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List of works by Francis J. Doyle III

12-Week 24/7 Ambulatory Artificial Pancreas With Weekly Adaptation of Insulin Delivery Settings: Effect on Hemoglobin A1c and Hypoglycemia

scientific article published on 13 October 2017

A Detailed Modular Analysis of Heat-Shock Protein Dynamics under Acute and Chronic Stress and Its Implication in Anxiety Disorders ⬇️

scientific article published on August 22, 2012

A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings

scientific article published in 2022

A Personalized Week-to-Week Updating Algorithm to Improve Continuous Glucose Monitoring Performance

scientific article published in October 2017

A Run-to-Run Control Strategy to Adjust Basal Insulin Infusion Rates in Type 1 Diabetes

scientific article published on January 2008

A model of the cell-autonomous mammalian circadian clock

scientific article

A molecular model for intercellular synchronization in the mammalian circadian clock

scientific article published on 16 March 2007

A novel adaptive basal therapy based on the value and rate of change of blood glucose

scientific article

A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9.

scientific article published on 14 November 2006

A physiological systems approach to modeling and resetting of mouse thermoregulation under heat stress ⬇️

scientific article published on June 23, 2011

A systems theoretic approach to analysis and control of mammalian circadian dynamics

scientific article

Accuracy of Wrist-Worn Activity Monitors During Common Daily Physical Activities and Types of Structured Exercise: Evaluation Study

scientific article published on 10 December 2018

Adaptive Zone Model Predictive Control of Artificial Pancreas Based on Glucose- and Velocity-Dependent Control Penalties

scientific article published on 21 August 2018

Adjustment of Open-Loop Settings to Improve Closed-Loop Results in Type 1 Diabetes: A Multicenter Randomized Trial

scientific article

Amplitude metrics for cellular circadian bioluminescence reporters

scientific article

An Enhanced Model Predictive Control for the Artificial Pancreas Using a Confidence Index Based on Residual Analysis of Past Predictions

scientific article published in December 2016

An advisory protocol for rapid- and slow-acting insulin therapy based on a run-to-run methodology

scientific article published on July 2010

Application of Zone Model Predictive Control Artificial Pancreas During Extended Use of Infusion Set and Sensor: A Randomized Crossover-Controlled Home-Use Trial

scientific article

Artificial pancreas (AP) clinical trial participants' acceptance of future AP technology

scientific article

Automatic Bolus and Adaptive Basal Algorithm for the Artificial Pancreatic β-Cell ⬇️

scientific article published on September 30, 2010

Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes

scientific article published in February 2018

Bolus calculator: a review of four "smart" insulin pumps

scientific article published on December 2008

Calculating the insulin to carbohydrate ratio using the hyperinsulinaemic-euglycaemic clamp-a novel use for a proven technique

scientific article published in September 2007

Challenges Associated With Exercise Studies in Type 1 Diabetes

scientific article published on 29 December 2015

Circadian phase resetting via single and multiple control targets

scientific article

Clinical Evaluation of a Personalized Artificial Pancreas ⬇️

scientific article published on November 27, 2012

Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range

scientific article published on 08 June 2019

Clinical evaluation of an automated artificial pancreas using zone-model predictive control and health monitoring system

scientific article

Clinical results of an automated artificial pancreas using technosphere inhaled insulin to mimic first-phase insulin secretion.

scientific article

Clinical update on optimal prandial insulin dosing using a refined run-to-run control algorithm

scientific article published on May 2009

Clinically Relevant Hypoglycemia Prediction Metrics for Event Mitigation ⬇️

scientific article published on June 12, 2012

Closed-Loop Control Performance of the Hypoglycemia-Hyperglycemia Minimizer (HHM) System in a Feasibility Study.

scientific article

Closed-loop artificial pancreas systems: engineering the algorithms

scientific article published on January 2014

Closed-loop control and advisory mode evaluation of an artificial pancreatic Beta cell: use of proportional-integral-derivative equivalent model-based controllers

scientific article published on July 2008

Closed-loop control of artificial pancreatic Beta -cell in type 1 diabetes mellitus using model predictive iterative learning control.

scientific article

Consensus Recommendations for the Use of Automated Insulin Delivery (AID) Technologies in Clinical Practice

scientific article published in 2022

Control to range for diabetes: functionality and modular architecture

scientific article

Control-Relevant Models for Glucose Control Using A Priori Patient Characteristics ⬇️

scientific article published on November 22, 2011

Coordinated basal-bolus infusion for tighter postprandial glucose control in insulin pump therapy

scientific article published on January 2009

Design and Clinical Evaluation of a Novel Low-Glucose Prediction Algorithm with Mini-Dose Stable Glucagon Delivery in Post-Bariatric Hypoglycemia

scientific article published in February 2018

Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas.

