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List of works by Ludger Johannes

(S)-N-Methyldihydroquinazolinones are the Active Enantiomers of Retro-2 Derived Compounds against Toxins

scientific article

1-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione: design, synthesis, and radiosynthesis of a new [18F]fluoropyridine-based maleimide reagent for the labeling of peptides and proteins.

scientific article

1st class ticket to class I: protein toxins as pathfinders for antigen presentation

scientific article

A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens

scientific article published on 9 September 2011

A Therapeutic Her2/neu Vaccine Targeting Dendritic Cells Preferentially Inhibits the Growth of Low Her2/neu-Expressing Tumor in HLA-A2 Transgenic Mice.

scientific article

A new delivery system for auristatin in STxB-drug conjugate therapy

scientific article published on 28 March 2015

A novel type of quantum dot-transferrin conjugate using DNA hybridization mimics intracellular recycling of endogenous transferrin

scientific article published on 4 October 2017

Actin dynamics drive membrane reorganization and scission in clathrin-independent endocytosis

scientific article published in February 2010

Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes.

scientific article

Bending "on the rocks"--a cocktail of biophysical modules to build endocytic pathways

scientific article published on January 2014

Biophysical approaches to protein-induced membrane deformations in trafficking

scientific article published on 06 June 2008

Building endocytic pits without clathrin

article

Carbohydrate conformation and lipid condensation in monolayers containing glycosphingolipid Gb3: influence of acyl chain structure

scientific article

Cells respond to mechanical stress by rapid disassembly of caveolae

scientific article

Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport

scientific journal article

Characterization of the non-native trifluoroethanol-induced intermediate conformational state of the Shiga toxin B-subunit

scientific article published on 25 April 2006

Chemistry-based protein modification strategy for endocytic pathway analysis

scientific article published on 25 March 2010

Cholera and Shiga toxin B-subunits: thermodynamic and structural considerations for function and biomedical applications.

scientific article

Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes

scientific article

Clathrin-dependent or not: is it still the question?

scientific article

Correlation between Shiga toxin B-subunit stability and antigen crosspresentation: a mutational analysis.

scientific article published on 10 December 2007

Correspondence to Creydt VP et al., Cytotoxic effect of Shiga toxin-2 holotoxin and its B subunit on human renal tubular epithelial cells, Microbes Infect. 8(2) (2006) 410–419

scientific article published on 24 May 2006

Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes

scientific article

Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

scientific article published on 29 April 2019

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription

article

Endocytosis and toxicity of clostridial binary toxins depend on a clathrin-independent pathway regulated by Rho-GDI

scientific article published on 19 October 2010

Endocytosis: Remote Control from Deep Inside

scientific article

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis.

scientific article

Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166

scientific article published on 19 March 2020

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

scientific article

Friction Mediates Scission of Tubular Membranes Scaffolded by BAR Proteins.

scientific article published on 21 June 2017

Functional Analysis of Arl1 and Golgin‐97 in Endosome‐to‐TGN Transport Using Recombinant Shiga Toxin B Fragment

scientific article published on 01 January 2005

Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2

scientific article published on 17 February 2020

Functionally different pools of Shiga toxin receptor, globotriaosyl ceramide, in HeLa cells

scientific article published on 24 October 2006

GM1 structure determines SV40-induced membrane invagination and infection

scientific article published on 20 December 2009

Galectin-3 Protein Regulates Mobility of N-cadherin and GM1 Ganglioside at Cell-Cell Junctions of Mammary Carcinoma Cells ⬇️

scientific article published on July 30, 2012

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

article

Galectins at a glance

scientific article published on 01 May 2018

Glycolipids and Lectins in Endocytic Uptake Processes

scientific article published on 27 October 2016

Glycosylation and raft endocytosis in cancer

scientific article published on 09 May 2020

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation.

