Search filters

List of works by Krister Wennerberg

8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia

scientific article published on 15 February 2019

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

scientific article published on 3 October 2017

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

scientific article published on 5 March 2013

A community effort to assess and improve drug sensitivity prediction algorithms.

scientific article

A high-throughput screen for chemical inhibitors of exocytic transport in yeast

scientific article

A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening

scientific article published on 23 January 2020

A normalized drug response metric improves accuracy and consistency of drug sensitivity quantification in cell-based screening

A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.

scientific article published on 30 October 2007

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury

scientific article from 2017

ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors

scientific article published on 03 December 2019

Abstract 5588: Functional drug sensitivity and resistance profiling of AML patient cells defines a disease-specific combination of druggable signal addictions

Anagrelide for Gastrointestinal Stromal Tumor

scientific article published on 07 December 2018

Antifungal application of nonantifungal drugs

scientific article

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

scientific article published on 24 October 2019

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

scientific article

Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.

scientific article published on July 1999

Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening

scientific article

Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening

scientific article

Breeze: an integrated quality control and data analysis application for high-throughput drug screening

scientific article published on 02 March 2020

Cancer Cell Drug Response Transcriptomes in 3D.

scientific article published on November 2016

Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies

scientific article published on 11 September 2019

Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

scientific article

Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

scientific article published on 15 February 2022

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

scientific article

Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors.

scientific article published on 07 August 2017

Consistency in drug response profiling

scientific article published in November 2016

Corrigendum to “Searching for drug synergy in complex dose–response landscapes using an interaction potency model” [Comput. Struct. Biotechnol. J. 13 (2015) 504–513].

scientific article published on 25 July 2017

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

scientific article published on 23 August 2016

DNA microfiltration assay: a simple technique for detecting DNA damage in mammalian cells

scientific article published in January 1994

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

scientific article

Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.

scientific article

Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

scientific article

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.

scientific article published on 14 August 2017

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

scientific article published on 17 April 2013

Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

scientific article

Drug screening approach combines epigenetic sensitization with immunochemotherapy in cancer

scientific article published on 11 December 2019

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

scientific article

Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas

scientific article published on 12 February 2019

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

scientific article published on 03 July 2018

Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.

scientific article published on 05 January 2017

Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

scientific article published on 11 November 2016

Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment

scientific article published on 30 December 2019

From drug response profiling to target addiction scoring in cancer cell models

scientific article published on October 2015

Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma

scientific article

Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.

scientific article published on 24 January 2014

Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach.

scientific article published on 27 November 2017

HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.

scientific article published on 8 August 2016

High-Throughput Dual Screening Method for Ras Activities and Inhibitors.

scientific article published on 20 March 2017

Human Tumor-Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing

scientific article published on 30 December 2019

Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

scientific article

Identification of novel regulators of STAT3 activity

scientific article published on 31 March 2020

Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening

scientific article published on January 2011

Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells.

scientific article published on 10 May 2016

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis.

scientific article

Immunogenomic Landscape of Hematological Malignancies

scientific article published on 24 June 2020

Immunogenomic Landscape of Hematological Malignancies

scientific article published on 01 September 2020

Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data

scientific article

Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics

scientific article published on 01 March 2020

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

scientific article published on 20 September 2013

Integrated Analysis of Drug Sensitivity and Selectivity to Predict Synergistic Drug Combinations and Target Coaddictions in Cancer

scientific article published on 01 January 2019

Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization

scientific article

Integrin signaling to the actin cytoskeleton.

scientific article published on October 2003

Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing

scientific article published on 18 December 2018

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma

scientific article published on 25 June 2019

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.

scientific article

KIFC1 is a novel potential therapeutic target for breast cancer.

scientific article

KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia

scientific article published on 17 July 2020

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

scientific article published on 01 November 2018

Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA

scientific article (publication date: 20 July 2001)

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

scientific article

MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.

scientific article published on October 2008

Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis

scientific article

Methods for High-throughput Drug Combination Screening and Synergy Scoring.

scientific article published in January 2018

MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity

scientific article published on 18 November 2015

Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments ⬇️

scientific article published on 04 December 2020

Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

scientific article published on 31 October 2016

Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

scientific article published on 01 March 2021

Multi-parametric single cell evaluation defines distinct drug responses in healthy hematological cells that are retained in corresponding malignant cell types

scientific article published on 22 August 2019

Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin β1A: Requirement for threonines 788-789 in receptor activation ⬇️

scientific article published on April 1, 1998

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

scientific article published on July 2015

Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

scientific article published on 08 July 2019

Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival

scientific article published on 16 October 2019

Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

scientific article published on May 2015

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

scientific article published on 01 July 2018

Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

scientific article published on 10 July 2020

Patient-customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

scientific article published on 26 February 2018

Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets

scientific article published on 02 May 2019

Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing.

scientific article published on 2 December 2015

Prediction of drug combination effects with a minimal set of experiments

scientific article published on 09 December 2019

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

scientific article

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.

scientific article published on 09 June 2015

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers

scientific article published on 18 July 2019

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

scientific article

Rho and Rac take center stage

scientific journal article

Rho-family GTPases: it's not only Rac and Rho (and I like it).

scientific article

RhoG signals in parallel with Rac1 and Cdc42

scientific article

Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

scientific article (publication date: July 2003)

SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

scientific article

Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model

scientific article published on 25 September 2015

Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

scientific article published on June 2017

Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells

scientific article published on 01 April 2021

Serine phosphorylation negatively regulates RhoA in vivo.

scientific article published on 24 March 2003

Somatic STAT3 mutations in large granular lymphocytic leukemia ⬇️

scientific article

Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles.

scientific article published on 22 July 2015

Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells

scientific article published on 16 January 2017

Systematic identification of feature combinations for predicting drug response with Bayesian multi-view multi-task linear regression

scientific article published on July 2017

TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples

scientific article

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways

scientific article

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

scientific article published on 25 July 2018

The Ras superfamily at a glance

scientific article (publication date: March 2005)

The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation

scientific article

The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

scientific article published in May 2014

Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma

scientific article published on 01 September 2020

Toward universal protein post-translational modification detection in high throughput format.

scientific article

Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

scientific article

What is synergy? The Saariselkä agreement revisited

scientific article

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

scientific article (publication date: 8 November 2002)

c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease

scientific article

p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.

scientific article published on 14 February 2004

Paulina is supported by:

About Paulina

Help