List of works by Sina Bavari

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

scientific article published on 04 September 2020

3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells

scientific article

4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity

scientific article published on 12 July 2013

A Call for Randomized Controlled Trials to Test the Efficacy of Chloroquine and Hydroxychloroquine as Therapeutics against Novel Coronavirus Disease (COVID-19)

scientific article published on 03 April 2020

A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With <i>Bacillus anthracis</i>

scientific article published on 14 March 2022

A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

scientific article

A STAT-1 knockout mouse model for Machupo virus pathogenesis

scientific article

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

scientific article

A high content imaging assay for identification of Botulinum neurotoxin inhibitors

scientific article

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

scientific article

A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor

scientific article

A race for an Ebola vaccine: promises and obstacles

scientific article published on 17 December 2014

A recombinant single-chain human class II MHC molecule (HLA-DR1) as a covalently linked heterotrimer of alpha chain, beta chain, and antigenic peptide, with immunogenicity in vitro and reduced affinity for bacterial superantigens.

scientific article published on August 1997

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease

scientific article published on 07 April 2007

A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection

scientific article

A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection

scientific article

A systematic screen of FDA-approved drugs for inhibitors of biological threat agents

scientific article

A thermostable, chromatographically purified Ebola nano-VLP vaccine

scientific article published on 15 July 2015

AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication.

scientific article published on 17 May 2016

AVI-7288 for Marburg Virus in Nonhuman Primates and Humans

scientific article published on July 2015

Adjuvant selection impacts the correlates of vaccine protection against Ebola infection

scientific article published on 06 May 2020

Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity

scientific article published on 27 November 2015

Advanced antisense therapies for postexposure protection against lethal filovirus infections.

scientific article

Advanced morpholino oligomers: a novel approach to antiviral therapy

scientific article published on 14 February 2012

African and Asian Zika Virus Isolates Display Phenotypic Differences Both In Vitro and In Vivo.

scientific article

Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses

scientific article

Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns

scientific article

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

scientific article

Analysis of Ebola virus and VLP release using an immunocapture assay.

scientific article

Analysis of botulinum neurotoxin serotype A metalloprotease inhibitors: analogs of a chemotype for therapeutic&amp;nbsp; development in the context of a three-zone pharmacophore ⬇️

scientific article published on April 1, 2010

Animal Models of Viral Hemorrhagic Fevers

Animal models for ebolavirus countermeasures discovery: what defines a useful model?

scientific article published on 25 May 2015

Anthrax biosensor, protective antigen ion channel asymmetric blockade.

scientific article published on 8 August 2005

Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival

scientific article

Anthrax toxin-induced rupture of artificial lipid bilayer membranes

scientific article published on August 2013

Antisense treatments for biothreat agents.

scientific article

Antiviral activity of a small-molecule inhibitor of filovirus infection

scientific article

Antiviral therapeutics for the treatment of Ebola virus infection

scientific article

Application of carbohydrate microarray technology for the detection of Burkholderia pseudomallei, Bacillus anthracis and Francisella tularensis antibodies.

scientific article published on 14 June 2008

Applications of in vivo imaging in the evaluation of the pathophysiology of viral and bacterial infections and in development of countermeasures to BSL3/4 pathogens

scientific article

Approach to Cataract Surgery in an Ebola Virus Disease Survivor with Prior Ocular Viral Persistence

scientific article published on 01 July 2020

Arenaviruses: Hemorrhagic Fevers

Arenaviruses: Hemorrhagic Fevers

Assembly of Ebola virus matrix protein VP40 is regulated by latch-like properties of N and C terminal tails

scientific article published in 2012

Assembly of a functional Machupo virus polymerase complex

scientific article

Association of ebola virus matrix protein VP40 with microtubules

scientific article

Asymptomatic Ebola virus infections-myth or reality?