scientific article

Design and in silico evaluation of an intraperitoneal-subcutaneous (IP-SC) artificial pancreas

scientific article

Design of an Artificial Pancreas using Zone Model Predictive Control with a Moving Horizon State Estimator

scientific article

Design of the Glucose Rate Increase Detector: A Meal Detection Module for the Health Monitoring System

scientific article published on 13 March 2014

Design of the health monitoring system for the artificial pancreas: low glucose prediction module

scientific article

Detection of a meal using continuous glucose monitoring: implications for an artificial beta-cell

scientific article published on 31 October 2007

Dynamic Insulin on Board: Incorporation of Circadian Insulin Sensitivity Variation ⬇️

scientific article published on July 1, 2013

Early Detection of Infusion Set Failure During Insulin Pump Therapy in Type 1 Diabetes

scientific article published on 12 September 2016

Early Detection of Physical Activity for People With Type 1 Diabetes Mellitus

scientific article

Effect of algorithm aggressiveness on the performance of the Hypoglycemia-Hyperglycemia Minimizer (HHM) System.

scientific article

Empirical Dynamic Model Identification for Blood-Glucose Dynamics in Response to Physical Activity

scientific article published on December 2015

Enhanced 911/global position system wizard: a telemedicine application for the prevention of severe hypoglycemia--monitor, alert, and locate

scientific article

Enhanced Model Predictive Control (eMPC) Strategy for Automated Glucose Control

scientific article published on 27 October 2016

Erratum. Application of Zone Model Predictive Control Artificial Pancreas During Extended Use of Infusion Set and Sensor: A Randomized Crossover-Controlled Home-Use Trial. Diabetes Care 2017;40:1096-1102.

scientific article

Experimental evaluation of a recursive model identification technique for type 1 diabetes

scientific article published on September 2009

Extremum Seeking Control for Personalized Zone Adaptation in Model Predictive Control for Type 1 Diabetes

scientific article published on 13 December 2017

Feasibility of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery

scientific article

Feasibility of outpatient fully integrated closed-loop control: first studies of wearable artificial pancreas

scientific article

Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia

scientific article

Functional network inference of the suprachiasmatic nucleus

scientific article published on 4 April 2016

Glucose estimation and prediction through meal responses using ambulatory subject data for advisory mode model predictive control

scientific article

Glucose sensing in the peritoneal space offers faster kinetics than sensing in the subcutaneous space

scientific article

Glycemic Outcomes of Use of CLC Versus PLGS in Type 1 Diabetes: A Randomized Controlled Trial

scientific article published on 29 May 2020

Guidelines for Genome-Scale Analysis of Biological Rhythms

scientific article published on November 2017

Identification of small molecule activators of cryptochrome

scientific article

In silico evaluation of an artificial pancreas combining exogenous ultrafast-acting technosphere insulin with zone model predictive control

scientific article

In silico evaluation platform for artificial pancreatic beta-cell development--a dynamic simulator for closed-loop control with hardware-in-the-loop

scientific article published in March 2009

In silico preclinical trials: methodology and engineering guide to closed-loop control in type 1 diabetes mellitus

scientific article

Intercellular coupling confers robustness against mutations in the SCN circadian clock network

scientific article

International Consensus on Use of Continuous Glucose Monitoring.

scientific article published in December 2017

Intraperitoneal insulin delivery provides superior glycaemic regulation to subcutaneous insulin delivery in model predictive control-based fully-automated artificial pancreas in patients with type 1 diabetes: a pilot study.

scientific article published on 5 May 2017

Is Psychological Stress a Factor for Incorporation Into Future Closed-Loop Systems?

scientific article

MPC Design for Rapid Pump-Attenuation and Expedited Hyperglycemia Response to Treat T1DM with an Artificial Pancreas

scientific article

Metabolomic analysis of male combat veterans with post traumatic stress disorder

Minority groups and the artificial pancreas: who is (not) in line?

scientific article

Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and post-traumatic stress disorder (PTSD) in humans

scientific article

Modeling the Drosophila melanogaster circadian oscillator via phase optimization

scientific article published on December 2008

Modeling the Effects of Subcutaneous Insulin Administration and Carbohydrate Consumption on Blood Glucose ⬇️

scientific article published on September 1, 2010

Modeling the inflammatory response in the hypothalamus ensuing heat stroke: iterative cycle of model calibration, identifiability analysis, experimental design and data collection

scientific article

Modeling the intra- and extracellular cytokine signaling pathway under heat stroke in the liver

scientific article

Modular artificial beta-cell system: a prototype for clinical research

scientific article published on September 2008

Moving-horizon-like state estimation via continuous glucose monitor feedback in MPC of an artificial pancreas for type 1 diabetes

scientific article

Multicenter closed-loop insulin delivery study points to challenges for keeping blood glucose in a safe range by a control algorithm in adults and adolescents with type 1 diabetes from various sites.

