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List of works by Edward G. Lakatta

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

scientific article published on 19 September 2016

A Vascular Theory of Aging

scientific article published on 22 July 2010

A bioluminescence method for direct measurement of phosphodiesterase activity

scientific article

A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.

scientific article

A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling

scientific article

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation

scientific article

A local proinflammatory signalling loop facilitates adverse age-associated arterial remodeling

scientific article

A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.

scientific article

A paradigm shift for the heart's pacemaker

scientific article

A quantitative and validated SAGE transcriptome reference for adult mouse heart

scientific article

A small nonerythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage.

scientific article

AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression

scientific article

AGEMAP: a gene expression database for aging in mice

scientific article

ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta

scientific article published on 16 October 2006

ATPase activity and force production in myofibrils and twitch characteristics in intact muscle from neonatal, adult, and senescent rat myocardium ⬇️

scientific article published on 01 March 1984

Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprusside

scientific article

Accelerated longitudinal decline of aerobic capacity in healthy older adults

scientific article published on 25 July 2005

Action potential prolongation in cardiac myocytes of old rats is an adaptation to sustain youthful intracellular Ca2+ regulation.

scientific article

Acute hemodynamic effects of erythropoietin do not mediate its cardioprotective properties

scientific article

Adaptive mechanisms of intracellular calcium homeostasis in mammalian hibernators.

scientific article

Age and gender affect ventricular-vascular coupling during aerobic exercise

scientific article published in August 2004

Age changes in myocardial function and exercise response ⬇️

scientific article

Age-Associated Alterations in Calcium Current and its Modulation in Cardiac Myocytes

scientific article published on 01 August 1998

Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling

scientific article

Age-associated cardiovascular changes are the substrate for poor prognosis with myocardial infarction

scientific article published on 01 July 2004

Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons

scientific article published on January 1, 2002

Age-associated decrease in heart rate response to isoproterenol in dogs ⬇️

scientific article published on April 1, 1979

Age-associated increase in salt sensitivity is accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump.

scientific article published on September 2012

Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.

scientific article published on 4 January 2012

Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases ⬇️

scientific article published on March 15, 1998

Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.

scientific article

Age-related changes of the retinal microvasculature

Aging Effects on the Vasculature in Health: Risk Factors for Cardiovascular Disease

scientific article published on 01 November 1994

Aging and cardiovascular structure and function in healthy sedentary humans

scientific article published on 01 April 1998

Aging hearts and vessels: masters of adaptation and survival

scientific article published on 01 May 2005

Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates

scientific article published on 12 May 2003

Aging-associated cardiovascular changes and their relationship to heart failure

scientific article

Alpha-adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes ⬇️

scientific article published on 01 March 1991

Alterations in properties of L-type Ca channels in aging rat heart

scientific article published on 01 March 2002

Alterations in the cardiovascular system that occur in advanced age

scientific article published on February 1, 1979

Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging.

scientific article

Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats

scientific article

Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential ⬇️

scientific article published on September 1, 1988

Antibody to Marinobufagenin Reverses Placenta-Induced Fibrosis of Umbilical Arteries in Preeclampsia

scholarly article by Olga V Fedorova published in August 2018

Antibody to marinobufagenin lowers blood pressure in pregnant rats on a high NaCl intake

scientific article published in April 2005

Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, is Reduced by a Monoclonal Antibody to Marinobufagenin.

scientific article published on 07 September 2015

Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects

scientific article

Are personality traits associated with white-coat and masked hypertension?

scientific article

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition).

scientific article published on 19 December 2016

Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels

scientific article

Arterial aging is risky

scientific article published on 28 August 2008

Arterial aging: a journey into subclinical arterial disease

scientific article

Arterial aging: is it an immutable cardiovascular risk factor?

scientific article

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease

scientific article

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease

scientific article

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging

scientific article

Arterial stiffness and gait speed in older adults with and without peripheral arterial disease

scientific article published on 9 September 2010

Arterial stiffness and influences of the metabolic syndrome: a cross-countries study

scientific article

Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging

scientific article published on 5 July 2012

Arterial-ventricular coupling with aging and disease

scientific article

Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise

scientific article published on 10 July 2008

Association of arterial rigidity with incident kidney disease and kidney function decline: the Health ABC study

scientific article published on 27 December 2012

Association of central hemodynamics with estimated 24-h urinary sodium in patients with hypertension

scientific article

Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study

scientific article published on 14 December 2011

Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure

scientific article published on 27 February 2013

Attenuated cardiovascular reserve during prolonged submaximal cycle exercise in healthy older subjects

scientific article published in October 2002

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4.

