Search filters

List of works by Franziska Michor

(A)symmetric stem cell replication and cancer

scientific article

A Mathematical Methodology for Determining the Temporal Order of Pathway Alterations Arising during Gliomagenesis ⬇️

scientific article published on January 5, 2012

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

scientific article published in Nature Communications

A Race between Tumor Immunoescape and Genome Maintenance Selects for Optimum Levels of (epi)genetic Instability ⬇️

scientific article published on February 16, 2012

A computational strategy to adjust for copy number in tumor Hi-C data

scientific article

A differentiation-based microRNA signature identifies leiomyosarcoma as a mesenchymal stem cell-related malignancy

scientific article

A differentiation-based phylogeny of cancer subtypes

scientific article

A mathematical framework to determine the temporal sequence of somatic genetic events in cancer

scientific article

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

scientific article

A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).

scientific article

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

A progenitor cell origin of myeloid malignancies

scientific article published on 21 September 2009

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

scientific article published on 26 July 2016

Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity

scientific article

Abstract A38: <i>Cd70</i> genetic perturbation limits the development of an effective CD8+ T-cell immune response to <i>Bcl6</i>-driven diffuse large B-cell lymphoma

scientific article published in 2022

Abstract PR05: The effect of chemotherapy on HER2+ breast cancer heterogeneity measured by STAR-FISH: Detection of PIK3CA mutation and HER2 amplification at single-cell level in situ

Accelerating massively parallel hemodynamic models of coarctation of the aorta using neural networks

scientific article published on 11 June 2020

Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer

scientific article published on 11 May 2020

An Evolutionary Approach for Identifying Driver Mutations in Colorectal Cancer

scientific article (publication date: September 2015)

Analysis of somatic microsatellite indels identifies driver events in human tumors.

scientific article published on 11 September 2017

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells

scientific article published on 20 February 2020

Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

scientific article published in 2022

Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells

scientific article published on 26 January 2017

Breast tumours maintain a reservoir of subclonal diversity during expansion

scientific article published on 24 March 2021

CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation

scientific article published on 16 July 2015

Can chromosomal instability initiate tumorigenesis?

scientific article

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

scientific article

Chromosomal instability and human cancer

scientific article published on March 2005

Chronic myeloid leukemia blast crisis arises from progenitors

scientific article published on 11 January 2007

Circadian clock effects on cellular proliferation: Insights from theory and experiments

scientific article published on 06 August 2020

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.

scientific article

Clonal evolution in breast cancer revealed by single nucleus genome sequencing.

scientific article

Combination of a novel gene expression signature with a clinical nomogram improves the prediction of survival in high-risk bladder cancer.

scientific article published on 6 January 2012

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

scientific article published on 25 May 2021

Computational Model of Progression to Multiple Myeloma Identifies Optimum Screening Strategies

scientific article published on 01 December 2018

Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies ⬇️

scientific article published on January 20, 2012

Computational modeling of pancreatic cancer patients receiving FOLFIRINOX and gemcitabine-based therapies identifies optimum intervention strategies

scientific article published on 26 April 2019

Correction: (A)Symmetric Stem Cell Replication and Cancer.

scientific article published on 27 April 2007

Correction: Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies.

scientific article

Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution

scientific article published on 01 December 2018

DIFFpop: a stochastic computational approach to simulate differentiation hierarchies with single cell barcoding

scientific article published on 01 October 2019

DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors

scientific article published on 9 April 2015

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation

scientific article

DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes ⬇️

scientific article published on January 1, 2013

DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes

scientific article

DNA secondary structures and epigenetic determinants of cancer genome evolution

scientific article published on 03 July 2011

DNA secondary structures and epigenetic determinants of cancer genome evolution.

scientific article

Designing optimal allocations for cancer screening using queuing network models

scientific article published on 27 May 2022

Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response

scientific article published in November 2004

Distance in cancer gene expression from stem cells predicts patient survival

scientific article

Dose-Dependent Mutation Rates Determine Optimum Erlotinib Dosing Strategies for EGFR Mutant Non-Small Cell Lung Cancer Patients

scientific article

Drug sensitivity and allele-specificity of first-line osimertinib resistance EGFR mutations

scientific article published on 19 March 2020

Dynamics of cancer progression

scientific article (publication date: March 2004)

