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List of works by Michel Chrétien

'Acrylamide-induced' neuropathy and impairment of axonal transport of proteins. I. Multifocal retention of fast transported proteins at the periphery of axons as revealed by light microscope radioautography

scientific article published on January 1981

60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9)

scientific article

7B2, a possible marker for nonfunctioning pancreatic islet cell tumor

scientific article published on 01 October 1991

A betaLPH precursor model: recent developments concerning morphine-like substances

scientific article published on October 1977

A chimeric proinsulin-CD5 protein expressed in AtT-20 cells is directed to the cell surface via the constitutive pathway

scientific article published on 01 September 1995

A fluorogenic peptide containing the processing site of human SARS corona virus S-protein: kinetic evaluation and NMR structure elucidation.

scientific article

A novel serine protease (IRCM-serine protease 1) from porcine neurointermediate and anterior pituitary lobes. Isolation, polypeptide chain structure, inhibitor sensitivity, and substrate specificity with fluorogenic peptide substrates

scientific article

A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus

scientific article

A specific homologous radioimmunoassay for human beta-endorphin: direct measurement in biological fluids

scientific article published on 01 February 1980

A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

scientific article published in April 2007

AIDS in Canada

scientific article published in Nature

ANF (Arg 101--Tyr 126) is the peptide secreted by rat atrial cardiocytes in culture

scientific article

ANF mRNA is detected by the polymerase chain reaction technique in the chorioidea and bodies but not in the retina of the rat eye

scientific article published on 01 July 1991

Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases

scientific article

Acromegaly and empty sella turcica

scientific article published on February 1, 1975

Acrylamide neuropathy and changes in the axonal transport and muscular content of the molecular forms of acetylcholinesterase ⬇️

scientific article published on April 1, 1982

Action of Testosterone on the Differentiation and Secretory Activity of a Target Organ: The Submaxillary Gland of the Mouse

scientific article published on January 1, 1977

Aldosterone secretion inhibitory factor: a novel neuropeptide in bovine chromaffin cells

scientific article published on 01 March 1989

Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample

scientific article

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

scientific article published on October 1997

Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

scholarly article

Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site

scientific article published on April 1988

Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1.

scientific article

An aldosterone stimulating agent: a novel human pituitary hormone from pro-opiomelanocortin

scientific article published on 01 January 1981

An infant with deletion of the distal long arm of chromosome 15 (q26.1----qter) and loss of insulin-like growth factor 1 receptor gene. ⬇️

scientific article

Analgesic action of chronic high levels of endogenous neuropeptides in rats bearing the MtT-F4 tumor

scientific article

Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection.

scientific article published on 5 September 2017

Apolipoprotein A-I binds to a family of bovine seminal plasma proteins

scientific article published on 01 October 1989

Application of the multiple antigenic peptides (MAP) strategy to the production of prophormone convertases antibodies: Synthesis, characterization and use of 8-branched immunogenic peptides

article

Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children

scientific article published on 16 September 2020

Associations Between Soluble LDLR and Lipoproteins in a White Cohort and the Effect of PCSK9 Loss-of-Function

scientific article published on 01 September 2018

Atrial natriuretic factor: isolation, identification, biological and pharmacological actions

scientific article published in January 1985

Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin

scientific article published on 01 June 1984

Axonal flow and toxic neuropathies

scientific article published on January 1, 1980

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

scientific article

Beta-endorphin and beta-lipotropin secretion by an ACTH-secreting mouse pituitary tumor

scientific article published on June 1978

Beta-endorphin induced akinesia in rats: a pharmacological study (author's transl)

scientific article published on October 1, 1979

Beta-endorphin induced akinesia in rats: effect of apomorhine and alpha-methyl-p-tyrosine and related modifications of dopamine turnover in the basal ganglia

scientific article

Beta-lipotropin precursor of beta-MSH and beta-endorphin

scientific article published on January 1, 1979

Binding inhibition by monoclonal antibodies of ovine placental lactogen to growth hormone receptors in human liver

scientific article published on 01 May 1986

Biochemical aspects of a new hormone: rat atrial natriuretic factor (rANF)

scientific article published on 01 January 1985

Biosynthesis of beta-endorphin

scientific article published on March 1, 1978

Biosynthesis of beta-endorphin by the neurointermediate lobes from rats treated with morphine or alcohol

scientific article published in November 1981

Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia ⬇️

scientific article published on October 1, 1978

Biosynthesis of beta-endorphin, beta-lipotropin and the putative ACTH-LPH precursor in the frog pars intermedia

scientific article published on December 1978

Blood cortisol in neoplasm cases

scientific article

CNS connections with the median raphe nucleus: retrograde tracing with WGA-apoHRP-Gold complex in the rat

scientific article published on 01 November 1989

Cataleptic effect of 61-91 beta-lipotropic hormone in rat.

scientific article published on February 1977

Cathepsin-B Fusion Proteins Misroute Secretory Protein Partners Such as the Proprotein Convertase PC2-7B2 Complex toward the Lysosomal Degradation Pathways

scientific article published on 01 September 2000

Cell-free synthesis of porcine proopiomelanocortin: two distinct primary translation products ⬇️

scientific article published on 01 June 1983

Changes of Endocrine Properties of a Transplantable, Multihormonal, Pituitary Tumor (MtT-F4) After Hypophysectomy of Host Rats ⬇️

scientific article published on March 1, 1975

Characterization of N-terminal fragment of proopiomelanocortin in cerebrospinal fluid

scientific article published in July 1987

Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene

scientific article published in June 2002

Characterization of multiple forms of porcine anterior pituitary proopiomelanocortin amino-terminal glycopeptide

scientific article

Characterization of peptides derived from pro-opiomelanocortin in the biological fluids of a patient with Nelson's syndrome.

scientific article

Chemical Characterization of Adrenocorticotropin and a Novel Peptide Biosynthesized from a Pituitary Adenoma of a Patient with Cushing' Disease* ⬇️

scientific article published on 01 August 1980

Chromogranin A can act as a reversible processing enzyme inhibitor

scientific article published on 01 January 1987

Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues

scientific article

Chronic ethanol treatment alters the biosynthesis of β -endorphin by the rat neurointermediate lobe ⬇️

scientific article published on September 1, 1983

Circular dichroism studies of sheep β-lipotropic hormone ⬇️

scientific article published on November 1, 1976

Comparing expression and activity of PCSK9 in SPRET/EiJ and C57BL/6J mouse strains shows lack of correlation with plasma cholesterol

scientific article published on 10 December 2016

Complete amino acid sequence of Shigella toxin B-chain. A novel polypeptide containing 69 amino acids and one disulfide bridge

scientific article published on 01 October 1986

Complete amino acid sequence of a VLDV-type neurophysin from ostrich differs markedly from known mammalian neurophysins

scientific article

Complete sequence of the glycosylated amino terminal segment of porcine pro-opiomelanocortin

scientific article published in November 1981

Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of doned cDNA ⬇️

scientific article published on November 25, 1983

Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia ⬇️

scientific article published on October 1, 1979

Content of beta-LPH and its fragments (including endorphins) in anterior and intermediate lobes of the bovine pituitary gland

scientific article

Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.

scientific article published on 20 February 2003

Corticotropin releasing factor (CRF): effects on the release of pro-opiomelanocortin (POMC)-related peptides by human anterior pituitary cells in vitro

scientific article published in October 1982

Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.

scientific article published on August 2003

Cyclic nucleotides and platelet aggregation in hypertensive rats with ectopic pituitary tumor.

scientific article published on January 1980

Cyclical edema and hypokalemia due to occult episodic hypercorticism

scientific article published on 01 January 1987

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

scientific article

Demonstration of the vasopressin associated glycopeptide in the brain and peripheral tissues of the Brattleboro rat.

