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List of works by Philip Van Damme

A 62-Year-Old Woman with Muscle Weakness

scientific article

A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis

scientific article

A mapping review of international guidance on the management and care of amyotrophic lateral sclerosis (ALS).

scientific article published on 14 April 2016

AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS

scientific article published on 20 January 2021

APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation.

scientific article published on 5 December 2013

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization

scientific article published on 19 May 2020

ATXN2 trinucleotide repeat length correlates with risk of ALS.

scientific article

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

scientific article

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

scientific article

An ALS case with 38 (G4C2)-repeats in the C9orf72 gene shows TDP-43 and sparse dipeptide repeat protein pathology

scientific article published on 27 March 2019

An unusual presentation of Guillain-Barré syndrome associated with monospecific anti-GD1b antibodies

scientific article published on 01 May 2010

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

scientific article published on December 2011

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access: An Editorial Comment for 'The interaction between progranulin and prosaposin is mediated by granulins and the linker reg

scientific article

Anti-HMGCR antibodies as a biomarker for immune-mediated necrotizing myopathies: A history of statins and experience from a large international multi-center study

scientific article published on August 2016

Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis

scientific article published in October 2021

Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis

scientific article published on 31 May 2016

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scientific article

Autosomal recessive spastic ataxia of Charlevoix-Saguenay

scientific article published on 01 May 2009

Awaji criteria improves the diagnostic sensitivity in amyotrophic lateral sclerosis: A systematic review using individual patient data

scientific article

Benefit of the Awaji diagnostic algorithm for amyotrophic lateral sclerosis: a prospective study

scientific article published on 17 March 2011

Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study

scientific article published on 24 January 2009

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis.

scientific article published on 10 December 2013

C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis

scientific article

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

scientific article published on 09 April 2021

C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport

scientific article published on 31 October 2019

Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules

scientific article published on 03 May 2022

Clinical implications of recent breakthroughs in amyotrophic lateral sclerosis ⬇️

scientific article published on October 1, 2013

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

preprint

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scholarly article

Comparison of elevated phosphorylated neurofilament heavy chains in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis

scientific article published on 20 October 2017

Defining Y-SNP variation among the Flemish population (Western Europe) by full genome sequencing.

scientific article published on 28 October 2017

Derivation of norms for the Dutch version of the Edinburgh cognitive and behavioral ALS screen

article by Leonhard A. Bakker et al published 12 October 2018 in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease

scientific article

Diagnostic Challenges and Clinical Characteristics of Hepatitis E Virus-Associated Guillain-Barré Syndrome.

scientific article published on 7 November 2016

Diagnostic yield of testing for RFC1 repeat expansions in patients with unexplained adult-onset cerebellar ataxia

scientific article published on 30 July 2020

Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.

scientific article published on 12 February 2016

EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--revised report of an EFNS task force

scientific article published on 14 September 2011

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

scientific article published in September 2012

Early stages of building a rare disease registry, methods and 2010 data from the Belgian Neuromuscular Disease Registry (BNMDR).

scientific article

Exome sequencing reveals HINT1 mutations as a cause of distal hereditary motor neuropathy

scientific article

Finger extension weakness and downbeat nystagmus motor neuron disease syndrome: A novel motor neuron disorder?

scientific article published on 25 April 2017

Frequency of C9orf72 repeat expansions in amyotrophic lateral sclerosis: a Belgian cohort study

scientific article published on 17 July 2013

G37R SOD1 mutant alters mitochondrial complex I activity, Ca(2+) uptake and ATP production.

scientific article published on 8 March 2011

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

scientific article published on 19 April 2016

Genetic Creutzfeldt-Jakob disease mimicking chronic inflammatory demyelinating polyneuropathy

scientific article published on 29 October 2015

Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice

scientific article published on 04 July 2016

Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice

scientific article

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

scientific article published on 25 July 2016

GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis.

scientific article published in July 2005

H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis

scientific article published on 11 October 2012

HDAC3 Inhibition Stimulates Myelination in a CMT1A Mouse Model

scientific article published on 23 March 2022

HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations

scientific article published on 10 March 2021

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

scientific article published on 11 October 2017

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

article

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.

scientific article published on 30 January 2013

How much of the missing heritability of ALS is hidden in known ALS genes?

scientific article published on 12 April 2018

Identification and characterization of Nanobodies targeting the EphA4 receptor.

scientific article

IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients

scientific article published on 10 December 2016

Inflammatory markers in cerebrospinal fluid: independent prognostic biomarkers in amyotrophic lateral sclerosis?

