List of works by Hugues de Thé

-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias

article

8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation

scientific article published on 4 February 2013

A Promyelocytic Leukemia Protein-Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma.

scientific article published on 13 April 2016

A meta-analysis of the relationship between FGFR3 and TP53 mutations in bladder cancer.

scientific article

A new oncoprotein catabolism pathway ⬇️

scientific article published on September 30, 2010

A nucleolar targeting signal in PML-I addresses PML to nucleolar caps in stressed or senescent cells

scientific article

A sumoylation site in PML/RARA is essential for leukemic transformation.

scientific article published on February 2005

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

scientific article

Acute promyelocytic leukaemia: novel insights into the mechanisms of cure

scientific article published on 22 October 2010

Adenovirus protein IX sequesters host-cell promyelocytic leukaemia protein and contributes to efficient viral proliferation

scientific article

All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia

scholarly article

Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions

scientific article published on 27 April 2004

Animal models on HTLV-1 and related viruses: what did we learn?

scientific article published on 21 September 2012

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

scientific article

Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

scientific article

Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity

scientific article published on June 2007

Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells

scientific article

CK2 and PML: regulating the regulator

scientific article published on 01 July 2006

Centrosomal latency of incoming foamy viruses in resting cells

scientific article

Centrosomal pre-integration latency of HIV-1 in quiescent cells

scientific article published on 10 September 2007

Characterization of endogenous human promyelocytic leukemia isoforms

scientific article

Chromatin tethering of incoming foamy virus by the structural Gag protein

scientific article

Classic and Variants APLs, as Viewed from a Therapy Response

scientific article published on 14 April 2020

Co-targeting leukemia-initiating cells and leukemia bulk leads to disease eradication

scientific article published in 2022

Combined treatment with arsenic trioxide and all-trans-retinoic acid in patients with relapsed acute promyelocytic leukemia

scientific article published in June 2003

Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML".

scientific article published on 9 August 2016

Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics

scientific article

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.

scientific article published on 24 February 2014

Controversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects?

scientific article

Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia

scientific article

Curing APL through PML/RARA degradation by As2O3.

scientific article

Cyclophosphamide dose intensification may circumvent anthracycline resistance of p53 mutant breast cancers

scientific article published on 12 March 2010

Deciphering the molecular basis of arsenic/interferon-alpha induced eradication of leukemia initiating cells in adult T cell leukemia.

scientific article

Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

scientific article published on 28 September 2018

Detection of Protein SUMOylation In Situ by Proximity Ligation Assays.

scientific article published in January 2016

Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization

scholarly article

Distinct p53 gene signatures are needed to predict prognosis and response to chemotherapy in ER-positive and ER-negative breast cancers

scientific article published on 19 January 2011

Distinct tumor protein p53 mutants in breast cancer subgroups

scientific article

Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation

scientific article

Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.

scientific article

Effective targeting of chronic myeloid leukemia initiating activity with the combination of arsenic trioxide and interferon alpha

scientific article

Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma

scientific article

Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-targeting

scientific article published on 11 May 2010

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

scientific journal article

Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen

scientific article published in March 2007

From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

scientific article

Hematopoietic stem cells burn fat to prevent exhaustion

scientific article published on 01 October 2012

High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors

scientific article published on January 2009

How acute promyelocytic leukaemia revived arsenic

scientific article

How animal models of leukaemias have already benefited patients

scientific article

Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells

scientific article

Human T-cell lymphotropic virus type I-infected cells extravasate through the endothelial barrier by a local angiogenesis-like mechanism

scientific article published on March 2004

Human skin carcinoma arising from kidney transplant-derived tumor cells

scientific article

Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect

scientific article

In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia

scientific article published in November 2002

Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication

scientific article published on 19 June 2014

JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

scientific article published on 01 February 2021

Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.

scientific article

New therapeutic approaches for adult T-cell leukaemia

scientific article

Obituary for guy de thé.

scientific article

Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia

scientific article published in October 2005

Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins

scientific article published on March 2014

PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence

scientific article

PML is a ROS sensor activating p53 upon oxidative stress.

scientific article

PML nuclear bodies

scientific article

PML nuclear bodies and apoptosis

scientific article published on April 2004

PML nuclear bodies, membrane-less domains acting as ROS sensors?

scientific article published on 20 November 2017

PML nuclear bodies: assembly and oxidative stress-sensitive sumoylation

scientific article

PML nuclear bodies: from architecture to function

scientific article published on 30 April 2018

PML nuclear bodies: regulation, function and therapeutic perspectives

scientific article

PML, SUMOylation, and Senescence

scientific article published on 04 July 2013

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

scientific article published on 20 September 2018

PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.

scientific article published on July 2010

Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL).

scientific article published in May 2009

Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma

scientific article published on January 2004

Prevalence and spectrum of microsatellite alterations in nonmuscle invasive bladder cancers.

scientific article

Primitive macrophages are dispensable for HSPC mobilization and definitive hematopoiesis

scientific article published on 16 July 2019

Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection

scientific article published on 10 January 2017

Promyelocytic Leukemia Protein, a Protein at the Crossroad of Oxidative Stress and Metabolism

scientific article published on 19 October 2016

Protease-dependent uncoating of a complex retrovirus

scientific article published on July 2005

Publisher Correction: RING tetramerization is required for nuclear body biogenesis and PML sumoylation.

scientific article

RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia

scholarly article

RING tetramerization is required for nuclear body biogenesis and PML sumoylation.

scientific article

RXR is an essential component of the oncogenic PML/RARA complex in vivo

scientific article published on 01 July 2007

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

scientific article published on 23 March 2015

Retinoic acid dramatically enhances the arsenic trioxide-induced cell cycle arrest and apoptosis in retinoic acid receptor α-positive human T-cell lymphotropic virus type-I-transformed cells

Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia?

scientific article published on 26 July 2013

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia

scientific article

SMAD4-related Familial Juvenile Polyposis Syndrome with Colon Cancer

scientific article published on 01 January 2004

Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner.

scientific article

Sulfur Derivatives of the Natural Polyarsenical Arsenicin A: Biologically Active, Organometallic Arsenic–Sulfur Cages Related to the Minerals Realgar and Uzonite

scientific article published on 11 February 2015

TP53 status and response to chemotherapy in breast cancer

scientific article published on 10 June 2008

Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia

scientific article published on 21 May 2007

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome.

scientific article

Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation

scientific article

The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies

scientific article

The combination of arsenic, interferon-alpha, and zidovudine restores an "immunocompetent-like" cytokine expression profile in patients with adult T-cell leukemia lymphoma.

scientific article published on 20 August 2013

The combination of arsenic, interferon-alpha, and zidovudine restores an “immunocompetent-like” micro-environment in patients with adult T-cell leukemia lymphoma.

scientific article published on 7 January 2014

The drug-induced degradation of oncoproteins: an unexpected Achilles' heel of cancer cells?

scientific article published on July 2011

The efficacy of combined therapy of arsenic trioxide and alpha interferon in human T-cell leukemia virus type-1-infected squirrel monkeys (Saimiri sciureus).

scientific article published on 28 February 2006

Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure

scientific article published on 06 October 2009

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia ⬇️

scientific article

Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.

scientific article published on 18 June 2015

Two populations of neuronal intranuclear inclusions in SCA7 differ in size and promyelocytic leukaemia protein content

scientific article

Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies

scientific article published on 18 March 2013

Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway

scientific article published on 24 July 2020

p53 as an Effector or Inhibitor of Therapy Response

scientific article

p53 dependent cell-cycle arrest triggered by chemotherapy in xenografted breast tumors.

scientific article

p53 in breast cancer subtypes and new insights into response to chemotherapy

scientific article published on August 2013

Paulina is supported by:

About Paulina

Help