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List of works by Louis Ignarro

17β-Estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells ⬇️

scientific article published on May 12, 2003

A multifaceted approach to maximize erectile function and vascular health

scientific article published on June 2010

A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits

scientific article published in October 2004

A new role for cardioplegic buffering: should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts?

scientific article

A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection

scientific article

A spectrophotometric assay for nitrate using NADPH oxidation by Aspergillus nitrate reductase

scientific article published in August 1993

Acetylcholine vasodilation of resistance vessels in vivo may not entirely depend on newly synthesized nitric oxide

scientific article published on 01 March 1991

Activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside, and nitrosoguanidine--inhibition by calcium, lanthanum, and other cations, enhancement by thiols

scientific article published on 01 November 1980

Activation of hepatic guanylate cyclase by nitrosyl-heme complexes. Comparison of unpurified and partially purified enzyme

scientific article published on 01 September 1981

Activation of purified guanylate cyclase by nitric oxide requires heme. Comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung

scientific article published on 01 September 1982

Activation of purified soluble guanylate cyclase by arachidonic acid requires absence of enzyme-bound heme

scientific article published in April 1987

Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid

scientific article published in June 1986

Activation of purified soluble guanylate cyclase by protoporphyrin IX.

scientific article

Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms

scientific article published on 01 April 1986

Acute arterial thrombosis causes endothelial dysfunction: a new paradigm for thrombolytic therapy

scientific article published in August 2001

Acute effects of transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women

scientific article published on 01 January 1997

Adenosine 3',5'-monophosphate formation by preparations of rat liver soluble guanylate cyclase activated with nitric oxide, nitrosyI ferroheme, S-nitrosothiols, and other nitroso compounds ⬇️

scientific article published on 01 December 1980

Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat

article

Adipose tissue-derived stem cell-seeded small intestinal submucosa for tunica albuginea grafting and reconstruction

scientific article published on 23 January 2012

After 130 years, the molecular mechanism of action of nitroglycerin is revealed

scientific article

Amplified nitric oxide production by pulmonary alveolar macrophages of newborn rats

scientific article

An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity

scientific article

Antagonistic modulatory roles of magnesium and calcium on release of endothelium-derived relaxing factor and smooth muscle tone

scientific article

Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice ⬇️

scientific article published on March 15, 1998

Appearance and concentrations of catecholamines and their biosynthesis in the embryonic and developing chick

scientific article published in January 1968

Arachidonic acid activation of guinea pig lung guanylate cyclase by two independent mechanisms ⬇️

scientific article published on October 1, 1979

Arachidonic acid and acetylcholine induced relaxation of bovine coronary artery: effect of indomethacin and methylene blue

scientific article published in May 1986

Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production

scientific article published in November 1996

Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery ⬇️

scientific article published on March 1, 1984

Atriopeptin II relaxes and elevates cGMP in bovine pulmonary artery but not vein

scientific article published in April 1986

Autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the diabetic mouse hindlimb

scientific article

Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis

scientific article published on December 1992

Basic polyamino acids rich in arginine, lysine, or ornithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein

scientific article published on February 1989

Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress

scientific article

Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb

scientific article published on 14 November 2005

Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress

scientific article

Bidirectional Regulation of Lysosomal Enzyme Secretion and Phagocytosis in Human Neutrophils by Guanosine 3',5'-Monophosphate and Adenosine 3',5'-Monophosphate ⬇️

scientific article published on March 1, 1976

Biochemical and immunohistochemical characterization of nitric oxide synthase in the rat retina

scientific article published on 01 January 1996

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein

scientific article

Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology

scientific article published on 24 May 2018

Bioregulation of lysosomal enzyme secretion from human neutrophils: roles of guanosine 3':5'-monophosphate and calcium in stimulus-secretion coupling ⬇️

scientific article published on January 1, 1975

Biosynthesis and metabolism of endothelium-derived nitric oxide

scientific article published on January 1990

Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum

scientific article published on July 15, 1992

Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: Essential role of astrocyte-derived plasminogen activator inhibitor-1 ⬇️