scientific article

Author Correction: Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model

scientific article published on 15 October 2019

Avoidance behavior independent of innate-immune signaling seen in Caenorhabditis elegans challenged with Bacillus anthracis

scientific article published on 18 July 2019

BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

scientific article published on 16 April 2016

BRILIA: Integrated Tool for High-Throughput Annotation and Lineage Tree Assembly of B-Cell Repertoires

scientific article published on January 2016

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.

scientific article

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

scientific article published on 14 November 2012

Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus

scientific article

Bolivian Hemorrhagic Fever

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

scientific article published on 4 October 2017

Broad-spectrum coronavirus antiviral drug discovery

scientific article published on 8 March 2019

Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics

scientific article published on 13 January 2020

Characterization of a putative filovirus vaccine: virus-like particles

scientific article published on 06 February 2013

Characterization of clinical and immunological parameters during Ebola virus infection of rhesus macaques

scientific article published on February 2015

Characterization of the Burkholderia thailandensis SOS response by using whole-transcriptome shotgun sequencing

scientific article published on 19 July 2013

Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species.

scientific article published on 6 November 2015

Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

scientific article published on 07 February 2019

Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis

scientific article published on March 2007

Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection

scientific article published on 17 February 2009

Chimpanzee adenovirus type 3 vectored Ebola vaccine: expanding the field

scientific article published on 19 March 2020

Cholesterol-conjugated stapled peptides inhibit Ebola and Marburg viruses in vitro and in vivo

scientific article published on 29 August 2019

Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates

scientific article published on August 2017

Clinical Laboratory Values in Human Ebola Virus Disease Support the Relevance of the Intramuscular Ebola-Kikwit Rhesus Model

scientific article published on 20 December 2017

Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates

scientific article published on 12 July 2010

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

scientific article published on January 2005

Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor

scientific article published on 4 April 2006

Considerations for the development of Zika virus vaccines

scientific article

Correlates of immunity to filovirus infection

scientific article published on 27 June 2011

Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule

scientific article published on June 2003

Countering Zika Virus: The USAMRIID Response.

scientific article published in January 2018

Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway

scientific article published on 19 June 2013

Crimean-Congo hemorrhagic fever: current and future prospects of vaccines and therapies

scientific article

Cross-protection conferred by filovirus virus-like particles containing trimeric hybrid glycoprotein

scientific article published on February 2015

Cross-reactive antibodies prevent the lethal effects of Staphylococcus aureus superantigens

scientific article published on 01 October 1999

Current status of chemically synthesized inhibitors of Ebola virus

scientific article published on January 2014

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection

scientific article published on 12 July 2018

Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

scientific article (publication date: February 2016)

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

scientific article published on 05 July 2016

Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.

scientific article

Detection of Highly Pathogenic Viral Agents

Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication

scientific article published on 5 June 2017

Development and characterization of a mouse model for Marburg hemorrhagic fever

scientific article

Development and characterization of rabbit and mouse antibodies against ebolavirus envelope glycoproteins

scientific article published on 13 April 2011

Development of a broad-spectrum antiviral with activity against Ebola virus

scientific article

Development of a liquid chromatography high resolution mass spectrometry method for the quantitation of viral envelope glycoprotein in Ebola virus-like particle vaccine preparations

scientific article published on 05 September 2016

Development of a model for marburgvirus based on severe-combined immunodeficiency mice

scientific article

Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies

scientific article published on 4 December 2009

Development of engineered vaccines effective against structurally related bacterial superantigens

scientific article published on 01 November 1998

Development of high-content imaging assays for lethal viral pathogens.

scientific article published on 16 July 2010

Discovering Drugs for the Treatment of Ebola Virus.

