List of works by Kris Huygen

1,2,3,4,8,9,10,11-octahydrobenzo[j]phenanthridine-7,12-diones as new leads against Mycobacterium tuberculosis.

scientific article

1,4-diarylpiperazines and analogs as anti-tubercular agents: synthesis and biological evaluation.

scientific article

2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.

scientific article

3rd annual DNA vaccines forum

scientific article published in June 2006

A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex.

scientific article published on 10 May 2016

A GRA1 DNA vaccine primes cytolytic CD8(+) T cells to control acute Toxoplasma gondii infection ⬇️

scientific article

A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system

scientific article published in October 1996

A booster vaccination with Mycobacterium bovis BCG does not increase the protective effect of the vaccine against experimental Mycobacterium ulcerans infection in mice

scientific article published on 26 February 2007

A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes

scientific article published on July 2003

A novel and more sensitive loop-mediated isothermal amplification assay targeting IS6110 for detection of Mycobacterium tuberculosis complex

scientific article published on 10 June 2009

A serine/threonine protein kinase from Mycobacterium tuberculosis

scientific journal article

Absence of IgM and IgG Antibody Response to the Three Components of the Mycobacterium bovis BCG 85 Complex Antigen After BCG Vaccination

scientific article published on 01 January 1993

An update on vaccines for tuberculosis - there is more to it than just waning of BCG efficacy with time

scientific article published on 08 September 2012

Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice

scientific article (publication date: 2014)

Anti-mycobacterial activity of 1,3-diaryltriazenes

scientific article

Anti-renin T cells trigger normal B cells to produce anti-renin antibodies and normalize blood pressure in spontaneously hypertensive rats

scientific article published on 01 December 1993

Antigen discovery: a postgenomic approach to paratuberculosis diagnosis

scientific article published in April 2007

Antimycobacterial activity of synthetic pamamycins

scientific article

Biochemical and immunological characterization of a cpn60.1 knockout mutant of Mycobacterium bovis BCG.

scientific article published on 2 December 2010

Biological evaluation of bisbenzaldehydes against four Mycobacterium species

scientific article published on 18 March 2013

Biological evaluation of diazene derivatives as anti-tubercular compounds

scientific article published on 8 January 2014

Bordetella pertussis seroprevalence in Belgian adults aged 20-39 years, 2012.

scientific article published on 27 September 2013

Buruli ulcer

scientific article

Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control

scientific article

Buruli ulcer disease: prospects for a vaccine

scientific article published on 07 February 2009

CORRELATION AND PROGNOSTIC SIGNIFICANCE OF p53, p21WAF1/CIP1 AND Ki-67 EXPRESSION IN PATIENTS WITH SUPERFICIAL BLADDER TUMORS TREATED WITH BACILLUS CALMETTE-GUERIN INTRAVESICAL THERAPY

Capture-Recapture Estimators in Epidemiology with Applications to Pertussis and Pneumococcal Invasive Disease Surveillance.

scientific article

Cellular immune responses induced in cattle by heterologous prime-boost vaccination using recombinant viruses and bacille Calmette-Guérin

scientific article published on July 2004

Cellular immunity confers transient protection in experimental Buruli ulcer following BCG or mycolactone-negative Mycobacterium ulcerans vaccination

scientific article

Characterization of New Alternaria alternata–Specific Rat Monoclonal Antibodies

scientific article published in 2011

Characterization of the culture filtrate-specific cytotoxic T lymphocyte response induced by Bacillus Calmette-Guérin vaccination in H-2b mice

scientific article published on February 1999

Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling

Clinical value of IS6110-based loop-mediated isothermal amplification for detection of Mycobacterium tuberculosis complex in respiratory specimens.

scientific article published on 4 March 2013

Cloning, sequencing, and cell surface expression pattern of bovine immunoreceptor NKG2D and adaptor molecules DAP10 and DAP12.

