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List of works by Christian Rosenmund

A Single Human Neuron Approach to Synapse Function

scientific article published on 30 May 2019

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release

scientific article published on 01 August 2020

A complete genetic analysis of neuronal Rab3 function.

scientific article published in July 2004

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

scientific article published in November 2006

A minimal domain responsible for Munc13 activity

scientific article

A point mutation in the glutamate binding site blocks desensitization of AMPA receptors

scientific article published on October 1998

A shared vesicular carrier allows synaptic corelease of GABA and glycine

scientific article published on May 2006

Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion

scientific article

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

scientific article published on 14 April 2015

Altered inhibition and excitation in neocortical circuits in congenital microcephaly

scientific article published on 15 May 2019

An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size

scientific journal article

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

scientific article published in April 1994

Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1

scientific article

Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology

article

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

scientific journal article

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.

scientific article

Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models

scientific article

C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1.

scientific article published on 23 November 2004

Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses

scientific article published on 01 December 2019

Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons

article

Calcium-induced actin depolymerization reduces NMDA channel activity

scientific article

Calmodulin and Munc13 Form a Ca2+ Sensor/Effector Complex that Controls Short-Term Synaptic Plasticity

scientific article published on 01 August 2004

Catching Up with Ultrafast Endocytosis.

scientific article published in May 2016

Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles

scientific article

Clathrin regenerates synaptic vesicles from endosomes.

scientific article

Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses.

scientific article

Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3.

scientific article published on 23 September 2015

Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25

scientific article published on 01 July 2020

Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.

scholarly article

Complexins regulate a late step in Ca2+-dependent neurotransmitter release

scientific article

Conformational restriction blocks glutamate receptor desensitization

scientific article published on 19 November 2006

Conformational switch of syntaxin-1 controls synaptic vesicle fusion

scientific article

Cooperative binding mitigates the high-dose hook effect.

scientific article published on 14 August 2017

Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

scientific article published on 4 June 2015

Correction: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones

scientific article published on 13 March 2017

Critical role for Piccolo in synaptic vesicle retrieval

scientific article published on 10 May 2019

CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles

scientific article published on 01 February 2020

Definition of the readily releasable pool of vesicles at hippocampal synapses

scientific article (publication date: June 1996)

Differences in Ca2+ buffering properties between excitatory and inhibitory hippocampal neurons from the rat

scientific article published on 01 June 2000

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms

scientific journal article

Differential pH Dynamics in Synaptic Vesicles From Intact Glutamatergic and GABAergic Synapses

scientific article published on 03 December 2018

Disentangling the roles of RIM and Munc13 in synaptic vesicle localization and neurotransmission

scientific article published on 02 November 2020

Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons.

scientific article published on July 2016

Distinct domains of complexin I differentially regulate neurotransmitter release

scientific article published on 9 September 2007

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

scientific article

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

scientific article published on 6 March 2017

Endocytosis gets in tune with action potential bursts

scientific article

Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons

scientific article published on 23 June 2020

Expression of NMDA channels on cerebellar Purkinje cells acutely dissociated from newborn rats

scientific article published in November 1992

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

scientific article published in March 2003

Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming

scientific article (publication date: April 2001)

Functional synergy between the Munc13 C-terminal C1 and C2 domains

scientific article published on 23 May 2016

Glutamatergic Innervation onto Striatal Neurons Potentiates GABAergic Synaptic Output

scientific article published on 01 April 2019

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming

scientific article

Heteromeric AMPA receptors assemble with a preferred subunit stoichiometry and spatial arrangement

scientific article

Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons

scientific article

Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)

scientific journal article

Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium

scientific article published in February 1993

Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice

scientific article published on 20 June 2007

Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate.

scientific article published on July 2006

Interplay between VGLUT isoforms and endophilin A1 regulates neurotransmitter release and short-term plasticity

scientific article published in March 2011

Investigation of synapse formation and function in a glutamatergic-GABAergic two-neuron microcircuit

scientific article published on 01 January 2014

Ion channels: how to be desensitized

scientific article

LSP5-2157 a new inhibitor of vesicular glutamate transporters

scientific article published on 04 December 2019

Layer 6b Is Driven by Intracortical Long-Range Projection Neurons

scientific article published on 01 March 2020

Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model ⬇️

scientific article published on 28 January 2015

Light-Activated ROS Production Induces Synaptic Autophagy

scientific article published on 17 January 2019

Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons

scientific article published on 26 October 2016

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

scientific article published on 10 August 2017

MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number

scientific journal article

Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

scientific article

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.