scientific article published on 4 August 2017

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

scientific article published on 26 January 2017

Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections

scientific article

Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1

scientific article

Discovery of common marburgvirus protective epitopes in a BALB/c mouse model

scientific article published on 27 August 2009

Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus

scientific article

Dominance of human innate immune responses in primary Francisella tularensis live vaccine strain vaccination

scientific article published on 31 March 2006

Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses

scientific article

Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates

scientific article published on 20 September 2018

Ebola Virus Persistence in Ocular Tissues and Fluids (EVICT) Study: Reverse Transcription-Polymerase Chain Reaction and Cataract Surgery Outcomes of Ebola Survivors in Sierra Leone.

scientific article

Ebola and Marburg virus-like particles activate human myeloid dendritic cells

scientific article published on September 2004

Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation

scientific article published on 14 November 2003

Ebola virus disease candidate vaccines under evaluation in clinical trials

scientific article published on 10 May 2016

Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection

scientific article

Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice

scientific article

Ebola virus inactivation with preservation of antigenic and structural integrity by a photoinducible alkylating agent

scientific article

Ebola virus uses clathrin-mediated endocytosis as an entry pathway

scientific article

Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge

scientific article

Ebola virus-like particles protect from lethal Ebola virus infection

scientific article

Ebola virus-like particles stimulate type I interferons and proinflammatory cytokine expression through the toll-like receptor and interferon signaling pathways.

scientific article published on 08 October 2013

Ebolavirus Glycoprotein Fc Fusion Protein Protects Guinea Pigs against Lethal Challenge

scientific article

Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry

scientific article

Efficacy of favipiravir (T-705) in nonhuman primates infected with Ebola virus or Marburg virus.

scientific article published on 28 December 2017

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.

scientific article published on 10 February 2010

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

scientific article

Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail

scientific article published on 9 September 2015

Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo

scientific article published on 15 December 2017

Evaluation of Ebola Virus Inhibitors for Drug Repurposing.

scientific article published on 11 May 2015

Evaluation of perceived threat differences posed by filovirus variants

scientific article published on 9 November 2011

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names

scientific article published on 26 September 2014

Filovirus infections

scientific article published on May 2009

Filovirus vaccines.

scientific article published on June 2011

Filovirus-like particles as vaccines and discovery tools

scientific article

Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents

scientific article published on November 2007

Filoviruses: Hemorrhagic Fevers

Filoviruses: Hemorrhagic Fevers

Flex-nucleoside analogues - Novel therapeutics against filoviruses

scientific article

Functional CD8+ T cell responses in lethal Ebola virus infection

scientific article

Gaining ground: assays for therapeutics against botulinum neurotoxin

scientific article published on 04 March 2010

Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.

scientific article

Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B.

scientific article

Generation of Marburg virus-like particles by co-expression of glycoprotein and matrix protein

scientific article published on January 2004

Generation of heterogeneous memory T cells by live attenuated tularemia vaccine in humans

scientific article published on 30 September 2009

Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity

scientific article published on 01 July 2003

Glucopyranosyl lipid adjuvant enhances immune response to Ebola virus-like particle vaccine in mice

scientific article published on 04 June 2019

HSPA5 is an essential host factor for Ebola virus infection

scientific article published on 11 July 2014

Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging

scientific article

High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus

scientific article

High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection

scientific article published on 25 September 2012

High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses

scientific article

High degree of correlation between Ebola virus BSL-4 neutralization assays and pseudotyped VSV BSL-2 fluorescence reduction neutralization test

scientific article published on 16 January 2018

High-content image-based screening of a signal transduction pathway inhibitor small-molecule library against highly pathogenic RNA viruses

scientific article

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

scientific article

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model

scientific article published on 19 January 2018

Homologous and heterologous protection of nonhuman primates by Ebola and Sudan virus-like particles

scientific article

Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.