scientific article published in January 1986

Dependence of tonin activity in rat submaxillary gland on growth hormone and testosterone

scientific article

Depolarizing action of secretory granule protein 7B2 on rat supraoptic neurosecretory neurons

scientific article

Development of hyperlipidemia associated with increased lipolytic response of isolated adipose tissue cells following prolonged stimulation by an ectopic pituitary tumor

scientific article published on November 1978

Developmental changes in immunoreactive content of novel pituitary protein 7B2 in human pancreas and its identification in pancreatic tumors

scientific article published in November 1987

Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1).

scientific article published on February 2006

Different processing of chromogranin B into GAWK-immunoreactive fragments in the bovine adrenal medulla and pituitary gland

scientific article

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations

scientific article published on 10 May 2013

Dynamics of 7B2 and galanin expression in solitary magnocellular hypothalamic vasopressin neurons of the homozygous Brattleboro rat.

scientific article published in July 1992

Effect of N-Terminal Portion of Pro-opiomelanocortin on Aldosterone Release by Human Adrenal Adenomain Vitro* ⬇️

scientific article published on 01 June 1981

Effect of beta-lipotropin on aldosterone production in the isolated rat adrenal cell preparation

scientific article published on March 1982

Effect of clofibrate treatment on chronic hyperlipidemia induced by an ACTH-producing tumor ⬇️

scientific article published on April 1, 1977

Effect of somatostatin on growth hormone release by MtT-F4 rat pituitary tumor in vitro ⬇️

scientific article published on August 1, 1977

Effects of Pituitary β-LPH on Blood Platelets and Coagulation in Rabbits ⬇️

scientific article published on 01 September 1971

Effects of glacial acetic acid on the extraction, chemical stability, and biological activities of beta-LPH.

scientific article published in April 1970

Effects of pro-opiomelanocortin fragments on release of catecholamines from adrenal chromaffin cells

scientific article

Effects of proopiomelanocortin-derived peptides, methionine-enkephalin and forskolin on the maturation of ovine fetal adrenal cells in culture

scientific article published on November 1984

Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity

scientific article published on 24 September 2011

Endoproteolysis in health and diseases--implications of proprotein convertases (PCs)

scientific article published on 08 September 2005

Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling

scientific journal article

Endorphins: structure, roles and biogenesis ⬇️

scientific article published on May 1, 1981

Enzymatic cleavage of pro-opiomelanocortin by anterior pituitary granules. Evidence for a chymotryptic-like enzyme

scientific article published in August 1983

Ethnic differences in the frequency of the cardioprotective C679X PCSK9 mutation in a West African population

scientific article published in September 2008

Eukaryotic protein processing: endoproteolysis of precursor proteins

scientific article published on October 1997

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.

scientific article published on 28 September 2005

Evidence for the release of a novel pituitary polypeptide (7B2) from the growth hormone-producing pituitary adenoma of patients with acromegaly

scientific article

Experimental hyperlipidemia in rats

scientific article published on January 1, 1979

Expression and Sorting of Rat Plasma Kallikrein in POMC-Producing AtT-20 Cells

scholarly article by N. SAWYER published in May 1991

Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

scientific article published in December 2005

Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.

scientific article published on 22 July 2008

Expression of neuroendocrine secretory protein 7B2 mRNA in the mouse and rat pituitary gland.

scientific article published in July 1993

Expression of the neuroendocrine cell marker 7B2 in human ACTH secreting tumours

scientific article published on June 1, 1992

Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors

scientific article published on November 1994

Formation of secretion granules in the Golgi apparatus of plasma cells in the rat

scientific article published on 01 January 1989

Formation of secretory granules in the Golgi apparatus of prolactin cells in the rat pituitary gland: a stereoscopic study

scientific article published in February 1992

From β-lipotropin to β-endorphin and 'pro-opio-melanocortin' ⬇️

scientific article published on September 1, 1979

Functional aspects of multitransmitter neurons. Studies of interactions among pro-opiomelanocortin products.

scientific article published on January 1987

Functional diversity of bioactive peptides in the nervous system itself: "how the brain may understand".

scientific article

Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis

scientific article published on 23 May 2005

GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence

scientific article published in January 1985

Gene expression of peptides: the pro-opiomelanocortin model

scientific article published on 01 January 1982

Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.

