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List of works by Jean-Charles Soria

10-year long-term survival of a metastatic EGFR-mutated nonsmall cell lung cancer patient

scientific article published on 16 April 2015

19q13-ERCC1 gene copy number increase in non--small-cell lung cancer

scientific article published on 15 June 2013

3rd generation's TKI in lung cancer non-small cell EGFR-mutated having acquired a secondary T790M resistance

scientific article

A Case-Control Study Brings to Light the Causes of Screen Failures in Phase 1 Cancer Clinical Trials

scientific article

A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors.

scientific article

A Phase III Study of Durvalumab (MEDI4736) With or Without Tremelimumab for Previously Treated Patients With Advanced NSCLC: Rationale and Protocol Design of the ARCTIC Study

scientific article published on 17 March 2016

A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers

scientific article published on 14 June 2017

A comparative and integrative approach identifies ATPase family, AAA domain containing 2 as a likely driver of cell proliferation in lung adenocarcinoma

scientific article published on 22 August 2012

A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas

scientific article

A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer

scientific article published on 12 August 2013

A never-smoker lung adenocarcinoma patient with a MET exon 14 mutation (D1028N) and a rapid partial response after crizotinib

scientific article published on 18 February 2016

A novel antibody-based approach to detect the functional ERCC1-202 isoform

scientific article published on 11 February 2018

A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinib

scientific article

A phase 1 dose-escalation study of the oral histone deacetylase inhibitor abexinostat in combination with standard hypofractionated radiotherapy in advanced solid tumors

scientific article

A phase 2 study of everolimus combined with trastuzumab and paclitaxel in patients with HER2-overexpressing advanced breast cancer that progressed during prior trastuzumab and taxane therapy

scientific article

A phase I, dose-escalation study of the Eg5-inhibitor EMD 534085 in patients with advanced solid tumors or lymphoma

scientific article published in December 2013

A phase I, dose-finding study of sunitinib in combination with irinotecan in patients with advanced solid tumours

scientific article

A phase I, open-label, multi-center study of the JAK2 inhibitor AZD1480 in patients with myelofibrosis

scientific article

A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors

scientific article published on 11 October 2016

A phase IB dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed and cisplatin (with or without bevacizumab) in patients with advanced

scientific article

A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours

scientific article published on 20 January 2014

A prospective examination of circulating tumor cell profiles in non-small-cell lung cancer molecular subgroups

scientific article published on 19 June 2017

A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer

scientific article

ALK translocation and crizotinib in non-small cell lung cancer: An evolving paradigm in oncology drug development ⬇️

scientific article published on March 6, 2012

Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers

scientific article

Acquired EGFR Mutation as the Potential Resistance Driver to Crizotinib in a MET-Mutated Tumor

scientific article published on 18 December 2015

Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis ⬇️

scientific article (publication date: November 2001)

Acute left ventricular dysfunction induced by a panHER and VEGFR tyrosine kinase inhibitor in a phase I trial.

scientific article published on 25 April 2009

Added value of molecular targeted agents in oncology

scientific article published on 07 February 2011

Adjuvant chemotherapy and radiotherapy in non-small cell lung cancer

scientific article

Adjuvant chemotherapy in early-stage non-small cell lung cancer

scientific article

Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial

scientific article published on 05 July 2015

An inhibitor of cyclin-dependent kinases suppresses TLR signaling and increases the susceptibility of cancer patients to herpesviridae

scientific article published in January 2011

An open-label, dose-escalation study to evaluate the safety and pharmacokinetics of CEP-9722 (a PARP-1 and PARP-2 inhibitor) in combination with gemcitabine and cisplatin in patients with advanced solid tumors

scientific article published in April 2016

Antiangiogenic agents and late anastomotic complications

scientific article published on February 2010

Antitumor activity in advanced cancer patients with thymic malignancies enrolled in early clinical drug development programs (Phase I trials) at Gustave Roussy

scientific article published on 22 June 2015

Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth

scientific article

Aquaporin expression in human lymphocytes and dendritic cells

scientific article published on March 2004

Are RAS mutations predictive markers of resistance to standard chemotherapy?

scientific article published on 14 July 2009

Are phase I trials safe for older patients?

scientific article published on 7 September 2017

Assessment of EGFR Mutation Status in Matched Plasma and Tumor Tissue of NSCLC Patients from a Phase I Study of Rociletinib (CO-1686).

scientific article published on 8 January 2016

Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients

scientific article published on 25 February 2016

Association of Vitiligo With Tumor Response in Patients With Metastatic Melanoma Treated With Pembrolizumab

scientific article

Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer ⬇️

scientific article published on October 16, 2003

BMS-690514, a VEGFR and EGFR tyrosine kinase inhibitor, shows anti-tumoural activity on non-small-cell lung cancer xenografts and induces sequence-dependent synergistic effect with radiation

scientific article

Baseline lymphopenia should not be used as exclusion criteria in early clinical trials investigating immune checkpoint blockers (PD-1/PD-L1 inhibitors).

scientific article published on 18 August 2017

Bioluminescent orthotopic mouse models of human localized non-small cell lung cancer: feasibility and identification of circulating tumour cells

scientific article

Brain Radionecrosis Treated with Bevacizumab in a Patient with Resected Squamous Cell Carcinoma of the Lung

scientific article published on 17 August 2016

Breast cancer molecular subclassification and estrogen receptor expression to predict efficacy of adjuvant anthracyclines-based chemotherapy: a biomarker study from two randomized trials

scientific article

Cardiac side effects of molecular targeted therapies: Towards a better dialogue between oncologists and cardiologists ⬇️

scientific article published on February 16, 2011

Cardiac troponin I elevation and overall survival among cancer patients receiving investigational compounds during phase I trials

scientific article

Cell cycle regulators and outcome of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer: the International Adjuvant Lung Cancer Trial Biologic Program

scientific article

Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial

scientific article published on 23 April 2015

Challenges of phase 1 clinical trials evaluating immune checkpoint-targeted antibodies

scientific article

Circulating Tumor Cells in Lung Cancer ⬇️

scientific article published on November 24, 2012

Circulating Tumor Cells with Aberrant ALK Copy Number Predict Progression-Free Survival during Crizotinib Treatment in ALK-Rearranged Non-Small Cell Lung Cancer Patients

scientific article published on May 2017

Cisplatin resistance associated with PARP hyperactivation

scientific article

Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: evaluation of concordance between genomic and transcriptional profiles

scientific article published on 18 March 2015

Concomitant chemo-radiotherapy in clinical trials: to promote step by step rational development

scientific article

Concurrent development of testicular seminoma and choriocarcinoma of the superior mediastinum, presented as cervical mass: a case report and implications about pathogenesis of germ-cell tumours

scientific article published on 20 November 2006

Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial

scientific article

Controversies and challenges regarding the impact of radiation therapy on survival

scientific article published on 16 August 2012

Corrigendum to "Precision medicine for patients with advanced biliary tract cancers: An effective strategy within the prospective MOSCATO-01 trial" [Eur J Cancer 87 (2017) 122-130].

scientific article published on 14 February 2018

Crizotinib Improves Osteoarthritis Symptoms in a ROS1-Fusion Advanced Non-Small Cell Lung Cancer Patient

scientific article

Crizotinib primary resistance overcome by ceritinib in a patient with ALK-rearranged non-small cell lung cancer

scientific article published on 13 May 2016

Crizotinib-Resistant ROS1 Mutations Reveal a Predictive Kinase Inhibitor Sensitivity Model for ROS1- and ALK-Rearranged Lung Cancers

scientific article published on 11 July 2016

Cross-validation study of class III beta-tubulin as a predictive marker for benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of four randomized trials ⬇️

scientific article published on April 6, 2011

Cutaneous side-effects of kinase inhibitors and blocking antibodies

scientific article

Cyclooxygenase 2 inhibitors and cancer chemoprevention

scientific article (publication date: May 2004)

Cyclooxygenase-2 as a target for anticancer drug development

scientific article (publication date: July 2006)

DNA damage repair and telomere length in normal breast, preneoplastic lesions, and invasive cancer

scientific article published in August 2010

DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy

scientific article

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade

scientific article published on 15 February 2018

Defining dose-limiting toxicity for phase 1 trials of molecularly targeted agents: results of a DLT-TARGETT international survey

scientific article

Delivering Cancer Care During the COVID-19 Pandemic: Recommendations and Lessons Learned From ASCO Global Webinars

scientific article published on 01 September 2020

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC.

scientific article published on 12 August 2015

Dendritic cell-derived exosomes for cancer therapy

scientific article published on April 2016

Dependence on phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combination

scientific article published on 2 February 2010

Detection of HER-2/neu-positive circulating epithelial cells in prostate cancer patients

scientific article published on January 2004

Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer

scientific article

Detection of circulating tumour cells in peripheral blood of patients with malignant pleural mesothelioma

scientific article published on January 2015

Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer ⬇️

scientific article published on October 4, 2011

Different expression levels of the TAP peptide transporter lead to recognition of different antigenic peptides by tumor-specific CTL.

scientific article

Differential expression of biomarkers in men and women

scientific article published on December 2009

Differential expression of biomarkers in primary non-small cell lung cancer and metastatic sites

scientific article published in October 2009

Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours

scientific article published on March 2004

Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast.

scientific article

Discrepancies between primary tumor and metastasis: a literature review on clinically established biomarkers

scientific article published on 17 June 2012

Discrepancies between primary tumor and metastasis: impact on personalized medicine ⬇️

scientific article published on June 1, 2013

Do all patients with advanced non-small-cell lung cancer benefit from cisplatin-based combination therapy?

scientific article published in December 2001

Does KRAS mutational status predict chemoresistance in advanced non-small cell lung cancer (NSCLC)?

scientific article published on 3 January 2014

Dose-levels and first signs of efficacy in contemporary oncology phase 1 clinical trials

scientific article

Drug insight: gastrointestinal and hepatic adverse effects of molecular-targeted agents in cancer therapy

scientific article published on 18 March 2008

Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies

scientific article published on 29 July 2013

Dynamic contrast-enhanced MRI parameters as biomarkers for the effect of vatalanib in patients with non-small-cell lung cancer

scientific article published on April 2014

Dysphonia induced by anti-angiogenic compounds

scientific article published on 18 December 2013

EGFR-independent mechanisms of acquired resistance to AZD9291 in EGFR T790M-positive NSCLC patients

scientific article

EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects

scientific article

EGFR-targeted therapies: what's new?

scientific article published in January 2006

ERCC1 and RRM1 in the international adjuvant lung trial by automated quantitative in situ analysis

scientific article

ERCC1 and RRM1: ready for prime time?

scientific article published on 11 February 2013

ERCC1 as a risk stratifier in platinum-based chemotherapy for nonsmall-cell lung cancer

scientific article

ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform

scientific article

ERCC1 isoform expression and DNA repair in non-small-cell lung cancer

scientific article

Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors

scientific article

Electrolyte disorders related to EGFR-targeting drugs

scientific article published on 28 April 2009

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

scientific article

Environmental, genetic, and molecular features of prostate cancer

scientific article published on May 2004

Epidermal growth factor receptor and chemoprevention of epithelial tumor: rationale and development methods

scientific article

Epidermal growth factor receptor signaling in colorectal cancer: preclinical data and therapeutic perspectives

scientific article published in February 2005

Erratum to: Successes and failures: what did we learn from recent first-line treatment immunotherapy trials in non-small cell lung cancer?

scientific article published on 20 April 2017

Europe Does It Better: Molecular Testing across a National Health Care System—The French Example ⬇️

scientific article published on January 1, 2013

Evaluation of sexuality, health-related quality-of-life and depression in advanced cancer patients: a prospective study in a Phase I clinical trial unit of predominantly targeted anticancer drugs

scientific article published on 6 September 2012

Evaluation of the VeriStrat® serum protein test in patients with advanced squamous cell carcinoma of the lung treated with second-line afatinib or erlotinib in the phase III LUX-Lung 8 study

scientific article

Everolimus and Erlotinib as Second- or Third-Line Therapy in Patients with Advanced Non–Small-Cell Lung Cancer ⬇️

scientific article published on October 1, 2012

Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacy

scientific article published on 16 January 2014

Expanding role of chemotherapy in lung cancer

scientific article published on September 2006

Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer

scientific article

Expression of cell cycle biomarkers and telomere length in papillary thyroid carcinoma: a comparative study between radiation-associated and spontaneous cancers

scientific article published in February 2009

Expression of chemokine receptors by cancer cells

scientific article

Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer

scientific article

Factors associated with success of image-guided tumour biopsies: Results from a prospective molecular triage study (MOSCATO-01).

scientific article published on 24 March 2016

Fibroblast growth factor receptor inhibitors as a cancer treatment: from a biologic rationale to medical perspectives

scientific article published on 15 February 2013

First Reported Case of Unexpected Response to an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in the I744M Uncommon EGFR Mutation

scientific article published on 24 June 2015

First case report of intrathecal panitumumab for treatment of meningeal carcinomatousis in an EGFR mutant lung adenocarcinoma patient

scientific article

First-in-Human Study Testing a New Radioenhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas

scientific article published on 6 October 2016

First-in-human phase I study of oral S49076, a unique MET/AXL/FGFR inhibitor, in advanced solid tumours

scientific article published on 15 June 2017

First-in-human, phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of RO5126766, a first-in-class dual MEK/RAF inhibitor in patients with solid tumors.

scientific article

From theoretical synergy to clinical supra-additive toxicity

scientific article published on 17 February 2009

Front-line doublets in advanced non-small cell lung cancer: The golden age for second line chemotherapy

scientific article published on 9 June 2005

Future Genetic/Genomic Biomarker Testing in Non-Small Cell Lung Cancer

scientific article published on January 2017

Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial

scientific article published on 6 July 2015

Gene expression profiling of non-small-cell lung cancer

scientific article published on March 2008

Genomes in the clinic: the Gustave Roussy Cancer Center experience

scientific article published on 26 February 2014

Harnessing the immune system to provide long-term survival in patients with melanoma and other solid tumors

scientific article published on 3 January 2014

Hemangiopericytoma and antiangiogenic therapy: clinical benefit of antiangiogenic therapy (sorafenib and sunitinib) in relapsed malignant haemangioperyctoma /solitary fibrous tumour

scientific article

High level of chromosomal instability in circulating tumor cells of ROS1-rearranged non-small-cell lung cancer

scientific article published on 6 April 2015

Histopathologic and genetic alterations as predictors of response to treatment and survival in lung cancer: a review of published data

scientific article

Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1.

scientific article

IFCT-0401 Trial: a phase II study of gefitinib administered as first-line treatment in advanced adenocarcinoma with bronchioloalveolar carcinoma subtype

scientific article published in September 2009

IGF-1R targeting increases the antitumor effects of DNA-damaging agents in SCLC model: an opportunity to increase the efficacy of standard therapy

scientific article published on 02 May 2013

Imatinib in small cell lung cancer

scientific article published on August 2003

Immune checkpoint inhibitors in advanced nonsmall cell lung cancer

scientific article

Immune-Modified Response Evaluation Criteria In Solid Tumors (imRECIST): Refining Guidelines to Assess the Clinical Benefit of Cancer Immunotherapy

scientific article published on 17 January 2018

Immune-checkpoints: the new anti-cancer immunotherapies ⬇️

scientific article published on June 1, 2013

Immune-related adverse events with immune checkpoint blockade: a comprehensive review

scientific article

Immunohistochemistry to identify EGFR mutations or ALK rearrangements in patients with lung adenocarcinoma ⬇️

scientific article published on November 18, 2011

Immunotherapy phase I trials in patients Older than 70 years with advanced solid tumours

scientific article published on 7 April 2018

Impact of centralization on aCGH-based genomic profiles for precision medicine in oncology

scientific article

Implementing precision medicine initiatives in the clinic: a new paradigm in drug development

scientific article published on May 2014

Improving brain penetration of kinase inhibitors in lung cancer patients with oncogene dependency

scientific article published in February 2017

In the immuno-oncology era, is anti-PD-1 or anti-PD-L1 immunotherapy modifying the sensitivity to conventional cancer therapies?

scientific article published on 7 November 2017

Inclusion of patients with advanced cancer in phase I trials: is this a tool for improving optimism and emotional well-being?

scientific article published on 22 January 2013

Incorporating immune-checkpoint inhibitors into systemic therapy of NSCLC

scientific article

Inflammatory gastrointestinal diseases associated with PD-1 blockade antibodies

scientific article

Inhibition of BCL-2 in small cell lung cancer cell lines with oblimersen, an antisense BCL-2 oligodeoxynucleotide (ODN): in vitro and in vivo enhancement of radiation response

scientific article published on October 1, 2010

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

scientific article

Involvement of aquaporins in colorectal carcinogenesis

scientific article published on October 2003

Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib.

scientific article published on 13 July 2009

Kidney diseases associated with anti-vascular endothelial growth factor (VEGF): an 8-year observational study at a single center

scientific article

LACE-Bio: Validation of Predictive and/or Prognostic Immunohistochemistry/Histochemistry-based Biomarkers in Resected Non-small-cell Lung Cancer

article

LDK378 compassionate use for treating carcinomatous meningitis in an ALK translocated non-small-cell lung cancer

scientific article published in August 2014

LKB1/STK11 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value

scientific article published on 7 August 2017

Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation

scientific article

Lack of interleukin-10 expression could predict poor outcome in patients with stage I non-small cell lung cancer

scientific article published on May 2003

Late-occurring nivolumab-induced cryptogenic organising pneumonia mimicking lung progression in a patient with metastatic non-small cell lung cancer

scientific article published on 13 September 2017

Leptomeningeal and medullary response to second-line erlotinib in lung adenocarcinoma

scientific article published in June 2008

Loss of PTEN Expression as a Prognostic Marker for Tongue Cancer ⬇️

scientific article published on December 1, 2001

Loss of PTEN expression is not uncommon, but lacks prognostic value in stage I NSCLC.

scientific article published in November 2003

Loss-of-function alleles of P2RX7 and TLR4 fail to affect the response to chemotherapy in non-small cell lung cancer

scientific article

Lung cancer stem cell: fancy conceptual model of tumor biology or cornerstone of a forthcoming therapeutic breakthrough?