scientific article

Human antibodies to bacterial superantigens and their ability to inhibit T-cell activation and lethality

scientific article

Human leukocyte antigen-DQ8 transgenic mice: a model to examine the toxicity of aerosolized staphylococcal enterotoxin B

scientific article

Humanized mice as a preclinical tool for infectious disease and biomedical research

scientific article

Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: a novel model for superantigen vaccines

scientific article published on 23 May 2002

ICTV Virus Taxonomy Profile: Filoviridae

scientific article published on 25 April 2019

ICU-like Care of Nonhuman Primates with Ebola Virus Disease

scientific article published on 25 December 2020

IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus

scientific article published on 29 May 2013

Identification and pathological characterization of persistent asymptomatic Ebola virus infection in rhesus monkeys

scientific article published on 17 July 2017

Identification of RUVBL1 and RUVBL2 as Novel Cellular Interactors of the Ebola Virus Nucleoprotein

scientific article published on 23 April 2019

Identification of a Small-molecule Antiviral with Broad-spectrum Application to Multiple, Lethal Virus Types

scientific article published in 2009

Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor

scientific article

Identification of a small-molecule entry inhibitor for filoviruses

scientific article

Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting

scientific article

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.

scientific article

Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen

scientific article

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

scientific article published in April 2008

Identification of small molecule inhibitors of anthrax lethal factor

scientific article

Identifying the principal protective antigenic determinants of type A botulinum neurotoxin.

scientific article

Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses

scientific article published on 11 May 2017

In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.

scientific article

Induced IL-10 splice altering approach to antiviral drug discovery.

scientific article published on 21 March 2014

Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection

scientific article

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin

scientific article

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes

scientific article

Inhibition of human serum complement activity by diisopropylfluorophosphate and selected anticholinesterase insecticides.

scientific article published in April 1989

Inhibition of interleukin-2-stimulated enhancement of human natural killer (NK) cell activity by carbaryl, an anticholinesterase insecticide

scientific article published on December 1, 1992

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons

scientific article published on 8 November 2006

Integrated bioassays in microfluidic devices: botulinum toxin assays.

scientific article published on 18 October 2005

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection

scientific article

Intracellular conversion and in vivo dose response of favipiravir (T-705) in rodents infected with Ebola virus.

scientific article published on 28 December 2017

Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction

scientific article

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

scientific article

Key genomic changes necessary for an in vivo lethal mouse marburgvirus variant selection process

scientific article

L1000CDS2: LINCS L1000 characteristic direction signatures search engine

scientific article

Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization

scientific article

Lethal shock induced by streptococcal pyrogenic exotoxin A in mice transgenic for human leukocyte antigen-DQ8 and human CD4 receptors: implications for development of vaccines and therapeutics

scientific article published on 19 July 2002

Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses

scientific article

Low potential for mechanical transmission of Ebola virus via house flies (Musca domestica).

scientific article

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry

scientific article

Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin

scientific article published on February 2001

Marburg Virus Disease

Marburg virus-like particles protect guinea pigs from lethal Marburg virus infection

scientific article

Marburgvirus hijacks nrf2-dependent pathway by targeting nrf2-negative regulator keap1.

scientific article published on 13 March 2014

Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis

scientific article published on January 2010

Mechanisms of immunity in post-exposure vaccination against Ebola virus infection

scientific article

Modeling mosquito-borne and sexual transmission of Zika virus in an enzootic host, the African green monkey

scientific article published on 22 June 2020

Modulation of interleukin-2-driven proliferation of human large granular lymphocytes by carbaryl, an anticholinesterase insecticide.

scientific article published in July 1991

Molecular mechanisms of filovirus cellular trafficking.

scientific article

Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses

scientific article

Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors

scientific article

Mutational effects on protein folding stability and antigenicity: the case of streptococcal pyrogenic exotoxin A.

scientific article published in July 2003

NKp30-dependent cytolysis of filovirus-infected human dendritic cells.

scientific article published on April 2007

Neglected filoviruses

scientific article

Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon

scientific article (publication date: 9 January 2017)

New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model.

scientific article published on 31 January 2018

Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014.

scientific article

Nonhuman primates as models for the discovery and development of ebolavirus therapeutics

scientific article published on March 2011

Nonhuman transferrin receptor 1 is an efficient cell entry receptor for Ocozocoautla de Espinosa virus

scientific article published on 09 October 2013

Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.

