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List of works by Kullervo Hynynen

500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls.

scientific article published in July 2004

5th International Symposium on Focused Ultrasound: North Bethesda, MD, USA. 28 August- 1 September 2016.

scientific article published on 21 November 2016

A Noninvasive Ultrasound Resonance Method for Detecting Skull Induced Aberrations May Provide a Signal for Adaptive Focusing

scientific article published on 16 January 2020

A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy

scientific article

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor

scientific article

A Tikhonov Regularization Scheme for Focus Rotations With Focused Ultrasound-Phased Arrays.

scientific article published in December 2016

A computer-controlled ultrasound pulser-receiver system for transskull fluid detection using a shear wave transmission technique.

scientific article

A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound

scientific article

A full-wave Helmholtz model for continuous-wave ultrasound transmission.

scientific article published in March 2005

A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy

scientific article published in August 2005

A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

scientific article published on 15 November 2016

A new ultrasound method for determining the acoustic phase shifts caused by the skull bone

scientific article

A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles.

scientific article published on 23 June 2014

A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound

scientific article

A novel phase assignment protocol and driving system for a high-density focused ultrasound array

scientific article published in April 2007

A numerical study of transcranial focused ultrasound beam propagation at low frequency

scientific article published on 6 April 2005

A numerical study on the oblique focus in MR-guided transcranial focused ultrasound

scientific article

A super-resolution ultrasound method for brain vascular mapping

scientific article

A unified model for the speed of sound in cranial bone based on genetic algorithm optimization

scientific article published in November 2002

A viscoelastic model for the prediction of transcranial ultrasound propagation: application for the estimation of shear acoustic properties in the human skull

scientific article

ACTR-42. INITIAL EXPERIENCE OF BLOOD-BRAIN BARRIER OPENING FOR CHEMOTHERAPEUTIC-DRUG DELIVERY TO BRAIN TUMOURS BY MR-GUIDED FOCUSED ULTRASOUND

Accumulated thermal dose in MRI-guided focused ultrasound for essential tremor: repeated sonications with low focal temperatures

scientific article published on 10 May 2019

Acoustic radiation force induced accumulation and dynamics of microbubbles on compliant surfaces

scientific article published on 02 July 2019

Acoustic transmission losses and field alterations due to human scalp hair

scientific article published on 01 August 2005

Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2

scientific article

Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose

scientific article published on 15 September 2017

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome.

scientific article

Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability

scientific article published on 28 February 2019

Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior

scientific article

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound ⬇️

scientific article published on May 21, 2013

An MR-based quantitative intraventricular hemorrhage porcine model for MR-guided focused ultrasound thrombolysis

scientific article published on 23 May 2018

An MRI-compatible system for focused ultrasound experiments in small animal models.

scientific article

Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy

scientific article

Angiogenic response of rat hippocampal vasculature to focused ultrasound-mediated increases in blood-brain barrier permeability

scientific article published in Scientific Reports

Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease

scientific article

Antidepressant effects of focused ultrasound induced blood-brain-barrier opening.

scientific article published on 8 January 2018

Antitumor effects of combining docetaxel (taxotere) with the antivascular action of ultrasound stimulated microbubbles

scientific article

Antitumor effects of combining metronomic chemotherapy with the antivascular action of ultrasound stimulated microbubbles.

scientific article published on 10 January 2013

Apoptosis signals in lymphoblasts induced by focused ultrasound

scientific article published in July 2004

Assessing the barriers to image-guided drug delivery

scientific article

Association of rectal toxicity with thermal dose parameters in treatment of locally advanced prostate cancer with radiation and hyperthermia

scientific article published on 01 July 2002

Bio-acoustic thermal lensing and nonlinear propagation in focused ultrasound surgery using large focal spots: a parametric study

scientific article published in June 2002

Blood-Brain Barrier Closure Time After Controlled Ultrasound-Induced Opening Is Independent of Opening Volume

scientific article published on 21 January 2017

Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study

scientific article published in Scientific Reports

Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions–based Controller ⬇️

scientific article published on February 13, 2012

Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index

scientific article

Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound

scientific article published in Nature Communications

Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier

scientific article

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery. ⬇️

scientific article

Cavitation detection for brain imaging and therapy.

