List of works by M. Arfan Ikram

12-year trajectories of depressive symptoms in community-dwelling older adults and the subsequent risk of death over 13 years

scientific article

A Transfer-Learning Approach to Image Segmentation Across Scanners by Maximizing Distribution Similarity

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

scientific article published on 19 June 2017

A functional variant in the miR-142 promoter modulating its expression and conferring risk of Alzheimer disease

scientific article published on 07 August 2019

A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly

scientific article published on 18 February 2014

A genome-wide association study identifies five loci influencing facial morphology in Europeans

scientific article

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A healthy diet in women is associated with less facial wrinkles in a large Dutch population-based cohort.

scientific article published on 27 March 2018

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

A novel Alzheimer disease locus located near the gene encoding tau protein.

scientific article

A study of the SORL1 gene in Alzheimer's disease and cognitive function

scientific article published in January 2009

A systematic evaluation of stroke surveillance studies in low- and middle-income countries

scientific article published on February 2013

ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study

scientific article published on 27 October 2016

ATP5H/KCTD2 locus is associated with Alzheimer's disease risk.

scientific article

Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods

scientific article published on 10 March 2010

Adherence to the 2015 Dutch dietary guidelines and risk of non-communicable diseases and mortality in the Rotterdam Study

scientific article

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

scientific article

Adverse outcomes of frailty in the elderly: the Rotterdam Study

scientific article

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

scientific article published on 23 February 2015

Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.

scientific article published on 09 April 2013

Alzheimer's disease genes and cognition in the nondemented general population

scientific article published on 15 May 2012

Anthropometric measures in cardiovascular disease prediction: comparison of laboratory-based versus non-laboratory-based model

article

Anxiety does not predict mortality. A population-based study

scientific article published in February 2015

Anxiety is not associated with the risk of dementia or cognitive decline: the Rotterdam Study

scientific article

Apolipoprotein E genotype influences spatial distribution of cerebral microbleeds

scientific article

Arterial Stiffness and Decline in Kidney Function

scientific article published on 12 November 2015

Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study

scientific article published on 9 August 2012

Assessment of cerebral small vessel disease predicts individual stroke risk

scientific article published on 23 August 2012

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

scientific article

Association of Adherence to a Healthy Diet with Cognitive Decline in European and American Older Adults: A Meta-Analysis within the CHANCES Consortium

scientific article

Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

scientific article

Association of HSP70 and its co-chaperones with Alzheimer's disease

scientific article

Association of Uric Acid Genetic Risk Score With Blood Pressure

Association of common genetic variants with brain microbleeds: A Genome-wide Association Study

scientific article published on 10 September 2020

Association of heat shock proteins with Parkinson's disease

scientific article published on 26 November 2011

Association of renal function with vascular stiffness in older adults: the Rotterdam study

scientific article published on 21 August 2014

Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia

scientific article published on 20 October 2011

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

article

Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium

scientific article

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline

scholarly article by Daniel Bos et al published June 2015 in Alzheimer's and Dementia

Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging

scientific article

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 01 May 2019

Automated measurement of local white matter lesion volume.

scientific article published on 11 November 2011

Better diet quality relates to larger brain tissue volumes

scientific article published on 16 May 2018

Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

Brain Volumes, Cognitive Decline, and Physical Activity in Older Inhabitants

article published in 2019

Brain cortical thickness in the general elderly population: the Rotterdam Scan Study

scientific article published on 3 July 2013

Brain tissue volumes and small vessel disease in relation to the risk of mortality

Brain tissue volumes in relation to cognitive function and risk of dementia.

scientific article published on 23 May 2008

Brain tissue volumes in the general elderly population. The Rotterdam Scan Study

scientific article

CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers

scientific article published on 19 May 2020

Calcification in major vessel beds relates to vascular brain disease

scientific article published on 25 August 2011

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.

scientific article published on 4 January 2018

Cardiovascular risk factors and future risk of Alzheimer's disease

scientific article

Carotid Plaque Morphology and Ischemic Vascular Brain Disease on MRI.

scientific article published on 13 July 2017

Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration

scientific article

Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis.