scientific article published in April 2002

Henry Friesen Lecture. Clinical relevance of convertases: atherosclerosis, Alzheimer's disease, obesity, diabetes and HIV.

scientific article

Homologous IRCM-serine protease 1 from pituitary, heart atrium and ventricle: a common pro-hormone maturation enzyme?

scientific article

How the prohormone theory solved two important controversies in hormonal and neural Peptide biosynthesis

scientific article published on 23 October 2013

Human NH2 terminal of pro-opiomelanocortin as a potential marker for pulmonary carcinoma

scientific article published on 01 July 1983

Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.

scientific article

Hyperlipoproteinemia induced by a transplantable pituitary tumor in the rat ⬇️

scientific article published on January 1, 1979

Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma

scientific article

Identification of a biologically active circulating form of rat atrial natriuretic factor

scientific article

Identification of the released form of atrial natriuretic factor by the perfused rat heart

scientific article published on May 1986

Immunocytochemistry of the C-terminal peptide of propressophysin (CPP): relationship to vasopressin, oxytocin and neurophysin

scientific article

Immunohistochemical localization of beta-lipotropic hormone in the pituitary gland

scientific article

Immunohistochemical localization of human pituitary glycopeptide (HPGP)-like immunoreactivity in the hypothalamus and pituitary of normal and homozygous diabetes insipidus (Brattleboro) rats

scientific article published on October 1982

Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.

scientific article

Immunological characterization of beta-lipotropin fragments (endorphin, beta-MSH, and N-fragment) from fish pituitaries

scientific article

Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2.

scientific article published on December 1991

Immunoreactive beta-endorphin in the rat mammotropic transplantable tumor (MtT-F4) ⬇️

scientific article published on June 1, 1978

Impairment of rapid axonal transport and concomitant anomaly of smooth endoplasmic reticulum in acrylamide induced neuropathy

scientific article published on February 19, 1979

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

scientific article published in January 2005

Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model.

scientific article

In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia ⬇️

scientific article published on July 1, 1978

In vitro biosynthesis of beta-endorphin in pituitary glands ⬇️

scientific article published on April 1, 1977

In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands ⬇️

scientific article published on October 1, 1977

In vitro biosynthesis of beta-lipotropin in brain tissue

scientific article published on February 5, 1979

In vitro biosynthesis of γ-lipotropic hormone ⬇️

scientific article published on June 1, 1976

In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides.

scientific article published in June 2004

In vivo bioassay of ACTH: new developments.

scientific article published in November 1970

Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.

scientific article

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

scientific article

Inhibition of binding of ovine placental lactogen to growth hormone and prolactin receptors by monoclonal antibodies

scientific article published in December 1986

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions

scientific article published on 11 June 2001

Inhibition of release of a novel pituitary polypeptide, 7B2, follicle-stimulating hormone, and luteinizing hormone from rat anterior pituitary cells in vitro by human beta-inhibin

scientific article

Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1.

scientific article

Intranuclear rodlets in the substantia nigra: interactions with marinesco bodies, ubiquitin, and promyelocytic leukemia protein

scientific article published on 01 November 2004

Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes.

scientific article published on June 2002

Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.

scientific article

Isolation and characterization of four proteases from porcine pituitary neurointermediate lobes: relationship to the maturation enzyme of prohormones

scientific article published in February 1985

Isolation and characterization of β-lipolytic hormone from porcine pituitary gland ⬇️

scientific article published on September 1, 1970

Isolation and partial characterization of a biosynthetic N-terminal methionyl peptide of bovine pars intermedia: relationship to ubiquitin

scientific article

Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin

scientific article published in September 1976

Lipogenic Activity of a Potent Lipolytic Hormone: Sheep β Lipotropin (β-LPH) - II. Further Effects of Sheep β-LPH on Specifically Labeled Glucose and the Localization of Lipogenic Active Center of the Molecule ⬇️

scientific article published on 01 January 1972

Lipogenic activity of a potent lipolytic hormone: sheep beta lipotropin (beta-LPH). A comparative study of the effects of beta-LPH and insulin on in vitro glucose metabolism of adipose tissue

