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List of works by Mark Wainberg

25 years of HIV-1 research - progress and perspectives

scientific article

A HIV-1 minimal gag protein is superior to nucleocapsid at in vitro annealing and exhibits multimerization-induced inhibition of reverse transcription

scientific article

A Plea for Justice for Jailed Medical Workers

scientific article published in Science

A Template-Dependent Dislocation Mechanism Potentiates K65R Reverse Transcriptase Mutation Development in Subtype C Variants of HIV-1 ⬇️

scientific article published on May 31, 2011

A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors

scientific article published in January 2003

A high-throughput assay for HIV-1 integrase 3'-processing activity using time-resolved fluorescence.

scientific article

A resveratrol analog termed 3,3',4,4',5,5'-hexahydroxy-trans-stilbene is a potent HIV-1 inhibitor

scientific article published on 18 May 2015

A significant reduction in the frequency of HIV-1 drug resistance in Québec from 2001 to 2011 is associated with a decrease in the monitored viral load

scientific article

A structurally disordered region at the C terminus of capsid plays essential roles in multimerization and membrane binding of the gag protein of human immunodeficiency virus type 1.

scientific article

AIDS. Promote HIV chemoprophylaxis research, don't prevent it.

scientific article

Accuracy, precision, and consistency of expert HIV type 1 genotype interpretation: an international comparison (The GUESS Study).

scientific article published on 24 May 2005

Achieving the 90-90-90 target: incentives for HIV testing

scientific article published on November 2016

Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.

scientific article

Afri-Can Forum 2 : Johannesburg, South Africa. 16-18 February 2015

An international collaboration to standardize HIV-2 viral load assays: results from the 2009 ACHI(E)V(2E) quality control study

scientific article

Antibody-Dependent Cellular Cytotoxicity Activity of Effector Cells from HIV-Infected Elite and Viral Controllers

scientific article published on 7 August 2016

Antiretroviral drug resistance in human immunodeficiency virus type 2.

scientific article published on 26 May 2009

Antiretroviral therapy : optimal sequencing of therapy to avoid resistance

scientific article published on January 2008

Antiretroviral therapy with integrase inhibitors: more options

scientific article published on 01 April 2013

Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.

scientific article published on 18 September 2017

Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors ⬇️

scientific article published on June 25, 2012

Apricitabine does not select additional drug resistance mutations in tissue culture in human immunodeficiency virus type 1 variants containing K65R, M184V, or M184V plus thymidine analogue mutations

scientific article (publication date: April 2009)

Apricitabine: a novel deoxycytidine analogue nucleoside reverse transcriptase inhibitor for the treatment of nucleoside-resistant HIV infection

scientific article published on January 2007

Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function

scientific article published on 01 April 2007

Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region

scientific article

Attenuated infectivity of HIV type 1 from epithelial cells pretreated with a tight-binding nonnucleoside reverse transcriptase inhibitor

scientific article published on July 2002

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity.

scientific article published on 17 July 2013

Basis for Early and Preferential Selection of the E138K Mutation in HIV-1 Reverse Transcriptase ⬇️

scientific article published on July 15, 2013

Benefits of an educational program for journalists on media coverage of HIV/AIDS in developing countries

scientific article

Beyond Condoms: Risk Reduction Strategies Among Gay, Bisexual, and Other Men Who Have Sex With Men Receiving Rapid HIV Testing in Montreal, Canada

scientific article published on 9 March 2016

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase.

scientific article published in January 2014

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase.

scientific article published in June 2014

Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase

scientific article published on 30 September 2013

Biochemical and virological analysis of the preference for the K65R multi-resistance nucleoside mutation in subtype C viruses

Biochemical mechanism of HIV-1 resistance to rilpivirine

scientific article

Biochemical mechanism of clinical resistance to rilpivirine

scientific article published on 4 May 2012

Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase

scientific article

CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape.

scientific article published on 07 April 2016

CRISPR/Cas9: a double-edged sword when used to combat HIV infection

scientific article published on 27 May 2016

Can the further clinical development of bevirimat be justified?

scientific article published in March 2010

Canadian consensus guidelines for the optimal use of maraviroc in the treatment of HIV-infected adults.

scientific article

Cell-to-cell transmission of HIV-1 between CD4+T-cells involves clathrin-mediated endocytosis.

scientific article published on 3 October 2011

Cellular and molecular mechanisms involved in the establishment of HIV-1 latency

scientific article published on February 2013

Cenicriviroc blocks HIV entry but does not lead to redistribution of HIV into extracellular space like maraviroc

scientific article published on 2 November 2014

Challenges for the clinical development of new nucleoside reverse transcriptase inhibitors for HIV infection.