scientific article published on January 2014

MMS19 as a potential predictive marker of adjuvant chemotherapy benefit in resected non-small cell lung cancer

scientific article published on September 2016

MVP and vinorelbine for malignant pleural mesothelioma

scientific article published in August 2008

Maintenance therapy and advanced non-small-cell lung cancer: a skeptic's view

scientific article published in September 2012

Management of hypertension in angiogenesis inhibitor-treated patients

scientific article published on 15 January 2009

Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper

scientific article

Management of non-small-cell lung cancer: recent developments ⬇️

scientific article published on August 24, 2013

Mechanisms of Disease: signal transduction in lung carcinogenesis -- a comparison of smokers and never-smokers

scientific article published on 15 July 2008

Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium

scientific article

Method for semi-automated microscopy of filtration-enriched circulating tumor cells

scientific article

Minimal residual disease in solid neoplasia: New frontier or red-herring? ⬇️

scientific article published on May 25, 2011

Mitogen-activated protein kinase activation in lung adenocarcinoma: a comparative study between ever smokers and never smokers

scientific article

Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients

scientific article

Modifying phase I methodology to facilitate enrolment of molecularly selected patients

scientific article published on 16 January 2013

Molecular Characteristics of ERCC1-Negative versus ERCC1-Positive Tumors in Resected NSCLC.

scientific article

Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial

scientific article

Molecular circuits of solid tumors: prognostic and predictive tools for bedside use.

scientific article published on 15 June 2010

Molecular detection of early-stage laryngopharyngeal squamous cell carcinomas

scientific article

Molecular screening for a personalized treatment approach in advanced adrenocortical cancer

scientific article

Molecular targeting: targeting angiogenesis in solid tumors

scientific article published in January 2004

Moving Immune Checkpoint Blockade in Thoracic Tumors beyond NSCLC.

scientific article published on 8 June 2016

Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Res

scientific article

Multidrug resistance proteins do not predict benefit of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: International Adjuvant Lung Cancer Trial Biologic Program

scientific article published on 01 July 2007

MutS homologue 2 and the long-term benefit of adjuvant chemotherapy in lung cancer

scientific article published on 9 February 2010

Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated lung adenocarcinomas

scientific article published on 26 October 2013

Mutational Landscape and Sensitivity to Immune Checkpoint Blockers

scientific article

NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors

scientific article published on November 2005

Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer

scientific article published on 17 May 2010

New concepts for phase I trials: evaluating new drugs combined with radiation therapy

scientific article

New treatments in immuno-oncology: a revolution and a formidable scientific and clinical challenge

scientific article published in June 2017

Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer

scientific article

No evidence for viral sequences in five lepidic adenocarcinomas (former "BAC") by a high-throughput sequencing approach

scientific article published on 15 December 2015

Nonapoptotic role for Apaf-1 in the DNA damage checkpoint

scientific article published on November 2007

Novel therapeutic targets in advanced urothelial carcinoma

scientific article

Open-label, multicentre expansion cohort to evaluate imgatuzumab in pre-treated patients with KRAS-mutant advanced colorectal carcinoma

scientific article published on 18 November 2013

Osimertinib in EGFR Mutation–Positive Advanced NSCLC.

scientific article

Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer

scientific article published on 18 November 2017

Otorhinolaryngological Toxicities of New Drugs in Oncology

scientific article published on 17 March 2017

Outcomes and prognostic factors for relapsed or refractory lymphoma patients in phase I clinical trials

scientific article published on 09 June 2017

Overexpression of cyclin B1 in early-stage non-small cell lung cancer and its clinical implication

scientific article (publication date: August 2000)

P2.39: Long-Term OS for Patients With Advanced NSCLC Enrolled in the KEYNOTE-001 Study of Pembrolizumab: Track: Immunotherapy

scientific article published on 22 September 2016

PARP inhibitors: an interesting pathway also for non-small cell lung cancer?

scientific article published on January 2014

PARP1 impact on DNA repair of platinum adducts: preclinical and clinical read-outs

scientific article published on 12 February 2013

PI3K-AKT-mTOR pathway inhibitors

scientific article published in January 2006

PS01.62: Long-Term Safety and Clinical Activity of Atezolizumab Monotherapy in Metastatic NSCLC: Final Results from a Phase Ia Study: Topic: Medical Oncology

scientific article

PS01.66: Biomarker Stratification of Outcomes of Third-Generation EGFR TKI Therapy in Patients with Previously-Treated Advanced NSCLC: Topic: Medical Oncology

scientific article

Patient selection for oncology phase I trials: a multi-institutional study of prognostic factors

scientific article published on 21 February 2012

Patients aged over 75 years enrolled in Phase I clinical trials: the Gustave Roussy experience

scientific article published on 15 September 2015

Patterns of responses in metastatic NSCLC during PD-1 or PDL-1 inhibitor therapy: Comparison of RECIST 1.1, irRECIST and iRECIST criteria

scientific article

Pemetrexed-induced pneumonitis: a case report

scientific article published in September 2009

Personalized radiation therapy and biomarker-driven treatment strategies: a systematic review

scientific article published on December 2013

Personalized treatments of cancer patients: a reality in daily practice, a costly dream or a shared vision of the future from the oncology community?