scientific article published in June 2018

Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

scientific article (publication date: 2013)

Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.

scientific article published on 14 September 2011

Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy

scientific article published on 16 August 2004

Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy

scientific article published on 24 July 2002

Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel

scientific article published on 07 October 2009

Beta-adrenergic stimulation modulation of heart rate via synchronization of ryanodine receptor Ca2+ release.

scientific article published in September 2002

Beyond Bowditch: the convergence of cardiac chronotropy and inotropy

scientific article published in June 2004

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signalling in NaCl-loaded Dahl-S rats

scientific article published in August 2005

Bringing prevention in geriatrics: Evidences from cardiovascular medicine supporting the new challenge ⬇️

scientific article published on March 3, 2012

COL4A1 is associated with arterial stiffness by genome-wide association scan

scientific article

Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells

scientific article published on 20 March 2008

Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel

scientific article published on February 2002

Ca(2+)-dependent components of inactivation of unitary cardiac L-type Ca(2+) channels

scientific article published on 16 November 2009

Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

scientific article published on 27 June 2016

Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis

scientific article

Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand

scientific article

Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes

scientific article published on 18 January 2007

CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases

scientific article published on 8 July 2016

Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size

scientific article published on 24 May 2007

Calcium overload and mechanical function in posthypoxic myocardium: biphasic effect of pH during hypoxia

scientific article published on July 1, 1979

Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype

scientific article published on 01 September 2018

Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis

scientific article

Can proteomics yield insight into aging aorta?

scientific article published on 19 July 2013

Captopril Modifies Gene Expression in Hypertrophied and Failing Hearts of Aged Spontaneously Hypertensive Rats ⬇️

scientific article published on 01 December 1997

Cardiac pacemaker cell failure with preserved I(f), I(CaL), and I(Kr): a lesson about pacemaker function learned from ischemia-induced bradycardia

scientific article published on 22 December 2006

Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice

scientific article

Cardioprotection by intermittent fasting in rats

scientific article published on 7 November 2005

Cardioprotection by recombinant human erythropoietin following acute experimental myocardial infarction: dose response and therapeutic window

scientific article published on August 2005

Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction.

scientific article

Cardiovascular Aging: Perspectives From Humans to Rodents.

scientific article published in November 1998

Cardiovascular ageing in health sets the stage for cardiovascular disease

scientific article

Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction

scientific article published on 29 December 2006

Carotid bifurcation hemodynamics in older adults: effect of measured versus assumed flow waveform

scientific article

Ca²+/calmodulin-dependent protein kinase II (CaMKII) activity and sinoatrial nodal pacemaker cell energetics

scientific article

Ca²⁺-dependent phosphorylation of Ca²⁺ cycling proteins generates robust rhythmic local Ca²⁺ releases in cardiac pacemaker cells

scientific article

Cell size and capillary supply of the hypertensive rat heart: quantitative study ⬇️

scientific article published on July 1, 1984

Central Arterial Aging and Angiotensin II Signaling

scientific article

Central arterial aging and the epidemic of systolic hypertension and atherosclerosis

scientific article published in September 2007

Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality?

scientific article

Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy

scientific article published on 30 January 2006

Central versus ambulatory blood pressure in the prediction of all-cause and cardiovascular mortalities

scientific article

Characterization of volumetric flow rate waveforms at the carotid bifurcations of older adults

scientific article

Cholesterol, triglycerides, and the Five-Factor Model of personality.

scientific article

Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).

scientific article published on 19 June 2009

Chronic administration of small nonerythropoietic peptide sequence of erythropoietin effectively ameliorates the progression of postmyocardial infarction-dilated cardiomyopathy

scientific article

Chronic alternate-day fasting results in reduced diastolic compliance and diminished systolic reserve in rats

scientific article

Chronic matrix metalloproteinase inhibition retards age-associated arterial proinflammation and increase in blood pressure

scientific article

Commentaries on viewpoint: The cardiac contraction cycle: is Ca2+ going local? Counterpoint

scientific article published on December 2009

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

scientific article published on 8 November 2011

Common variants at 30 loci contribute to polygenic dyslipidemia

scientific article

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

scientific article

Compatibility of superparamagnetic iron oxide nanoparticle labeling for ¹H MRI cell tracking with ³¹P MRS for bioenergetic measurements.