scientific article published on 18 November 2009

Cerebral hemodynamics and incident depression: the Rotterdam Study

scientific article published on 28 February 2012

Cerebral microbleeds and the risk of mortality in the general population

scientific article

Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study

scientific article

Cerebral microbleeds are related to loss of white matter structural integrity

scientific article published on 30 October 2013

Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection

scientific article published on 19 May 2008

Cerebral small vessel disease genomics and its implications across the lifespan

scientific article published on 08 December 2020

Cerebral vasomotor reactivity and risk of mortality: the Rotterdam Study

scientific article

Changes in normal-appearing white matter precede development of white matter lesions

scientific article published on 21 February 2013

Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy

scientific article published on 24 May 2017

Chronic obstructive pulmonary disease and cerebral microbleeds. The Rotterdam Study

scientific article published in October 2013

Circulating Levels of Interleukin 1-Receptor Antagonist and Risk of Cardiovascular Disease: Meta-Analysis of Six Population-Based Cohorts

scientific article

Circulating biomarkers of immunity and inflammation, risk of Alzheimer's disease, and hippocampal volume: a Mendelian randomization study

scientific article published on 17 May 2021

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

scientific article

Circulating metabolites are associated with brain atrophy and white matter hyperintensities

scientific article published on 04 September 2020

Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study

scientific article published on 26 September 2013

Coffee consumption and incident dementia

scholarly article by Saira Saeed Mirza et al published 26 August 2014 in European Journal of Epidemiology

Cognition and gait show a distinct pattern of association in the general population

scientific article published on 10 July 2013

Cognition, structural brain changes and complicated grief. A population-based study

scientific article published on 3 November 2014

Cognitive and physical impairment and the risk of stroke - A prospective cohort study

scientific article published on 14 April 2020

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

scientific article published on 10 June 2020

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

article by Padhraig Gormley et al published September 2018 in Neuron

Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: the USE-IMT initiative.

scientific article

Common carotid intima-media thickness measurements do not improve cardiovascular risk prediction in individuals with elevated blood pressure: the USE-IMT collaboration.

scientific article

Common genetic variants influence human subcortical brain structures

scientific article

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

scientific article published on 8 November 2011

Common variants at 12q14 and 12q24 are associated with hippocampal volume

scientific article

Common variants at 12q15 and 12q24 are associated with infant head circumference

scientific article published on 15 April 2012

Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

scientific article published on 2 September 2012

Common variants at 6q22 and 17q21 are associated with intracranial volume

scientific article published on 15 April 2012

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

scientific article published on 7 June 2021

Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease

scientific article

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.

scientific article

Comparative effectiveness and cost-effectiveness of computed tomography screening for coronary artery calcium in asymptomatic individuals

scientific article

Comparing a marginal structural model with a Cox proportional hazard model to estimate the effect of time-dependent drug use in observational studies: statin use for primary prevention of cardiovascular disease as an example from the Rotterdam Study

article

Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study).

scientific article published on 2 October 2013

Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies

scientific article published on September 2014

Correction: Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo.

scientific article

Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

scientific article published in PLoS ONE

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 7 July 2017

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

scientific article published on 21 October 2019

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

scientific article

Dairy products and the risk of stroke and coronary heart disease: the Rotterdam Study

scientific article published on 9 October 2014

Depressive symptoms predict incident dementia during short- but not long-term follow-up period.

scientific article published on 12 February 2014

Design of a frailty index among community living middle-aged and older people: The Rotterdam study

scientific article published on 12 December 2016

Determinants of cerebellar and cerebral volume in the general elderly population

scientific article published on 8 March 2012

Determinants, MRI Correlates, and Prognosis of Mild Cognitive Impairment: The Rotterdam Study

Development and External Validation of a Deep Learning Algorithm for Prognostication of Cardiovascular Outcomes

scientific article published on 19 August 2019

Development and verification of prediction models for preventing cardiovascular diseases

scientific article published on 19 September 2019

Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study

scientific article published on 08 August 2020

Dietary patterns and changes in frailty status: the Rotterdam study.

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Disability and not osteoarthritis predicts cardiovascular disease: a prospective population-based cohort study.

scientific article published on 2 January 2014

Diversity, compositional and functional differences between gut microbiota of children and adults

scientific article published on 23 January 2020

Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium

scientific article

EN-RAGE: a novel inflammatory marker for incident coronary heart disease

scientific article published on 23 October 2014

Effect of genetic variants associated with plasma homocysteine levels on stroke risk

scientific article

Erratum: Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function and bipolar disorder susceptibility

scholarly article published in Molecular Psychiatry

Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

scholarly article published in Nature Genetics

Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume

article

Erratum: Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

scientific article published in October 2016

Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

scientific article published in September 2017

Erratum: Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

article

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease

scientific article published on 18 June 2016

Exercise interventions for the prevention of depression: a systematic review of meta-analyses

scientific article published on 18 August 2020

Exome Chip Analysis Identifies Low-Frequency a on Brain Magnetic Imaging

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

scientific article published on 06 June 2019

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

scientific article published on 01 September 2019

Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.

scientific article published on 19 July 2016

Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality

scientific article

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo

scientific article published in October 2010

GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

scientific article

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

article

Gait characteristics in older adults with diabetes and impaired fasting glucose: The Rotterdam Study

scientific article published on 20 October 2015

Gait patterns associated with thyroid function: The Rotterdam Study

scientific article published on 14 December 2016

Gait patterns in a community-dwelling population aged 50 years and older

scientific article published on 25 September 2012

Gait shows a sex-specific pattern of associations with daily functioning in a community-dwelling population of older people

article published in 2015

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

scientific article published on 8 December 2015

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

scientific article

Genes from a translational analysis support a multifactorial nature of white matter hyperintensities

scientific article

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

scholarly article published 28 August 2017

Genetic Determinants of Circulating Estrogen Levels, and Evidence of a Causal Effect of Estradiol on Bone Density in Men.

scientific article published on 9 January 2018

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

article published in 2018

Genetic Variants in MicroRNAs and Their Binding Sites Are Associated with the Risk of Parkinson Disease

scientific article published on 16 December 2015

Genetic analysis for a shared biological basis between migraine and coronary artery disease

scientific article published on June 2015

Genetic architecture of subcortical brain structures in 38,851 individuals

scientific article published on 21 October 2019

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).

scientific article

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

scientific article published on 22 September 2020

Genetic determinants of von Willebrand factor plasma levels and the risk of stroke: the Rotterdam Study

scientific article

Genetic diversity is a predictor of mortality in humans

scientific article

Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification

scientific article published on 16 December 2012

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus

scientific article

Genetic overlap between diagnostic subtypes of ischemic stroke

scientific article

Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population

scientific article published on 26 August 2019

Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population

scientific article published on 28 July 2010

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

scientific article published on 5 October 2012

Genetic variants associated with earlier age at menopause increase the risk of cardiovascular events in women

scientific article published on 6 November 2017

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease

scientific article

Genetic variation at 16q24.2 is associated with small vessel stroke

scientific article

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

scientific article published on 30 October 2017

Genetics of vascular dementia - review from the ICVD working group

scientific article

Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2

scientific article

Genome-Wide Association Study of Vascular Dementia

scholarly article by Elisabeth M.C. Schrijvers et al published February 2012 in Stroke Journal

Genome-wide Association Study Links APOEϵ4 and BACE1 Variants with Plasma Amyloid β Levels

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

scientific article published in Nature Communications

Genome-wide analysis of genetic loci associated with Alzheimer disease

scientific article

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

scientific article published on 14 January 2019

Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

scientific article

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

scientific article published on 11 September 2019

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment

scientific article published on 23 October 2019

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

article

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

scientific article published on 22 May 2017

Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability.

scientific article published on 16 April 2018

Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium

scientific article

Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium

scientific article

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

scientific article

Genome-wide association study identifies 48 common genetic variants associated with handedness

scientific article published on 28 September 2020

Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure. ⬇️

scientific article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

scientific article published in Nature Communications

Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine

scientific article published on 21 September 2014

Genome-wide compound heterozygote analysis highlights alleles associated with adult height in Europeans

scientific article published on 18 September 2017

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

scientific article published on 20 March 2012

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

scientific article published on 28 August 2020

Genome-wide identification of microRNA-related variants associated with risk of Alzheimer's disease

scientific article published on 22 June 2016

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

scientific article published on 13 October 2017

Genome-wide meta-analysis identifies new susceptibility loci for migraine

scientific article

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

scientific article

Genome-wide profiling of blood pressure in adults and children

scientific article published on 27 December 2011

Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium

scientific article

Genomewide association studies of stroke

scientific article published on 15 April 2009

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

scientific article published on 23 September 2016

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

scientific article published on 24 April 2017

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

scientific article published on 11 May 2020

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

scientific article

Global Efficiency of Structural Networks Mediates Cognitive Control in Mild Cognitive Impairment

scientific article published on 15 December 2016

Grey Matter Age Prediction as a Biomarker for Risk of Dementia: A Population-based Study

scholarly article published 12 January 2019

Gut microbiome-wide association study of depressive symptoms

Hearing Impairment Is Associated with Smaller Brain Volume in Aging

scientific article

Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI

scientific article published on 31 July 2019

Heritability of the shape of subcortical brain structures in the general population

