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List of works by Jean Davignon

3FS07-5 NARC-1: A potential new target for drug therapy of hypercholesterolemia

A new method for measurement of total plasma PCSK9: clinical applications

scientific article published on January 2010

ACAT activity in freshly isolated human mononuclear cell homogenates from hyperlipidemic subjects ⬇️

scientific article published on 01 February 1992

An improved radiological method for the evaluation of Achilles tendon xanthomatosis ⬇️

scientific article published on January 6, 1973

An unusual band that binds hemoglobin after ultracentrifugation of hemolyzed plasma for lipoprotein separation

scientific article

Analytical isoelectric focusing with immobilized pH gradients of human apolipoprotein E from very low density lipoproteins and total plasma

scientific article published on 01 January 1990

Angiotensin converting enzyme insertion/deletion polymorphism in French Canadian subjects with premature coronary artery disease

scientific article published on 01 May 1998

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

scientific article

Apo E allele frequency in primary endogenous hypertriglyceridemia (type IV) with and without hyperapobetalipoproteinemia

scientific article published on 01 November 1985

ApoE phenotype influences plasma ASP in hyperapoB subjects ⬇️

scientific article published on October 1, 2003

Apolipoprotein E and atherosclerosis: insight from animal and human studies

scientific article

Apolipoprotein E limits oxidative stress-induced cell dysfunctions in human adipocytes.

scientific article

Apolipoprotein E phenotyping with a single gel method: application to the study of informative matings

scientific article published on 01 August 1983

Apolipoprotein E polymorphism and atherosclerosis

scientific article published on 01 January 1988

Apolipoprotein E polymorphism and atherosclerosis: insight from a study in octogenarians

scientific article published on January 1988

Apolipoprotein E polymorphism and heterozygous familial hypercholesterolemia. Sex-specific effects

scientific article published on 01 October 1994

Apolipoprotein E polymorphism and plasma cholesterol response to probucol

scientific article published on 01 August 1987

Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia

scientific article published on 01 March 1991

Apolipoprotein(a) is present in the triglyceride-rich fraction in type IV hypertriglyceridemia

scientific article published on 01 February 1993

Association of an exon 3 mutation (Trp66-->Gly) of the LDL receptor with variable expression of familial hypercholesterolemia in a French Canadian family

scientific article published on 01 February 1997

Canadian Cardiovascular Society position statement on familial hypercholesterolemia

scientific article

Cardiovascular risk factors and lipoprotein profile in French Canadians with premature CAD: impact of the National Cholesterol Education Program II.

scientific article

Changes in total and central fat mass after a hypocaloric diet associate with changes of apoC-I in postmenopausal obese women

scientific article published on 17 June 2014

Characterization of a new LCAT mutation causing familial LCAT deficiency (FLD) and the role of APOE as a modifier gene of the FLD phenotype.

scientific article

Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects ⬇️

scientific article published on 01 April 1991

Characterization of human plasma apolipoprotein E-containing lipoproteins in the high density lipoprotein size range: focus on pre-beta1-LpE, pre-beta2-LpE, and alpha-LpE.

scientific article published in January 1997

Characterization of inherited scavenger receptor overexpression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthomas

scientific article published on 01 July 1996

Cholesteryl sulfate; measurement with β-sitosteryl sulfate as an internal standard ⬇️

scientific article published on 01 August 1981

Clearance of Plasma Proprotein Convertase Subtilisin/Kexin 9 by Low-Density Lipoprotein Apheresis

scientific article published on 01 June 2014

Coexisting dysbetalipoproteinemia and familial hypercholesterolemia. Clinical and laboratory observations

scientific article published on 01 January 2000

Combined electrophoresis and ultracentrifugation in diagnosis of primary hyperlipidemia

scientific article published on 01 November 1971

Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia

article

Cyclic fluctuations in human serum lipid and apolipoprotein levels during the normal menstrual cycle: comparison with changes occurring during oral contraceptive therapy

scientific article published on 01 August 1991

Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins

scientific article

Diet and probucol in lowering cholesterol concentrations. Additive effects on plasma cholesterol concentrations in patients with familial type ii hyperlipoproteinemia

scientific article

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations

scientific article published on 10 May 2013

Differential effects of oxidized LDL on apolipoprotein AI and B synthesis in HepG2 cells.

