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List of works by Matthijs Hesselink

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

scientific article published on 17 February 2016

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

scientific article published on 21 August 2011

Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats

scientific article published on 29 October 2009

Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity

scientific article

Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults

scientific article

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

scientific article

Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction

scientific article

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans

scientific article

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

scientific article published on 7 November 2017

Diurnal Regulation of Peripheral Glucose Metabolism: Potential Effects of Exercise Timing

scientific article published on 31 May 2020

Eat the meat or feed the meat: protein turnover in remodeling muscle

scientific article published on November 2006

Effects of exercise training on intrahepatic lipid content in humans

scientific article

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans

scientific article

Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans

scientific article published on 01 January 2021

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

scientific article (publication date: 18 March 2014)

Genomic and transcriptomic predictors of triglyceride response to regular exercise

scientific article

Geometrical models for cardiac MRI in rodents: comparison of quantification of left ventricular volumes and function by various geometrical models with a full-volume MRI data set in rodents

scientific article

Human uncoupling protein-3 and obesity: an update

scientific article published on December 2003

Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes

scientific article

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo

scientific article

Intramyocellular lipid content in human skeletal muscle

scientific article

Intramyocellular lipid droplets and insulin sensitivity, the human perspective

scientific article

Invasive and noninvasive markers of human skeletal muscle mitochondrial function

scientific article published in 2023

Involvement of UCP3 in mild uncoupling and lipotoxicity

scientific article

Label-free CARS microscopy reveals similar triacylglycerol acyl chain length and saturation in myocellular lipid droplets of athletes and individuals with type 2 diabetes

scientific article published on 03 September 2020

Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection

scientific article

Microscopy tools for the investigation of intracellular lipid storage and dynamics

scientific article

Mitochondrial dysfunction and lipotoxicity

scientific article published on 24 September 2009

Modulation of myocellular fat stores: lipid droplet dynamics in health and disease

scientific article published on 19 August 2009

Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes

scientific article published on 5 March 2013

Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes

scientific article published on June 2004

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

scientific article published on 21 November 2012

Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels

scientific article

Physical activity and health, novel concepts and new targets: report from the 12th Conference of the International Research Group on the Biochemistry of Exercise

scientific article published in May 2004

Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance

scientific article

Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein

scientific article

Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism?

scientific article

Quantum coherence spectroscopy to measure dietary fat retention in the liver

scientific article published on 18 August 2016

Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity

scientific article

Reduced incorporation of fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes

scientific article published on 31 January 2014

Regional variations in intramyocellular lipid concentration correlate with muscle fiber type distribution in rat tibialis anterior muscle

scientific article

Relationship of C5L2 receptor to skeletal muscle substrate utilization

scientific article

Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity

scientific article

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

scientific article

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women

scientific article published on 12 September 2021

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

scientific article

Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes

scientific article published on 19 October 2016

The ceramide transporter and the Goodpasture antigen binding protein: one protein--one function?

scientific article published on 17 March 2010

The effect of diet and exercise on lipid droplet dynamics in human muscle tissue

scientific article published on 07 March 2018

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

scientific journal article

The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?

scientific article published in May 2004

Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?

scientific article published on July 2013

UCP2 and UCP3 in muscle controlling body metabolism

scientific article

UCP3 in muscle wasting, a role in modulating lipotoxicity?

scientific journal article

Uncoupling protein 3 and physical activity: the role of uncoupling protein 3 in energy metabolism revisited

scientific article published on August 2003

Uncoupling protein 3 as a mitochondrial fatty acid anion exporter

scientific article (publication date: December 2003)

What are the benefits of being big?

scientific article published on 23 June 2017

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