scientific article

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

scientific article

Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases

scientific article

Contractile response of individual cardiac myocytes to norepinephrine declines with senescence

scientific article published on 01 January 1992

Contrasting effects of anoxia and graded hypoxia on single cardiac myocyte function

scientific article published on 01 January 1992

Contribution of central adiposity to left ventricular diastolic function (from the Baltimore Longitudinal Study of Aging)

scientific article published on 17 January 2012

Contribution of spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocytes

scientific article

Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension

scientific article published in February 2004

Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution.

scientific article published on 27 July 2009

Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study

scientific article published in January 2002

Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart

scientific article published in August 2004

Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity

scientific article

Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance

scientific article

Cytosolic calcium and myofilaments in single rat cardiac myocytes achieve a dynamic equilibrium during twitch relaxation ⬇️

scientific article published on February 1, 1992

Derivation and validation of diagnostic thresholds for central blood pressure measurements based on long-term cardiovascular risks

scientific article published on 10 July 2013

Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial

scientific article

Design, generation, and testing of mammalian expression modules that tag membrane proteins

scientific article

Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in vivo

scientific article published on 10 May 2016

Deterioration of beta-adrenergic modulation of cardiovascular function with aging

scientific article published on December 26, 1992

Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process.

scientific article published in April 2004

Diastolic scattered light fluctuation, resting force and twitch force in mammalian cardiac muscle ⬇️

scientific article published on 01 June 1981

Did clinical trials in which erythropoietin failed to reduce acute myocardial infarct size miss a narrow therapeutic window?

scientific article

Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness

scientific article published on 08 August 2013

Differences in the Bioenergetic Response of the Isolated Perfused Rat Heart to Selective β 1 - and β 2 -Adrenergic Receptor Stimulation

article

Different effects of alpha- and beta-adrenergic stimulation on cytosolic pH and myofilament responsiveness to Ca2+ in cardiac myocytes

scientific article published on 01 October 1992

Differential response of cardiac fibroblasts from young adult and senescent rats to ANG II.

scientific article

Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions

scientific article published on 25 January 2005

Dilated cardiomyopathy with increased SR Ca2+ loading preceded by a hypercontractile state and diastolic failure in the alpha(1C)TG mouse

scientific article

Diminished inotropic response of aged myocardium to catecholamines

scientific article published on 01 February 1975

Diminished inotropic responses but unaltered toxicity to acetylstrophanthidin in the senescent beagle ⬇️

scientific article published on December 1, 1979

Diminished inotropic responsiveness to ouabain in aged rat myocardium ⬇️

scientific article published on April 1, 1979

Diminished tolerance of prehypertrophic, cardiomyopathic Syrian hamster hearts to Ca2+ stresses ⬇️

scientific article published on July 1, 1991

Distance correction for precordial electrocardiographic voltage in estimating left ventricular mass: an echocardiographic study ⬇️

scientific article published on March 1, 1977

Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis

scientific article

Do hypertensive individuals have enlarged aortic root diameters? Insights from studying the various subtypes of hypertension.

scientific article published on 28 February 2008

Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?

Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function

scientific article

EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy

scientific article

Effect of common carotid artery inlet length on normal carotid bifurcation hemodynamics

scientific article published on December 2010

Effect of light-to-moderate alcohol consumption on age-associated arterial stiffening

scientific article published in April 2005

Effects of calorie restriction on cardioprotection and cardiovascular health

scientific article

Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

scientific article published on 20 May 2016

Electrophysiological heterogeneity of pacemaker cells in rabbit intercaval region, including SA node: insights from recording multiple ion currents in each cell

scientific article

Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults

scientific article

Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent

scientific article published on 26 April 2010

Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats.

