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List of works by Nils Brose

A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia

scientific article

A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein

scientific journal article

A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles

scientific journal article

A common molecular basis for membrane docking and functional priming of synaptic vesicles

scientific journal article

A conformational switch in collybistin determines the differentiation of inhibitory postsynapses

scientific article

A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function

scientific article (publication date: 26 December 2003)

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells

scientific article published on 27 April 2017

A shared vesicular carrier allows synaptic corelease of GABA and glycine

scientific article published on May 2006

A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse

scientific article published on October 2005

Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4.

scientific article published in May 2009

Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse

scientific article

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2

scientific article

Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release

scientific article published on 01 March 2019

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

scientific article published on 14 April 2015

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons

scientific article published on 01 May 2019

An LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells

scientific journal article

Analysis of SUMO1-conjugation at synapses.

scientific article

Analysis of neurotransmitter release mechanisms by photolysis of caged Ca²⁺ in an autaptic neuron culture system

scientific article published on 21 June 2012

Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex

scientific article published on 5 July 2017

Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses

scientific article published on 03 May 2018

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

scientific article published on 11 January 2018

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

scientific journal article

Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2.

scientific article published on 16 May 2006

Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.

scientific article

Building Bridges through Science.

scientific article published in November 2017

CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles

scientific article published in May 2008

CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.

scientific article

CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells

scientific article published in January 2008

CAPS1 regulates catecholamine loading of large dense-core vesicles

scientific journal article

Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake

scientific journal article

CaMKII binding to GluN2B is critical during memory consolidation ⬇️

scientific article published on January 10, 2012

Calmodulin and Munc13 Form a Ca2+ Sensor/Effector Complex that Controls Short-Term Synaptic Plasticity

scientific article published on 01 August 2004

Characterization of the Munc13-calmodulin interaction by photoaffinity labeling

scientific article published on 19 September 2006

Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission

scientific article

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission

scientific article published on 2 December 2013

Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses

scientific article

Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming.

scholarly article

Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix

scientific article published on 19 February 2019

Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.

scientific article

Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.

scientific article published on March 2014

Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse.

scientific article published in June 2009

Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.

scholarly article

Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

scientific article published on 4 June 2015

Correction: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones

scientific article published on 13 March 2017

Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons

scientific article published on 21 May 2018

Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease ⬇️

scientific article published on February 7, 2011

Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HD.

scientific article

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism

scientific article published on 23 November 2012

Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23

scientific article published on 01 July 2003

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms

scientific journal article

Distinct domains of complexin I differentially regulate neurotransmitter release

scientific article published on 9 September 2007

Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice

scientific article published on 7 May 2016

Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals

scientific article

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

scientific article

Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling

scientific article published on 13 June 2013

Dynamically Primed Synaptic Vesicle States: Key to Understand Synaptic Short-Term Plasticity

scientific article published on 01 December 2018

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

scientific article published on 6 March 2017

Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses

scientific article

EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin

scientific article published on 01 September 2007

Erythropoietin enhances hippocampal long-term potentiation and memory

scientific article

Evidence for a common endocannabinoid-related pathomechanism in autism spectrum disorders

scientific article

Evidence of presynaptic location and function of the prion protein

scientific article (publication date: 15 October 1999)

Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents

scientific article published on 03 February 2020

Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

scientific article

Fast cerebellar reflex circuitry requires synaptic vesicle priming by munc13-3

scientific article

Flowers for synaptic endocytosis

scientific article published in September 2009

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release

scientific article

Functional Roles of Complexin 3 and Complexin 4 at Mouse Photoreceptor Ribbon Synapses.

scientific article

Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans

scientific article published on 24 July 2013

Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants

scientific article published on 11 October 2016

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells

scientific journal article

Homodimerization and isoform-specific heterodimerization of neuroligins

scientific article (publication date: September 2012)

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

scientific journal article

Identification of the minimal protein domain required for priming activity of Munc13-1.

scientific article published on 3 November 2005

IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses

scientific article published in Nature Communications

In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice.

scientific article published in October 2011

In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice

scientific article

Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo

scientific article

Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis.

scientific article

Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism

scientific article

Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability.

scientific article

Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion

scientific article

Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms

scientific article published in September 2010

Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity

scientific article

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

scientific article published in August 2017

Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant mice.

scientific article published in December 2006

Molecular mechanisms of active zone function

scientific article published on October 2003

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

scientific article

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

scientific article

Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.