scientific article

Pharmacokinetic results of a phase I trial of sorafenib in combination with dacarbazine in patients with advanced solid tumors

scientific article

Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I.

scientific article

Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers.

scientific article published on 21 June 2009

Phase 2 study of frontline bortezomib in patients with advanced non-small cell lung cancer ⬇️

scientific article published on December 18, 2011

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors

scientific article published on 31 August 2015

Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies

scientific article published in August 2017

Phase I Dose-Escalation and Pharmacokinetic Study of Intravenous Aflibercept in Combination with Docetaxel, Cisplatin, and 5-Fluorouracil in Patients with Advanced Solid Malignancies

scientific article

Phase I Study of Everolimus Plus Weekly Paclitaxel and Trastuzumab in Patients With Metastatic Breast Cancer Pretreated With Trastuzumab ⬇️

scientific article published on October 25, 2010

Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors

scientific article published on 4 November 2016

Phase I clinical and pharmacokinetic study of ombrabulin (AVE8062) combined with cisplatin/docetaxel or carboplatin/paclitaxel in patients with advanced solid tumors

scientific article published on 6 June 2014

Phase I clinical trial combining imatinib mesylate and IL-2 in refractory cancer patients: IL-2 interferes with the pharmacokinetics of imatinib mesylate

scientific article published on February 2013

Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR(+) NK cell levels correlate with disease outcome

scientific article published on February 2013

Phase I dose-escalation studies of roniciclib, a pan-cyclin-dependent kinase inhibitor, in advanced malignancies

scientific article published on 2 May 2017

Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors

scientific article

Phase I dose-escalation study of pazopanib combined with bevacizumab in patients with metastatic renal cell carcinoma or other advanced tumors

scientific article published on 15 August 2017

Phase I dose-escalation study of pilaralisib (SAR245408, XL147), a pan-class I PI3K inhibitor, in combination with erlotinib in patients with solid tumors

scientific article

Phase I dose-escalation study of plitidepsin in combination with bevacizumab in patients with refractory solid tumors

scientific article published on 8 September 2016

Phase I dose-escalation study of plitidepsin in combination with sorafenib or gemcitabine in patients with refractory solid tumors or lymphomas

scientific article

Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations

scientific article

Phase I open-label study of afatinib plus vinorelbine in patients with solid tumours overexpressing EGFR and/or HER2.

scientific article published on 16 January 2018

Phase I safety, pharmacokinetic and pharmacodynamic evaluation of the vascular disrupting agent ombrabulin (AVE8062) in patients with advanced solid tumors

scientific article published on 5 July 2013

Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors

scientific article

Phase I study of afatinib combined with nintedanib in patients with advanced solid tumours

scientific article published on 29 October 2015

Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma

scientific article published on 21 January 2013

Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors

scientific article published on 26 October 2012

Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors

scientific article published on 9 December 2013

Phase I trial evaluating the antiviral agent Cidofovir in combination with chemoradiation in cervical cancer patients

scientific article published on 21 March 2016

Phase I trial of bortezomib daily dose: safety, pharmacokinetic profile, biological effects and early clinical evaluation in patients with advanced solid tumors

scientific article published on 2 November 2017

Phase I trial of sorafenib in combination with IFN alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma

scientific article published on March 2007

Phase I, dose-finding, and pharmacokinetic study of raltitrexed combined with oxaliplatin in patients with advanced cancer

scientific article published in June 2000

Phase I-IIa study of BMS-690514, an EGFR, HER-2 and -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor, in patients with advanced or metastatic solid tumours

scientific article published on 13 March 2013

Phase II, double-blinded, randomized study of enzastaurin plus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer

scientific article

Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy

scientific article published on 28 April 2017

Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy

scientific article

Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway

scientific article

Precision medicine for patients with advanced biliary tract cancers: An effective strategy within the prospective MOSCATO-01 trial

scientific article published on 13 November 2017

Predicting response to Iressa: unexpected mechanism

scientific article published in August 2004

Prediction of early death among patients enrolled in phase I trials: development and validation of a new model based on platelet count and albumin ⬇️

scientific article published on August 21, 2012

Prevalence and causes of burnout amongst oncology residents: a comprehensive nationwide cross-sectional study

scientific article

Prevalence of immune-related systemic adverse events in patients treated with anti-Programmed cell Death 1/anti-Programmed cell Death-Ligand 1 agents: A single-centre pharmacovigilance database analysis

scientific article

Prioritizing targets for precision cancer medicine

scientific article

Prognostic Effect of Tumor Lymphocytic Infiltration in Resectable Non-Small-Cell Lung Cancer

scientific article published on February 2016

Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis

scientific article

Prognostic factors and outcome of patients with hematological malignancies in phase I trials: the Gustave Roussy scoring system

scientific article published on 20 February 2017

Prognostic value of HLA-A2 status in advanced non-small cell lung cancer patients

scientific article published on 29 July 2017

Prognostic value of LIPC in non-small cell lung carcinoma

scientific article

Prospective validation of a prognostic score for patients in immunotherapy phase I trials: The Gustave Roussy Immune Score (GRIm-Score).

