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List of works by Michael Botchan

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

scientific article published on 08 October 2013

A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity

scientific article

A new class of disordered elements controls DNA replication through initiator self-assembly

scientific article published on 27 September 2019

A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention

scientific article published in May 1997

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

scientific article

Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1.

scientific article published on July 1994

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

scientific article published in January 2010

Assembly of functionally active Drosophila origin recognition complex from recombinant proteins

scientific article

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

scientific article

CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex

scientific article published on 27 September 2005

CRISPR germline engineering--the community speaks

scientific article published on May 2015

Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.

scientific article

Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase

scientific article

Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex.

scientific article

Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment

scientific article

Climate change and the integrity of science

scientific article

Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.

scientific article

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

Crystal structure of the eukaryotic origin recognition complex

scientific article

DNA Replication: Making Two Forks from One Prereplication Complex ⬇️

scientific article published on December 22, 2010

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.

scientific article

DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding

scientific article published on 05 February 2004

DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects.

scientific article published on October 1993

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

scientific article published on May 1991

Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.

scientific article

Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication

scientific article published on July 2004

Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex

scientific article

E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes

scientific article

Functional analysis of mutant and wild-type Drosophila origin recognition complex

scientific article

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells

scientific article

Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes

scientific article

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

scientific article

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

scientific article

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

scientific article

Mechanisms and regulation of DNA replication initiation in eukaryotes

scientific article published on 17 January 2017

Mechanisms for initiating cellular DNA replication

scientific article published on 16 February 2017

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

scientific article published on 01 September 2019

Not just Salk

scientific article published in September 2017

Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.

scientific article published on 9 July 2006

Role for a Drosophila Myb-containing protein complex in site-specific DNA replication.

scientific article published in December 2002

Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation ⬇️

scientific article published on April 14, 1998

Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping

scientific article published on 11 September 2008

Site-specific DNA-binding proteins important for replication and transcription have multiple activities

scientific article published on 01 January 1993

Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.

scientific article published on March 2011

Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association

scientific article

The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase

scientific article

The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site.

scientific article published on March 1993

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.

scientific article published on 02 August 2004

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

scientific article

The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops

scientific article published on April 1991

The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase

scientific article

The minichromosome maintenance replicative helicase

scientific article

The retinoblastoma gene product regulates Sp1-mediated transcription

scientific article published on June 1992

The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

scientific article

Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition

scientific article

cis-Acting components of human papillomavirus (HPV) DNA replication: linker substitution analysis of the HPV type 11 origin

scientific article published on February 1995

humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila

scientific article published in April 2005

p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner

scientific article

trans Activation of the simian virus 40 enhancer

scientific article published on April 1986

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