scientific article published on December 28, 2010

Bone marrow cell-mediated cardiovascular repair: potential of combined therapies

scientific article

Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia

scholarly article

Breakdown of noncollagenous chondromucoprotein matrix by leukocyte lysosome granule lysates from guinea pig, rabbit, and human

scientific article published in November 1973

CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy

scientific article

Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties

scientific article

Catechol-O-methyl transferase and monoamine oxidase activities in the heart and liver of the embryonic and developing chick

scientific article published on 01 January 1968

Cell density-enhanced expression of inducible nitric oxide synthase in murine macrophages mediated by interferon-beta

scientific article published in June 2003

Certain S-Substituted Isothioureas Not Only Inhibit NO Synthase Catalytic Activity but Also Decrease Translation and Stability of Inducible NO Synthase Protein ⬇️

scientific article published on January 1, 1998

Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritis

scientific article published on 01 March 1972

Characterization and actions of human umbilical endothelium derived relaxing factor

scientific article published on February 1991

Circulating levels of nitric oxide in fertile women in relation to the menstrual cycle

scientific article published on 01 December 1996

Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells

scientific article

Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide

scientific article published on May 1995

Combined effect of testosterone and apocynin on nitric oxide and superoxide production in PMA-differentiated THP-1 cells

scientific article published in September 2004

Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release ⬇️

scientific article published on June 1, 1991

Concomitant production of nitric oxide and superoxide in human macrophages ⬇️

scientific article (publication date: 17 October 2003)

Condensed expirate nitrite as a home marker for acute asthma

scientific article published on 01 November 1995

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine ⬇️

scientific article published on November 30, 1992

Contractile effects of 5-hydroxytryptamine in isolated intrapulmonary arteries and veins ⬇️

scientific article published on February 1, 1981

Contributions to a quest

scientific article published on 01 December 1987

Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO

scientific article published on 01 October 1993

Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N'-nitrosonornicotine and nitric oxide ⬇️

scientific article published on July 1, 1980

Cytidine 3′,5′-Monophosphate (Cyclic CMP) Formation in Mammalian Tissues ⬇️

scientific article published on December 9, 1977

Cytidine 3′,5′-monophosphate (cyclic CMP) formation by homogenates of mouse liver ⬇️

scientific article published on January 13, 1978

D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet

scientific article published on 11 July 2006

Deep hypothermic circulatory arrest and global reperfusion injury: avoidance by making a pump prime reperfusate--a new concept

scientific article published in March 2003

Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis

scientific article

Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation

scientific article published in October 1989

Detrimental effects of Bartonella henselae are counteracted by L-arginine and nitric oxide in human endothelial progenitor cells

scholarly article

Differences in responsiveness of intrapulmonary artery and vein to arachidonic acid: mechanism of arterial relaxation involves cyclic guanosine 3':5'-monophosphate and cyclic adenosine 3':5'-monophosphate

scientific article published in June 1985

Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol

scientific article published in January 2008

Different plasma levels of nitric oxide in arterial and venous blood

scientific article published on 01 September 1999

Directed in vivo angiogenesis assay and the study of systemic neoangiogenesis in cancer

scientific article published on 06 January 2011

Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liver ⬇️

scientific article published on October 1, 1971

Dissimilarities between methylene blue and cyanide on relaxation and cyclic GMP formation in endothelium-intact intrapulmonary artery caused by nitrogen oxide-containing vasodilators and acetylcholine

scientific article published in January 1986

Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide

scientific article published on 28 February 2011

EDRF generation and release from perfused bovine pulmonary artery and vein

scientific article published in April 1988

Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients

scientific article published on 29 March 2011

Effects of a Pomegranate Fruit Extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis

article

Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro ⬇️

scientific article published on October 1, 1971

Effects of estrogen replacement therapy on plasma levels of nitric oxide in postmenopausal women

scientific article published on 01 February 1999

Effects of methylene blue on hypoxic cerebral vasodilatation in the rabbit

scientific article

Effects of nitric oxide on cell proliferation: novel insights

scientific article

Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice

scholarly article

Effects of short-term transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women

scientific article published on 01 January 1998

Effects of tibolone on plasma levels of nitric oxide in postmenopausal women

scientific article

Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis.

scientific article

Electrical field stimulation causes endothelium-dependent and nitric oxide-mediated relaxation of pulmonary artery ⬇️

scientific article published on April 1, 1992

Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation

scientific article

Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes

scientific article published on 07 January 2014

Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes

scholarly article

Endothelial dysfunction after arterial thrombosis is ameliorated by L-arginine in combination with thrombolysis

scientific article

Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo

scientific article

Endothelial progenitor cells as therapeutic agents in the microcirculation: an update

scientific article

Endothelial stunning and myocyte recovery after reperfusion of jeopardized muscle: a role of L-arginine blood cardioplegia

scientific article published on 01 February 1997

Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein

scientific article published in January 1987

Endothelium-dependent relaxation and the acute pulmonary vascular response to alveolar hyperoxia in neonatal pigs

scientific article

Endothelium-derived nitric oxide relaxes nonvascular smooth muscle

scientific article published in February 1989

Endothelium-derived nitric oxide: actions and properties

scientific article

Endothelium-derived nitric oxide: pharmacology and relationship to the actions of organic nitrate esters

scientific article published on August 1989

Endothelium-derived relaxing factor and nitric oxide possess identical pharmacologic properties as relaxants of bovine arterial and venous smooth muscle

scientific article published on 01 July 1988

Endothelium-derived relaxing factor as a mediator of bradykinin-induced perinatal pulmonary vasodilatation in fetal sheep

scientific article published in January 1997

Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical

scientific article published on 01 December 1987

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide

scientific article (publication date: December 1987)

Enzyme Release from Guinea-pig Polymorphonuclear Leucocyte Lysosomes Inhibited in vitro by Anti-Inflammatory Drugs ⬇️

scientific article published on October 4, 1972

Enzyme release from polymorphonuclear leukocyte lysosomes: regulation by autonomic drugs and cyclic nucleotides.

scientific article

Erectile hydraulics: maximizing inflow while minimizing outflow

scientific article

Estrogen receptor-mediated vascular responsiveness to nebivolol: a novel endothelium-related mechanism of therapeutic vasorelaxation

scientific article published in May 2004

Estrogen-related receptor α1 up-regulates endothelial nitric oxide synthase expression ⬇️

scientific article published on November 10, 2003

Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators ⬇️

scientific article published on 01 May 1981

Evidence for the presence of an unusual nitric oxide- and citrulline-producing enzyme in rat kidney

scientific article published in March 1997

Evidence that regulation of hepatic guanylate cyclase activity involves interactions between catalytic site SH groups and both substrate and activator ⬇️

scientific article published on April 15, 1981

Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery

scientific article published on March 2009

Experimental evidences of nitric oxide-dependent vasodilatory activity of nebivolol, a third-generation beta-blocker

scientific article

Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.

scientific article published in November 1994

Free radical biology and medicine: it's a gas, man!

scientific article

Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease

scientific article published on 07 December 2007

Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves

scientific article published on 01 October 2000

Gender differences in atherosclerosis: possible role of nitric oxide.

scientific article published in November 1995

Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis ⬇️

scientific article published on July 1, 1997

Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits

scientific article

Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat.

scientific article published on September 1999

Glucocorticosteroid inhibition of nonphagocytic discharge of lysosomal enzymes from human neutrophils

scientific article published on 01 January 1977

Glycoxidized low-density lipoprotein downregulates endothelial nitricoxide synthase in human coronary cells

scientific article

Glycoxydation promotes vascular damage Via MAPK-ERK/JNK pathways

scientific article published on 01 November 2012

Guanylate cyclase activation by nitroprusside and nitrosoguanidine is related to formation of S-nitrosothiol intermediates ⬇️