scientific article published on 19 July 2008

Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency

scientific article

Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains

scientific article published on 27 July 2009

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

scientific article published in October 2003

Novel therapeutic uses and formulations of botulinum neurotoxins: a patent review (2012 - 2014).

scientific article published on 05 April 2015

Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses

scientific article published on 14 January 2008

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization

scientific article published on 15 May 2006

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

scientific article

Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators

scientific article published in September 2005

Persistent Marburg Virus Infection in the Testes of Nonhuman Primate Survivors

scientific article published on 30 August 2018

Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease

scientific article

Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease

scientific article published on 13 February 2009

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

scientific article

Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors

scientific article

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

scientific article published on 25 October 2013

Potentiation of inhaled staphylococcal enterotoxin B-induced toxicity by lipopolysaccharide in mice

scientific article published on 01 September 1996

Pre-positioned Outbreak Research: The Joint Medical Emerging Diseases Intervention Clinical Capability Experience in Uganda

scientific article published on 01 March 2020

Pre-symptomatic diagnosis and treatment of filovirus diseases

scientific article

Predictive systems biology approach to broad-spectrum, host-directed drug target discovery in infectious diseases

scientific article published on January 2013

Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.

scientific article published in March 2007

Production and purification of a recombinant Staphylococcal enterotoxin B vaccine candidate expressed in Escherichia coli

scientific article published in March 2002

Protection against Staphylococcus aureus sepsis by vaccination with recombinant staphylococcal enterotoxin A devoid of superantigenicity

scientific article published on 01 October 1999

Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination

scientific article published on May 2002

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

scientific article

Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase

scientific article published on 2 February 2016

Purified Bacillus anthracis lethal toxin complex formed in vitro and during infection exhibits functional and biological activity

scientific article published on 11 January 2005

Quantitative Analysis of Repertoire-Scale Immunoglobulin Properties in Vaccine-Induced B-Cell Responses

scientific article published on 14 August 2017

Rational design of small molecules as vaccine adjuvants.

scientific article published on November 2014

Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells

scientific article published on 15 December 2013

Recent advances in botulinum neurotoxin inhibitor development.

scientific article

Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery

scientific article published on 23 January 2014

Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis

scientific article

Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection

scientific article published on August 2009

Reemergence of monkeypox: prevalence, diagnostics, and countermeasures

scientific article

Reidentification of Ebola Virus E718 and ME as Ebola Virus/H.sapiens-tc/COD/1976/Yambuku-Ecran

scientific article

Repurposing potential of 1st generation H-specific antihistamines as anti-filovirus therapeutics

scientific article published on 04 July 2018

Retrovirus-Based Surrogate Systems for BSL-2 High-Throughput Screening of Antivirals Targeting BSL-3/4 Hemorrhagic Fever-Causing Viruses

scientific article published on January 2018

Ribavirin has a Demonstrable Effect on Crimean-Congo Hemorrhagic Fever Viral Populations and Viral Load during Patient Treatment.

scientific article

Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms

scholarly article by Kelly L Warfield et al published 22 November 2018 in Journal of Infectious Diseases

Role of Rodents and Bats in Human Viral Hemorrhagic Fevers

Role of natural killer cells in innate protection against lethal ebola virus infection

scientific article

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons

scientific article published on 18 March 2015

Searching for Therapeutics Against Botulinum Neurotoxins: A True Challenge for Drug Discovery.

scientific article published on 13 April 2016

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

scientific article published on 31 October 2018

Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria

scientific article

Shedding light on filovirus infection with high-content imaging

scientific article

Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols)

scientific article published on August 2008

Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses

scientific article published on 8 April 2013

Sorafenib impedes Rift Valley fever virus egress by inhibiting Valosin-containing protein function in the cellular secretory pathway

scientific article published on 09 August 2017

Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex

scientific article published on 14 October 2015

Standardization of the filovirus plaque assay for use in preclinical studies

scientific article

Staphylococcal enterotoxin A and toxic shock syndrome toxin compete with CD4 for human major histocompatibility complex class II binding.