scientific article published on 15 December 2016

High blood pressure and cerebral white matter lesion progression in the general population

scientific article published on 25 March 2013

Hippocampal shape is predictive for the development of dementia in a normal, elderly population

scientific article

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

scientific article published on 9 October 2017

Identification of common variants associated with human hippocampal and intracranial volumes

scientific article published on 15 April 2012

Implementation and validation of ASL perfusion measurements for population imaging

scientific article published on 02 April 2020

Improved MR Imaging Detection of Cerebral Microbleeds More Accurately Identifies Persons with Vasculopathy

scientific article published on 05 April 2012

Improved Tissue Segmentation by Including an MR Acquisition Model

Improving alignment in Tract-based spatial statistics: evaluation and optimization of image registration

scientific article

Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study

scientific article published on 9 February 2011

Incidental findings on brain MRI in the general population

scientific article

Inconsistency of Association between Coffee Consumption and Cognitive Function in Adults and Elderly in a Cross-Sectional Study (ELSA-Brasil)

scientific article

Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration

scientific article

Inhibition of serotonin reuptake by antidepressants and cerebral microbleeds in the general population

scientific article published on 29 May 2014

Insulin resistance and the risk of stroke and stroke subtypes in the nondiabetic elderly

scientific article published on 3 October 2012

Insulin-like growth factor-I receptor stimulating activity is associated with dementia.

scientific article

International epidemiology of intracerebral hemorrhage

scientific article

Interpretation of Studies on the Occurrence of Atrial Fibrillation in Elite Athletes

Intestinal microbiome composition and its relation to joint pain and inflammation

scientific article published on 25 October 2019

Intracranial Carotid Artery Atherosclerosis

Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the Rotterdam Study

scientific article

Intravestibular lipoma: an important imaging diagnosis

scientific article published in November 2008

Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study

scientific article published on 2 May 2012

Is the time ripe for new diagnostic criteria of cognitive impairment due to cerebrovascular disease? Consensus report of the International Congress on Vascular Dementia working group

scientific article published on 3 November 2016

Ischemic stroke is associated with the ABO locus: the EuroCLOT study

scientific article published on January 2013

Kidney Function and Cerebral Blood Flow: The Rotterdam Study

scientific article published on 6 August 2015

Kidney function and microstructural integrity of brain white matter

scientific article published on 17 June 2015

Kidney function is related to cerebral small vessel disease.

scientific article published on 29 November 2007

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

scientific article (publication date: September 2014)

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

scientific article published on 03 April 2019

Left-sided strokes are more often recognized than right-sided strokes: the Rotterdam study

scientific article published on 9 December 2014

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

scientific article published in January 2018

Lifetime risk and multimorbidity of non-communicable diseases and disease-free life expectancy in the general population: A population-based cohort study

scientific article published on 04 February 2019

Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2

scientific article published on 08 August 2012

Lobar Distribution of Cerebral Microbleeds

Local appearance features for robust MRI brain structure segmentation across scanning protocols

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

scientific article

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

scientific article published on 01 December 2018

Lower microstructural integrity of brain white matter is related to higher mortality

scientific article published on 3 August 2016

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

article

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.

scientific article

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

scientific article

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

scientific article

Meta-analysis of epigenome-wide association studies of cognitive abilities

scientific article published on 8 January 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function

scientific article published on 12 January 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Meta-analysis of genome-wide association for migraine in six population-based European cohorts

scientific article

Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

scientific article published on 30 October 2020

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

scientific article published on 14 August 2020

Metabolic syndrome is related to polyneuropathy and impaired peripheral nerve function: a prospective population-based cohort study

scientific article

Metabolically Healthy Obesity and the Risk of Cardiovascular Disease in the Elderly Population

scientific article

Migraine and cerebral blood flow in the general population

scientific article published on 3 October 2014

Modifiable etiological factors and the burden of stroke from the Rotterdam study: a population-based cohort study

scientific article

Modifiable lifestyle factors in dementia: a systematic review of longitudinal observational cohort studies

scientific article published on January 2014

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

scientific article published on 12 November 2019

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification

scientific article published on 21 May 2007

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

scientific article published on 7 February 2015

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies

scientific article

N-terminal pro-B-type natriuretic peptide and the risk of stroke and transient ischaemic attack: the Rotterdam Study.

scientific article published on 9 January 2015

Next frontiers in the genetic epidemiology of Alzheimer's disease

scientific article published on 7 November 2012

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts.