scientific article

Changing patterns in the selection of viral mutations among patients receiving nucleoside and nucleotide drug combinations directed against human immunodeficiency virus type 1 reverse transcriptase

scientific article

Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag.

scientific article published on November 2002

Characterization of antiviral activity of benzamide derivative AH0109 against HIV-1 infection

scientific article published on 13 May 2013

Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.

scientific article

Characterization of the E138K Resistance Mutation in HIV-1 Reverse Transcriptase Conferring Susceptibility to Etravirine in B and Non-B HIV-1 Subtypes ⬇️

scientific article published on December 6, 2010

Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir

scientific article

Chemoprophylaxis of HIV Infection: Moving Forward with Caution

article

Clinical benefit of dolutegravir in HIV-1 management related to the high genetic barrier to drug resistance

scientific article

Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana.

scientific article

Combination of the R263K and M184I/V resistance substitutions against dolutegravir and lamivudine decreases HIV replicative capacity.

scientific article published on 9 February 2015

Combination therapies, effectiveness, and adherence in patients with HIV infection: clinical utility of a single tablet of emtricitabine, rilpivirine, and tenofovir ⬇️

scientific article published on February 5, 2013

Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes.

scientific article

Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C ⬇️

scientific article published on October 7, 2010

Comparative biochemical analysis of wildtype and drug resistant HIV-1 integrase subtypes B and C

article

Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations

scientific article

Complete inactivation of HIV-1 using photo-labeled non-nucleoside reverse transcriptase inhibitors ⬇️

scientific article published on October 19, 2010

Correction for Anstett et al., "HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity"

article

Cost-effectiveness of public-health policy options in the presence of pretreatment NNRTI drug resistance in sub-Saharan Africa: a modelling study

scientific article

Could chemoprophylaxis be used as an HIV prevention strategy while we wait for an effective vaccine?

scientific article published in April 2003

Criminalizing HIV transmission may be a mistake

scientific article published in March 2009

Criteria for drugs used in pre-exposure prophylaxis trials against HIV infection

scientific article

Dates of HIV infection can be estimated for seroprevalent patients by coalescent analysis of serial next-generation sequencing data

scientific article

Defective HIV-1 quasispecies in the form of multiply drug-resistant proviral DNA within cells can be rescued by superinfection with different subtype variants of HIV-1 and by HIV-2 and SIV.

scientific article published on 20 August 2013

Deficient dimerization of human immunodeficiency virus type 1 RNA caused by mutations of the u5 RNA sequences

scientific article published on November 2002

Deletion of stem-loop 3 is compensated by second-site mutations within the Gag protein of human immunodeficiency virus type 1 ⬇️

scientific article (publication date: 15 September 2003)

Detection of human immunodeficiency virus (HIV) type 1 M184V and K103N minority variants in patients with primary HIV infection.

scientific article published on 26 January 2009

Development of a DNA vaccine expressing a secreted HIV-1 gp41 ectodomain that includes the membrane-proximal external region

scientific article published on 6 April 2017

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors

scientific article published on 29 March 2016

Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors.

scientific article

Development of an allele-specific PCR for detection of the K65R resistance mutation in patients infected with subtype C human immunodeficiency virus type 1

scientific article published on 7 December 2009

Development of antiretroviral drug resistance

scientific article published on 01 August 2011

Didanosine, interferon-alfa and ribavirin: a highly synergistic combination with potential activity against HIV-1 and hepatitis C virus

scientific article published on May 2, 2003

Differences among HIV-1 subtypes in drug resistance against integrase inhibitors

scientific article published on 25 June 2016

Differences in resistance mutations among HIV-1 non-subtype B infections: a systematic review of evidence (1996-2008)

scientific article published on 30 June 2009

Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase

scientific article

Differential impact of the HIV-1 non-nucleoside reverse transcriptase inhibitor mutations K103N and M230L on viral replication and enzyme function ⬇️

scientific article published on September 18, 2010

Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture

scientific article published on November 2004

Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator.

scientific article

Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity

scientific article published on August 2003

Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug resistance mutations

scientific article published on March 2007

Diminished representation of HIV-1 variants containing select drug resistance-conferring mutations in primary HIV-1 infection

scientific article published in December 2004

Discrepancies in assignment of subtype/recombinant forms by genotyping programs for HIV type 1 drug resistance testing may falsely predict superinfection.