scientific article published on 30 June 2015

Cavitation threshold of microbubbles in gel tunnels by focused ultrasound

scientific article

Cavitation-based third ventriculostomy using MRI-guided focused ultrasound

scientific article

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles

scientific article published in July 2004

Chemotherapy delivery issues in central nervous system malignancy: a reality check.

scientific article published on June 2007

Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: a numerical study

scientific article published on 30 July 2007

Combined Therapeutic and Monitoring Ultrasonic Catheter for Cardiac Ablation Therapies

scientific article published on 29 September 2015

Comparison of analytical and numerical approaches for CT-based aberration correction in transcranial passive acoustic imaging.

scientific article

Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound

scientific article

Contrast-enhanced transcranial two-dimensional ultrasound imaging using shear-mode conversion at low frequency

scientific article published on 14 December 2012

Correlation of ultrasound phase with physical skull properties

scientific article

Creating Brain Lesions with Low-Intensity Focused Ultrasound with Microbubbles: A Rat Study at Half a Megahertz ⬇️

scientific article published on June 4, 2013

Current Progress in Magnetic Resonance-Guided Focused Ultrasound to Facilitate Drug Delivery across the Blood-Brain Barrier

scientific article published on 27 May 2024

Delivery of stem cells to the brain: potential for treatment of neurodegenerative disease.

scientific article published on 30 June 2015

Design of a HIFU array for the treatment of deep venous thrombosis: a simulation study

scientific article published on 9 May 2017

Design of patient-specific focused ultrasound arrays for non-invasive brain therapy with increased trans-skull transmission and steering range.

scientific article published on 30 June 2017

Does the phase of menstrual cycle affect MR-guided focused ultrasound surgery of uterine leiomyomas?

scientific article published in August 2006

Driving Circuitry for Focused Ultrasound Noninvasive Surgery and Drug Delivery Applications ⬇️

scientific article published on January 7, 2011

Drug delivery across the blood-brain barrier using focused ultrasound

scientific article

Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy

scientific article

ET-03CAVITATION-BASED THIRD VENTRICULOSTOMY USING MRI-GUIDED FOCUSED ULTRASOUND

scientific article published in November 2014

Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival

scientific article published on 26 January 2016

Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium

scientific article

Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption

scientific article

Effects of parameter errors in the simulation of transcranial focused ultrasound

scientific article published in January 2002

Emerging non-cancer applications of therapeutic ultrasound.

scientific article

Energy-Based Adaptive Focusing: Optimal Ultrasonic Focusing Using Magnetic Resonance Guidance

Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound ⬇️

scientific article published on February 17, 2012

Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia

scientific article published in January 2012

Enhancing Checkpoint Inhibitor Therapy with Ultrasound Stimulated Microbubbles

scientific article published on 15 November 2018

Enhancing Glioblastoma Treatment using Cisplatin-Gold-Nanoparticle Conjugates and Targeted Delivery with Magnetic Resonance-Guided Focused Ultrasound

scientific article published on 19 February 2018

Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound ⬇️

scientific article published on May 2, 2013

Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability

scientific article published on 29 January 2019

Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids

scientific article published on October 2008

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT-based aberration corrections.

scientific article

Feasibility of internally referenced brain temperature imaging with a metabolite signal

scientific article published in April 2003

Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy

scientific article

First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

scientific article published on 26 September 2019

Focal beam distortion and treatment planning in abdominal focused ultrasound surgery

scientific article published in May 2005

Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery

scientific article

Focused Ultrasound Hyperthermia Mediated Drug Delivery Using Thermosensitive Liposomes and Visualized With in vivo Two-Photon Microscopy

scientific article published on 07 July 2017

Focused Ultrasound Surgery in Oncology: Overview and Principles ⬇️

scientific article published on April 1, 2011

Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability.

