Search filters

List of works by Ludo Van Den Bosch

A shortened tamoxifen induction scheme to induce CreER recombinase without side effects on the male mouse skeleton

scientific article

A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism.

scientific article published on 4 January 2018

AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS

scientific article published on 20 January 2021

Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.

scientific article

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism

scientific article published on 06 December 2012

Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations

scientific article published on 01 September 2019

Alternative processing of the gene transcripts encoding a plasma-membrane and a sarco/endoplasmic reticulum Ca2+ pump during differentiation of BC3H1 muscle cells.

scientific article published on May 1993

Amyotrophic lateral sclerosis and excitotoxicity: from pathological mechanism to therapeutic target.

scientific article published on July 2010

Amyotrophic lateral sclerosis: pathogenesis.

scientific article

Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis

scientific article published in October 2021

Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis

scientific article published on 26 July 2018

Astrocytes in amyotrophic lateral sclerosis: direct effects on motor neuron survival.

scientific article published on 21 March 2009

Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity

scholarly article

Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications

scientific article published on 18 September 2019

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis.

scientific article published on 10 December 2013

Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease

scientific article published on 24 November 2015

Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome

scientific article published on 14 December 2018

C-kit is important for SOD1(G93A) mouse survival independent of mast cells.

scientific article

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

scientific article published on 09 April 2021

C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport

scientific article published on 31 October 2019

CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model

scientific article published on 13 March 2020

Ca(2+)-transport ATPases and their regulation in muscle and brain

scientific article published on November 30, 1992

Calcium handling proteins in isolated spinal motoneurons

scientific article published on 01 January 1999

Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules

scientific article published on 03 May 2022

Characteristics of Na+-dependent hexose transport in OK, an established renal epithelial cell line

scientific article published on 01 February 1989

Charcot-Marie-Tooth disease: emerging mechanisms and therapies.

scientific article published on 30 April 2012

Chloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death.

scientific article published in June 2003

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1G93A mice.

scientific article published on 3 April 2018

Crosstalk between astrocytes and motor neurons: what is the message?

scientific article published on 26 January 2008

Current Advances and Limitations in Modeling ALS/FTD in a Dish Using Induced Pluripotent Stem Cells

scientific article published on 13 December 2017

D90A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis

article

Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G⁹³A) mice.

scientific article

Defective axonal transport: A common pathological mechanism in inherited and acquired peripheral neuropathies

scientific article published on 23 February 2017

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

scientific article published in June 2001

Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease

scientific article

Differential contribution of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons.

scientific article

Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

scientific article published on 12 September 2019

Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy

scientific article

Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.

scientific article published on 12 February 2016

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

scientific article published in September 2012

Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration

scientific article published on 01 October 2004

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition

scientific article

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition.

scientific article

Endoplasmic reticulum stress plays an important role in amyotrophic lateral sclerosis (Commentary on Prell et al.)

scientific article published on 01 March 2012

Energy metabolism in ALS: an underappreciated opportunity?

scientific article published on 16 March 2018

EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease

scientific article published on 12 December 2019

Excitotoxicity and amyotrophic lateral sclerosis.

scientific article published on January 2005

Existing and Emerging Metabolomic Tools for ALS Research

scientific article published on 05 December 2019

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins

scientific article published on 01 December 2018

Familial Juvenile Focal Amyotrophy of the Upper Extremity (Hirayama Disease)

scientific article published on 01 January 1997

G37R SOD1 mutant alters mitochondrial complex I activity, Ca(2+) uptake and ATP production.

scientific article published on 8 March 2011

Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice

scientific article published on 04 July 2016

Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice

scientific article

Genetic rodent models of amyotrophic lateral sclerosis

scientific article

Genetic variant in the HSPB1 promoter region impairs the HSP27 stress response

scientific article

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

scientific article published on 16 December 2007

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

scientific article published in March 2018

Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system.

scientific article published on October 1998

GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis.

scientific article published in July 2005

GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity.

scientific article published in September 2002

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HDAC3 Inhibition Stimulates Myelination in a CMT1A Mouse Model

scientific article published on 23 March 2022

HDAC6 and Miro1: Another interaction causing trouble in neurons

scientific article published on 22 May 2019

HDAC6 as a potential therapeutic target for peripheral nerve disorders

scientific article published on 01 December 2018

HDAC6 at the Intersection of Neuroprotection and Neurodegeneration.

scientific article published on 26 March 2012

HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations

scientific article published on 10 March 2021

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

scientific article published on 11 October 2017

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

article

HDAC6 inhibitors: Translating genetic and molecular insights into a therapy for axonal CMT

scientific article published on 30 January 2020

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.

scientific article published on 5 February 2018

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.

scientific article published on 30 January 2013

Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy

scientific article

Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells

scientific article published on 21 December 2017

ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study

scientific journal article

Identification and characterization of Nanobodies targeting the EphA4 receptor.

scientific article

In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

scientific article published on 15 May 2019

Increased sensitivity of fibroblasts from amyotrophic lateral sclerosis patients to oxidative stress ⬇️

scientific article published on April 1, 1998

Inflammatory markers in cerebrospinal fluid: independent prognostic biomarkers in amyotrophic lateral sclerosis?

scientific article published on 07 June 2019

Influence of PMA and a low extracellular Ca2+ concentration on the development of the Na+-dependent hexose carrier in LLC-PK1 cells ⬇️

scientific article published on April 17, 1991

Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth

scientific article published on 29 November 2017

Inside out: the role of nucleocytoplasmic transport in ALS and FTLD

scientific article

Integrated molecular landscape of amyotrophic lateral sclerosis provides insights into disease etiology.