scientific article

Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension

scientific article

Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives

scientific article published on 20 February 2008

Enhanced Contractile Response and Protein Kinase Activation to Threshold Levels of β-Adrenergic Stimulation in Hyperthyroid Rat Heart ⬇️

scientific article published on April 1, 1980

Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts

scientific article published on 15 September 2003

Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes ⬇️

scientific article published on March 15, 1998

Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats

scientific article

Erythropoietin, modified to not stimulate red blood cell production, retains its cardioprotective properties.

scientific article

Excitation-Contraction Coupling in Heart Failure ⬇️

scientific article published on July 15, 1991

Excitation-contraction coupling in the heart: the state of the question ⬇️

scientific article published on September 1, 1992

Executive Summary: Pivotal Research in Cardiovascular Syndromes in the Elderly

scientific article published on 01 October 2000

Exercise-Induced Silent Myocardial Ischemia in Master Athletes ⬇️

scientific article published on 01 February 1998

Experimental models that mimic the differentiation and dedifferentiation of vascular cells ⬇️

scientific article published on December 1, 1992

Expression of the sarcomeric actin isogenes in the rat heart with development and senescence

scientific article published on May 1, 1992

Fenoterol enantiomers do not possess beneficial therapeutic properties of their racemic mixture in the rat model of post myocardial infarction dilated cardiomyopathy

scientific article

From two competing oscillators to one coupled-clock pacemaker cell system

scientific article

Functional Correlates of Central Arterial Geometric Phenotypes ⬇️

scientific article published on December 1, 2001

Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart

scientific article (publication date: March 1992)

Funny current provides a relatively modest contribution to spontaneous beating rate regulation of human and rabbit sinoatrial node cells

scientific article

Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia

scientific article

GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells

scientific article published on 25 December 2013

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genome-wide association analysis identifies multiple loci related to resting heart rate

scientific article

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide association study of PR interval

scientific article

Gi-biased β2AR signaling links GRK2 upregulation to heart failure

scientific article published on 15 December 2011

Greater glycogen utilization during 1- than 2-adrenergic receptor stimulation in the isolated perfused rat heart

scientific journal article

Heart failure after long-term supravalvular aortic constriction in rats

scientific article published on 01 February 2005

Hemodynamic Determinants of the Short-Term Blood Pressure Variability: Differential Roles of Arterial Stiffness and Wave Reflection

scientific article published on 17 January 2017

Heritability of cardiovascular and personality traits in 6,148 Sardinians

scientific article published on 10 July 2006

Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility

scientific article published on 7 July 2005

Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells

scientific article

High Short-Term Blood Pressure Variability Predicts Long-Term Cardiovascular Mortality in Untreated Hypertensives But Not in Normotensives

scientific article published on February 2016

High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells

scientific article published on 19 January 2006

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Impact of T2 decay on carotid artery wall thickness measurements

scientific article

Impact of central obesity on the estimation of carotid-femoral pulse wave velocity

scientific article

Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease

scientific article published in March 2014

Increased Carotid Artery Intimal-Medial Thickness in Asymptomatic Older Subjects With Exercise-Induced Myocardial Ischemia ⬇️

scientific article published on October 13, 1998

Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells

scientific article

Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study

scientific article published on 30 December 2010

Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL/6 mice

scientific article published on March 2004

Inflammation and endothelial dysfunction during aging: role of NF-kappaB

scientific article published on 03 July 2008

Interaction between nutrition and aging: a summary of effects on the cardiovascular system

scientific article published on December 1, 1992

Intrahippocampal microinjection of an exquisitely low dose of ouabain mimics NaCl loading and stimulates a bufadienolide Na/K-ATPase inhibitor

scientific article published on 01 September 2007

Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial

scientific article published in May 2011

Introduction: chronic heart failure in older persons

scientific article published on January 1, 2002

Involvement of NADPH oxidase in age-associated cardiac remodeling

scientific article

Ischemic preconditioning increases the bioavailability of cardiac enkephalins

scientific article

Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart ⬇️

scientific article published on 01 August 1995

Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons

scientific article published on January 1, 1992

Kappa-opioid peptide receptor stimulation increases cytosolic pH and myofilament responsiveness to Ca2+ in cardiac myocytes ⬇️

scientific article published on November 1, 1991

Left ventricular remodeling with age in normal men versus women: novel insights using three-dimensional magnetic resonance imaging

scientific article published on 01 December 2002

Length-dependent activation: its effect on the length-tension relation in cat ventricular muscle

scientific article published on March 1, 1977

Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity".