scientific article

Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance

scientific article published in May 2006

Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing

scientific journal article

Munc13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum.

scientific article

Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

scientific article

Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses

scientific journal article

Neurobeachin regulates neurotransmitter receptor trafficking to synapses.

scientific article published on 31 December 2012

Neurobiology of autism gene products: towards pathogenesis and drug targets.

scientific article published on 14 January 2014

Neuroligin 2 deletion alters inhibitory synapse function and anxiety-associated neuronal activation in the amygdala

scientific article

Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin

scientific article

Neuroligin 2 is exclusively localized to inhibitory synapses

scientific journal article

Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo

scientific article published on January 2015

Neuroligin-2 dependent conformational activation of Collybistin reconstituted in supported hybrid membranes

scientific article published on 30 October 2020

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina

scientific article

Neuroligins determine synapse maturation and function

scientific journal article

Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity

scientific article

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors

scientific article published on 05 February 2020

Organizers of inhibitory synapses come of age.

scientific article

Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism

scientific article

Photoswitchable diacylglycerols enable optical control of protein kinase C.

scientific article published on 25 July 2016

Postsynaptic Neuroligin1 regulates presynaptic maturation

scientific journal article

Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis

scientific article

Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits

scientific article published on 6 July 2005

Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting

scientific article published on 10 January 2014

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

scientific article

Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development

article

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

scientific article

Regulation of dendritic development by E3 ubiquitin ligase Nedd4

Regulation of insulin exocytosis by Munc13-1.

scientific article

Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matter

scientific article published on July 2007

Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25.

scientific article published in February 2004

Response: Commentary: Analysis of SUMO1-conjugation at synapses.

scientific article published in May 2018

SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming

scientific journal article

SUMOylation controls the neurodevelopmental function of the transcription factor Zbtb20

scientific article published on 31 March 2020

Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain.

scientific article

Selective expression of a constitutively active erythropoietin receptor in GABAergic neurons alters hippocampal network properties without affecting cognition

scientific article published on 28 November 2015

Specificity emerges in the dissection of diacylglycerol- and protein kinase C-mediated signalling pathways

scholarly article

Specificity of Collybistin-Phosphoinositide Interactions: IMPACT OF THE INDIVIDUAL PROTEIN DOMAINS.

scientific article published on 6 November 2015

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change ⬇️

scientific article published on April 7, 2013

Structural insights into the calmodulin-Munc13 interaction obtained by cross-linking and mass spectrometry

scientific journal article

Structurally and functionally unique complexins at retinal ribbon synapses

scientific journal article

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse

scientific article published on 22 July 2020

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

scientific article published on 03 June 2019

Synapse biology in the 'circuit-age'-paths toward molecular connectomics

scientific article published on 26 December 2016

Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors.

scholarly article

Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder

scientific article

Synaptic and vesicular co-localization of the glutamate transporters VGLUT1 and VGLUT2 in the mouse hippocampus

scientific article published on 29 August 2006

Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding

scientific journal article

Synaptic vesicle fusion: today and beyond

scientific article published on 01 August 2019

Systematic Localization and Identification of SUMOylation Substrates in Knock-In Mice Expressing Affinity-Tagged SUMO1.

scientific article

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

The RacGAP β2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus ⬇️

scientific article published on June 22, 2012

The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex

scientific article published on 01 March 2020

The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin

scientific article

The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients

scientific article

The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves

scientific article published on 30 January 2012

The function of glutamatergic synapses is not perturbed by severe knockdown of 4.1N and 4.1G expression.

scientific article published in March 2009

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones

scientific journal article

The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses

scientific article published on 15 March 2012

The specific α-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse development

scientific journal article

The ubiquitin E3 ligase Nedd4-1 controls neurite development

scientific article published in July 2010

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

scientific article

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1

scientific journal article

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

scientific journal article

Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

scientific article published on 23 February 2017

Two distinct secretory vesicle-priming steps in adrenal chromaffin cells

scientific article published on September 2010

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

scientific article

Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses

scientific article published on 01 March 2020

Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices

scientific article published on 21 September 2020

Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein

scientific article

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells

scientific journal article

Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin

scientific article

Vesicular Glutamate Transporter Expression Ensures High-Fidelity Synaptic Transmission at the Calyx of Held Synapses

scientific article published on 01 August 2020

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