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List of works by Ruben van Boxtel

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

scientific article published on 11 March 2020

Characterizing Mutational Load and Clonal Composition of Human Blood

scientific article published on 11 July 2019

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

scientific article published on 20 June 2019

Different responses to DNA damage determine ageing differences between organs

scientific article published on 04 March 2022

ENU mutagenesis to generate genetically modified rat models

scientific article published in January 2010

Early divergence of mutational processes in human fetal tissues

scientific article published on 29 May 2019

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells

scientific article

Forkhead Box P family members at the crossroad between tolerance and immunity: a balancing act.

scientific article published on 25 July 2013

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

scientific article published on 07 March 2017

Genome sequencing of normal cells reveals developmental lineages and mutational processes

scientific article published on 29 June 2014

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

scientific article published on January 2013

Genomic landscape of rat strain and substrain variation

scientific article published on 6 May 2015

Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency

scientific article

Identification of multipotent luminal progenitor cells in human prostate organoid cultures

scientific article published on 4 September 2014

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

scientific article

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis

scientific article published on 15 April 2008

Long-term culture of genome-stable bipotent stem cells from adult human liver

scientific article

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

scientific article published on 7 December 2017

Megakaryocyte lineage development is controlled by modulation of protein acetylation

scientific article published on 26 April 2018

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat

scientific journal article

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

scientific article

Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples

scientific article published on 17 October 2010

Mutation signatures of pediatric acute myeloid leukemia and normal blood progenitors associated with differential patient outcomes

scientific article published on 01 September 2021

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

scientific article published on 27 February 2020

MutationalPatterns: comprehensive genome-wide analysis of mutational processes.

scientific article

Organoid models of human and mouse ductal pancreatic cancer

scientific article

Portrait of a cancer: mutational signature analyses for cancer diagnostics

scientific article published on 15 May 2019

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

scientific article published on 18 November 2021

Prime editing for functional repair in patient-derived disease models

scientific article published on 23 October 2020

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

scientific article published on 23 May 2019

Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells

scientific article published on 04 August 2020

Rat traps: filling the toolbox for manipulating the rat genome

scientific article published on 29 September 2010

SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition

scientific article

STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells

Sequential cancer mutations in cultured human intestinal stem cells

scientific article published on 29 April 2015

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

article published in 2018

The forkhead transcription factor FOXP1 represses human plasma cell differentiation

scientific article published on 19 August 2015

The mutational impact of culturing human pluripotent and adult stem cells

scientific article published on 19 May 2020

The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe? ⬇️

scientific article published on December 17, 2012

Tissue-specific mutation accumulation in human adult stem cells during life

scientific article published on 3 October 2016

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney

scientific article published on 13 December 2017

Tubuloids derived from human adult kidney and urine for personalized disease modeling

scientific article published on 04 March 2019

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

scientific article

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