scientific article published on 01 November 1970

Lipolytic activity of rat pituitaries in vitro

scientific article published in July 1973

Lipolytic response, cyclic AMP and cyclic GMP accumulation in rat adipocytes stimulated with ACTH: Effect of MtT-F4 tumor and clofibrate treatment ⬇️

scientific article published on July 1, 1979

Lipotropic and adrenocorticotropic hormones. Biological activities of the carboxyl-modified hormones

scientific article published in June 1974

Localization of the human prostatic secretory protein PSP94 and its mRNA in the epithelial cells of the prostate

scientific article published on 01 July 1988

Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation

scientific article published on 8 August 2012

Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface-expression of LDLR and CD36 and NLRP3 inflammasome

scientific article published on 01 February 2021

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children

scientific article published on 15 February 2018

Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma

scientific article published on January 1, 1975

Measurement of N-Terminal (1–76) of Human Proopiomelanocortin in Human Plasma: Correlation with Adrenocorticotropin* ⬇️

scientific article published on 01 April 1983

Mechanisms required to ensure research integrity ⬇️

scientific article published on October 18, 2011

Medical research: an absolute necessity and not a tollerated luxury

scientific article

Metabolic clearance rate and half-time disappearance rate of human N-terminal and adrenocorticotropin of pro-opiomelanocortin in the rat: a comparative study.

scientific article

Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas.

scientific article published on 3 February 2018

Modification of Cunningham's method for the detection of proteases in tissue sections

scientific article published on January 1975

Modification of Cunningham's method for the detection of proteases in tissue sections

scientific article

Modulation of the Golgi apparatus in stimulated and nonstimulated prolactin cells of female rats.

scientific article published in March 1993

Molecular heterogeneity of pro-atrial natriuretic factor

scientific article published in 1989

Morphine-like substances and the pituitary gland ⬇️

scientific article published on September 18, 1976

Morphological aspects of protein synthesis

scientific article published on 01 January 1973

Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species.

scientific article

Multipotent lipotropic hormones. In search of a pituitary cell producing multipotent LPH

scientific article published on November 1, 1975

My road to Damascus: how I converted to the prohormone theory and the proprotein convertases ⬇️

scientific article published on November 8, 2012

N-Terminal amino acid sequence of rat tonin: homology with serine proteases ⬇️

scientific article published on September 1, 1978

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

scientific article

NH2-terminal specificity and axonal localization of adrenocorticotropin binding sites in rat median eminence

scientific article

Neuroanatomical and functional studies of peptide precursor-processing enzymes

scientific article published on January 1991

Neuropeptides in human cerebrospinal fluid

scientific article published on September 1985

New perspectives in neuropeptides. Biosynthesis from large precursors. The pro-opio-melanocortin model in the pars intermedia

scientific article published on 01 September 1980

Novel approach to rapid and sensitive localization of protein disulfide bridges by high-performance liquid chromatography and electrochemical detection

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture

scientific article published on 3 August 2011

Obesity and pituitary lipolytic hormones.

scientific article

Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms

scientific article published on 14 May 2007

On the circulating form of atrial natriuretic factor

scientific article

On the isolation of human pituitary hormones

scientific article published on November 1978

Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine

scientific article published in November 1985

Ostrich MSEL-neurophysin belongs to the class of two-domain "big" neurophysin as indicated by complete amino acid sequence of the neurophysin/copeptin

scientific article published on January 1989

PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.

scientific article published on 16 November 2010

PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans

scientific article

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

scientific article published on 16 December 2009

PCSK9: a key modulator of cardiovascular health

scientific article

Partial Sequence of Trypsin Inhibitor From Ovomucoid ⬇️

scientific article published on November 1, 1973

Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity

scientific article

Peptides of the neurointermediary lobe of rat pituitary stimulate GH secretion in vitro

scientific article published in September 1983

Peptides related to the N-terminus of pro-opiomelanocortin in the human adrenal medulla

scientific article published on 01 April 1989

Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression

scientific article published on January 1997

Pituitary lipotropins (LPH)

scientific article published on April 1, 1973

Plasma PCSK9 levels are significantly modified by statins and fibrates in humans

scientific article published on 11 June 2008

Plasma PCSK9 levels correlate with cholesterol in men but not in women

scientific article published on 18 July 2007

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

scientific article

Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins

scientific article

Presence of a pre-sequence (signal sequence) in the common precursor to ACTH and endorphin and the role of glycosylation in processing of the precursor and secretion of ACTH and endorphin

scientific article published in January 1980

Presence of the novel pituitary protein "7B2" in bovine chromaffin granules: possible co-release of 7B2 and catecholamine as induced by nicotine

scientific article

Presence of vasopressin, oxytocin and neurophysin in the retina of mammals, effect of light and darkness, comparison with the neuropeptide content of the neurohypophysis and the pineal gland

scientific article

Primary hyperaldosteronism: a pituitary--adrenal dysfunction related to a new pituitary glycopeptide?

scientific article published in January 1982

Primary structure and morphine-like activity of human β-endorphin ⬇️

scientific article published on June 1, 1977

Primary structure determination of Escherichia coli heat-stable enterotoxin of porcine origin ⬇️

scientific article published on 01 May 1983

Primary structure of a high M r form of rat atrial natriuretic factor

scientific article published on 01 February 1984

Primary structure of mouse chromogranin B deduced from cDNA sequence

scientific article published on March 1990

Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity

scientific article published on 01 August 1981

Primary structure of the ovine pituitary follitropin beta-subunit

scientific article published on September 1981

Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts ⬇️

scientific article published on October 1, 1991

Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection

scientific article published on 13 June 2016

Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain

scientific article published in July 1986

Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives

scientific article published on May 1992

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

scientific article

Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells

scientific journal article

Proprotein convertases and the pathophysiology of human diseases: prospective considerations

scientific article published on April 1995

Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells.

scientific article published on March 2002

Proprotein convertases as therapeutic targets

scientific article published on 01 October 2008

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

scientific article

Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor

scientific article published in August 2004

Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions

scientific article published on 08 July 2013

Proprotein convertases: lessons from knockouts

scientific article published on October 2006

Proteases and posttranslational processing of prohormones: a review ⬇️

scientific article published on July 1, 1983

Proteomic analysis of neuroendocrine peptidergic system disruption using the AtT20 pituitary cell line as a model

scientific article

Pulmonary neoplasms and adrenal gland insufficiency: study of a case and hypothesis on an ACTH-inhibiting factor (ACTH-IF) or an abnormal ACTH secreted by the tumor

scientific article published on May 1973

Purification and partial chemical characterization of human pituitary lipolytic hormone ⬇️

scientific article published on September 1, 1976

Purification and primary structure of pro-aldosterone secretion inhibitory factor from bovine adrenal chromaffin cells

article published in 1989

Purification of ovine placental lactogen (oPL) using high-performance liquid chromatography

scientific article published on 01 April 1986

Purification of three rat atrial natriuretic factors and their amino acid composition

article

Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells

scientific article published on 10 March 2011

Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture

scientific article published on 2 September 2014

Radioimmunoassay of ovine beta-lipotropic hormone

scientific article published in October 1972

Radiolabeled biotinyl peptides as useful reagents for the study of proteolytic enzymes

scientific article published on 01 March 1993

Recent progress in endocrinology. Polypeptide hormones

scientific article published on 01 August 1972

Regional distribution of a novel pituitary protein (7B2) in the rat brain

scientific article published in July 1985

Regional distribution of a novel pituitary protein (7B2) in the rat spinal cord: effect of neonatal capsaicin treatment and thoracic cord transection

scientific article published in April 1985

Regional heterogeneity in the processing of pro-opiomelanocortin in rat brain

scientific article published in January 1983

Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes

scientific article

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase

scientific journal article

Reinvestigation of the N-terminal amino acid sequence of beta-lipotropin from human pituitary glands

scientific article published in December 1981

Relationship between testosterone, estradiol and circulating PCSK9: Cross-sectional and interventional studies in humans

scientific article published on 07 April 2015

Renin-angiotensin system in chronically hypophysectomized rats

scientific article published in November 1972

Request for hormone-producing tumour material

scientific article published on April 1968

Request for hormone-producing tumour material

scientific article published on 01 November 1968

Request for hormone-producing tumour material.