scientific article published on June 2011

Linkage of cardiac gene expression profiles and ETS2 with lifespan variability in rats

scientific article published on 15 February 2012

List of Contributors

Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling ⬇️

scientific article published on 01 September 1997

Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats

scientific article published on 17 December 2016

Longitudinal Association Between Serum Uric Acid and Arterial Stiffness: Results From the Baltimore Longitudinal Study of Aging

scientific article

Longitudinal paths to the metabolic syndrome: can the incidence of the metabolic syndrome be predicted? The Baltimore Longitudinal Study of Aging

scientific article

Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging.

scientific article

Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging.

scientific article published on 03 September 2013

Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low-Normal Ankle-Brachial Index

scientific article published on 30 August 2017

MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling

scientific article

Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity

scientific article published in June 2002

Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists.

scientific article

Matching ATP supply and demand in mammalian heart: in vivo, in vitro, and in silico perspectives

scientific article

Matrix Metalloproteinase 2 Activation of Transforming Growth Factor-β1 (TGF-β1) and TGF-β1–Type II Receptor Signaling Within the Aged Arterial Wall

scientific article published on 11 May 2006

Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis

scientific article

Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.

scientific article published on October 2013

Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand

scientific article published on 19 April 2013

Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state

scientific article published on 28 September 2006

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

scientific article published on 11 September 2011

Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness

scientific article published on April 2004

Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion

scientific article published on 14 May 2009

Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility".

scientific article published on 13 March 2013

Modern concepts concerning the origin of the heartbeat.

scientific article

Modern perspectives on numerical modeling of cardiac pacemaker cell

scientific article

Modulation of sarcoplasmic reticulum Ca(2+) cycling in systolic and diastolic heart failure associated with aging.

scientific article

Modulation of the conductance of unitary cardiac L-type Ca(2+) channels by conditioning voltage and divalent ions.

scientific article

Modulation of the gating of unitary cardiac L-type Ca(2+) channels by conditioning voltage and divalent ions

scientific article

Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids ⬇️

scientific article published on 01 February 1998

Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension

scientific article published on December 2008

Mouse RAGE Variant 4 Is a Dominant Membrane Receptor that Does Not Shed to Generate Soluble RAGE.

scientific article

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

scientific article published on 21 May 2020

Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension

scientific article (publication date: March 2003)

Myocardial aging: functional alterations and related cellular mechanisms ⬇️

scientific article published on June 1, 1982

NF-κB inhibition compromises cardiac fibroblast viability under hypoxia

scientific article published on 4 January 2011

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.

scientific article published on 05 May 2013

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

scientific article

Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women

scientific article

Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells

scientific article

Novel diazinone derivatives separate myofilament Ca2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium

scientific article published on 01 June 1992

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Novel perspectives on the beating rate of the heart

scientific article published in August 2002

Novel technique to load indo-1 free acid into single adult cardiac myocytes to assess cytosolic Ca2+ ⬇️

scientific article published on June 1, 1992

Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking

scientific article

Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes ⬇️

scientific article published on September 13, 1994

On the shape of the common carotid artery with implications for blood velocity profiles

scientific article

Ongoing dual-angle measurements for the correction of partial saturation in 31P MR spectroscopy.

scientific article

Opposing effects of α1-adrenergic receptor subtypes on Ca2+and pH homeostasis in rat cardiac myocytes ⬇️

scientific article published on 01 April 1998

PKC-alpha regulates cardiac contractility and propensity toward heart failure

scientific journal article

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

scientific article published in Nature Communications

Pacemaker gene mutations, bradycardia, arrhythmias and the coupled clock theory

scientific article published on 09 September 2013

Payments for debts associated with exercise can become higher as we age and limit exercise capacity

scientific article published on 09 February 2006

Personality traits and circadian blood pressure patterns: a 7-year prospective study

scientific article

Personality traits in Sardinia: testing founder population effects on trait means and variances

