List of works by Raymond J. Deshaies

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

scientific article

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins.

scientific article published on 23 August 2016

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway

scientific article published on 22 December 2015

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

scientific article published on 28 February 2017

Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases

scientific article published on 26 October 2017

Discovery of an Inhibitor of the Proteasome Subunit Rpn11.

scientific article

Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon

scientific article published on March 2016

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline

scientific article

Multispecific drugs herald a new era of biopharmaceutical innovation

scientific article published on 15 April 2020

Nrf1 can be processed and activated in a proteasome-independent manner

scientific article published in September 2016

Protein degradation: Prime time for PROTACs

scientific article published on August 2015

Ribosomal proteins produced in excess are degraded by the ubiquitin-proteasome system

scientific article

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.

scientific article

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

scientific article published on 31 March 2016

Tag Team Ubiquitin Ligases

scientific article published in August 2016

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

scientific article published on 22 December 2016

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

scientific article

Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy

scientific article published on 16 May 2017

Valosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor

scientific article published on 12 July 2016

p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates

scientific article

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