List of works - Zachary B. Mackey

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei

scientific article published on 23 August 2004

A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection

scientific article published on 23 September 2013

A parasite cysteine protease is key to host protein degradation and iron acquisition

scientific article published on 13 August 2008

An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei

scientific article published on 19 February 2002

Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues.

scientific article published on March 2006

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

scientific article published on 15 August 2012

Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei

scientific article

DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III.

scientific article

Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression

scientific article published in January 2015

Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor

scientific article

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

scientific article published in January 2005

Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei

scientific article published in May 2006

Drugs targeting parasite lysosomes

scientific article published on January 2008

Early invasion of brain parenchyma by African trypanosomes ⬇️

scientific article published in 2012

Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei

scientific article

Extracellular-signal regulated kinase 8 of Trypanosoma brucei uniquely phosphorylates its proliferating cell nuclear antigen homolog and reveals exploitable properties

scientific article

High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei

scientific article

Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii

scientific article

Mining a cathepsin inhibitor library for new antiparasitic drug leads

scientific article

Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair

scientific article

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model

scientific article

Structure and function of mammalian DNA ligases

scientific article

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi

scientific article published in June 2004

List of works by Zachary B. Mackey

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei

A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection

A parasite cysteine protease is key to host protein degradation and iron acquisition

An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei

Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues.

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei

DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III.

Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression

Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei

Drugs targeting parasite lysosomes

Early invasion of brain parenchyma by African trypanosomes ⬇️

Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei

Extracellular-signal regulated kinase 8 of Trypanosoma brucei uniquely phosphorylates its proliferating cell nuclear antigen homolog and reveals exploitable properties

High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei

Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii

Mining a cathepsin inhibitor library for new antiparasitic drug leads

Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model

Structure and function of mammalian DNA ligases

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi