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List of works by Jiří Lukáš

53BP1 fosters fidelity of homology-directed DNA repair

scientific article published on 27 June 2016

53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

scientific article published on 25 February 2019

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

scientific article published on 13 February 2011

A common path to tumor growth

scientific article published on 01 March 1996

A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression

scientific article

A lncRNA to repair DNA.

scientific article published on 29 September 2015

A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes

scientific article

ATM activation in normal human tissues and testicular cancer

scientific article published on 13 June 2005

ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

scientific article

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

scientific article

ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

scientific article published on November 2013

Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines

article

Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer

scientific article published on 01 November 2004

Aberrations of the G1- and G1/S-regulating genes in human cancer

scientific article published on January 1997

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene

scientific article (publication date: December 2008)

Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer

scientific article

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

scientific article

Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response

scientific article published on May 2013

Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases

scientific article published on November 2006

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

scientific article

Alternative splicing and mutation status of CHEK2 in stage III breast cancer

scientific article

Are all cancer genes equal?

scientific article published in Nature

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

scientific article published on 14 February 2003

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

scientific article published on 5 March 2012

BCL-1/cyclin D1 oncoprotein oscillates and subverts the G1 phase control in B-cell neoplasms carrying the t(11;14) translocation

scientific article published on August 1994

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

scientific article

CHEK2 variant I157T may be associated with increased breast cancer risk

scientific article published in September 2004

CHK2 kinase--a busy messenger.

scientific article

Cell biology. Balancing life-or-death decisions

scientific article

Cell biology. The stress of finding NEMO.

scientific article

Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity

scientific article

Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein

scientific article published on 01 March 1994

Cell cycle. Order from destruction

scientific article

Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium

scientific article

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

scientific article

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

scientific article

Checking on DNA damage in S phase

scientific article published in October 2004

Checking out the centrosome

scientific article published on 22 November 2004

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

scientific article published on March 2003

Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events

scientific article published on 25 September 2006

Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

scientific article published on 01 September 2001

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

scientific article published on 23 July 2006

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

scientific article

Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint

scientific article published on December 1996

Correction to Oplustilova L, et al. Cell Cycle Volume 11, Issue 20; pp. 3837–50.

scientific article published on 19 June 2013

Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients

scientific article published in February 2005

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

scientific article

Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

scientific article published on May 1995

Cyclin D1 multitasks

scientific article published in Nature

Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis

scientific article published on 01 February 1995

Cyclin D1 protein expression and function in human breast cancer

scientific article published on 01 May 1994

Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types

scientific article published on June 1995

Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation

scientific article published on August 1998

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

scientific article published in June 1997

DNA damage checkpoints: from initiation to recovery or adaptation

scientific article published on 15 February 2007

DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

scientific article published on 18 July 2007

DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy

scientific article published on 15 June 2007

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

scientific article

DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function

scientific article published on 30 July 2007

DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy

scholarly article by Martin V Bennetzen published in September 2018

DNA damage: a histone-code mediator leaves the stage

scientific article published on 01 May 2008

DNA repair: Damage alert

scientific article published in Nature

DNA repair: New tales of an old tail

scientific article

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1

scientific article

DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

scientific article

Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

scientific article published on March 1996

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

scientific article (publication date: April 2002)

Deregulation of the G1/S-phase control in human testicular germ cell tumours

scientific article

Deregulation of the RB pathway in human testicular germ cell tumours ⬇️

scientific article published on June 1, 2003

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

scientific article

Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway

scientific article

Differentiation-induced radioresistance in muscle cells

scientific article published on July 2004

Dissecting functions of the retinoblastoma tumor suppressor and the related pocket proteins by integrating genetic, cell biology, and electrophoretic techniques

scientific article published on 01 February 1999

Distinct forms of human CDC2 identified by novel monoclonal antibodies

scientific article published on 01 July 1992

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

scientific article published in April 2004

Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines

scientific article published on 01 November 2003

Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.

scientific article

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

scientific article

Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors

scientific article (publication date: 24 March 2000)

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

scientific article

E2F activity is essential for survival of Myc-overexpressing human cancer cells

scientific article

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

scientific article

Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining

scientific article published on 27 April 2015

Efficient transfer of antibodies into mammalian cells by electroporation

scientific article published on April 1994

Enhanced protein stability: a novel mechanism of D-type cyclin over-abundance identified in human sarcoma cells

scientific article published on 01 July 1996

Equilibrium between nascent and parental MCM proteins protects replicating genomes

scientific article published on 21 October 2020

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment

scientific article

Guarding against collateral damage during chromatin transactions

scientific article published on June 2013

HCLK2 is required for activity of the DNA damage response kinase ATR.

scientific article published on 19 December 2008

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

scientific article

Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours

scientific article published on August 2010

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

scientific article

Human Asf1 regulates the flow of S phase histones during replicational stress

scientific article

Human CtIP promotes DNA end resection

scientific article

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

scientific article

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

scientific article

Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint

scientific article

Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks

scientific article published on 16 May 2007

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

scientific article published on October 1995

Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges

scientific article

Immunochemical analysis of the p53 oncoprotein in matched primary and metastatic human tumours.

scientific article published on January 1993

Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies

scientific article published in January 1993

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

scientific article

Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

scientific article

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

scientific article

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks

scientific article published on 17 November 2013

Jiri Lukas: Visualizing genome integrity maintenance. Interview by Caitlin Sedwick

scientific article published on July 2012

LEDGF (p75) promotes DNA-end resection and homologous recombination

scientific article

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).

scientific article

Loss of Geminin induces rereplication in the presence of functional p53

scientific article

Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis

scientific article

Mammalian G1- and S-phase checkpoints in response to DNA damage

scientific article (publication date: December 2001)

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

scientific article published on December 2016

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

scientific article published in August 2004

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

scientific article

Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

scientific article

Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation.

scientific article published on April 1994

Molecular biology. Shielding broken DNA for a quick fix.

scientific article published in February 2013

Molecular pathology of the cell cycle in human cancer cells

scientific article published in May 1993

Monoclonal antibody probes for p21WAF1/CIP1 and the INK4 family of cyclin-dependent kinase inhibitors

scientific article published on February 2000

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

scientific article published on 03 October 2011

NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

scientific article published on 30 May 2008

NQO1 expression correlates inversely with NFκB activation in human breast cancer

article published in 2011

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

scientific article

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

scientific article published on 11 November 2011

Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

scientific article

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

scientific article (publication date: 30 November 2006)

Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control

scientific article published on 01 November 1995

Pathways governing G1/S transition and their response to DNA damage

scientific article (publication date: 16 February 2001)

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

scientific article published on 14 April 2008

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

scientific article

Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.

scientific article

Phyllogenetically conserved epitopes of the keratin 8 polypeptide recognized by a novel set of monoclonal antibodies

scientific article published on January 1991

Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin's lymphomas. Functional studies in a cell line (Granta 519).

scientific article published on January 1997

Profiling DNA damage response following mitotic perturbations

scientific article published on 15 December 2016

Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses

scientific article published on 19 September 2013

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

scientific article

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

scientific article

Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation

scientific article published on July 1998

Rapid destruction of human Cdc25A in response to DNA damage

scientific journal article

Redox-sensitive alteration of replisome architecture safeguards genome integrity

scientific article

Regulated expression of the retinoblastoma susceptibility gene in mammary carcinoma cells restores cyclin D1 expression and G1-phase control

scientific article

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

scientific journal article

Regulation of replication fork progression through histone supply and demand

scientific article

Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

scientific article

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

scientific article published on 28 June 2010

Repression of p15INK4b expression by Myc through association with Miz-1

scientific article (publication date: April 2001)

Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

scientific article published on November 2006

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

scientific article published in Nature

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

scientific article published on February 2011

Sensitivity to growth suppression by 1alpha,25-dihydroxyvitamin D(3) among MCF-7 clones correlates with Vitamin D receptor protein induction

scientific article published on June 2002

Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response

scientific article

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

scientific article (publication date: 24 April 2006)

Structure meets function--centrosomes, genome maintenance and the DNA damage response

scientific article published on 20 June 2006

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

scientific article published on 25 January 2016

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

scientific article

Tethered genes get checked during replication

scientific article published in July 2011

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

scientific article

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

scientific article published on 12 July 2013

The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

scientific article published on 5 November 2007

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

scientific article published on 19 February 2002

The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

scientific article published on 27 July 2014

The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas

scientific article published on 01 August 1994

The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling

scientific article published on 19 September 2013

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

scientific article

The heart of the cycle

scientific article published in Nature

The interface between the ubiquitin family and the DNA damage response ⬇️

scientific article published on November 12, 2010

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

scientific article

The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.

scientific article published on December 1996

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).

scientific article published on November 2002

The retinoblastoma protein modulates expression of genes coding for diverse classes of proteins including components of the extracellular matrix

article

The retinoblastoma protein pathway and the restriction point

scientific article published on December 1996

The retinoblastoma protein pathway in cell cycle control and cancer

scientific article published on November 1997

To spread or not to spread—chromatin modifications in response to DNA damage ⬇️

scientific article published on 09 January 2013

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

scientific article

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

scientific article

Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle

scientific article published on 01 June 2000

Unrestricted cell cycling and cancer

scientific article published on 01 December 1995

Watching the DNA repair ensemble dance

scientific article published in September 2004

p16 and p53 genes transferred with the help of adenovirus to induce apoptic tumor cell death

scientific article published in November 1997

p21WAF1/CIP1 mutants deficient in inhibiting cyclin-dependent kinases (CDKs) can promote assembly of active cyclin D/CDK4(6) complexes in human tumor cells

scientific article published on 01 November 1998

p27 destruction: Cks1 pulls the trigger

scientific article published on 01 April 2001

p53 protein alterations in human testicular cancer including pre-invasive intratubular germ-cell neoplasia

scientific article published on September 1991

p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors

scientific article published in August 2010

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