scientific article published on 26 May 2007

Comparative Analysis of Different Vaccine Constructs Expressing Defined Antigens fromMycobacterium tuberculosis

article

Comparison of IFN-gamma responses to mycobacterial antigens as markers of response to BCG vaccination

scientific article published on January 2008

Correction: Capture-Recapture Estimators in Epidemiology with Applications to Pertussis and Pneumococcal Invasive Disease Surveillance

scientific article published on 18 October 2016

Correlation and prognostic significance of p53, p21WAF1/CIP1 and Ki-67 expression in patients with superficial bladder tumors treated with bacillus Calmette-Guerin intravesical therapy

scientific article published on 01 March 1999

Creating hybrid proteins by insertion of exogenous peptides into permissive sites of a class A beta-lactamase

scientific article published on 11 September 2008

Cross-reactive immune responses against Mycobacterium bovis BCG in mice infected with non-tuberculous mycobacteria belonging to the MAIS-Group

scientific article published in July 1997

DNA injection in combination with electroporation: a novel method for vaccination of farmed ruminants

scientific article published in March 2003

DNA vaccination for the priming of neutralizing antibodies against non-immunogenic STa enterotoxin from enterotoxigenic Escherichia coli

scientific article

DNA vaccines against mycobacterial diseases

scientific article published on June 2006

DNA vaccines against mycobacterial diseases

DNA vaccines against tuberculosis

scholarly article by Nicolas Bruffaerts et al published 22 August 2014 in Expert Opinion on Biological Therapy

DNA vaccines against tuberculosis

scientific article published on 01 January 1998

DNA vaccines: application to tuberculosis

scientific article published on 01 December 1998

Detection of anti-85A and anti-85B IgG antibodies in HIV-infected patients with active pulmonary tuberculosis

article

Detection of mycobacterial antigens present in short-term culture media using particle counting immunoassay

article

Detection of rifampicin and isoniazid resistances of Mycobacterium tuberculosis strains by particle counting immunoassay (PACIA)

scientific article published on 01 June 1997

Development and validation of a triplex real-time PCR for rapid detection and specific identification of M. avium sub sp. paratuberculosis in faecal samples.

scientific article

Development of a Dot-Blot Assay for the Detection of Mould-Specific IgE in the Belgian Population

scientific article published on 22 November 2016

Development of human monoclonal antibodies to diphtheria toxin: A solution for the increasing lack of equine DAT for therapeutic use?

scientific article published on 19 May 2016

Development of luminescent Mycobacterium avium subsp. paratuberculosis for rapid screening of vaccine candidates in mice

scientific article

Differential production of systemic and intralesional gamma interferon and interleukin-10 in nodular and ulcerative forms of Buruli disease

scientific article published on February 2004

Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis

scientific article

Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients

scientific article published on 01 March 1993

Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis

scientific article

Evaluation of the immunogenicity of pBudCE4.1 plasmids encoding mycolyl-transferase Ag85A and phosphate transport receptor PstS-3 from Mycobacterium tuberculosis

scientific article

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

scientific article published on 20 January 2005

Evolution and clinical significance of the T cell proliferative and cytokine response directed against the fibronectin binding antigen 85 complex of bacillus Calmette-Guerin during intravesical treatment of superficial bladder cancer

article

Evolution of cellular and humoral response against Tuberculin and antigen 85 complex during intravesical treatment with BCG of superficial bladder cancer

scientific article published on 01 September 1994

Expression and immunogenicity of Mycobacterium tuberculosis antigen 85 by DNA vaccination

scientific article published on 01 June 1997

Failure of athymic-nude mice sensitized with Bacillus Calmette-Guérin to produce interferon in response to purified protein derivative

scientific article published on 01 February 1983

Fibronectin-binding antigen 85 and the 10-kilodalton GroES-related heat shock protein are the predominant TH-1 response inducers in leprosy contacts

scientific article

Field performance of six Mycobacterium avium subsp. paratuberculosis antigens in a 20h interferon gamma release assay in Belgium

scientific article published on 30 May 2017

Functional characterization of in vivo effector CD4+ and CD8+ T cell responses in acute Toxoplasmosis: An interplay of IFN-γ and cytolytic T cells

article

GRA7 provides protective immunity in cocktail DNA vaccines against Toxoplasma gondii

scientific article published on 01 September 2007

Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adults

scientific article

Genetic resistance of mice to Mycobacterium paratuberculosis is influenced by Slc11a1 at the early but not at the late stage of infection

scientific journal article

Genome Sequences of Four Strains of Mycobacterium avium subsp. hominissuis, Isolated from Swine and Humans, Differing in Virulence in a Murine Intranasal Infection Model

scientific article published on 16 June 2016

Genotyping and strain distribution of Mycobacterium avium subspecies hominissuis isolated from humans and pigs in Belgium, 2011-2013.

scientific article published on January 2016

Heterologous expression of the Mycobacterium tuberculosis gene encoding antigen 85A in Corynebacterium glutamicum

scientific article

Hooping cough in adults, think about it!

scientific article published on April 2013

Humoral and cell mediated immune responses to a pertussis containing vaccine in pregnant and nonpregnant women

scientific article published on 14 July 2015

Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette-Guérin (BCG) in patients with superficial bladder cancer.

scientific article published in July 1997

Humoral responses against the 85A and 85B antigens of Mycobacterium bovis BCG in patients with leprosy and tuberculosis.

scientific article published on June 1992

IFN-γ diagnostic tests in the context of bovine mycobacterial infections in Belgium

article

IL-6 Production in Response to Purified Mycobacterial Heat-Shock Proteins and to Antigen 85 in Leprosy

article

Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter

scientific article

IgG Humoral Response Against the Antigen 85 Complex Homologues in Leprosy

scientific article published on 01 December 1994

Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG

scientific article published on February 2006

Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex

scientific article published on 01 June 1997

Immunogenicity and protective efficacy of DNA vaccines encoding MAP0586c and MAP4308c of Mycobacterium avium subsp. paratuberculosis secretome

article

Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A.

scientific article

Immunogenicity and protective efficacy of a tuberculosis DNA vaccine

scientific article

Immunogenicity and protective efficacy of a tuberculosis DNA vaccine co-expressing pro-apoptotic caspase-3.

scientific article published on 31 January 2008

Immunogenicity and protective efficacy of tuberculosis DNA vaccines combining mycolyl-transferase Ag85A and phosphate transport receptor PstS-3.

scientific article published on July 2006

Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors

scientific article published on 01 January 1999

Immunogenicity and protective efficacy of tuberculosis subunit vaccines expressing PPE44 (Rv2770c).

scientific article published on 24 September 2008

Immunogenicity of eight Mycobacterium avium subsp. paratuberculosis specific antigens in DNA vaccinated and Map infected mice

scientific article published on 28 October 2011

Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice

scientific article

Improved cellular and humoral immune responses against Mycobacterium tuberculosis antigens after intramuscular DNA immunisation combined with muscle electroporation

article

Improved protective efficacy of a species-specific DNA vaccine encoding mycolyl-transferase Ag85A from Mycobacterium ulcerans by homologous protein boosting

scientific article

In silico epitope analysis of unique and membrane associated proteins from Mycobacterium avium subsp. paratuberculosis for immunogenicity and vaccine evaluation

scientific article published on 13 August 2015

Increased B and T Cell Responses in M. bovis Bacille Calmette-Guérin Vaccinated Pigs Co-Immunized with Plasmid DNA Encoding a Prototype Tuberculosis Antigen

scientific article

Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine-treated, Mycobacterium bovis BCG-vaccinated mice

scientific article

Increasing the Vaccine Potential of Live M. bovis BCG by Coadministration with Plasmid DNA Encoding a Tuberculosis Prototype Antigen

scientific article published on 5 March 2014

Induction of cytotoxic T-cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guérin-infected mice

scientific article published on February 1997

Induction of humoral and cellular immune responses by vaccination with M. tuberculosis antigen 85 DNA.

scientific article published on May 1997

Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis

scientific article published in June 2004

Induction of the specific allergic immune response is independent of proteases from the fungus Alternaria alternata

scientific article published on 20 February 2013

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

scientific article

Influence of genes from the major histocompatibility complex on the antibody repertoire against culture filtrate antigens in mice infected with live Mycobacterium bovis BCG

scientific article

Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium

scientific article published on 22 February 2017

Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines

scientific article

Investigation of inflammatory and allergic responses to common mold species: Results from in vitro experiments, from a mouse model of asthma, and from a group of asthmatic patients.

scientific article

Isoelectrophoretic characterization of protein antigens present in mycobacterial culture filtrates and recognized by monoclonal antibodies directed against the Mycobacterium bovis BCG antigen 85 complex

scientific article published in November 1992

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination

scientific article published on 14 May 2007

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice

scientific article

Lymph node targeting of BCG vaccines amplifies CD4 and CD8 T-cell responses and protection against Mycobacterium tuberculosis

scientific article

M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model

scientific article

Mapping of TH1 helper T-cell epitopes on major secreted mycobacterial antigen 85A in mice infected with live Mycobacterium bovis BCG.

scientific article published on February 1994

Mapping of murine Th1 helper T-Cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis

scientific article

Members of the 30- to 32-kilodalton mycolyl transferase family (Ag85) from culture filtrate of Mycobacterium avium subsp. paratuberculosis are immunodominant Th1-type antigens recognized early upon infection in mice and cattle

scientific article published in January 2006

Mice genetically inactivated in interleukin-17A receptor are defective in long-term control of Mycobacterium tuberculosis infection

scientific article published in October 2013

Mucosal and systemic immune responses to Mycobacterium tuberculosis antigen 85A following its co-delivery with CpG, MPLA or LTB to the lungs in mice

scientific article

Mucosal prime-boost vaccination for tuberculosis based on TLR triggering OprI lipoprotein from Pseudomonas aeruginosa fused to mycolyl-transferase Ag85A

scholarly article by Tatiana Gartner et al published July 2007 in immunology Letters

Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice

scientific article

Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence

scientific journal article

Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity

scientific article published on 28 June 2016

Novel GMO-Based Vaccines against Tuberculosis: State of the Art and Biosafety Considerations

scientific article published on 16 June 2014

Novel bacterial delivery system with attenuated Salmonella typhimurium carrying plasmid encoding Mtb antigen 85A for mucosal immunization: establishment of proof of principle in TB mouse model.

scientific article

On the use of DNA vaccines for the prophylaxis of mycobacterial diseases

scientific article

Overexpression of DosR in Mycobacterium tuberculosis does not affect aerobic replication in vitro or in murine macrophages

scholarly article by Mario Alberto Flores-Valdez et al published 24 May 2014 in Annals of Microbiology

Partial reconstitution of the CD4+-T-cell compartment in CD4 gene knockout mice restores responses to tuberculosis DNA vaccines

scientific article

Pathophysiology of Antigen 85 in Patients with Active Tuberculosis: Antigen 85 Circulates as Complexes with Fibronectin and Immunoglobulin G.

scientific article

Pathophysiology of antigen 85 in patients with active tuberculosis: antigen 85 circulates as complexes with fibronectin and immunoglobulin G.

scientific article

Pertussis diagnosis in Belgium: results of the National Reference Centre for Bordetella anno 2015.

scientific article published on 05 June 2017

Pertussis serodiagnosis in Belgium from 1990 to 2009.

scientific article

Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age.

scientific article published on 30 April 2016

Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study

scientific article

Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy

scientific article published on 31 October 2015

PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence

scientific article

Plasmid DNA vaccination

scientific article

Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines

scientific article published on 31 August 2011

Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care

scientific article

Priming but not boosting with plasmid DNA encoding mycolyl-transferase Ag85A from Mycobacterium tuberculosis increases the survival time of Mycobacterium bovis BCG vaccinated mice against low dose intravenous challenge with M. tuberculosis H37Rv

scientific article published on 06 February 2006

Prospects for vaccine development against Buruli disease

scientific article published on August 2003

Protein kinase G from pathogenic mycobacteria promotes survival within macrophages

scientific journal article

Pulmonary necrosis resulting from DNA vaccination against tuberculosis

scientific article

Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

scientific article

Role of the TH1-TH2 balance in the development of autoimmunity in rats

scientific article published on 01 October 1993

Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial

scientific article

Serodiagnosis of whooping cough in Belgium: results of the National Reference Centre for Bordetella pertussis anno 2013.

scientific article

Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis

scientific article

Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice

scientific article published on July 1992

Straightforward palladium-mediated synthesis and biological evaluation of benzo[j]phenanthridine-7,12-diones as anti-tuberculosis agents

scientific article

Structure of the Mycobacterium tuberculosis antigen 88, a protein related to the Escherichia coli PstA periplasmic phosphate permease subunit.

scientific article published on March 1994

Successful alpha-2b-interferon therapy for chronic neutrophilic leukemia

scientific article published on 01 August 1993

Superficial bladder tumors and increased reactivity against mycobacterial antigens before bacillus Calmette-Guerin therapy

scientific article published in June 1998

Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin

scientific article

Synthesis and anti-tubercular activity of N(2)-arylbenzo[g]isoquinoline-5,10-dione-3-iminium bromides

scientific article published on 14 January 2016

Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine

scientific article

T cell reactivity against antigen 85 but not against the 18- and 65-kD heat shock proteins in the early stages of acquired immunity against Mycobacterium leprae

scientific article published on 01 April 1994

T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections

scientific article

T-cell stimulation with purified mycobacterial antigens in patients and healthy subjects infected with Mycobacterium leprae: secreted antigen 85 is another immunodominant antigen

scientific article published in August 1993

T-cell-epitope mapping of the major secreted mycobacterial antigen Ag85A in tuberculosis and leprosy.

scientific article

TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease

scholarly article by Abdelhadi Saoudi et al published December 1993 in European Journal of Immunology

Targeting the deep lungs, Poloxamer 407 and a CpG oligonucleotide optimize immune responses to Mycobacterium tuberculosis antigen 85A following pulmonary delivery

scientific article

The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam

scientific article published on December 2016

The Immunodominant T-Cell Epitopes of the Mycolyl-Transferases of the Antigen 85 Complex of M. tuberculosis

scientific article

The humoral immune response after BCG vaccination: an immunoblotting study using two purified antigens

scientific article published on 01 June 1992

The major secreted antigen complex (Ag 85) from Mycobacterium bovis bacille Calmette-Guérin is associated with protective T cells in leprosy: a follow-up study of 45 household contacts

scientific article

Three different putative phosphate transport receptors are encoded by the Mycobacterium tuberculosis genome and are present at the surface of Mycobacterium bovis BCG

scientific journal article

Trend analysis suggested a change in subspecies among Mycobacterium avium isolated from pigs in Belgium, 1967-2013.

scientific article published on 10 March 2017

Use of Mycobacterium avium subsp. paratuberculosis specific coding sequences for serodiagnosis of bovine paratuberculosis

scientific article published on 24 September 2008

Use of Strep-tag II for rapid detection and purification of Mycobacterium tuberculosis recombinant antigens secreted by Streptomyces lividans

scientific article published on 17 June 2013

Vaccination against paratuberculosis

scientific article published on August 2008

Vaccination of guinea pigs with DNA encoding Ag85A by gene gun bombardment

article

Vaccination with plasmid DNA encoding mycobacterial antigen 85A stimulates a CD4+ and CD8+ T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection

scientific article

Validation of a medium-throughput method for evaluation of intracellular growth of Mycobacterium tuberculosis.

scientific article

Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection

scientific article

[The need of prolonged BCG treatment in superficial bladder cancer is suggested by the development of a peripheral immune response induced by BCG]

scientific article published on 01 March 1997

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