scientific article published on 3 June 2006

Discussion on endocrine physiology and intermediary metabolism

scientific article published on 01 April 1968

Effect of atorvastatin on ApoE and ApoC-I synthesis and secretion by THP-1 macrophages

scientific article published in August 2003

Effect of atorvastatin on plasma apoE metabolism in patients with combined hyperlipidemia

scientific article published in September 2002

Effect of exercise training on in vitro LDL oxidation and free radical-induced hemolysis: the HERITAGE Family Study

scientific article published on 01 January 2007

Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health

scientific article

Effect of methyl linoleate administration on phospholipid fatty acid composition and osmotic fragility of erythrocytes in essential fatty acid deficient rats

scientific article published on 01 January 1983

Effect of micronized fenofibrate on plasma lipoprotein levels and hemostatic parameters of hypertriglyceridemic patients with low levels of high-density lipoprotein cholesterol in the fed and fasted state

scientific article

Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study

scientific article published on 19 September 2006

Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial

scientific article

Efficacy and Safety of a New Hydroxymethylglutaryl-Coenzyme A Reductase Inhibitor, Atorvastatin, in Patients with Combined Hyperlipidemia: Comparison with Fenofibrate ⬇️

scientific article published on September 1, 1997

Efficacy and short-term safety of a new ACAT inhibitor, avasimibe, on lipids, lipoproteins, and apolipoproteins, in patients with combined hyperlipidemia

scientific article

Enrichment of Triglyceride-Rich Lipoproteins with Apolipoprotein C-I Is Positively Associated with Their Delayed Plasma Clearance Independently of Other Transferable Apolipoproteins in Postmenopausal Overweight and Obese Women

scientific article published on 29 March 2017

Evaluating the incremental benefits of raising high-density lipoprotein cholesterol levels during lipid therapy after adjustment for the reductions in other blood lipid levels

scientific article published on October 2009

Evidence for a cholesterol-lowering gene in a French-Canadian kindred with familial hypercholesterolemia ⬇️

scientific article published on 01 July 1995

Experience with probucol in the treatment of hypercholesterolemia

scientific article published on 01 January 1982

Failure to isolate cortisol from a pheochromocytoma

scientific article published on 01 November 1960

Familial HDL deficiency characterized by hypercatabolism of mature apoA-I but not proapoA-I

scientific article published on 01 April 1998

Fish-oil supplementation reduces Ip(a) concentrations in type III dysbetalipoproteinemia

scientific article published on 01 August 1992

Gene set enrichment analyses revealed several affected pathways in Niemann-pick disease type C fibroblasts

scientific article published on 01 September 2007

Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells

scientific article

Genealogy and regional distribution of lipoprotein lipase deficiency in French-Canadians of Quebec

scientific article published on 01 February 1993

Genetic epidemiology of lipoprotein lipase deficiency in Saguenay-Lac-St-Jean (Québec, Canada).

scientific article published in January 1992

Guanethidine administration in 28 hypertensive patients ⬇️

scientific article published in September 1960

Halofenate versus clofibrate in the management of true diabetes insipidus.

scientific article

High expression of apolipoprotein E impairs lipid storage and promotes cell proliferation in human adipocytes.

scientific article

High-density lipoprotein particles in octogenarians

scientific article published on December 1991

Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate

scientific article published on 01 June 1995

Homozygous familial hypercholesterolemia among French Canadians in Québec Province

scientific article published on 01 March 1989

Hypertriglyceridemia induced by carbohydrates in primary hyperlipoproteinemia

scientific article published on April 1, 1977

Hypocholesterolaemia in chronic Hepatitis C virus (HCV) infection – Reduced production or increased LDL clearance?

Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins

scientific article published on 01 January 1995

Identification of a gamma-interferon-responsive element in the promoter of the human macrophage scavenger receptor A gene.

scientific article published on May 2001

Increased apoC-III production is a characteristic feature of patients with hypertriglyceridemia

scientific article published in November 2004

Influence of a triphasic oral contraceptive preparation on plasma lipids and lipoproteins

scientific article published on 01 January 1990

Influence of genetic variability in the nondeletion LDL-receptor allele on phenotypic variation in French-Canadian familial hypercholesterolemia heterozygotes sharing a 'null' LDL-receptor gene defect

scientific article published on 01 January 1996

Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients

scientific article published on 01 December 1993

Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance

scientific article

Interaction of two lipid disorders in a large French-Canadian kindred.