scientific article published on June 1969

Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

scientific article published on May 1998

Response of Human Aldosteronoma Cells in Culture to the N-Terminal Glycopeptide of Pro-Opiomelanocortin and γ3-MSH

article

Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors

scientific article

Selective cleavage of human ACTH, beta-lipotropin, and the N-terminal glycopeptide at pairs of basic residues by IRCM-serine protease 1. Subcellular localization in small and large vesicles

scientific article

Selective cleavage of proenkephalin-derived peptides (less than 23,300 daltons) by plasma kallikrein ⬇️

scientific article published on 01 September 1988

Sequence determination of a protein with N-terminal glutamic acid after modification of carboxyl groups with carbodiimide as the coupling agent.

scientific article published in June 1974

Species specificity of the inhibition of adenylate cyclase activation by products of ACTH-stimulated fat cells.

scientific article

Specific cleavage of beta-LPH and ACTH by tonin: release of an opiate-like peptide beta-LPH (61-78).

scientific article published on February 1979

Specific release of a novel pituitary polypeptide, 7B2, from rat anterior pituitary cells in vitro by luteinizing hormone-releasing hormone

scientific article

Structural and biochemical investigation of heptad repeat derived peptides of human SARS corona virus (hSARS-CoV) spike protein

scientific article

Structural and immunological homology of human and porcine pituitary and plasma IRCM-serine protease 1 to plasma kallikrein: marked selectivity for pairs of basic residues suggests a widespread role in pro-hormone and pro-enzyme processing

scientific article

Structure and maturation process of pro-opiomelanocortin: a model for other neuropeptides

scientific article published on 01 January 1980

Structure of the carboxyl propeptide of chicken type II procollagen determined by DNA and protein sequence analysis

scientific article published in 1984

Structure-function analysis of the prosegment of the proprotein convertase PC5A.

scientific article

Subcellular fractionation of pituitary neurointermediate lobes: revelation of various basic proteases

scientific article published on August 1984

Substrate specificity of the enzyme tonin: cleavage of substance P

scientific article published on 01 May 1980

Synergistical effects of ovine corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) on the release of pro-opiomelanocortin (POMC) related peptides by pituitary adenoma of a patient with Nelson's syndrome in vitro

scientific article published on 01 January 1984

Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice

scientific article published in October 2009

The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response.

scientific article published on 30 June 2017

The French Language Medical Association of Canada and medical research

scientific article published on 01 April 1979

The IRCM: a model of organization in the quest for scientific excellence. Interview by Robert Henry

scientific article published in February 1988

The Importance of Axonal Transport and Endoplasmic Reticulum in the Function of Cholinergic Synapse in Normal and Pathological Conditions

scientific article published on January 1, 1979

The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit‐1/GHF‐1‐independent pathway in corticotroph AtT20 cells ⬇️

scientific article published on July 24, 1998

The Prohormone Theory and the Proprotein Convertases: It Is All About Serendipity ⬇️

scientific article published on January 1, 2011

The amino acid sequences of frog heart atrial natriuretic-like peptide and mammalian ANF are closely related

scientific article published in October 1988

The apoB-to-PCSK9 ratio: A new index for metabolic risk in humans.

scientific article published on 2 July 2015

The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain

scientific article

The clinical investigator of the 1990's.

scientific article published on November 1986

The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analysis

scientific article published on April 1987

The enigma of soluble LDLR: could inflammation be the key?

scientific article published on 03 February 2020

The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation

scientific article published on 15 January 2018

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

scientific article published on 19 November 2020

The major 40-kDa glycoprotein in human prostatic fluid is identical to Zn-alpha 2-glycoprotein

scientific article

The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid sequencing

scientific article published on 01 September 1984

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

scientific article

The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary.

scientific article published on December 1994

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions

scientific article

The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase

scientific article published on 01 July 1994

The pituitary and morphinomimetic peptides

scientific article published on April 1, 1977

The primary structure of human beta-lipotropin. Further peptide sequencing resolves the controversy and suggests the existence of only one human beta-lipotropin

scientific article

The propeptide Asn1-Tyr126 is the storage form of rat atrial natriuretic factor

scientific article published on January 1987

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

scientific article published on April 2003

The role of research centers and institutes for biomedical contemporary research

scientific article published on June 1992

The role of the NH2-terminal portion of pro-opiomelanocortin as a biomarker for human lung cancer

scientific article published on 01 September 1987

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

scientific article

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

scientific article (publication date: June 2003)

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

The structure of type IX collagen.

scientific article

The use of biomarkers in the prediction of survival in patients with pulmonary carcinoma

scientific article published on May 1990

Thyrotropin releasing hormone (TRH)-induced release of 7B2 (neuroendocrine polypeptide) in vivo and in vitro using adenoma cells of a patient with acromegaly

scientific article published on May 1991

Tissue distribution and molecular forms of a novel pituitary protein in the rat.

scientific article published in November 1984

Tri-dimensional structure of the forming face of the Golgi apparatus as seen in the high voltage electron microscope after osmium impregnation of the small nerve cells in the semilunar ganglion of the trigeminal nerve ⬇️

scientific article published on January 1, 1973

Two anatomical pathways for the renewal of surface glycoproteins in chloride cells of fish gills

scientific article published on November 1983

Two glycosylation sites on the N-terminal segment of porcine pars distalis pro-opiomelanocortin

scientific article published on 01 December 1980

Ultrastructural localization of secretory granule constituent chromogranin and 7 B 2

scientific article published on 01 September 1988

Urinary levels of immunoreactive NH2-terminal of pro-opiomelanocortin in patients with malignant pulmonary disease

scientific article published in August 1989

Urinary molecular forms of human N-terminal of proopiomelanocortin: possible deglycosylation and degradation by the kidney

scientific article published on 01 October 1984

Value of plasma NH2-terminal fragment of pro-opiomelanocortin in marking human lung cancer in various clinical settings

scientific article published in October 1989

Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6.

scientific article published on 27 March 2014

White Adipose Tissue Surface Expression of LDLR and CD36 is Associated with Risk Factors for Type 2 Diabetes in Adults with Obesity

scientific article published on 11 October 2020

[Antidiuretic effect of clofibrate in diabetes insipidus]

scientific article published on 01 October 1971

[Corticoadrenal insufficiency (Addison's disease)]

scientific article published on 01 August 1984

[Decrease in the immunoreactivity of protein 7B2 in vasopressinergic cells in the supraoptic nucleus and in fibers of the neurohypophysis, in Brattleboro rats]

scientific article published on 01 January 1988

[Endorphins 1989: neuroendocrine aspects]

scientific article published on 01 January 1989

[Endorphins: structure, role and biogenesis]

scientific article published on 01 December 1983

[Evaluation of the change process during treatment of adolescent psychotics]

scientific article published on January 1990

[In vitro biosynthesis of bovine beta-lipotropic hormone]

scientific article published on 01 May 1974

[Physiological roles of endorphins in 1987]

scientific article published on 01 February 1988

beta 2-Inhibin contains the active core of human seminal plasma beta-inhibin: synthesis and bioactivity

scientific article published in February 1985

pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation.

scientific article published on May 2001

β-Endorphin concentrations in serum, hypothalamus and central gray of hypophysectomized and mediobasal hypothalamus lesioned rats ⬇️

scientific article published on January 7, 1982

β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells

scientific article published on 18 May 2015

‘Acrylamide-induced‘ neuropathy and impairment of axonal transport of proteins. II. Abnormal accumulations of smooth endoplasmic reticulum as sites of focal retention of fast transported proteins. Electron microscope radioautographic study ⬇️

scientific article published on January 26, 1981

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