Dynamics of chronic myeloid leukaemia.

scientific article published on June 2005

Dynamics of chronic myeloid leukemia response to dasatinib, nilotinib, and high-dose imatinib

scientific article published on 12 September 2014

Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells

scientific article published on 8 June 2011

Dynamics of colorectal cancer

scientific article

Dynamics of metastasis suppressor gene inactivation

scientific article published on 23 February 2006

ESTIpop: A computational tool to simulate and estimate parameters for continuous-time Markov branching processes

scientific article published on 19 May 2020

Effects of pharmacokinetic processes and varied dosing schedules on the dynamics of acquired resistance to erlotinib in EGFR-mutant lung cancer

scientific article published on October 2012

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor–Resistant Disease ⬇️

scientific article published on February 11, 2013

Epigenetic diversity in hematopoietic neoplasms

scientific article published on 18 September 2014

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

scientific article published on 20 September 2017

Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib

scientific article

Estimating mono- and bi-phasic regression parameters using a mixture piecewise linear Bayesian hierarchical model

scientific article published on 19 July 2017

Evolution of acquired resistance to anti-cancer therapy

scientific article

Evolution of resistance during clonal expansion

scientific article published on April 2006

Evolution of resistance to anti-cancer therapy during general dosing schedules

scientific article published on 11 December 2009

Evolution of resistance to cancer therapy

scientific article

Evolution of resistance to targeted anti-cancer therapies during continuous and pulsed administration strategies

scientific article

Evolution of the cancer genome

scientific article (publication date: April 2012)

Evolution: the good, the bad and the lonely

scientific article published in October 2002

Evolutionary Pathways in BRCA1-Associated Breast Tumors ⬇️

scientific article published on April 10, 2012

Evolutionary dynamics of BRCA1 alterations in breast tumorigenesis ⬇️

scientific article published on December 29, 2010

Evolutionary dynamics of escape from biomedical intervention

scientific article

Evolutionary dynamics of intratumor heterogeneity.

scientific article

Evolutionary dynamics of invasion and escape

scientific article published in January 2004

Evolutionary dynamics of tumor progression with random fitness values

scientific article published on 19 May 2010

Evolutionary dynamics of tumor suppressor gene inactivation.

scholarly article

Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer

scientific article published on 25 October 2011

Evolutionary theory of cancer

scientific article published on June 2009

FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder

scientific article published on 21 May 2014

Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia

scientific article

Fitness variation in isogenic populations leads to a novel evolutionary mechanism for crossing fitness valleys

scientific article published on 26 September 2018

Genetic and phenotypic diversity in breast tumor metastases

scientific article published on 21 January 2014

Genetic instability and clonal expansion

scientific article published on 6 January 2006

Genetic instability and the quasispecies model

scientific article published on 04 January 2006

Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2

scientific article published on 23 November 2020

Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages

scientific article published in Nature Communications

Histone modifications are associated with transcript isoform diversity in normal and cancer cells

scientific article

Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

scientific article published on 26 June 2017

Improving Cancer Treatment via Mathematical Modeling: Surmounting the Challenges Is Worth the Effort

scientific article

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer

scientific article

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies

scientific article published in 2022

Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.

scientific article published on 9 April 2018

Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity

scientific article published on 23 January 2014

Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

scientific article published on 31 January 2014

Intratumor Heterogeneity in Evolutionary Models of Tumor Progression ⬇️

scientific article published on March 15, 2011

JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response

scientific article

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

scientific article

Linear model of colon cancer initiation

scientific article published in March 2004

Local regulation of homeostasis favors chromosomal instability

scientific article (publication date: April 2003)

Mathematical Modeling Links Pregnancy-Associated Changes and Breast Cancer Risk

scientific article published on 30 March 2017

Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients

scientific article

Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules

scientific article published on January 2014

Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease.

scientific article published on 14 June 2016

Mathematical modeling reveals alternative JAK inhibitor treatment in myeloproliferative neoplasms

scientific article published on 14 August 2019

Mathematical models of cancer stem cells

scientific article published on June 2008

Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.