scientific article published in January 1983

Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells

scientific article published on 01 December 2000

Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects

scientific article published on 01 February 1996

Lecithin: cholesterol acyltransferase activity and fatty acid composition of erythrocyte phospholipids in Friedreich's ataxia

scientific article published on 01 November 1980

Lipoprotein composition changes induced by fenofibrate in dysbetalipoproteinemia type III

scientific article published on 01 August 1989

Lipoprotein lipase gene mutations in coronary artery disease

scientific article published on May 1, 1998

Lp(a) levels and atherosclerotic vascular disease in a sample of patients with familial hypercholesterolemia sharing the same gene defect

scientific article published in January 1996

Metabolic factors clustering, lipoprotein cholesterol, apolipoprotein B, lipoprotein (a) and apolipoprotein E phenotypes in premature coronary artery disease in French Canadians.

scientific article published in March 1997

Moderate intake of n-3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjects

scientific article published on 01 October 2001

Modulation of chylomicron remnant metabolism by an hepatic hydroxymethylglutaryl coenzyme A reductase inhibitor

scientific article published on March 1990

Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis ⬇️

scientific article published on 01 April 1992

Most biological effects of zinc deficiency corrected by γ-linolenic acid (18: 3ω6) but not by linoleic acid (18: 2ω6) ⬇️

scientific article published on 01 February 1982

Mutations of low-density-lipoprotein-receptor gene, variation in plasma cholesterol, and expression of coronary heart disease in homozygous familial hypercholesterolaemia

scientific article published on 01 May 1993

New methods for rapid detection of low-density lipoprotein receptor and apolipoprotein B gene mutations causing familial hypercholesterolemia

scientific article published on 01 June 1995

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture

scientific article published on 3 August 2011

Oxidative stress leads to cholesterol accumulation in vascular smooth muscle cells

scientific article published on July 1999

PCSK9 R46L, lower LDL, and cardiovascular disease risk in familial hypercholesterolemia: a cross-sectional cohort study

scientific article published on 02 October 2014

PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: evidence for genotype-specific regulation of lipoprotein metabolism.

scientific article published on 21 November 2014

Parallel biochemical and histochemical studies of an adrenocortical adenoma from a patient with primary aldosteronism

scientific article published on 01 October 1961

Patterns of association between genetic variability in apolipoprotein (apo) B, apo AI-CIII-AIV, and cholesterol ester transfer protein gene regions and quantitative variation in lipid and lipoprotein traits: influence of gender and exogenous hormones ⬇️

scientific article published on January 1, 1992

Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents

scientific article

Plasma apolipoproteins

scientific article published on December 1, 1976

Plasma apolipoproteins in dyslipoproteinemias. III. Classical hyperlipemias

scientific article published on 01 March 1978

Plasma apoproteins in dyslipoproteinemias. I. The hypolipidemias

scientific article published on July 1, 1977

Plasma cholesteryl sulfate in Friedreich's ataxia

scientific article published on 01 November 1984

Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism

scientific article published on 01 July 2003

Plasma concentration of apolipoprotein E in intermediate-sized remnant-like lipoproteins in normolipidemic and hyperlipidemic subjects

scientific article published on 01 January 1996

Plasma kinetics of VLDL and HDL apoC-I in normolipidemic and hypertriglyceridemic subjects

scientific article published in October 2002

Plasma lipids and lipoprotein patterns in angiographically graded atherosclerosis of the legs and in coronary heart disease

scientific article published in June 1977

Plasma remnant-like particle lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects ⬇️

scientific article published on July 1, 1998

Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits

scientific article published in October 1996

Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans: in vivo evidence for a link between HDL apoC-III and apoA-I metabolism

scientific article published on 16 July 2003

Post-transcriptional regulation of apoC-I synthesis and secretion in human HepG2 cells

scientific article published in February 2005

Preliminary study of the characteristics of the blood lipid pattern as related to the presence of the corneal ring in a group of Haitians

scientific article published on 01 September 1975

Prevalence of Double Pre-Beta Lipoproteinemia in Hyperlipidemic Patients Is Influenced by Gender, Menopausal Status, and ApoE Phenotype ⬇️

scientific article published on November 1, 1997

Prevalence of alleles encoding defective lipoprotein lipase in hypertriglyceridemic patients of French Canadian descent

scientific article published on 01 January 1995

Probucol protects lipoprotein (a) against oxidative modification

scientific article published on November 1, 1992

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

scientific article

Pseudo type III dyslipoproteinemia is associated with normal fibroblast lipoprotein receptor activity ⬇️