scientific article

Staphylococcal enterotoxins A and B share a common structural motif for binding class II major histocompatibility complex molecules

scientific article published on 01 July 1995

Superantigen vaccines: a comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A

scientific article published on 01 August 1996

Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors

scientific article

T-705 induces lethal mutagenesis in Ebola and Marburg populations in macaques

scientific article published on 10 June 2019

T-cell-dependent mechanisms promote Ebola VLP-induced antibody responses, but are dispensable for vaccine-mediated protection

scientific article published on 07 June 2017

Taxonomy of the order Mononegavirales: second update 2018

scientific article published on 01 April 2019

Taxonomy of the order Mononegavirales: update 2016

scientific article published in August 2016

Taxonomy of the order Mononegavirales: update 2017.

scientific article

Taxonomy of the order Mononegavirales: update 2018.

scientific article published on 11 April 2018

Taxonomy of the order Mononegavirales: update 2019

scientific article published on 01 July 2019

The C terminus of the catalytic domain of type A botulinum neurotoxin may facilitate product release from the active site

scientific article published on 18 June 2013

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

scientific article published on 05 August 2020

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

scientific article published on 26 November 2020

The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus

scientific article published on 08 August 2019

The International Code of Virus Classification and Nomenclature (ICVCN): proposal for text changes for improved differentiation of viral taxa and viruses

scientific article published on 16 February 2013

The International Code of Virus Classification and Nomenclature (ICVCN): proposal to delete Rule 3.41.

scientific article published on 31 August 2012

The evolving field of biodefence: therapeutic developments and diagnostics

scientific article

The osmolyte trimethylamine N-oxide (TMAO) increases the proteolytic activity of botulinum neurotoxin light chains A, B, and E: implications for enhancing analytical assay sensitivity

scientific article

The rapidly advancing field of biodefense benefits many other, critical public health concerns

scientific article published on August 2005

The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease

scientific article

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

scientific article

Therapeutic potential of the heme oxygenase-1 inducer hemin against Ebola virus infection

scientific article published on January 2016

Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design

scientific article

Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore.

scientific article published in December 2008

Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors

scientific article

Time-lapse confocal imaging of development of Bacillus anthracis in macrophages

scientific article published on 19 March 2004

Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation

scientific article

Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccination

scientific article

Treatment of highly pathogenic filovirus infections using advanced antisense technology

Treatment-focused Ebola trials, supportive care and future of filovirus care.

scientific article published on 6 December 2017

TrkA in vivo function is negatively regulated by ubiquitination

scientific article published on March 2014

United States FDA's emergency use authorization of Ebola virus diagnostics: current impact and lessons for the future

scientific article published on 7 September 2015

VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice

scientific article

Vaccine adjuvant uses of poly-IC and derivatives

scientific article

Validation of the Filovirus Plaque Assay for Use in Preclinical Studies

scientific article published on 21 April 2016

Viral Hemorrhagic Fevers

Viral diversity and clonal evolution from unphased genomic data.

scientific article

Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis

scientific article published on 21 November 2018

Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA

scientific article published on 5 November 2013

Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae

scientific article published on 29 January 2013

Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae

scientific article published on 23 September 2012

Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges).

scientific article published on 8 April 2016

Virus-like particles activate type I interferon pathways to facilitate post-exposure protection against Ebola virus infection

scientific article

Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections

scientific article published on April 2005

Will There Be a Cure for Ebola?

scientific article published on 7 December 2016

Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs

scientific article published on 5 February 2018

siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection

scientific article

“Venezuelan” Hemorrhagic Fever

Paulina is supported by:

About Paulina

Help