scientific article

Focused Ultrasound: Crossing Barriers to Treat Alzheimer‘s Disease ⬇️

scientific article published on March 1, 2011

Focused ultrasound as a novel strategy for Alzheimer disease therapeutics

scientific article published on 10 April 2017

Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia

scientific article published on 10 February 2020

Focused ultrasound delivers targeted immune cells to metastatic brain tumors

scientific article

Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors

scientific article

Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology ⬇️

scientific article published on January 1, 2012

Focused ultrasound effects on nerve action potential in vitro

scientific article

Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain

scientific article

Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression ⬇️

scientific article published on August 19, 2012

Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor

scientific article published on 01 December 2018

Focused ultrasound treatment of VX2 tumors controlled by local harmonic motion

scientific article published on 13 May 2009

Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats

scientific article

Focused ultrasound-mediated drug delivery through the blood-brain barrier

scientific article

Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate

scientific article

Forward planar projection through layered media.

scientific article published in December 2003

Frequency considerations for deep ablation with high-intensity focused ultrasound: A simulation study

scientific article published in August 2015

Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound.

scientific article published on January 2008

Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans

scientific article published on 17 October 2019

Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney

scientific article published on 5 February 2004

High-Intensity Focused Ultrasound (HIFU) for Dissolution of Clots in a Rabbit Model of Embolic Stroke ⬇️

scientific article published on January 1, 2012

High-intensity focused ultrasound sonothrombolysis: the use of perfluorocarbon droplets to achieve clot lysis at reduced acoustic power

scientific article

Hyperthermia classic commentary: 'A scanned, focused, multiple transducer ultrasonic system for localised hyperthermia treatments', by K. Hynynen, R. Roemer, D. Anhalt, et al., International Journal of Hyperthermia 1987;3:21-35.

scientific article published in February 2010

Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153.

scientific article published on 30 September 2010

Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile

scientific article published on 01 November 2005

Hyperthermia in bone generated with MR imaging-controlled focused ultrasound: control strategies and drug delivery

scientific article published in April 2012

Hyperthermia-induced drug delivery in humans

scientific article published on 01 September 2018

Hyperthermia-mediated doxorubicin release from thermosensitive liposomes using MR-HIFU: therapeutic effect in rabbit Vx2 tumours

scientific article published on 13 January 2015

Image-guided neurosurgery at Brigham and Women's Hospital

scientific article published in September 2006

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

scientific article published on 5 August 2016

Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma ⬇️

scientific article published on July 19, 2012

In vitro and in vivo high-intensity focused ultrasound thrombolysis

scientific article

In vitrocharacterization of perfluorocarbon droplets for focused ultrasound therapy

scientific article published on August 6, 2010

In vivo monitoring of focused ultrasound surgery using local harmonic motion

scientific article

Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison

scientific article published in December 2006

Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures

scientific article

Interlaboratory acoustic power measurement

scientific article published on 01 February 2003

International Society for Therapeutic Ultrasound Conference 2016: Tel Aviv, Israel. 14-18 March, 2016.

scientific article published on 17 March 2017

Intracellular delivery of Bak BH3 peptide by microbubble-enhanced ultrasound

scientific article

Intracranial applications of magnetic resonance-guided focused ultrasound.

scientific article

Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors

scientific article

Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure

scientific article published on 01 January 2020

Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease.

scientific article published on 21 October 2017

Investigation of Standing-Wave Formation in a Human Skull for a Clinical Prototype of a Large-Aperture, Transcranial MR-Guided Focused Ultrasound (MRgFUS) Phased Array: An Experimental and Simulation Study ⬇️

scientific article published on October 28, 2011

Investigation of optimal method for inducing harmonic motion in tissue using a linear ultrasound phased array--a simulation study

scientific article published on 01 April 2006

Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging

scientific article published on 22 August 2017

Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation

scientific article

Large improvement of the electrical impedance of imaging and high-intensity focused ultrasound (HIFU) phased arrays using multilayer piezoelectric ceramics coupled in lateral mode ⬇️

scientific article published on July 1, 2012

Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays

scientific article

Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

scientific article

Local harmonic motion monitoring of focused ultrasound surgery--a simulation model

scientific article published on 9 October 2009

Localised drug release using MRI-controlled focused ultrasound hyperthermia

scientific article published on 15 December 2010

Localized anesthesia of a specific brain region using ultrasound-responsive barbiturate nanodroplets

scientific article published on 03 February 2020

Localized harmonic motion imaging for focused ultrasound surgery targeting

scientific article

Localized harmonic motion imaging: theory, simulations and experiments

scientific article

MR Guidance, Monitoring and Control of Brain HIFU Therapy in Small Animals: In Vivo Demonstration in Rats

MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking

scientific article

MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery

scientific article

MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study

scientific article published in March 2003

MR-Guided Focused Ultrasound for Brain Ablation and Blood–Brain Barrier Disruption ⬇️

scientific article published on January 1, 2011

MR-Guided Ultrasonic Brain Therapy: High Frequency Approach

article

MR-guided Focused Ultrasound Facilitates Sonodynamic Therapy with 5-Aminolevulinic Acid in a Rat Glioma Model

scientific article published on 18 July 2019

MR-guided focused ultrasound surgery

scientific article published on November 1, 1992

MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study

scientific article

MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain

scientific article published in May 2004

MRI monitoring of heating produced by ultrasound absorption in the skull: in vivo study in pigs

scientific article published in May 2004

MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain

scientific article published on 01 January 2019

MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids.

scientific article published on February 2009

MRI-controlled ultrasound thermal therapy

scientific article

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model ⬇️

scientific article published on March 13, 2012

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

scientific article published on 13 December 2017

MRI-guided focused ultrasound surgery in the brain: tests in a primate model.

scientific article

MRI-guided focused ultrasound treatments

scientific article published on 06 September 2009

MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits

scientific article

MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate

scientific article

MRIgFUS in the treatment of spontaneous intracerebral hemorrhage.

scientific article published on 30 June 2015

MRIgHIFU: A tool for image‐guided therapeutics ⬇️

scientific article published on September 1, 2011

Macromolecular delivery across the blood-brain barrier

scientific article published in January 2009

Magnetic Resonance-Guided High-Intensity Focused Ultrasound Hyperthermia for Recurrent Rectal Cancer: MR Thermometry Evaluation and Preclinical Validation

scientific article published on 24 March 2016

Magnetic Resonance-Guided High-Intensity-Focused Ultrasound for Palliation of Painful Skeletal Metastases: A Pilot Study.

scientific article published in August 2016

Magnetic resonance guided focused ultrasound for noninvasive pain therapy of osteoid osteoma in children.

scientific article published on 30 June 2015

Magnetic resonance image-guided focused ultrasound surgery.

scientific article

Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials

scientific article published on 14 May 2020

Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: A 2-year outcome study

scientific article published on 04 October 2018

Magnetic resonance-guided high-intensity focused ultrasound combined with radiotherapy for palliation of head and neck cancer-a pilot study

scientific article published on 2 April 2016

Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia

scientific article

Megahertz rate, volumetric imaging of bubble clouds in sonothrombolysis using a sparse hemispherical receiver array

scientific article published on 8 August 2017

Micro-receiver guided transcranial beam steering

scientific article published in April 2002

Microbubble Localization for Three-Dimensional Superresolution Ultrasound Imaging Using Curve Fitting and Deconvolution Methods

scientific article published on 08 March 2018

Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits

scientific article published in October 2006

Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System

scientific article

Microbubble-assisted MRI-guided focused ultrasound for hyperthermia at reduced power levels

scientific article published on 08 October 2018

Microbubbles and blood-brain barrier opening: a numerical study on acoustic emissions and wall stress predictions

scientific article

Modeling localized delivery of Doxorubicin to the brain following focused ultrasound enhanced blood-brain barrier permeability

scientific article published on 17 September 2014

Modeling of anomalies due to hydrophones in continuous-wave ultrasound fields

scientific article published in November 2003

Modular design for in vivo optical imaging and ultrasound treatment in the murine brain

scientific article

Multi-frequency characterization of the speed of sound and attenuation coefficient for longitudinal transmission of freshly excised human skulls ⬇️

scientific article published on December 9, 2010

Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo

scientific article

NT-02EARLY TREATMENT OF HER2-AMPLIFIED BRAIN TUMOURS WITH TARGETED NK-92 CELLS AND FOCUSED ULTRASOUND IMPROVES SURVIVAL

scientific article published in November 2014

New design for an endoesophageal sector- based array for the treatment of atrial fibrillation: a parametric simulation study

scientific article published on 01 March 2009

Non invasive transcostal focusing based on the decomposition of the time reversal operator: in vitro validation