scientific article

Protein kinases C: a new cytoplasmic target

scientific article published in July 2008

Proteinuria and proximal tubule lesions induced by an anti-integrin monoclonal antibody treatment: case report

scientific article

QT interval prolongation among patients treated with angiogenesis inhibitors

scientific article published on April 2009

Quantitative proteomics profiling of primary lung adenocarcinoma tumors reveals functional perturbations in tumor metabolism

scientific article published on 13 August 2013

RECIST response and variation of circulating tumour cells in phase 1 trials: A prospective multicentric study

scientific article published on 22 July 2017

Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer

scientific article

Randomized phase II study of dulanermin in combination with paclitaxel, carboplatin, and bevacizumab in advanced non-small-cell lung cancer

scientific article

Rapid and objective CT scan prognostic scoring identifies metastatic patients with long-term clinical benefit on anti-PD-1/-L1 therapy

scientific article published on 20 July 2016

Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer

scientific article published on 21 March 2012

Rationale for anti-OX40 cancer immunotherapy

scientific article

Reappraisal of treatment-induced renal dysfunction in patients receiving antiangiogenic agents in phase I trials ⬇️

scientific article published on April 21, 2011

Response of ovarian carcinomas to gefitinib-carboplatin-paclitaxel combination is not associated with EGFR kinase domain somatic mutations

scientific article

Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers

scientific article published in January 2003

Reversible cardiogenic shock following 5-fluorouracil infusion.

scientific article published on 5 June 2009

Rhinitis in patients treated with a combination of an mTOR inhibitor and an EGFR inhibitor

scientific article published on 22 June 2010

Rociletinib in EGFR-mutated non-small-cell lung cancer

scientific article

Role of human aquaporin 5 in colorectal carcinogenesis

scientific article published on 26 June 2008

Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT).

scientific article published on 14 January 2016

STEAP, a prostate tumor antigen, is a target of human CD8+ T cells

scientific article published on 19 April 2006

Safety and Antitumor Activity of Pembrolizumab in Advanced Programmed Death Ligand 1-Positive Endometrial Cancer: Results From the KEYNOTE-028 Study

scientific article published on 10 May 2017

Safety and Efficacy of Buparlisib (BKM120) in Patients with PI3K Pathway-Activated Non-Small Cell Lung Cancer: Results from the Phase II BASALT-1 Study

scientific article

Safety and efficacy of anti-programmed death 1 antibodies in patients with cancer and pre-existing autoimmune or inflammatory disease

scientific article published on 10 January 2018

Safety of repeated administrations of ixabepilone given as a 3-hour infusion every other week in combination with irinotecan in patients with advanced malignancies

scientific article published on 4 March 2008

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

scientific article

Second generation ALK inhibitors in non-small cell lung cancer: systemic review

scientific article

Second or third additional chemotherapy drug for non-small cell lung cancer in patients with advanced disease

scientific article (publication date: 18 April 2012)

Second or third additional chemotherapy drug for non-small cell lung cancer in patients with advanced disease

scientific article

Should progression-free survival be the primary measure of efficacy for advanced NSCLC therapy?

scientific article published on 23 May 2010

Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer.

scientific article

Sorafenib plus dacarbazine in solid tumors: a phase I study with dynamic contrast-enhanced ultrasonography and genomic analysis of sequential tumor biopsy samples

scientific article published on 27 August 2013

Subtype Classification of Lung Adenocarcinoma Predicts Benefit From Adjuvant Chemotherapy in Patients Undergoing Complete Resection

scientific article

Successes and failures: what did we learn from recent first-line treatment immunotherapy trials in non-small cell lung cancer?