scientific article

Distinct resistance patterns to etravirine and rilpivirine in viruses containing nonnucleoside reverse transcriptase inhibitor mutations at baseline ⬇️

scientific article published on March 27, 2013

Do HIV-1 non-B subtypes differentially impact resistance mutations and clinical disease progression in treated populations? Evidence from a systematic review

scientific article

Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study

scientific article

Dolutegravir inhibits HIV-1 Env evolution in primary human cells

scientific article published on March 2015

Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout

scientific article

Dolutegravir monotherapy of simian immunodeficiency virus-infected macaques selects for several patterns of resistance mutations with variable virological outcomes

scientific article published on 04 January 2019

Dolutegravir reshapes the genetic diversity of HIV-1 reservoirs.

scientific article published on 13 December 2017

Dolutegravir resistance mutation R263K cannot coexist in combination with many classical integrase inhibitor resistance substitutions

scientific article published on 4 February 2015

Dolutegravir-Selected HIV-1 Containing the N155H and R263K Resistance Substitutions Does Not Acquire Additional Compensatory Mutations under Drug Pressure That Lead to Higher-Level Resistance and Increased Replicative Capacity.

scientific article published on 5 August 2015

Drug Resistance Profiles of Recombinant Reverse Transcriptases from Human Immunodeficiency Virus Type 1 Subtypes A/E, B, and C ⬇️

scientific article published on September 1, 2003

Drugs that prevent HIV infection ⬇️

scientific article published on January 20, 2011

Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout

article

EDITORIAL

scientific article published in February 1999

Early HIV treatment to forestall drug resistance

scientific article published on 29 January 2016

Early immune adaptation in HIV-1 revealed by population-level approaches

scientific article

Editorial Commentary: Clinical Significance of HIV Subtype Variability in Regard to Treatment Outcome

scientific article published on 13 February 2015

Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors

scientific article

Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine

scientific article published on 22 April 2013

Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses

scientific article published on 30 April 2016

Effects of a single amino acid substitution within the p2 region of human immunodeficiency virus type 1 on packaging of spliced viral RNA

scientific article

Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance

scientific article

Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors

scientific article

Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study

scientific article

Erratum for Mesplède et al., "The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration"

article

Eurifoloids A-R, structurally diverse diterpenoids from Euphorbia neriifolia

scientific article published on 25 September 2014

Evaluation of Sofosbuvir (β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine) as an inhibitor of Dengue virus replication

scientific article published on 24 July 2017

Evolution of HIV integrase resistance mutations.

scientific article published on February 2013

Evolution of a novel pathway leading to dolutegravir resistance in a patient harbouring N155H and multiclass drug resistance

scientific article published on 3 October 2014

Evolutionary mechanisms of retroviral persistence

scientific article published on October 1, 2011

Evolving uses of oral reverse transcriptase inhibitors in the HIV-1 epidemic: from treatment to prevention ⬇️

scientific article published on July 31, 2013

Exposure to entry inhibitors alters HIV infectiousness and sensitivity to broadly neutralizing monoclonal antibodies.

scientific article

Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes

scientific article

Factors affecting template usage in the development of K65R resistance in subtype C variants of HIV type-1.

scientific article published on 5 January 2010

Factors associated with a decrease in the prevalence of drug resistance in newly HIV-1 infected individuals in Montreal

scientific article published in November 2004

Fitness impaired drug resistant HIV-1 is not compromised in cell-to-cell transmission or establishment of and reactivation from latency

scientific article

Five-year follow up of genotypic resistance patterns in HIV-1 subtype C infected patients in Botswana after failure of thymidine analogue-based regimens

scientific article published on 25 October 2009

Flueggether A and Virosinine A, Anti-HIV Alkaloids from Flueggea virosa

scientific article published on 3 December 2015

Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

scientific article published on 3 April 2013

Future of phylogeny in HIV prevention

scientific article published on July 2013

Gender-sensitive reporting in medical research

scientific article published on 8 March 2012

Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells

scientific article

Generic HIV drugs--enlightened policy for global health

scientific article

Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT.

scientific article

Global HIV Antiretroviral Drug Resistance: A Perspective and Report of a National Institute of Allergy and Infectious Diseases Consultation

scientific article published on 17 June 2017

HIV Drug Resistance and the Advent of Integrase Inhibitors.

scientific article published on February 2013

HIV and Ebola: similarities and differences

scientific article published in December 2014

HIV and Zika: When will we be able to end these epidemics?

scientific article (publication date: 15 November 2016)

HIV drug resistance against strand transfer integrase inhibitors

scientific article published on 5 June 2017

HIV drug resistance and optimization of antiviral treatment in resource-poor countries

scientific article published in October 2004

HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug.

scientific article published on 21 May 2012

HIV inactivation by cross-linking of photo-labeled anti-retroviral compounds with HIV reverse transcriptase

scientific article

HIV resistance to nevirapine and other non-nucleoside reverse transcriptase inhibitors

scientific article published on September 2003

HIV transmission and primary drug resistance.

scientific article

HIV transmission should be decriminalized: HIV prevention programs depend on it

scientific article published on December 2008

HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing

scientific article

HIV-1 Group O Resistance Against Integrase Inhibitors

scientific article published on 21 May 2015

HIV-1 Subtype Variability in Vif Derived from Molecular Clones Affects APOBEC3G-Mediated Host Restriction ⬇️

scientific article published on May 8, 2013

HIV-1 drug resistance: can we overcome?

scientific article

HIV-1 group O integrase displays lower enzymatic efficiency and higher susceptibility to raltegravir than HIV-1 group M subtype B integrase

scientific article

HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M.

scientific article published on 2 November 2014

HIV-1 protease codon 36 polymorphisms and differential development of resistance to nelfinavir, lopinavir, and atazanavir in different HIV-1 subtypes

scientific article published on 19 April 2010

HIV-1 resistance to dolutegravir is affected by cellular histone acetyltransferase activity

scientific article published on 23 August 2017

HIV-1 resistance to dolutegravir: update and new insights

scientific article

HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters

scientific article published on 2 May 2017

HIV-1 subtype B and C integrase enzymes exhibit differential patterns of resistance to integrase inhibitors in biochemical assays

scientific article published on September 2010

HIV-1 subtype C viruses rapidly develop K65R

HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.

scientific article published in June 2006

HIV-1 subtype distribution and the problem of drug resistance

scientific article published in June 2004

HIV-1 tropism testing and clinical management of CCR5 antagonists: Quebec review and recommendations

scientific article published on January 2013

Harnessing the therapeutic potential of host antiviral restriction factors that target HIV ⬇️

scientific article published on 01 January 2013

Has the time come to abandon efavirenz for first-line antiretroviral therapy?

scientific article published on 05 March 2014

Has the world ceased to care about HIV? And what can we do about it?

scientific article

High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens

scientific article

High rates of forward transmission events after acute/early HIV-1 infection

scientific article published on 16 February 2007

Higher levels of Zidovudine resistant HIV in the colon compared to blood and other gastrointestinal compartments in HIV infection

scientific article

Highlights from the 2014 International Symposium on HIV & Emerging Infectious Diseases (ISHEID): from cART management to the end of the HIV pandemic.

scientific article

Highly diversified multiply drug-resistant HIV-1 quasispecies in PBMCs: a case report.

scientific article published on 30 May 2008

How will the ebola crisis impact the HIV epidemic?

scientific article published on 30 November 2014

Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine.

scientific article published on 24 August 2009

Hydroxyurea in the treatment of HIV infection: clinical efficacy and safety concerns

scientific article

Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase

scientific article published on 16 November 2015

Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor

scientific article published on February 2015

Identification of an env-defective HIV-1 mutant capable of spontaneous reversion to a wild-type phenotype in certain T-cell lines

scientific article published on 6 October 2014

Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor

scientific article

Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay

scientific article published on 10 August 2016

Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance

scientific article

Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen

scientific article

Impact of the 16th International Conference on AIDS: can these conferences lead to policy change?

scientific article published on 8 February 2007

Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239.

scientific article published on 21 December 2006

Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase

scientific article published on July 2005

Implications for the future of the HIV epidemic if drug resistance against dolutegravir cannot occur in first-line therapy

scientific article

In tribute to Joep Lange

scientific article published on 20 September 2014

In vitro and structural evaluation of PL-100 as a potential second-generation HIV-1 protease inhibitor

scientific article

In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1

scientific article

In vitro identification and characterization of an early complex linking HIV-1 genomic RNA recognition and Pr55Gag multimerization

scientific article published on 9 July 2004

In vitro resistance profile of the candidate HIV-1 microbicide drug dapivirine

scientific article published on 28 November 2011

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

scientific article published on 21 February 2018

Integrase Strand Transfer Inhibitors in HIV Therapy.

scientific article

Integrase strand transfer inhibitors in the management of HIV-positive individuals

scientific article published on 03 March 2014

Interactions of different drug resistance mutations in HIV Reverse Transcriptase in defining patterns of drug resistance.

scientific article published on 3 October 2011

Investigational HIV integrase inhibitors in phase I and phase II clinical trials

scientific article published on 28 September 2017

Is HIV drug resistance a limiting factor in the development of anti-HIV NNRTI and NRTI-based vaginal microbicide strategies?