Noninvasive and Targeted Drug Delivery to the Brain Using Focused Ultrasound ⬇️

scientific article published on February 4, 2013

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

scientific article

Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound

article

Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption

scientific article

Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound

scientific article published in November 2004

Noninvasive transesophageal cardiac thermal ablation using a 2-D focused, ultrasound phased array: a simulation study

scientific article published in June 2006

Nonuniform temperature rise in in vitro osteoblast ultrasound exposures with associated bioeffect

scientific article published on March 2014

Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs

scientific article published on 02 September 2020

Numerical simulations of clinical focused ultrasound functional neurosurgery

scientific article

Opening the Blood-Brain Barrier with MR Imaging-guided Focused Ultrasound: Preclinical Testing on a Trans-Human Skull Porcine Model.

scientific article

Optical monitoring of ultrasound-induced bioeffects in glass catfish

scientific article published in January 2004

Overview of therapeutic ultrasound applications and safety considerations

scientific article

PDTM-33. FOCUSED ULTRASOUND DISRUPTION OF THE BLOOD BRAIN BARRIER IN THE BRAINSTEM: A FEASIBILITY AND SAFETY STUDY

Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery

scientific article published in October 2004

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study.

scientific article

Predicting lesion size by accumulated thermal dose in MR-guided focused ultrasound for essential tremor

scientific article published on 31 August 2018

Preliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases.

scientific article published on 13 June 2018

Progress and problems in the application of focused ultrasound for blood-brain barrier disruption

scientific article

Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging

scientific article

Pulsed Focused Ultrasound-Induced Displacements in Confined In Vitro Blood Clots ⬇️

scientific article published on December 21, 2011

Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience

scientific article published in November 2006

Quantitative MRI in a non-surgical model of cervical spinal cord injury.

scientific article

Receiver array design for sonothrombolysis treatment monitoring in deep vein thrombosis

scientific article published on 28 November 2018

Registration of human skull computed tomography data to an ultrasound treatment space using a sparse high frequency ultrasound hemispherical array

scientific article

Reply to Kovacs et al.: Concerning acute inflammatory response following focused ultrasound and microbubbles in the brain.

scientific article

Resting state functional connectivity changes after MR-guided focused ultrasound mediated blood-brain barrier opening in patients with Alzheimer's disease

scientific article published on 26 June 2019

SCDT-51. INITIAL EXPERIENCE OF BLOOD-BRAIN BARRIER OPENING FOR CHEMOTHERAPEUTIC-DRUG DELIVERY TO BRAIN TUMOURS BY MR-GUIDED FOCUSED ULTRASOUND

article published in 2017

Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies

scientific article published on 18 July 2019

Scanning path optimization for ultrasound surgery

scientific article published on 13 July 2005

Simulation study for thermal dose optimization in ultrasound surgery of the breast

scientific article published in May 2004

Simulation study of the effects of near- and far-field heating during focused ultrasound uterine fibroid ablation using an electronically focused phased array: A theoretical analysis of patient safety

scientific article published in July 2014

Simulations and measurements of transcranial low-frequency ultrasound therapy: skull-base heating and effective area of treatment.

scientific article published on 6 July 2011

Simulations of lesion detection using a combined phased array LHMI-technique

scientific article

Simulations of localized harmonic motions on a blood vessel wall induced by an acoustic radiation force used in ultrasound elastography

scientific article published on 30 August 2006

Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation

scientific article published on 08 May 2020

Skull bone marrow injury caused by MR-guided focused ultrasound for cerebral functional procedures

scientific article published on 01 May 2018

Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice

scientific article

Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease

scientific article published on 18 October 2019

Study of Factors Affecting the Magnitude and Nature of Ultrasound Exposure with In Vitro Set-Ups ⬇️

scientific article published on March 16, 2012

Super-resolution Ultrasound Imaging

scientific article published on 21 January 2020

Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier ⬇️

scientific article published on November 16, 2011

Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound ⬇️

scientific article published on October 15, 2012

Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound

scientific article

Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound

scientific article

Temperature change near microbubbles within a capillary network during focused ultrasound

scientific article

Temperature mapping considerations in the breast with line scan echo planar spectroscopic imaging

scientific article

The Effect of Attenuation Coefficient on Radiation Force Impulse Monitoring of Thermal Lesions

