plasma membrane

scientific article

Eps8 controls actin-based motility by capping the barbed ends of actin filaments

scientific journal article

Eps8 in the midst of GTPases

scientific article (publication date: October 2002)

Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)

scientific article

Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells

scientific article

Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

scientific article published on 07 October 2019

HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype.

scientific article published on 26 March 2018

In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.

scientific article

Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics

scientific journal article

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

scientific article

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice

scientific article (publication date: 2 March 2010)

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping

scientific article

NUMB controls p53 tumour suppressor activity

scientific article

Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers.

scientific article

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.

scientific article

Reciprocal repression between P53 and TCTP

scientific article

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex

scientific journal article

Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8

scientific journal article

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

scientific article published in May 2017

Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi

scientific journal article

Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis

scientific article

TTP specifically regulates the internalization of the transferrin receptor

scientific article

The Eps15 homology (EH) domain

scientific article

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

scientific article

The alternative splicing factor Nova2 regulates vascular development and lumen formation

scientific article

The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway

scientific article

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

scientific article

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

scientific article

Threshold-controlled ubiquitination of the EGFR directs receptor fate

scientific article

Zebrafish numb and numblike are involved in primitive erythrocyte differentiation

scientific article (publication date: 2010)

List of works by Pier Paolo Di Fiore

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.

A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

Abi1 is essential for the formation and activation of a WAVE2 signalling complex

Alterations of the Notch pathway in lung cancer.

Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

Endocytic control of signaling at the plasma membrane

Eps8 controls actin-based motility by capping the barbed ends of actin filaments

Eps8 in the midst of GTPases

Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)

Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells

Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype.

In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.

Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping

NUMB controls p53 tumour suppressor activity

Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers.

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.

Reciprocal repression between P53 and TCTP

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex

Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi

Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis

TTP specifically regulates the internalization of the transferrin receptor

The Eps15 homology (EH) domain

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

The alternative splicing factor Nova2 regulates vascular development and lumen formation

The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Threshold-controlled ubiquitination of the EGFR directs receptor fate

Zebrafish numb and numblike are involved in primitive erythrocyte differentiation