scientific article published on May 14, 1980

Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme ⬇️

scientific article published on November 25, 1982

Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes ⬇️

scientific article published on May 10, 1984

Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism

scientific article published on May 1, 1992

Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: a unique transduction mechanism for transcellular signaling

scientific article published on July 1990

Heart mtNOS, a key mediator of oxidative injury in ischemia/reperfusion

scientific article published on 24 July 2007

Heme-Dependent Activation of Guanylate Cyclase by Nitric Oxide: A Novel Signal Transduction Mechanism ⬇️

scientific article published on January 1, 1991

Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins

scientific article

Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase

scientific article published on April 1987

Herbalife nutritional products and liver injury revisited

scientific article published on 23 May 2008

High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: Implications for atherosclerosis

Hormonal control of lysosomal enzyme release from human neutrophils. Effects of autonomic agents on enzyme release, phagocytosis, and cylic nucleotide levels

scientific article published on June 1974

Hormonal control of lysosomal enzyme release from human neutrophils: elevation of cyclic nucleotide levels by autonomic neurohormones

scientific article published on May 1974

Hormonal control of neutrophil lysosomal enzyme release: effect of epinephrine on adenosine 3',5'-monophosphate

scientific article published on 01 March 1974

Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation

scientific article

Hypoxia increases cGMP and decreases calcium uptake in rabbit cranial arteries

scientific article published on 01 January 1988

IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells

scientific article published on July 2000

IL-4 and IL-13 upregulate ornithine decarboxylase expression by PI3K and MAP kinase pathways in vascular smooth muscle cells

scientific article

Immunosuppressive effects of interleukin-12 coexpression in melanoma antigen gene-modified dendritic cell vaccines

scientific article

Increased nitric oxide concentrations in posterior hypothalamus and central sympathetic function on nitrate tolerance following subcutaneous nitroglycerin

scientific article published on January 1999

Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes

scientific article published in May 1997

Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide.

scientific article published on December 1993

Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis

scientific article published in April 1997

Induction of arginase II in human Caco-2 tumor cells by cyclic AMP.

scientific article published on February 2000

Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed.

scientific article published in April 1993

Inhaled Nitric Oxide and COVID-19

scientific article published on 28 April 2020

Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation ⬇️

scientific article published on May 1, 1983

Inhibition of lysosomal enzyme release by adenosine 5' triphosphate and N 6 ,O 2 -dibutyryl cyclic 3',5'-adenosine monophosphate

scientific article published on 01 April 1972

Inhibition of lysosomal enzyme release by catecholamines: possible mediation by cyclic 3',5'-adenosine monophosphate

scientific article published on 01 November 1971

Inhibition of mammalian soluble guanylate cyclase activity by adenosine 5'-tetraphosphate, guanosine 5'-tetraphosphate and other nucleotides

scientific article published on September 1, 1976

Inhibition of soybean lipoxygenase by SKF 525-A and metyrapone

scientific article published on 01 October 1985

Inhibitors of nitric oxide promote microvascular thrombosis

scientific article

Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B

scientific article published on April 1996

Interference with stimulus-secretion coupling by glucocorticosteroids

scientific article published on January 1, 1978

Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function

scientific article

L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation

scientific article published in June 1989

L-arginine inhibits balloon catheter-induced intimal hyperplasia

scientific article published on 01 May 1993

L-arginine-dependent vascular smooth muscle relaxation and cGMP formation

scientific article

Letter in response to: "Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial

scientific article published on 24 June 2019

Levels of nitric oxide metabolites do not increase during penile erection

scientific article published on 01 November 1993

Lifestyle and metabolic approaches to maximizing erectile and vascular health ⬇️

scientific article published on November 10, 2011

Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages

scientific article

Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice

scholarly article

Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima-media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension

scientific article published in December 2008

Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution.

scientific article published in January 1994

Low-dose L-arginine administration increases microperfusion of hindlimb muscle without affecting blood pressure in rats

scientific article

Lysosomal Enzyme Release: A Possible Mechanism of Action of Cobalt as an Erythropoietic Stimulant

scientific article published on July 1, 1974

Lysosomal enzyme release in vivo: an evaluation of the mechanism of cobalt polycythemia

scientific article published on 01 December 1974

Lysosomal enzyme secretion from human neutrophils mediated by cyclic CMP: inhibition of cyclic GMP accumulation and neutrophil function by glucocorticosteroids

scientific article published on January 1, 1975

Lysosome membrane stabilization in vivo: effects of steroidal and nonsteroidal anti-inflammatory drugs on the integrity of rat liver lysosomes ⬇️

scientific article published on July 1, 1972

May Mangafodipir or Other SOD Mimetics Contribute to Better Care in COVID-19 Patients?

scientific article published on 10 October 2020

Mechanism of action of nitric oxide: heme-dependent activation of guanylate cyclase represents a unifying signal transduction mechanism.

scientific article

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates ⬇️

scientific article published on 01 September 1981

Mechanisms by which exercise training benefits patients with heart failure

scientific article published on April 2009

Mechanisms of endothelium-dependent vascular smooth muscle relaxation elicited by bradykinin and VIP.

scientific article published in November 1987

Mediation of immunologic discharge of lysosomal enzymes from human neutrophils by guanosine 3',5'-monophosphate. Requirement of calcium, and inhibition by adenosine 3',5'-monophosphate

scientific article published on July 1974

Melatonin synergistically increases resveratrol‐induced heme oxygenase‐1 expression through the inhibition of ubiquitin‐dependent proteasome pathway: a possible role in neuroprotection ⬇️

scientific article published on November 15, 2010

Methemoglobin blockade of coronary arterial soluble guanylate cyclase activation by nitroso compounds and its reversal with dithiothreitol ⬇️

scientific article published on June 15, 1979

Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite ⬇️

scientific article published on February 1, 1981

Microcirculation and oxidative stress

scientific article published on December 2007

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide

scientific article published on 01 August 1993

Muscarinic stimulation of cardiac guanylate cyclase

scientific article published on January 1, 1975

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na/H exchange

scientific article

NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice

scientific article

NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts

scientific article

NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols

scientific article

NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation

scientific article published on 01 April 1990

NG-hydroxy-l-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms ⬇️

scientific article published on October 1, 1998

NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein

scientific article

NO is more important than PGI2 in maintaining low vascular tone in feto-placental vessels

scientific article

Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP.

scientific article published in September 2002

Nebivolol: a selective beta(1)-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide- and cyclic GMP-dependent mechanisms

scientific article published in September 2002

Negative feedback regulation of endothelial cell function by nitric oxide ⬇️

scientific article published on November 1, 1993

Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds

scientific article published on January 1995

Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis

scientific article

Neuroprotective effects of valproic acid against hemin toxicity: Possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin–proteasomal pathway ⬇️

scientific article published on January 5, 2013

Neurotransmitter identity doubt

scientific article published in September 1990

Neurotransmitters and cytokines in CNS pathology.

scientific article published on January 1994

Neutral protease release from human leukocytes regulated by neurohormones and cyclic nucleotides.

scientific article

New species may create new problems: norepinephrine in the heart of the avian embryo

scientific article published on July 1967

Nitric Oxide and the Cyclic GMP System in the Penis.

scientific article

Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission ⬇️

scientific article published on January 9, 1992

Nitric Oxide in Vascular Damage and Regeneration

Nitric Oxide in the Development of Vascular Diseases and Regenerative Angiogenesis

article

Nitric Oxide is a Potent Relaxant of Human and Rabbit Corpus Cavernosum ⬇️

scientific article published on June 1, 1992

Nitric Oxide, Oxidative Stress, Immune Response and Critical Care

Nitric oxide

scientific article published on 01 January 2005

Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin

scientific article published on 21 June 2006

Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties

scholarly article

Nitric oxide and atherosclerosis

scientific article

Nitric oxide and atherosclerosis: an update

scientific article

Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs

scientific article

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle.

scientific article published in July 1990

Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

scientific article published on 29 August 2009

Nitric oxide and prostacyclin inhibit fetal platelet aggregation: a response similar to that observed in adults

scientific article published in December 1992

Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro

scientific article published in August 1994

Nitric oxide as a signaling molecule in the vascular system: an overview.

scientific article

Nitric oxide as a unique signaling molecule in the vascular system: a historical overview

scientific article

Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview

scientific article

Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins

scientific article published on 01 October 1995

Nitric oxide improves cisplatin cytotoxicity in head and neck squamous cell carcinoma

scientific article published on November 2001

Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes

scientific article published on March 1995

Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.

scientific article published on August 1994

Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation

scientific article published on August 1999

Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme

scientific article published on 18 July 2001

Nitric oxide is not just blowing in the wind

scientific article published on 01 January 2019

Nitric oxide reduces early growth response-1 gene expression in rat lung macrophages treated with interferon-gamma and lipopolysaccharide ⬇️

scientific article published on October 14, 1994

Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo.

scientific article published in July 1996

Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine

scientific article published on June 30, 1992

Nitric oxide-cyclic GMP signal transduction system.

scientific article published on January 1996

Nitric oxide-mediated neuronal injury in multiple sclerosis

scientific article published on October 1992

Nitric oxide-mediated vasorelaxation

scientific article published on July 1, 1993

Nitric oxide-releasing drugs

scientific article

Nitric oxide. A novel signal transduction mechanism for transcellular communication

scientific article

Nitric oxide: a unique endogenous signaling molecule in vascular biology

scientific article

Nitric oxide: inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression

scientific article published in April 2004

Nitric-oxide-induced reoxygenation injury in the cyanotic immature heart is prevented by controlling oxygen content during initial reoxygenation

scientific article published on 01 March 1997

Nitroaspirin (NCX-4016), an NO donor, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells

scientific article (publication date: November 2007)

Nonphagocytic release of neutral protease and beta-glucuronidase from human neutrophils. Regulation by autonomic neurohormones and cyclic nucleotides

scientific article published on 01 January 1974

Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene

scientific article published on March 1995

Norepinephrine and epinephrine in the embryo and embryonic heart of the chick: uptake and subcellular distribution ⬇️

scientific article published in January 1968

Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis

scientific article published on July 2004

Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis

scientific article published in February 2005

Nuclear Fusion‐Independent Smooth Muscle Differentiation of Human Adipose‐Derived Stem Cells Induced by a Smooth Muscle Environment ⬇️

scientific article published on 01 March 2012

Nuclear factor-kappa B and mitogen-activated protein kinases mediate nitric oxide-enhanced transcriptional expression of interferon-beta

scientific article

Nutrition and cardiovascular disease: Putting a pathogenic framework into focus

scientific article published on 29 November 2006

Nutrition, physical activity, and cardiovascular disease: an update

scientific article

Opposing regulatory influences of cyclic guanosine monophosphate and cyclic adenosine monophosphate in the control of cardiac muscle contraction

scientific article published on January 1, 1975

Oppositional effects of acetylcholine and isoproterenol on isometric tension and cyclic nucleotide concentrations in rabbit atria

scientific article published on January 1, 1975

Oxidation of LDL to a biologically active form by derivatives of nitric oxide and nitrite in the absence of superoxide. Dependence on pH and oxygen

scientific article published on November 1994

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine ⬇️

scientific article published on September 1, 1993

Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis

scientific article

Oxidative insult associated with hyperoxic cardiopulmonary bypass in the infantile heart and lung

scientific article published on 01 June 1996

Oxygen-mediated regulation of neonatal and adult rabbit aortic tension

scientific article published on January 1, 1992

Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation

scientific article

Pharmacology of endothelium-derived nitric oxide and nitrovasodilators

scientific article

Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer

scientific article

Physical training and metabolic supplementation reduce spontaneous atherosclerotic plaque rupture and prolong survival in hypercholesterolemic mice

scientific article

Physiological release of nitric oxide is dependent on the level of vascular tone

scientific article published on 01 November 1990

Physiological significance of endogenous nitric oxide

scientific article published on February 1, 1991

Physiology and pathophysiology of nitric oxide.