scientific article published on 9 November 2011

Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin?

scientific article published on 8 January 2016

Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2.

scientific article published in August 2016

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study

scientific article published on 3 March 2017

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways ⬇️

scientific article published in Nature Communications

Older age relates to worsening of fine motor skills: a population-based study of middle-aged and elderly persons

scientific article

Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association

scientific article published on 01 March 2019

PLD3 variants in population studies

scientific article published on April 2015

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

Patterns of cognitive function in aging: the Rotterdam Study

scientific article published on 20 February 2014

Performance of Framingham cardiovascular disease (CVD) predictions in the Rotterdam Study taking into account competing risks and disentangling CVD into coronary heart disease (CHD) and stroke.

scientific article

Physical Exercise Interventions Targeting Cognitive Functioning and the Cognitive Domains in Nondementia Samples: A Systematic Review of Meta-Analyses

scientific article published on 15 April 2020

Plant versus animal based diets and insulin resistance, prediabetes and type 2 diabetes: the Rotterdam Study

article

Plasma amyloid β, depression, and dementia in community-dwelling elderly

scientific article

Pleiotropic genes for metabolic syndrome and inflammation

scientific article

Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease

scientific article

Population-specific genetic variation in large sequencing data sets: why more data is still better

scientific article published on 19 July 2017

Positive affect is not associated with incidence of cardiovascular disease: a population-based study of older persons

scientific article

Predicting stroke through genetic risk functions: the CHARGE Risk Score Project

scientific article (publication date: February 2014)

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.

scientific article published on 12 April 2018

Prevalence and Risk Factors of Cerebral Microbleeds: An Update of the Rotterdam Scan Study

scientific article published on 01 October 2010

Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study

scientific article

Prevalence of cerebral small-vessel disease in long-term breast cancer survivors exposed to both adjuvant radiotherapy and chemotherapy

scientific article published on 5 January 2015

Primary prevention of cardiovascular disease: The past, present, and future of blood pressure- and cholesterol-lowering treatments.

scientific article published on 20 March 2018

Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

scientific article published on 16 October 2019

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Psoriasis is not associated with atherosclerosis and incident cardiovascular events: the Rotterdam Study

scientific article published on 14 March 2013

Publisher Correction: Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability

scientific article published on 01 July 2019

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 01 July 2019

Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways ⬇️

scientific article published in Nature Communications

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article

Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease

scientific article

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study

article

Rare gene deletions in genetic generalized and Rolandic epilepsies

scientific article published in PLoS ONE

Rare variants in γ-aminobutyric acid type A receptor genes in rolandic epilepsy and related syndromes

scientific article

Rating method for dilated Virchow-Robin spaces on magnetic resonance imaging

scientific article published on 2 May 2013

Reference values for white blood-cell-based inflammatory markers in the Rotterdam Study: a population-based prospective cohort study.

scientific article published on 12 July 2018

Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study

scientific article published on 31 March 2017

Relationship between gut microbiota and circulating metabolites in population-based cohorts

scientific article published on 20 December 2019

Replication study of chr17q25 with cerebral white matter lesion volume

scientific article published on 25 August 2011

Response to Dr Fried & Dr Kievit, and Dr Malhi et al

scientific article published on 23 February 2016

Retinal vascular calibers associate differentially with cerebral gray matter and white matter atrophy

scientific article

Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease

scientific article published on 13 June 2013

Separate prediction of intracerebral hemorrhage and ischemic stroke

scientific article (publication date: 20 May 2014)

Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study

scientific article published on 28 December 2016

Serum levels of pregnancy zone protein are elevated in presymptomatic Alzheimer's disease

scientific article published on 28 September 2011

Serum lipid levels and the risk of intracerebral hemorrhage: the Rotterdam Study

scientific article published on 15 September 2011

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants

scientific article

Silent brain infarcts: a cause of depression in the elderly?

scientific article published on 13 November 2012

Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis

scientific article published on 16 November 2020

Statistical analysis of minimum cost path based structural brain connectivity

article

Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint Pain.