scientific article

Symptom and Quality of Life Improvement in LUX-Lung 8, an Open-Label Phase III Study of Second-Line Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung After First-Line Platinum-Based Chemotherapy

scientific article published on 23 June 2017

Symptomatic leptomeningeal metastasis improvement with nivolumab in advanced non-small cell lung cancer patient

scientific article published on 27 February 2017

Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer

scientific article published on 21 February 2013

Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines

scientific article published on 14 September 2009

Systematic review and meta-analysis of phase I/II targeted therapy combined with radiotherapy in patients with glioblastoma multiforme: quality of report, toxicity, and survival

scientific article published on 15 May 2015

Systematic review and meta-analysis of randomised, phase II/III trials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients with advanced non-small-cell lung cancer

scientific article

Targeted molecular therapy: the example of Iressa (ZD1839)

scientific article

Targeted therapies in lung cancer

scientific article published in July 2007

Targeted therapy-induced radiation recall

scientific article published on 8 January 2013

Targeting FGFR Signaling in Cancer

scientific article published on June 2015

Targeting angiogenesis with oral agents

scientific article published on September 2006

Targeting epidermal growth factor receptor in non-small cell lung cancer: current advances and perspectives

scientific article published in January 2007

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

scientific article published on 10 April 2016

Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study

scientific article published on 9 April 2018

Telomerase expression in lung preneoplasia and neoplasia

scientific article published on May 2007

Telomere length, telomeric proteins and DNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases

scientific article published on 16 December 2008

Telomere length, telomeric proteins and genomic instability during the multistep carcinogenic process

scientific article published on 14 February 2008

Telomere maintenance and DNA damage responses during lung carcinogenesis

scientific article published on 19 April 2010

Temsirolimus in the treatment of mantle cell lymphoma: frequency and management of adverse effects

scientific article published on March 2013

The European Society for Medical Oncology (ESMO) Precision Medicine Glossary

scientific article published on 13 November 2017

The Evolving Role of Histology in the Management of Advanced Non–Small-Cell Lung Cancer ⬇️

scientific article published on November 15, 2010

The NER proteins are differentially expressed in ever smokers and in never smokers with lung adenocarcinoma

scientific article

The challenge to bring personalized cancer medicine from clinical trials into routine clinical practice: the case of the Institut Gustave Roussy ⬇️

scientific article published on 16 March 2012

The efficacy and toxicity of EGFR in the settings of radiotherapy: Focus on published clinical trials

scientific article published on 07 August 2008

The genetic complexity of common cancers and the promise of personalized medicine: is there any hope?

scientific article published on January 2014

The potential diagnostic power of circulating tumor cell analysis for non-small-cell lung cancer

scientific article

The potential of exploiting DNA-repair defects for optimizing lung cancer treatment

scientific article published on 14 February 2012

The role of anti-epidermal growth factor receptor and anti-vascular endothelial growth factor therapies in the treatment of non-small-cell lung cancer

scientific article published on March 2010

Therapeutic implications of epidermal growth factor receptor in lung cancer

scientific article published in November 2003

Towards new methods for the determination of dose limiting toxicities and the assessment of the recommended dose for further studies of molecularly targeted agents--dose-Limiting Toxicity and Toxicity Assessment Recommendation Group for Early Trials

scientific article

Transcriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study

scientific article

Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3.

scientific article published on 30 October 2017

Translating metastasis-related biomarkers to the clinic--progress and pitfalls

scientific article published on 05 February 2013

Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance

scientific article published on January 2016

Tumor assessment criteria in phase I trials: beyond RECIST.

scientific article published on 17 December 2012

Tumor growth rate provides useful information to evaluate sorafenib and everolimus treatment in metastatic renal cell carcinoma patients: an integrated analysis of the TARGET and RECORD phase 3 trial data

scientific article

Tumour molecular profiling for deciding therapy—the French initiative ⬇️

scientific article published on July 10, 2012

Tumour stem cell-targeted treatment: elimination or differentiation

scientific article

Unlikely association of nephrectomy post-mRCC with anti-VEGF-induced renal TMA.

scientific article published on 7 October 2010

Update to Rociletinib Data with the RECIST Confirmed Response Rate

scientific article published on 11 May 2016

Use of angiogenesis inhibitors in tumour treatment

scientific article

VEGF signalling inhibition-induced proteinuria: Mechanisms, significance and management

scientific article published on 16 December 2009

VEGF-A Expression Correlates with TP53 Mutations in Non-Small Cell Lung Cancer: Implications for Antiangiogenesis Therapy

scientific article published on 11 February 2015

Vascular disrupting agents: a delicate balance between efficacy and side effects

scientific article published on May 2012

What can be done for patients with NSCLC without druggable targets? ⬇️

scientific article published on March 1, 2013

Whole exome sequencing for determination of tumor mutation load in liquid biopsy from advanced cancer patients

scientific article published on 21 November 2017

Wound healing delay after central venous access following DCF/VEGF-trap therapy

scientific article published on 17 February 2009

[Focus on targeting the Ras-MAPK pathway: the Mek inhibitors].

scientific article published in September 2012

p38 mitogen‐activated protein kinase signaling, ERCC1 expression, and viability of lung cancer cells from never or light smoker patients ⬇️

scientific article published on March 13, 2012

rCGH: a comprehensive array-based genomic profile platform for precision medicine

scientific article published on 26 December 2015

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