scientific article published on 3 August 2016

How curvature-generating proteins build scaffolds on membrane nanotubes

scientific article published on 21 September 2016

Human GII.4 norovirus VLP induces membrane invaginations on giant unilamellar vesicles containing secretor gene dependent α1,2-fucosylated glycosphingolipids.

scientific article published on 23 March 2013

Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxB-vectorized chemotherapeutic compounds.

scientific article

Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

scientific article published on 7 August 2008

In vivo tumor targeting using a novel intestinal pathogen-based delivery approach.

scientific article published in July 2006

Increasing Diversity of Biological Membrane Fission Mechanisms

scientific article published on 4 January 2018

Induced domain formation in endocytic invagination, lipid sorting, and scission

scientific article published on 01 August 2010

Induction of resident memory T cells enhances the efficacy of cancer vaccine

scientific article

Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales

scientific article

Inhibitors of the cellular trafficking of ricin.

scientific article published on 06 January 2012

Intracellular trafficking of Shiga-toxin-B-subunit-functionalized spherulites

scientific article published in December 2008

Key role of receptor density in colloid/cell specific interaction: a quantitative biomimetic study on giant vesicles

scientific article published on 15 May 2008

Lipid cosorting mediated by shiga toxin induced tubulation.

scientific article published on 30 September 2010

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway.

scientific article published on 16 April 2013

Lipid reorganization induced by Shiga toxin clustering on planar membranes

scientific article

Mechanism of Shiga Toxin Clustering on Membranes

scientific article

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

scientific article published on 12 April 2016

Metal-Free Activation of a C(sp)-H Bond of Aryl Acetylenes.

scientific article published on 9 August 2016

Mucosal imprinting of vaccine-induced CD8⁺ T cells is crucial to inhibit the growth of mucosal tumors

scientific article

N-methyldihydroquinazolinone derivatives of Retro-2 with enhanced efficacy against Shiga toxin

scientific article published on 05 April 2013

Noninvasive measurement of the pH of the endoplasmic reticulum at rest and during calcium release.

scientific article

PD-1-Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

scientific article published on 07 November 2012

Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network

scientific article

Persistent cell migration and adhesion rely on retrograde transport of β(1) integrin.

scientific article published on 7 December 2015

Protein interaction mapping: a Drosophila case study

scientific article published on 14 February 2005

Protein toxins: intracellular trafficking for targeted therapy.

scientific article

Quantum dot-loaded monofunctionalized DNA icosahedra for single-particle tracking of endocytic pathways

scientific article

Rab12 localizes to Shiga toxin-induced plasma membrane invaginations and controls toxin transport.

scientific article published on 5 May 2014

Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.

scientific article published on 12 February 2018

Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking

scientific article

Rab7 Is Functionally Required for Selective Cargo Sorting at the Early Endosome

scientific article published on 13 January 2014

Retrograde Trafficking Inhibitor of Shiga Toxins Reduces Morbidity and Mortality of Mice Infected with Enterohemorrhagic Escherichia coli

scientific article

Retrograde delivery of photosensitizer (TPPp-O-beta-GluOH)3 selectively potentiates its photodynamic activity

scientific article

Retrograde transport of KDEL-bearing B-fragment of Shiga toxin

scientific article published on 01 August 1997

Retrograde transport: two (or more) roads diverged in an endosomal tree?

scientific article published on 28 April 2011

Retromer Sets a Trap for Endosomal Cargo Sorting

scientific article published in December 2016

SNAP-tag based proteomics approach for the study of the retrograde route

scientific article published on 16 April 2012

SNAP-tagging the retrograde route

scientific article published in January 2013

STAM Interaction with Hrs Controls JAK/STAT Activation by Interferon-α at the Early Endosome: Supplementary figures

Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit

scientific article published on 10 July 2020

Shiga Toxin-A Model for Glycolipid-Dependent and Lectin-Driven Endocytosis

scientific article published on 25 October 2017

Shiga toxin B-subunit binds to the chaperone BiP and the nucleolar protein B23.