scientific article published on 08 February 2017

Membrane bridging by Munc13-1 is crucial for neurotransmitter release

scientific article published on 28 February 2019

Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant mice.

scientific article published in December 2006

Molecular mechanisms governing Ca(2+) regulation of evoked and spontaneous release

scientific article published on June 2015

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

scientific article

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

scientific article

Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.

scientific article

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

scientific article

N-glycosylation is essential for vesicular targeting of synaptotagmin 1.

scientific article published on January 2004

NOMA-GAP/ARHGAP33 regulates synapse development and autistic-like behavior in the mouse.

scientific article published on 14 April 2015

Nanometer-resolution fluorescence electron microscopy (nano-EM) in cultured cells

scientific article

Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses

scientific article published on 01 October 2019

New Concepts for Presynaptic Optogenetics

Nonuniform probability of glutamate release at a hippocampal synapse

scientific article published in Science

On the brink: a new synaptic vesicle release model at the calyx of held

article

Optogenetic acidification of synaptic vesicles and lysosomes

scientific article published on 9 November 2015

Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice

scientific article published on 04 May 2020

Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1.

scientific article published on 4 April 2006

RIM-BP2 primes synaptic vesicles recruitment of Munc13-1 at hippocampal mossy fiber synapses

scientific article published on 19 September 2019

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

scientific article published on 26 September 2016

Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.

scientific article published in January 2006

RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission ⬇️

scientific article published on August 12, 2013

Re-examining how complexin inhibits neurotransmitter release

scientific article

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

scientific article published in October 1994

Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development

article

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

scientific article

Regulation of dendritic development by E3 ubiquitin ligase Nedd4

Reinvestigation of the role of snapin in neurotransmitter release

scientific article published on 14 April 2004

Rundown of N-methyl-D-aspartate channels during whole-cell recording in rat hippocampal neurons: role of Ca2+ and ATP

scientific article published on 01 October 1993

SV2

scientific article published on 01 December 1999

Should I stop or should I go? The role of complexin in neurotransmitter release.

scientific article

Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions

scientific article

Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization

scientific article

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7

scientific article

Structurally and functionally unique complexins at retinal ribbon synapses

scientific journal article

Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1

article

Subunit composition and alternative splicing regulate membrane delivery of kainate receptors

scientific journal article

Synapses as therapeutic targets for autism spectrum disorders: an international symposium held in pavia on july 4th, 2014

scientific article

Synapses, networks, brain development – funding basic neuroscience research in Germany by the Schram Foundation

scientific article published on 05 October 2020

Synaptic NMDA receptor channels have a low open probability.

scientific article

Synaptic vesicle fusion

scientific article published on July 2008

Synaptobrevin 1 mediates vesicle priming and evoked release in a subpopulation of hippocampal neurons.

scientific article

Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis

scientific article published on 01 June 2018

Synaptotagmin I functions as a calcium regulator of release probability

scientific article (publication date: March 2001)

Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment.

scientific article published on 11 December 2017

Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions

scientific article published on 22 July 2015

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

scientific article

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

scientific article published on 01 November 2019

The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.

scientific article published on 26 October 2008

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons

scientific article published in March 2002

The headache of a hyperactive calcium channel

scientific article published on March 2009

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones

scientific journal article

The rate of aldehyde fixation of the exocytotic machinery in cultured hippocampal synapses

scientific article published in September 1997

The synaptic vesicle protein CSP alpha prevents presynaptic degeneration.

scientific article

The tetrameric structure of a glutamate receptor channel

scientific article

Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.

scientific article

Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability

scientific journal article

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

scientific journal article

Ultrafast Recycling of Synaptic Vesicles

Ultrafast endocytosis at mouse hippocampal synapses.

scientific article published on 04 December 2013

Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapses

scientific article published on December 2008

VGLUT2 EXPRESSION IN DOPAMINE NEURONS CONTRIBUTES TO POST-LESIONAL STRIATAL REINNERVATION

scientific article published on 14 September 2020

Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission

scientific journal article

Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain.

scientific article published in November 2006

Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture.

scientific article published in August 2014

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