scientific article published on 13 June 2013

Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma

scientific article

Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution.

scientific article

Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

scientific article published on 03 June 2013

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

scientific article

Nuclear topology modulates the mutational landscapes of cancer genomes.

scientific article

On the validity of using increases in 5-year survival rates to measure success in the fight against cancer

scientific article

Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling

scientific article

Patterns of Proliferative Activity in the Colonic Crypt Determine Crypt Stability and Rates of Somatic Evolution ⬇️

scientific article published on June 13, 2013

Pharmacokinetic profiles determine optimal combination treatment schedules in computational models of drug resistance

scientific article published on 19 June 2020

Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution

scientific article published on 31 May 2017

Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer.

scientific article

Polyploidy can drive rapid adaptation in yeast

scientific article published on 2 March 2015

Population genetics of tumor suppressor genes

article

Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells

scientific article published on December 2016

Proceedings of the third international molecular pathological epidemiology (MPE) meeting

scientific article

Progression signature underlies clonal evolution and dissemination of multiple myeloma

scientific article published on 04 November 2020

Punctuated copy number evolution and clonal stasis in triple-negative breast cancer

scientific article published on 15 August 2016

Quantitative approaches to analyzing imatinib-treated chronic myeloid leukemia

scientific article published on 06 April 2007

Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms

publication published on 22 February 2021

Reply to Parsons: Many tumor types follow the monoclonal model of tumor initiation

scientific article

Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples.

scientific article

SIApopr: A computational method to simulate evolutionary branching trees for analysis of tumor clonal evolution

scientific article published in July 2017

Safety and efficacy of pulsed imatinib with or without G-CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up

scientific article published on 19 August 2013

Selection pressure exerted by imatinib therapy leads to disparate outcomes of imatinib discontinuation trials ⬇️

scientific article published on March 14, 2012

Somatic selection for and against cancer

scientific article published in December 2003

Some basic properties of immune selection

scientific article published on 01 July 2004

Stochastic Evolution of Pancreatic Cancer Metastases During Logistic Clonal Expansion

scientific article published on 01 March 2019

Stochastic Tunneling of Two Mutations in a Population of Cancer Cells

scientific article (publication date: 2013)

Stochastic dynamics of cancer initiation ⬇️

scientific article published on February 7, 2011

Stochastic dynamics of metastasis formation

scientific article published on 15 December 2005

Stochastic elimination of cancer cells

scientific article

Stochastic tunneling and metastable states during the somatic evolution of cancer. ⬇️

scientific article

Stochastic tunnels in evolutionary dynamics

scientific article published on March 2004

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

scientific article published on 13 April 2015

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

scientific article published on 01 July 2019

Successful therapy must eradicate cancer stem cells

scientific article published on 24 August 2006

Synergy and discounting of cooperation in social dilemmas

scientific article published on 19 October 2005

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

scientific article published on 07 May 2020

The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells

scientific article published on 15 July 2015

The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.

scientific article published on April 2017

The Origins and Implications of Intratumor Heterogeneity ⬇️

scientific article published on October 19, 2010

The Probable Cell of Origin of NF1- and PDGF-Driven Glioblastomas ⬇️

scientific article published on September 9, 2011

The Therapeutic Implications of Plasticity of the Cancer Stem Cell Phenotype ⬇️

scientific article published on December 17, 2010

The age incidence of chronic myeloid leukemia can be explained by a one-mutation model

scholarly article

The emergence of tumor metastases

scientific article published on 16 March 2007

The evolution of tumor metastases during clonal expansion

scientific article published on 14 November 2009

The evolution of two mutations during clonal expansion

scientific article published on December 2007

The linear process of somatic evolution.

scientific article

The mathematics of cancer: integrating quantitative models

scientific article

Understanding tissue context influences on intratumour heterogeneity

scientific article

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

scientific article published in Nature Communications

Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes.

scientific article published on 02 January 2014

Virus evolution within patients increases pathogenicity

scientific article published in January 2005

What does physics have to do with cancer?

scientific article

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

scientific article published on 29 September 2017

Paulina is supported by:

About Paulina

Help