scientific article published in February 2006

Shiga toxin B-subunit sequential binding to its natural receptor in lipid membranes

scientific article published on 23 December 2006

Shiga toxin induces membrane reorganization and formation of long range lipid order

scientific article published on 01 January 2015

Shiga toxin induces tubular membrane invaginations for its uptake into cells

scientific article

Shiga toxin stimulates clathrin-independent endocytosis of the VAMP2, VAMP3 and VAMP8 SNARE proteins.

scientific article published on 12 June 2015

Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug.

scientific article published in January 2007

Slow Relaxation of Shape and Orientational Texture in Membrane Gel Domains

scientific article published on 11 November 2015

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex.

scientific article published on 05 December 2016

Specific adsorption of functionalized colloids at the surface of living cells: a quantitative kinetic analysis of the receptor-mediated binding

scientific article published on 16 July 2008

Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors

scientific article published on 19 April 2006

Surfing on a retrograde wave: how does Shiga toxin reach the endoplasmic reticulum? ⬇️

scientific article published on April 1, 1998

Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer

scientific article

Synthesis and properties of a mitochondrial peripheral benzodiazepine receptor conjugate.

scientific article published on November 2008

Synthesis of globo- and isoglobotriosides bearing a cinnamoylphenyl tag as novel electrophilic thiol-specific carbohydrate reagents

scientific article published on 13 June 2006

Synthesis of peptide-protein conjugates using N-succinimidyl carbamate chemistry

scientific article published in February 2010

Synthesis, Chiral Separation, Absolute Configuration Assignment, and Biological Activity of Enantiomers of Retro-1 as Potent Inhibitors of Shiga Toxin.

scientific article published on June 2015

Targeted Shiga toxin-drug conjugates prepared via Cu-free click chemistry

scientific article published on 8 October 2015

The 2018 biomembrane curvature and remodeling roadmap

scientific article published on 20 July 2018

The B subunit of Shiga toxin coupled to full-size antigenic protein elicits humoral and cell-mediated immune responses associated with a Th1-dominant polarization

scientific article

The Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis

scientific article published in 2021

The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication.

scientific article published on July 2013

The SNXy flavours of endosomal sorting ⬇️

scientific article published on July 3, 2011

The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunity.

scientific article published on May 2006

The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step

scientific article

The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages

scientific article

The effects of globotriaosylceramide tail saturation level on bilayer phases

scientific article published on 01 February 2015

The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak

scientific article

The epithelial cell cytoskeleton and intracellular trafficking. I. Shiga toxin B-subunit system: retrograde transport, intracellular vectorization, and more

scientific article

The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus

scientific article (publication date: November 2002)

The retromer complex and clathrin define an early endosomal retrograde exit site.

scientific article

The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network.

scientific article

The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.

scientific article published on September 2008

Thermodynamic Analysis of the Structural Stability of the Shiga Toxin B-Subunit†

article

Tracing the retrograde route in protein trafficking.

scientific article published on December 2008

Trafficking of Shiga toxin/Shiga-like toxin-1 in human glomerular microvascular endothelial cells and human mesangial cells

scientific article published on 25 October 2006

Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16

scientific article

Tumor delivery of ultrasound contrast agents using Shiga toxin B subunit.

scientific article published in April 2011

Tumor-specific targeting of pancreatic cancer with Shiga toxin B-subunit

scientific article

Two distinct Gb3/CD77 signaling pathways leading to apoptosis are triggered by anti-Gb3/CD77 mAb and verotoxin-1.

scientific article published on 27 August 2003

Two-dimensional structures of the Shiga toxin B-subunit and of a chimera bound to the glycolipid receptor Gb3.

scientific article published in August 2002

Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site.

scientific article published on 11 August 2015

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

scientific article published on 4 August 2013

tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre

scientific article

βIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex

scientific article published on 11 December 2012

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