scientific article published on 07 June 2019

Inside out: the role of nucleocytoplasmic transport in ALS and FTLD

scientific article

Insights into the identification of a molecular signature for amyotrophic lateral sclerosis exploiting integrated microRNA profiling of iPSC-derived motor neurons and exosomes

scientific article published on 14 March 2022

Investigating the Endo-Lysosomal System in Major Neurocognitive Disorders Due to Alzheimer’s Disease, Frontotemporal Lobar Degeneration and Lewy Body Disease: Evidence for SORL1 as a Cross-Disease Gene

scientific article published on 20 December 2021

Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients

scientific article published on 21 December 2016

Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

scientific article published on 12 October 2006

July 2017 ENCALS statement on edaravone

scientific article

Long-lasting changes in GABA responsiveness in cultured neurons

scientific article published in July 2004

Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia

Metabolic Syndrome, Neurotoxic 1-Deoxysphingolipids and Nervous Tissue Inflammation in Chronic Idiopathic Axonal Polyneuropathy (CIAP)

scientific article

Microbleeds and the risk of recurrent stroke

scientific article

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome mimicking herpes simplex encephalitis on imaging studies

scientific article published in March 2013

Modelling amyotrophic lateral sclerosis: progress and possibilities

scientific article

Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS

article

Multicentre quality control evaluation of different biomarker candidates for amyotrophic lateral sclerosis

Myasthenia gravis with muscle specific kinase antibodies mimicking amyotrophic lateral sclerosis

scientific article

NEK1 genetic variability in a Belgian cohort of ALS and ALS-FTD patients

scientific article

NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis

scientific article published on 28 February 2012

Negative commercial screening test for paraneoplastic antibodies in a case of opsoclonus.

scientific article published on 3 February 2017

Neurofilament light chain and C reactive protein explored as predictors of survival in amyotrophic lateral sclerosis

scientific article published on 06 February 2020

Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease.

scientific article published on 12 May 2017

Neurological picture. FDG-PET findings in three cases of Mills' syndrome

scientific article published on 28 April 2015

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice

scientific article

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis

scientific article

Normalization of 14-3-3 in CJD.

scientific article published in June 2008

Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration

scientific article

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis ⬇️

scientific article published on January 31, 2013

PCYT2 mutations disrupting etherlipid biosynthesis: phenotypes converging on the CDP-ethanolamine pathway

scientific article published on 23 November 2020

Pathogenic cysteine mutations affect progranulin function and production of mature granulins

scientific article

Patient-ventilator asynchrony, leaks and sleep in patients with amyotrophic lateral sclerosis

scientific article published on 14 April 2016

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics ⬇️

scientific article published on March 2017

Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis

scientific article

Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.

scientific article published on 8 December 2016

Possible influence of AMPD1 on cholinergic neurotransmission and sleep

scientific article published on 6 October 2015

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice

scientific article

Prognostic value of clinical and electrodiagnostic parameters at time of diagnosis in patients with amyotrophic lateral sclerosis

scientific article published on 15 February 2017

Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats

scientific article published on 19 April 2013

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

scientific article published on 26 April 2017

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy

scientific article

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

scientific article published on 16 October 2018

Prospective Validation of 18F-FDG Brain PET Discriminant Analysis Methods in the Diagnosis of Amyotrophic Lateral Sclerosis.

scientific article

Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration

publication published on 20 June 2020

REVEALS—a longitudinal cohort study of multifaceted respiratory assessment in ALS

scientific article published on 6 June 2024

Randomized cross-over trial of ventilator modes during non-invasive ventilation titration in amyotrophic lateral sclerosis

scientific article

Rapamycin increases survival in ALS mice lacking mature lymphocytes.

scientific article published on 11 September 2013

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

scientific article

Recent advances in motor neuron disease.

scientific article published on October 2009

Respiratory measurements, respiratory symptoms, and quality of life in ALS: results from the REVEALS study

scientific article published on 6 March 2025

Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

scientific article

Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons

Screening for lipoprotein receptor-related protein 4-, agrin-, and titin-antibodies and exploring the autoimmune spectrum in myasthenia gravis.

scientific article published on 17 May 2017

Serum biomarker for progranulin-associated frontotemporal lobar degeneration

scientific article published in May 2009

Sporadic late-onset nemaline myopathy: clinico-pathological characteristics and review of 76 cases

scientific article

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

scientific article published on 28 January 2022

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

scientific article published on 23 December 2016

TDP-43 proteinopathies: a new wave of neurodegenerative diseases

scientific article published on 11 November 2020

TRICALS: creating a highway toward a cure

scientific article published on 09 July 2020

The effect of SMN gene dosage on ALS risk and disease severity

scientific article published on 02 January 2021

The neurobiology of amyotrophic lateral sclerosis.

scientific article published on 07 June 2010

The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding.

scientific article

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

scientific article

Treatment-related peripheral neuropathy in multiple myeloma: the challenge continues

scientific article

UNC13A is a modifier of survival in amyotrophic lateral sclerosis

scientific article published on 25 November 2011

Unraveling the genetic landscape of autosomal recessive Charcot-Marie-Tooth neuropathies using a homozygosity mapping approach

scientific article published on 18 September 2014

Upregulation of HSP27 in a Transgenic Model of ALS

article

VEGF protects motor neurons against excitotoxicity by upregulation of GluR2.

scientific article published on 29 January 2009

Value of 18fluorodeoxyglucose-positron-emission tomography in amyotrophic lateral sclerosis: a prospective study

scientific article

Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases.

scientific article

Whole-genome sequencing reveals a coding non-pathogenic variant tagging a non-coding pathogenic hexanucleotide repeat expansion in C9orf72 as cause of amyotrophic lateral sclerosis

scientific article

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