scientific article published on 30 December 2016

Kinetics of the non-specific calcium leak from non-mitochondrial calcium stores in permeabilized A7r5 cells

scientific article published on August 1996

L-β-N-oxalyl-α,β-diaminopropionic acid toxicity in motor neurons.

scientific article published in February 2011

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

article

Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.

scientific article published on 4 January 2012

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy

scientific article published on 19 November 2019

Mibefradil (Ro 40m5967) blocks multiple types of voltage-gated calcium channels in cultured rat spinal motoneurones

article

Microglia in amyotrophic lateral sclerosis.

scientific article published on September 2007

Microglial upregulation of progranulin as a marker of motor neuron degeneration

scientific article published in December 2010

Minocycline delays disease onset and mortality in a transgenic model of ALS.

scientific article

Modelling amyotrophic lateral sclerosis: progress and possibilities

scientific article

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS.

scientific article published on August 2015

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

article

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

scientific article published in Nature Communications

Mutant HSPB8 causes motor neuron-specific neurite degeneration.

scientific article published on 10 June 2010

Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

scientific article

NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons

scientific article published on 14 July 2015

Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration

scientific article

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis ⬇️

scientific article published on January 31, 2013

Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish

article by Robin Lemmens et al published 17 July 2007 in Human Molecular Genetics

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics ⬇️

scientific article published on March 2017

Phasing in on the cell cycle.

scientific article published on 25 January 2018

Polyamine transport systems in the LLC-PK1 renal epithelial established cell line

scientific article published on 01 July 1989

Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis

scientific article

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice

scientific article

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

scientific article published on 26 April 2017

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

scientific article published on 31 March 2008

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy

scientific article

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

scientific article published on 16 October 2018

Prospective exploration of biochemical tissue composition via imaging mass spectrometry guided by principal component analysis.

scientific article

Protective effect of parvalbumin on excitotoxic motor neuron death.

scientific article published in April 2002

Protein Phase Separation: A New Phase in Cell Biology

scientific article published on 27 March 2018

Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration

publication published on 20 June 2020

RNA toxicity in non-coding repeat expansion disorders

scientific article published on 13 November 2019

RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease

scientific article published on 04 December 2019

Rapamycin increases survival in ALS mice lacking mature lymphocytes.

scientific article published on 11 September 2013

Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis

scientific article published on 01 October 2019

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis

scientific article published on 12 July 2019

Regulation of Alternative Splicing of the SERCA2 Pre-mRNA in Muscle

scientific article published on 01 September 1998

Regulation of alternative processing of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2) gene transcripts during muscle differentiation.

scientific article published on January 1998

Regulation of splicing is responsible for the expression of the muscle-specific 2a isoform of the sarco/endoplasmic-reticulum Ca2+-ATPase ⬇️

scientific article published on September 1, 1994

Regulation of the Na(+)-dependent and the Na(+)-independent polyamine transporters in renal epithelial cells (LLC-PK1).

scientific article published on September 1990

Regulation of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 2 gene transcript in neuronal cells ⬇️

scientific article published on March 30, 1998

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model

scientific article published on 05 July 2019

Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

scientific article

Role of heat shock response and Hsp27 in mutant SOD1-dependent cell death.

scientific article published on 27 June 2006

Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis

article

Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons

S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients

scientific article

Sequence and spatial requirements for regulated muscle-specific processing of the sarco/endoplasmic reticulum Ca(2+)-ATPase 2 gene transcript.

scientific article published on May 1995

Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy.

scientific article published in October 2011

Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties

scientific article published on 29 March 2019

Synaptopodin and 4 novel genes identified in primary sensory neurons

scientific article published in September 2005

Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

scientific article published on 29 January 2016

Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane- or Cycloheptane-Annulated 1,5-Benzothiazepine Scaffold

scientific article published on 7 October 2016

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

scientific article published on June 2015

TDP-43 M311V mutation in familial amyotrophic lateral sclerosis.

scientific article published in March 2009

Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse.

scientific article

Testosterone boosts physical activity in male mice via dopaminergic pathways.

scientific article published on 17 January 2018

The cellular mRNA expression of GABA and glutamate receptors in spinal motor neurons of SOD1 mice.

scientific article published on 8 August 2005

The functional importance of the extreme C-terminal tail in the gene 2 organellar Ca(2+)-transport ATPase (SERCA2a/b).

scientific article published on November 1994

The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications

scientific article published on 24 March 2020

The neurobiology of amyotrophic lateral sclerosis.

scientific article published on 07 June 2010

The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding.

scientific article

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

scientific article published on 17 May 2006

Therapeutic potential of HDAC6 in amyotrophic lateral sclerosis

scientific article published on 19 December 2017

Tissue-type plasminogen activator is not required for kainate-induced motoneuron death in vitro

scientific article published on 01 August 1998

Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice.

scientific article published on 20 February 2015

Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS).

scientific article published on 11 July 2014

Transport systems for polyamines in the established renal cell line LLC-PK. Polarized expression of an Na(+)-dependent transporter.

scientific article published on January 1990

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

scientific article

Upregulation of HSP27 in a Transgenic Model of ALS

article

VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation

scientific article

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

scientific article

Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis

scientific article published on 01 October 2007

Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases.

scientific article

Paulina is supported by:

About Paulina

Help