scientific article published on 9 June 2006

Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?

scientific article

Is resistance to dolutegravir possible when this drug is used in first-line therapy?

scientific article

Is there any hope for AIDS?

scientific article published in February 2004

Isolation of drug-resistant mutant HIV variants using tissue culture drug selection.

scientific article

JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1.

scientific article published on 15 February 2017

Jean-Luc Darlix: Renaissance scientist and retrovirologist par excellence ⬇️

scientific article published on July 18, 2011

Jewish religious ethics mandate access to antiretroviral drugs in developing countries.

scientific article

Journal of the International AIDS Society: an important step forward

scientific article published on 22 September 2008

Kinetics of HIV-1 CTL epitopes recognized by HLA I alleles in HIV-infected individuals at times near primary infection: the Provir/Latitude45 study

scientific article

Kinetics of inhibition of HIV type 1 reverse transcriptase-bearing NRTI-associated mutations by apricitabine triphosphate

scientific article published on 01 January 2007

Lack of effect of recombinant human growth hormone on the in vitro activities of antiretroviral drugs against human immunodeficiency virus type 1

scientific article

Lamivudine can exert a modest antiviral effect against human immunodeficiency virus type 1 containing the M184V mutation

scientific article

Large cluster outbreaks sustain the HIV epidemic among men having sex with men (MSM) in Quebec from 2002 to 2015.

scientific article

Latent HIV-1 Can Be Reactivated by Cellular Superinfection in a Tat-Dependent Manner, Which Can Lead to the Emergence of Multidrug-Resistant Recombinant Viruses ⬇️

scientific article published on June 26, 2013

Latent HIV-1 can be reactivated by superinfection in a Tat-dependent manner, which can lead to the emergence of recombinant viruses.

scientific article published on 19 September 2013

Limonoids with Anti-HIV Activity from Cipadessa cinerascens

scientific article published on 13 May 2015

Logeracemin A, an anti-HIV Daphniphyllum alkaloid dimer with a new carbon skeleton from Daphniphyllum longeracemosum

scientific article published on 16 May 2014

Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis.

scientific article

M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.

scientific article published on 22 August 2017

Maraviroc and Other HIV-1 Entry Inhibitors Exhibit a Class-Specific Redistribution Effect That Results in Increased Extracellular Viral Load ⬇️

scientific article published on May 21, 2012

Mechanistic study of BST-2 down-modulation by HIV-1 Vpu.

scientific article published on 24 September 2009

Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression

scientific article

Might dolutegravir be part of a functional cure for HIV?

scientific article

Might the M184V substitution in HIV-1 RT confer clinical benefit?

scientific article

Molecular mechanism of antagonism between the Y181C and E138K mutations in HIV-1 reverse transcriptase

scientific article

Monotherapy with either dolutegravir or raltegravir fails to durably suppress HIV viraemia in humanized mice.

scientific article published on 13 June 2017

Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: landmark HIV-1 research honoured.

scientific article published on 5 April 2013

Multi-low-dose mucosal simian immunodeficiency virus SIVmac239 challenge of cynomolgus macaques immunized with "hyperattenuated" SIV constructs

scientific article

Multidrug-resistant variants of HIV type 1 (HIV-1) can exist in cells as defective quasispecies and be rescued by superinfection with other defective HIV-1 variants

scientific article published on November 2009

Multiple choices for HIV therapy with integrase strand transfer inhibitors ⬇️

scientific article published on December 19, 2012

Multiple effects of the M184V resistance mutation in the reverse transcriptase of human immunodeficiency virus type 1

scientific article published on November 2003

Mutation of the SP1 sequence impairs both multimerization and membrane-binding activities of human immunodeficiency virus type 1 Gag.

scientific article

Mutations and polymorphisms associated with antiretroviral drugs in HIV-1C-infected African patients

scientific article

Natural killer cell education does not affect the magnitude of granzyme B delivery to target cells by antibody-dependent cellular cytotoxicity

scientific article

Natural polymorphisms in the human immunodeficiency virus type 2 protease can accelerate time to development of resistance to protease inhibitors

scientific article published on 20 November 2006

Near full-length genomic analysis of a novel subtype A1/C recombinant HIV type 1 isolate from Canada.

scientific article

Negative effect of the M184V mutation in HIV-1 reverse transcriptase on initiation of viral DNA synthesis

scientific article

Neither ritonavir nor darunavir affect cell surface expression of tetherin or Vpu-mediated tetherin down-modulation.