scientific article published on July 11, 1997

Rapid measurement of erythrocyte osmotic fragility

scientific article published on 01 February 1984

Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensit

scientific article

Reference values of plasma apolipoproteins A-I and B, and association with nonlipid risk factors in the populations of two Canadian provinces: Quebec and Saskatchewan. Canadian Heart Health Surveys Research Group

scientific article published in April 1999

Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype

scientific article published on 3 June 2013

Relationship between plasma cholesterol levels and cholesterol esterification in isolated human mononuclear cells

scientific article published on 01 January 1990

Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state

scientific article published in September 2000

Residual macrovascular risk in 2013: what have we learned?

scientific article

Response to HMG CoA reductase inhibitors in heterozygous familial hypercholesterolemia due to the 10-kb deletion ("French Canadian mutation") of the LDL receptor gene

scientific article published on 01 August 1994

STATINS AND EZETIMIBE UPREGULATE PLASMA PCSK9

Secreted apolipoprotein E reduces macrophage-mediated LDL oxidation in an isoform-dependent way.

scientific article published on November 2003

Severe familial HDL deficiency in French-Canadian kindreds. Clinical, biochemical, and molecular characterization

scientific article published in August 1995

Severe oily ichthyosis in monozygotic twins mimicking Chanarin-Dorfman syndrome but not associated with a mutation of the CGI58 gene

scientific article published on 01 March 2006

Short-term response to dietary counseling of hyperlipidemic outpatients of a lipid clinic

scientific article published on 01 June 1994

Simple, reproducible procedure for selective measurement of lipoprotein lipase and hepatic lipase

scientific article published on 01 January 1983

Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages

scientific article published on 01 January 1993

Sources of variation in plasma lipid and lipoprotein traits in a sample selected for health

scientific article published on 01 December 1999

Statin therapy in Canadian patients with hypercholesterolemia: the Canadian Lipid Study -- Observational (CALIPSO).

scientific article published in November 2005

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

scientific article

Storage of human plasma samples leads to alterations in the lipoprotein distribution of apoC-III and apoE.

scientific article

Studies on a new hypotensive agent: bretylium tosylate.

scientific article published in April 1960

Studies on the in vitro production of corticosteroids by adrenal glands from normotensive individuals and hypertensive patients

scientific article published on 01 February 1962

Synthesis and secretion of apoC-I and apoE during maturation of human SW872 liposarcoma cells

scientific article published in November 2004

Tendon xanthomas associated with cholestanolosis and hyperapobetalipoproteinemia

scientific article published on 01 January 1986

The effect of insulin on circulating PCSK9 in postmenopausal obese women

scientific article published on 8 April 2014

The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis

scientific article published on September 2010

The relation between triglyceride synthesis in peripheral tissues and postprandial plasma triglyceride levels: preliminary evidence of a role for acylation stimulating protein

scientific article published on April 1, 1992

The response to lovastatin treatment in patients with heterozygous familial hypercholesterolemia is modulated by apolipoprotein E polymorphism

scientific article published on 01 July 1993

Triglycerides: a risk factor for coronary heart disease

scientific article published on 01 July 1996

Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the proposed catalytic triad of human lipoprotein lipase. In vivo evidence that aspartic acid 156 is essential for catalysis ⬇️

scientific article published on January 25, 1992

Two new large deletions in the low density lipoprotein receptor (LDLR) gene not revealed by PCR-based molecular diagnosis of familial hypercholesterolemia.

scientific article

Unexpected consequences of deletion of the first two repeats of the ligand-binding domain from the low density lipoprotein receptor. Evidence from a human mutation

scientific article published on 01 October 1995

Usefulness of probucol in treating primary hypercholesterolemia

scientific article

WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects

scientific article published on 03 April 2016

White Adipose Tissue Apolipoprotein C-I Secretion in Relation to Delayed Plasma Clearance of Dietary Fat in Humans ⬇️

scientific article published on September 20, 2012

Xanthoma and atherosclerosis in the presence of normal plasma lipids

scientific article published on January 1983

[Clinical evaluation of dexamethasone.]

scientific article published on 01 September 1959

[Nutritional aspects of managing hyperlipidemias and atherosclerosis]

scientific article published on 01 May 1980

[Primary hyperaldosteronism. A review of the medical literature from 1995 to June 1958.]

scientific article published on 01 December 1959

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