scientific article

Multicenter closed-loop/hybrid meal bolus insulin delivery with type 1 diabetes.

scientific article

Multinational Home Use of Closed-Loop Control Is Safe and Effective

scientific article

Novel insulin delivery profiles for mixed meals for sensor-augmented pump and closed-loop artificial pancreas therapy for type 1 diabetes mellitus

scientific article

Oscillator model reduction preserving the phase response: application to the circadian clock

scientific article published on 16 May 2008

Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report

scientific article

Periodic zone-MPC with asymmetric costs for outpatient-ready safety of an artificial pancreas to treat type 1 diabetes

scientific article

Periodic-zone model predictive control for diurnal closed-loop operation of an artificial pancreas

scientific article

Phase sensitivity analysis of circadian rhythm entrainment

scientific article published in April 2007

Pilot studies of wearable outpatient artificial pancreas in type 1 diabetes

scientific article published in September 2012

Prandial insulin dosing using run-to-run control: application of clinical data and medical expertise to define a suitable performance metric

scientific article

Predicting Subcutaneous Glucose Concentration Using a Latent-Variable-Based Statistical Method for Type 1 Diabetes Mellitus ⬇️

scientific article published on May 1, 2012

Preliminary Evaluation of a Long-Term Intraperitoneal Glucose Sensor With Flushing Mechanism

scientific article published on 17 March 2016

Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension

scientific article

Proposed clinical application for tuning fuzzy logic controller of artificial pancreas utilizing a personalization factor

scientific article

Quantifying Stochastic Noise in Cultured Circadian Reporter Cells

scientific article published on 20 November 2015

Quantitative performance metrics for robustness in circadian rhythms

scientific article published on 8 December 2006

Quantity and accessibility for specific targeting of receptors in tumours

scientific article

Quest for the artificial pancreas: combining technology with treatment

scientific article

Randomized Controlled Trial of Mobile Closed-Loop Control

scientific article published on 14 January 2020

Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas

scientific article published on 11 June 2016

Real-Time Detection of Infusion Site Failures in a Closed-Loop Artificial Pancreas

scientific article published in January 2018

Real-Time hypoglycemia prediction suite using continuous glucose monitoring: a safety net for the artificial pancreas ⬇️

scientific article

Reducing Glucose Variability Due to Meals and Postprandial Exercise in T1DM Using Switched LPV Control: In Silico Studies

scientific article published on 27 March 2016

Response to Comment on Pinsker et al. Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas. Diabetes Care 2016;39:1135-1142.

scientific article published in January 2017

Response to comment on Doyle et al. Closed-loop artificial pancreas systems: engineering the algorithms. Diabetes Care 2014;37:1191-1197.

scientific article

Robust parameter estimation in a model for glucose kinetics in type 1 diabetes subjects

scientific article published in January 2006

Robustness properties of circadian clock architectures

scholarly article

Run-to-run control of blood glucose concentrations for people with Type 1 diabetes mellitus

scientific article published in June 2006

Safety constraints in an artificial pancreatic beta cell: an implementation of model predictive control with insulin on board

scientific article published on May 2009

Safety of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas

scientific article

Sensitivity Measures for Oscillating Systems: Application to Mammalian Circadian Gene Network

scientific article published on January 2008

Sensitivity analysis of discrete stochastic systems

scientific article published on 4 February 2005

Sensitivity of the Predictive Hypoglycemia Minimizer System to the Algorithm Aggressiveness Factor

scientific article

Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock

scientific article published on 21 January 2014

Survey on iterative learning control, repetitive control, and run-to-run control

scientific article (publication date: December 2009)

Synchrony and entrainment properties of robust circadian oscillators

scientific article published on August 2008

Systems biology approach to understanding post-traumatic stress disorder

scientific article

Use of continuous glucose monitoring to estimate insulin requirements in patients with type 1 diabetes mellitus during a short course of prednisone

scientific article published on July 2008

Velocity response curves support the role of continuous entrainment in circadian clocks

scientific article published in April 2010

Velocity-weighting to prevent controller-induced hypoglycemia in MPC of an artificial pancreas to treat T1DM

scientific article

Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology

scientific article

Wavelet measurement suggests cause of period instability in mammalian circadian neurons

scientific article published on August 2011

Weakly circadian cells improve resynchrony

scientific article

Zone model predictive control: a strategy to minimize hyper- and hypoglycemic events

scientific article

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