scientific article published on July 2010

New findings on blockage of HIV-1 RNase H activity

scientific article published on 01 January 2009

New pandemics: HIV and AIDS, HCV and chronic hepatitis, influenza virus and flu

scientific article

Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review

scientific article published on 31 May 2016

Novel therapeutic strategies targeting HIV integrase

scientific article

Nucleoside and nucleotide analogs select in culture for different patterns of drug resistance in human immunodeficiency virus types 1 and 2.

scientific article published on 08 December 2008

Nucleoside and nucleotide analogue reverse transcriptase inhibitors: a clinical review of antiretroviral resistance.

scientific article published on December 2003

Nucleotide and amino acid polymorphisms at drug resistance sites in non-B-subtype variants of human immunodeficiency virus type 1.

scientific article published on August 2004

Obituary: Kuan-Teh Jeang

scientific article

On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection

scientific article

Optimal use of raltegravir (Isentress(R)) in the treatment of HIV-infected adults - Canadian consensus guidelines.

scientific article published on January 2009

Oral Antiretroviral Drugs as Public Health Tools for HIV Prevention: Global Implications for Adherence, Drug Resistance, and the Success of HIV Treatment Programs ⬇️

scientific article published on June 15, 2013

PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study

scientific article published in December 2008

PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA

scientific article

Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection

scientific article

Persistence of multidrug-resistant HIV-1 in primary infection leading to superinfection

scientific article

Perspectives on antiviral drug development

scientific article published on 21 October 2008

Phylogenetic inferences on HIV-1 transmission: implications for the design of prevention and treatment interventions

scientific article published on April 2013

Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity

scientific article

Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance

scientific article

Pre-Exposure Chemoprophylaxis (PREP) as an HIV Prevention Strategy ⬇️

scientific article published on July 1, 2003

Pre-exposure prophylaxis against HIV: pros and cons.

scientific article published on 25 May 2012

Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1.

scientific article published on July 2002

Prevalence of Rilpivirine and Etravirine Resistance Mutations in HIV-1 Subtype C-Infected Patients Failing Nevirapine or Efavirenz-Based Combination Antiretroviral Therapy in Botswana

scientific article published on 12 June 2018

Prevalence of the K65R resistance reverse transcriptase mutation in different HIV-1 subtypes in Israel.

scientific article published in September 2009

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Productive entry of HIV-1 during cell-to-cell transmission via dynamin-dependent endocytosis

scientific article published on 15 May 2013

Protease inhibitor resistance in HIV-infected patients: molecular and clinical perspectives

scientific article published on 16 July 2007

Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

scientific article (publication date: 8 January 2017)

RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I ⬇️

scientific article published on November 17, 2010

Reconsidering the lifetime deferral of blood donation by men who have sex with men

scientific article

Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome

scientific article

Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

scientific article published on 16 October 2017

Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.

scientific article

Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1.

scientific article published on 25 November 2003

Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactions

scientific article

Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence

scientific article (publication date: July 2015)

Resistance issues with new nucleoside/nucleotide backbone options

scientific article published in September 2004

Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors

scientific article published on March 2014

Resistance profile of the new nucleoside reverse transcriptase inhibitor apricitabine

scientific article published on 09 December 2009

Resistance to HIV integrase inhibitors.

scientific article published on September 2012

Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection

scientific article published on 30 October 2015

Review: immunologic response to protease inhibitor-based highly active antiretroviral therapy: a review

scientific article published on September 2007

Reviewer acknowledgement 2013

Reviewer acknowledgement 2014

Reviewer acknowledgement 2015

Role of HIV Subtype Diversity in the Development of Resistance to Antiviral Drugs.

scientific article

Role of RNA in facilitating Gag/Gag-Pol interaction

scientific article published on April 2002

Role of genetic diversity amongst HIV-1 non-B subtypes in drug resistance: a systematic review of virologic and biochemical evidence

scientific article published on October 2008

Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors

scientific article published on 03 September 2013

Selection of TAR RNA-binding chameleon peptides by using a retroviral replication system

scientific article published in February 2004

Sequences downstream of the 5' splice donor site are required for both packaging and dimerization of human immunodeficiency virus type 1 RNA.

scientific article

Sequencing of therapy to avoid resistance and the need for new antiretroviral drugs in the treatment of HIV disease

scientific article published on April 2009

Short communication: antibody responses to human immunodeficiency virus envelope from infections with multiple subtypes utilize the 1F7-idiotypic repertoire

scientific article published on 29 January 2013

Signature nucleotide polymorphisms at positions 64 and 65 in reverse transcriptase favor the selection of the K65R resistance mutation in HIV-1 subtype C.

scientific article

Simian-tropic HIV as a model to study drug resistance against integrase inhibitors.

scientific article

Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference

scientific article published on 3 October 2017

Spliced human immunodeficiency virus type 1 RNA is reverse transcribed into cDNA within infected cells

scientific article published on February 2004

Stage-dependent inhibition of HIV-1 replication by antiretroviral drugs in cell culture.

scientific article

Staying ahead of viruses: a never ending task ⬇️

scientific article published on September 29, 2012

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor

scientific article

Structural and functional properties of the HIV-1 RNA-tRNA(Lys)3 primer complex annealed by the nucleocapsid protein: comparison with the heat-annealed complex

scientific article

Structural changes in the SL5 and SL6 leader sequences of HIV-1 RNA following interactions with the viral mGag protein

scientific article published on 22 September 2010

Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs

scientific article published on 23 March 2005

Substitutions in the reverse transcriptase and protease genes of HIV-1 subtype B in untreated individuals and patients treated with antiretroviral drugs.

scientific article published on 24 March 2005

Subtype diversity associated with the development of HIV‐1 resistance to integrase inhibitors ⬇️

scientific article published on February 25, 2011

Subtype-specific analysis of the K65R substitution in HIV-1 that confers hypersusceptibility to a novel nucleotide-competing reverse transcriptase inhibitor

scientific article published on 16 March 2015

Subunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase

scientific article

Suppression of an intrinsic strand transfer activity of HIV-1 Tat protein by its second-exon sequences

scientific article

Synergy against drug-resistant HIV-1 with the microbicide antiretrovirals, dapivirine and tenofovir, in combination ⬇️

scientific article published on August 24, 2011

Targeting host nucleotide biosynthesis with resveratrol inhibits emtricitabine-resistant HIV-1.

scientific article published on January 2014

Targeting of the Purine Biosynthesis Host Cell Pathway Enhances the Activity of Tenofovir Against Sensitive and Drug-Resistant HIV-1 ⬇️

scientific article published on 06 August 2013

Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1.

scientific article published on 10 December 2008

Tetherin and Its Viral Antagonists ⬇️

scientific article published on January 11, 2011

Tetherin restricts direct cell-to-cell infection of HIV-1 ⬇️

scientific article published on December 24, 2010

The 16th International Conference on AIDS: Will It Leave a Legacy?

scientific article published on 19 April 2007

The 16th International Conference on AIDS: will it leave a legacy?

scientific article published on 19 April 2007

The 20th International AIDS Conference: where do we go from here?

scientific article published on 18 July 2014

The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA

scientific article

The Combination of the R263K and T66I Resistance Substitutions in HIV-1 Integrase Is Incompatible with High-Level Viral Replication and the Development of High-Level Drug Resistance.

scientific article published on 26 August 2015

The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism

scientific article (publication date: 2011)

The Impact of HIV Genetic Polymorphisms and Subtype Differences on the Occurrence of Resistance to Antiretroviral Drugs ⬇️

scientific article published on June 26, 2012

The M184I/V and K65R nucleoside resistance mutations in HIV-1 prevent the emergence of resistance mutations against dolutegravir

scientific article published on 29 June 2016

The M184V mutation in HIV-1 reverse transcriptase reduces the restoration of wild-type replication by attenuated viruses

scientific article published in December 2002

The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus.

scientific article

The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates

scientific article

The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity.

scientific article published on 22 March 2010

The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness

scientific article published on 17 January 2014

The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance

scientific article published on 31 December 2012

The R262K substitution combined with H51Y in HIV-1 subtype B integrase confers low-level resistance against dolutegravir

scientific article published on 27 October 2014

The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration

scientific article published on 4 April 2017

The R263K mutation in HIV integrase that is selected by dolutegravir may actually prevent clinically relevant resistance to this compound

scientific article

The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B.

scientific article published on July 2015

The R362A mutation at the C-terminus of CA inhibits packaging of human immunodeficiency virus type 1 RNA.

scientific article published on 23 September 2005

The S230R Integrase Substitution Associated with Viral Rebound during DTG Monotherapy Confers Low Levels INSTI Drug Resistance.

scientific article published on 29 March 2018

The Tat protein of human immunodeficiency virus type 1 (HIV-1) can promote placement of tRNA primer onto viral RNA and suppress later DNA polymerization in HIV-1 reverse transcription.

scientific article published on April 2002

The Viral Protein Tat Can Inhibit the Establishment of HIV-1 Latency ⬇️

scientific article published on January 11, 2012

The XVI International Conference on AIDS: the place to be!

scientific article

The antimalarial drug amodiaquine possesses anti-ZIKA virus activities.