scientific article published on 5 November 2015

Structural Brain MRI Trait Polygenic Score Prediction of Cognitive Abilities

scientific article published on 2 October 2015

Structural and microstructural brain changes predict impairment in daily functioning

scientific article published on 10 July 2014

Structural disconnectivity and the risk of dementia in the general population

scientific article published on 08 July 2020

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 29 May 2018

Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis

scientific article

Subclinical cardiac dysfunction increases the risk of stroke and dementia: the Rotterdam Study

scientific article published on 28 January 2015

Subclinical thyroid dysfunction and the risk of stroke: a systematic review and meta-analysis

scientific article published on 02 September 2014

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

scientific article

Subjective memory complaints and the risk of stroke

scientific article published on 11 December 2014

Superficial siderosis in the general population

scientific article

Supervised Image Segmentation across Scanner Protocols: A Transfer Learning Approach

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

scientific article published on 02 October 2019

The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis.

scientific article published on 31 December 2008

The Rotterdam Scan Study: design and update up to 2012

scientific article published on 16 October 2011

The Rotterdam Study: 2012 objectives and design update

scientific article

The Rotterdam Study: 2014 objectives and design update

scientific article

The Rotterdam Study: 2016 objectives and design update

scientific article

The Stroke Riskometer(TM) App: validation of a data collection tool and stroke risk predictor

scientific article

The association between physical activity and dementia in an elderly population: the Rotterdam Study

scientific article

The association of innate and adaptive immunity, subclinical atherosclerosis, and cardiovascular disease in the Rotterdam Study: A prospective cohort study

scientific article published on 07 May 2020

The association of thyroid function and the risk of kidney function decline: a population-based cohort study

scientific article

The changing prevalence and incidence of dementia over time - current evidence.

scientific article

The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study

scientific article published on 27 April 2016

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

scientific article

The dystrophin gene and cognitive function in the general population

scientific article published on 17 September 2014

The functions of estrogen receptor beta in the female brain: A systematic review

scientific article

The genetic architecture of the human cerebral cortex

The genetic architecture of the human cerebral cortex

scientific article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The heart-brain connection: a multidisciplinary approach targeting a missing link in the pathophysiology of vascular cognitive impairment.

scientific article

The relation of uric acid to brain atrophy and cognition: the Rotterdam Scan Study

scientific article

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

The role of cerebellar volume in cognition in the general elderly population

scientific article

The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project

scientific article published on 05 June 2013

The thyroid hormone receptor alpha locus and white matter lesions: a role for the clock gene REV-ERBα.

scientific article

The thyroid hormone receptor α locus and white matter lesions: a role for the clock gene REV-ERBα

article

Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis

scientific article

Thyroid function and life expectancy with and without noncommunicable diseases: A population-based study

scientific article published on 25 October 2019

Thyroid function and the risk of dementia: The Rotterdam Study

scientific article published on 16 September 2016

Total antioxidant capacity of the diet and major neurologic outcomes in older adults

scientific article published on 20 February 2013

Total cerebral blood flow and total brain perfusion in the general population: the Rotterdam Scan Study

scientific article published on 11 July 2007

Total cerebral blood flow in relation to cognitive function: the Rotterdam Scan Study

scientific article

Tract-specific white matter degeneration in aging: the Rotterdam Study

scientific article

Transfer learning improves supervised image segmentation across imaging protocols

scientific article published on 4 November 2014

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project

scientific article

Trends in stroke incidence rates and stroke risk factors in Rotterdam, the Netherlands from 1990 to 2008.

scientific article

Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

scientific article

Unrecognized Myocardial Infarction in Relation to Risk of Dementia and Cerebral Small Vessel Disease

scholarly article by M. Arfan Ikram et al published May 2008 in Stroke Journal

Unrecognized myocardial infarction and the risk of stroke: the Rotterdam Study

scientific article published in November 2006

Use of coumarin anticoagulants and cerebral microbleeds in the general population

scientific article published on 14 October 2014

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

scientific article

Variation in blood pressure and long-term risk of dementia: A population-based cohort study

scientific article published on 12 November 2019

Vascular brain disease and depression in the elderly

scientific article

Vascular risk factors, apolipoprotein E, and hippocampal decline on magnetic resonance imaging over a 10-year follow-up

scientific article published on 13 January 2012

Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study.

scientific article

White Matter Lesion Progression: Genome-Wide Search for Genetic Influences

scientific article

White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging

scientific article published on 8 August 2008

White matter lesion extension to automatic brain tissue segmentation on MRI.

scientific article published in May 2009

White matter lesions relate to tract-specific reductions in functional connectivity

scientific article

White matter microstructural integrity and cognitive function in a general elderly population

scientific article published in May 2009

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

article

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

scholarly article

von Willebrand Factor, ADAMTS13 Activity, and Decline in Kidney Function: A Population-Based Cohort Study

scientific article published on 3 August 2016

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