The application of sparse arrays in high frequency transcranial focused ultrasound therapy: a simulation study

scientific article

The design of a focused ultrasound transducer array for the treatment of stroke: a simulation study ⬇️

scientific article published on July 17, 2012

The effects of desiccation on skull bone sound speed in porcine models

scientific article published on 01 August 2007

The evaluation of steerable ultrasonic catheters for minimally invasive MRI-guided cardiac ablation

scientific article published on 20 September 2013

The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model

scientific article

The reduction in treatment efficiency at high acoustic powers during MR-guided transcranial focused ultrasound thalamotomy for Essential Tremor

The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasound

scientific article published on 03 May 2019

The temperature dependence of ultrasound-stimulated acoustic emission

scientific article published in March 2002

The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison®) ⬇️

scientific article published on March 1, 2003

The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain

scientific article published on 01 March 2002

The use of ultrasound-stimulated acoustic emission in the monitoring of modulus changes with temperature

scientific article published on 01 July 2003

The utility of sparse 2D fully electronically steerable focused ultrasound phased arrays for thermal surgery: a simulation study.

scientific article published on 19 July 2011

Therapeutic effects of focused ultrasound-mediated blood-brain barrier opening in a mouse model of Alzheimer’s disease.

scientific article published on 30 June 2015

Thermal therapy with a fully electronically steerable HIFU phased array using ultrasound guidance and local harmonic motion monitoring

scientific article published on 24 October 2019

Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening.

scientific article published on 16 April 2018

Three-dimensional transcranial ultrasound imaging of microbubble clouds using a sparse hemispherical array

scientific article

Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease

scientific article published in Scientific Reports

To heat or not to heat: Challenges with clinical translation of thermosensitive liposomes

scientific article

Tractography-based targeting of the ventral intermediate nucleus: accuracy and clinical utility in MRgFUS thalamotomy

scientific article published on 27 September 2019

Transcranial Photoacoustic Detection of Blood-Brain Barrier Disruption Following Focused Ultrasound-Mediated Nanoparticle Delivery

scientific article published on 01 April 2020

Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients

scientific article

Transcranial passive acoustic mapping with hemispherical sparse arrays using CT-based skull-specific aberration corrections: a simulation study ⬇️

scientific article published on June 27, 2013

Transcranial shear-mode ultrasound: assessment of imaging performance and excitation techniques

scientific article published on 13 January 2009

Transcranial ultrasound focus reconstruction with phase and amplitude correction

scientific article published in September 2005

Transducer design and characterization for dorsal-based ultrasound exposure and two-photon imaging of in vivo blood-brain barrier disruption in a rat model.

scientific article

Treatment of near-skull brain tissue with a focused device using shear-mode conversion: a numerical study

scientific article

Two-Photon Fluorescence Microscopy Study of Cerebrovascular Dynamics in Ultrasound-Induced Blood—Brain Barrier Opening ⬇️

scientific article published on April 20, 2011

Ultrafast 1D MR thermometry using phase or frequency mapping

scientific article

Ultrasound Induced Activation of Cell Signaling on Human MG-63 Osteoblastic Cells

Ultrasound Insertion Loss of Rat Parietal Bone Appears to Be Proportional to Animal Mass at Submegahertz Frequencies ⬇️

scientific article published on September 16, 2011

Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain

scientific article published on 01 January 2018

Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models

scientific article

Ultrasound enhanced drug delivery to the brain and central nervous system

scientific article

Ultrasound for drug and gene delivery to the brain

scientific article

Ultrasound stimulates proteoglycan synthesis in bovine primary chondrocytes

scientific article published on 01 January 2006

Ultrasound-Guided Focused Ultrasound Treatment for Painful Bone Metastases: A Pilot Study

scientific article published on 04 March 2020

Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery

scientific article published on 09 March 2020

Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells

scientific article

Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro ⬇️

scientific article published on September 1, 2003

Urinary cytokines/chemokines after magnetic resonance-guided high intensity focused ultrasound for palliative treatment of painful bone metastases

scientific article published in January 2017

Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study

scientific article

Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation

scientific article

Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of success

scientific article

Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols

scientific article published on 19 April 2007

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