scientific article published on 9 January 2018

The connection domain mutation N348I in HIV-1 reverse transcriptase enhances resistance to etravirine and rilpivirine but restricts the emergence of the E138K resistance mutation by diminishing viral replication capacity

scientific article

The development of novel HIV integrase inhibitors and the problem of drug resistance.

scientific article published on 16 September 2012

The dolutegravir R263K resistance mutation in HIV-1 integrase is incompatible with the emergence of resistance against raltegravir

scientific article published on 13 September 2015

The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline.

scientific article

The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition.

scientific article published on July 2012

The emergence of HIV resistance and new antiretrovirals: are we winning?

scientific article published in June 2004

The impact of the M184V substitution on drug resistance and viral fitness

scientific article published in February 2004

The impact of the journalist-to-journalist program on worldwide HIV awareness

article

The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients.

scientific article published in June 2004

The need to promote public health in the field of illicit drug use.

scientific article

The paradoxical effects of using antiretroviral-based microbicides to control HIV epidemics ⬇️

scholarly article

The preferential selection of K65R in HIV-1 subtype C is attenuated by nucleotide polymorphisms at thymidine analogue mutation sites ⬇️

scientific article published on June 7, 2013

The role of Tat in HIV-1 replication: an activator and/or a suppressor?

scientific article

The role of polymorphisms at position 89 in the HIV-1 protease gene in the development of drug resistance to HIV-1 protease inhibitors ⬇️

scientific article published on February 7, 2012

The role of surrogate markers in the clinical development of antiretroviral therapy: a model for early evaluation of targeted cancer drugs

scientific article published on January 2004

The role of unintegrated DNA in HIV infection

scientific article

The transmembrane domain of BST-2 determines its sensitivity to down-modulation by human immunodeficiency virus type 1 Vpu.

scientific article published on 27 May 2009

Time for gender mainstreaming in editorial policies

scientific article published on 8 March 2011

Time to act: global apathy towards HIV/AIDS is a crime against humanity

scientific article published in November 2002

Tissue culture drug resistance analysis of a novel HIV-1 protease inhibitor termed PL-100 in non-B HIV-1 subtypes.

scientific article published on 10 June 2010

Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef.

scientific article published on 5 January 2011

Translation of Pr55(gag) augments packaging of human immunodeficiency virus type 1 RNA in a cis-acting manner

scientific article

Transmission clustering drives the onward spread of the HIV epidemic among men who have sex with men in Quebec

scientific article

Transmission dynamics of the M184V drug resistance mutation in primary HIV infection ⬇️

scientific article published on July 12, 2011

Transmission networks of drug resistance acquired in primary/early stage HIV infection

scientific article

Trichiconins A-C, limonoids with new carbon skeletons from Trichilia connaroides

scientific article published on 08 October 2014

Twenty-five years of AIDS: where are we now?

scientific article published on 27 October 2006

Two standards of care for HIV: why are Africans being short-changed?

scientific article published on December 2009

Update on rilpivirine: a new potent non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV replication

scientific article

Use of new resistance markers to predict virologic response to antiretrovirals

scientific article published on 11 May 2010

Variability in the PR and RT genes of HIV-1 isolated from recently infected subjects

scientific article

Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine

scientific article

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

scientific article published on 22 February 2013

Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase

scientific article

Vpu-mediated tetherin antagonism of ongoing HIV-1 infection in CD4+ T-cells is not directly related to the extent of tetherin cell surface downmodulation ⬇️

scientific article published on July 14, 2011

We need to use the best antiretroviral drugs worldwide to prevent HIV drug resistance.

scientific article

What if HIV were unable to develop resistance against a new therapeutic agent?

scientific article

Whither or wither microbicides?

scientific article

Will LEDGIN molecules be able to play a role in a cure for HIV infection?

scientific article published on 7 May 2016

Will drug resistance against dolutegravir in initial therapy ever occur?

scientific article published on 29 April 2015

Women hold up half the sky – and half the burden of the HIV epidemic ⬇️

scientific article published on March 8, 2013

World AIDS Day 2015.

scientific article published in December 2015

World AIDS Day: together we will stop HIV transmission and conquer AIDS.

scientific article published on 15 November 2013

XMRV as a Human Pathogen? ⬇️

scientific article (publication date: 21 April 2011)

eJIAS: Editor's Welcome

scientific article published on 8 July 2004

eJIAS: Editor's Welcome

scientific article published on 08 July 2004

eJIAS: The Journal of HIV/AIDS Science and Medicine in the Developing World

scientific article published on 15 July 2004

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