scientific article published on 14 September 2006

Perspectives on mammalian cardiovascular aging: humans to molecules

scientific article

Perspectives on the Aged Myocardium ⬇️

scientific article published on January 1, 1978

Pharmacological Strategies to Retard Cardiovascular Aging ⬇️

scientific article published on May 2016

Pharmacological stimulation of beta2-adrenergic receptors (beta2AR) enhances therapeutic effectiveness of beta1AR blockade in rodent dilated ischemic cardiomyopathy

scientific article published on 01 December 2005

Phorbol diacetate potentiates na(+)-k(+) ATPase inhibition by a putative endogenous ligand, marinobufagenin

scientific article published in February 2002

Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

scientific article published on 11 November 2004

Phosphorylation and hypoxia-induced heme oxygenase-1 gene expression in cardiomyocytes

scientific article published in December 2004

Physiologic gating properties of unitary cardiac L-type Ca2+ channels

scientific article

Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.

scientific article

Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study

scientific article published on 30 March 2009

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials

scientific article published in March 2018

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.

scientific article

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

scientific article

Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging).

scientific article published on 07 June 2013

Prevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131).

scientific article published in January 2004

Prevalence, clinical correlates, and functional impact of subaortic ventricular septal bulge (from the Baltimore Longitudinal Study of Aging).

scientific article published on 19 June 2014

Prognostic Utility of Morning Blood Pressure Surge for 20-Year All-Cause and Cardiovascular Mortalities: Results of a Community-Based Study

scientific article published on 9 December 2017

Prognostic significance of mechanical biomarkers derived from pulse wave analysis for predicting long-term cardiovascular mortality in two population-based cohorts

scientific article

Proinflammation of aging central arteries: a mini-review

scientific article

Proinflammation: the key to arterial aging

scientific article

Proinflammatory Profile Within the Grossly Normal Aged Human Aortic Wall

scientific article published on 23 April 2007

Prolonged contraction duration in aged myocardium ⬇️

scientific article published on January 1, 1975

Protection in the aged heart: preventing the heart-break of old age?

scientific article

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Pulse pressure is inversely related to aortic root diameter implications for the pathogenesis of systolic hypertension

scientific article published on 24 December 2007

Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging

scientific article published on April 2008

Pulse wave velocity is associated with muscle mass decline: Health ABC study

scientific article published on 9 April 2011

Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart ⬇️

scientific article published on August 28, 2012

RAGE signaling in inflammation and arterial aging

scientific article

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling

scientific journal article

RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells

scientific article

Race, psychosocial factors, and aortic pulse wave velocity: the Health, Aging, and Body Composition Study

scientific article

Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function

scientific journal article

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells

scientific article

Rebuttal: What If the shoe doesn't fit? “The funny current has a major pacemaking role in the sinus node” ⬇️

scientific article published on September 16, 2011

Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association ⬇️

scientific article

Reduced vasorin enhances angiotensin II signaling within the aging arterial wall.

scientific article

Regulation of Cardiac Muscle Function in the Hypertensive Heart ⬇️

scientific article published on January 1, 1991

Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels

scientific article published on 30 June 2009

Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements

scientific article

Relationship between inter-arm difference in systolic blood pressure and arterial stiffness in community-dwelling older adults

scientific article published on 07 August 2013

Relationship between vitamin D status and left ventricular geometry in a healthy population: results from the Baltimore Longitudinal Study of Aging ⬇️

scientific article published on November 12, 2012

Relationship of intramyocardial oxygen tension and epicardial ST segment changes following acute coronary artery ligation: effects of coronary perfusion pressure

scientific article published on 01 January 1975

Reprogramming paces the heart

scientific article

Research Agenda for Cardiovascular Aging: Humans to Molecules

scientific article published on 01 October 2000

Resveratrol improves health and survival of mice on a high-calorie diet

scientific article (publication date: 16 November 2006)

Rhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.

scientific article

Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling

scientific article

Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization

scientific article published on 12 February 2004

Role of Inflammation in the Pathogenesis of Arterial Stiffness ⬇️

scientific article published on March 1, 2012

Role of body size on cardiovascular function: can we see the meat through the fat?

scientific article published on 6 July 2009

Role of bone mineral density in the inverse relationship between body size and aortic calcification: results from the Baltimore Longitudinal Study of Aging

scientific article

RyR-NCX-SERCA local cross-talk ensures pacemaker cell function at rest and during the fight-or-flight reflex

scientific article

Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design

scientific article

Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells

scientific article

Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults

scientific article

Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro.

scientific article

Sex- and age-dependent human transcriptome variability: implications for chronic heart failure

scholarly article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

So! What's aging? Is cardiovascular aging a disease?

scientific article

Spontaneous sarcoplasmic reticulum Ca2+ release leads to heterogeneity of contractile and electrical properties of the heart

scientific article published on January 1, 1992

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

scientific article published on 25 September 2017

Starling's Law reactivated

scientific article published on 01 May 1977

Stimulation of P2Y receptors activates c-fos gene expression and inhibits DNA synthesis in cultured cardiac fibroblasts ⬇️

scientific article published on March 1, 1998

Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells

scientific article

Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes ⬇️

scientific article published on February 5, 1991

Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart

scientific article

Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications

scientific article published in July 2004

Superoxide flashes in single mitochondria

scientific article published on July 2008

Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals

scientific article

Synchronization of stochastic Ca²(+) release units creates a rhythmic Ca²(+) clock in cardiac pacemaker cells

scientific article

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.

scientific article published on 09 January 2009

Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway

scientific article

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness

scientific article published on 8 February 2018

The "funny" current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells

scientific article published on 9 July 2012

The "heartbreak" of older age.

scientific article published on November 2002

The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts

scientific article

The Pressure of Aging

scientific article

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction

scientific article

The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study

scientific article

The conundrum of arterial stiffness, elevated blood pressure, and aging

scientific article published in February 2015

The dietary sodium-blood pressure plot "stiffens".

scientific article published in June 2004

The emergence of a general theory of the initiation and strength of the heartbeat

scientific article published on January 2006

The end effector of circadian heart rate variation: the sinoatrial node pacemaker cell

scientific article published on 22 May 2015

The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells

scientific article

The funny current in the context of the coupled-clock pacemaker cell system ⬇️

scientific article published on September 16, 2011

The future of aging therapies

scientific article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.

scientific article published on October 2006

The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry

scientific article published on 29 July 2003

The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study

scientific article published in April 2005

The missing link in the mystery of normal automaticity of cardiac pacemaker cells.

scientific article published on March 2008

The reality of aging viewed from the arterial wall☆ ⬇️

scientific article published on June 1, 2013

The regulation of the Na/Ca exchanger and plasmalemmal Ca2+ ATPase by other proteins

scientific article published on March 2007

The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted

scientific article published on 15 October 2016

The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development

scientific article

The salted artery and angiotensin II signaling: a deadly duo in arterial disease

scientific article published on January 2009

The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise

scientific article published on 2 May 2008

Therapeutic effectiveness of a single vs multiple doses of erythropoietin after experimental myocardial infarction in rats

scientific article published on August 2006

Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor

scientific article published on 08 July 2009

Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks

scientific article

Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men.

scientific article

Transdermal 17 beta-oestradiol reduces salt sensitivity of blood pressure in postmenopausal women

scientific article

Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy

scientific article

Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load

scientific article published on 14 October 2011

Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study

scientific article published on April 2009

Variants in MTNR1B influence fasting glucose levels

scientific article

Vessel ultrasound sonographic assessment of soluble receptor for advanced glycation end products efficacy in a rat balloon injury model

scientific article

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

scientific article (publication date: 17 June 2015)

Walking may be related to less vascular stiffness in the Activity Counseling Trial (ACT).

scientific article published in August 2005

Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study

scientific article

What keeps us ticking: a funny current, a calcium clock, or both?

scientific article

Which Arterial and Cardiac Parameters Best Predict Left Ventricular Mass? ⬇️

scientific article published on August 4, 1998

White coat hypertension is more risky than prehypertension: important role of arterial wave reflections

scientific article

Yin and yang of the cardiac pacemaker clock system in health and disease

scientific article

apoE4 allele and the natural history of cardiovascular risk factors

scientific article

beta-Adrenergic stimulation modulates ryanodine receptor Ca(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells

scientific article published in January 2002

cGMP prevents delayed relaxation at reoxygenation after brief hypoxia in isolated cardiac myocytes ⬇️

scientific article published on 01 June 1995

β₂ AR agonists in treatment of chronic heart failure: long path to translation

scientific article

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