scientific article

Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release

scientific article

Polymorphisms in endothelial nitric oxide synthase and carotid artery atherosclerosis

scientific article

Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide

scientific article published on 19 April 2006

Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells

scientific article published on 18 January 2006

Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds

scientific article published on February 1980

Potential cardioprotective actions of no-releasing aspirin

scientific article (publication date: May 2002)

Preface to this special journal issue on nitric oxide chemistry and biology

scientific article published in August 2009

Preservation of endothelium-dependent vasodilation with low-potassium University of Wisconsin solution

scientific article published on 01 July 1996

Preservation of structural integrity of liver lysosomes and membrane-stabilizing action of anti-inflammatory drugs, catecholamines and cyclic adenosine monophosphate in isotonic salt media

scientific article published on 01 June 1973

Production and excretion of nitrate by human newborn infants: neonates are not little adults

scientific article published on February 2000

Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart

scientific article

Pulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass

scientific article published on 01 June 1996

Pulmonary vasodilator responses to nitroprusside and nitroglycerin in the dog.

scientific article published on March 1981

Purification and properties of heme-deficient hepatic soluble guanylate cyclase: Effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX ⬇️

scientific article published on 01 October 1982

Pyrrolidine Dithiocarbamate Inhibits Induction of Nitric Oxide Synthase Activity in Rat Alveolar Macrophages ⬇️

scientific article published on March 31, 1993

Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: regulation of estrogen-dependent gene transcription

scientific article

Reduction of reoxygenation injury and nitric oxide production in the cyanotic immature heart by controlling pO2.

scientific article published on January 1995

Regulation of cytosolic guanylyl cyclase by porphyrins and metalloporphyrins.

scientific article published on January 1994

Regulation of inducible nitric oxide synthase expression in advanced glycation end product-stimulated raw 264.7 cells: the role of heme oxygenase-1 and endogenous nitric oxide

scientific article published on July 2004

Regulation of lysosomal enzyme release by prostaglandins, autonomic neurohormones and cyclic nucleotides

scientific article published on January 1, 1975

Regulation of lysosomal enzyme secretion: role in inflammation

scientific article

Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept

scientific article published on January 1, 1984

Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins

scientific article published on May 1984

Regulation of tissue plasminogen activator/plasminogen activator inhibitor‐1 by hydrocortisone in rat primary astrocytes ⬇️

scientific article published on March 15, 2011

Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin ⬇️

scientific article published on October 1, 1981

Relaxation of bovine coronary arterial smooth muscle by cyclic GMP, cyclic AMP and analogs ⬇️

scientific article published on 01 March 1980

Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine

scientific article published on January 1, 1979

Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP.

scientific article published on January 1984

Release of cartilage mucopolysaccharide-degrading neutral protease from human leukocytes

scientific article published on August 1973

Release of enzymes from a rat liver lysosome fraction: inhibition by catecholamines and cyclic3', 5'-adenosine monophosphate, stimulation by cholinergic agents and cyclic 3', 5'-guanosine monophosphate

scientific article published on 01 July 1973

Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants

scientific article published on July 1, 1974

Reply to Klar: Key role of YY1 in neoangiogenesis.

scientific article published on 17 December 2010

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols ⬇️

scientific article published on August 13, 1980

Research recommendations and conclusions from the National Institutes of Child Health and Human Development Conference on Endothelium-Derived Vasoactive Substances in Perinatal Research

scientific article published in February 1991

Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin

scholarly article

Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury

scientific article published on February 1, 1992

Role of controlled cardiac reoxygenation in reducing nitric oxide production and cardiac oxidant damage in cyanotic infantile hearts

scientific article

Role of nitric oxide in the relationship of pancreatic blood flow and exocrine secretion in cats

scientific article

Role of oxidative stress in experimental sepsis and multisystem organ dysfunction

scientific article published on July 2006

Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide

scientific article

Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation

scientific article (publication date: 27 March 2001)

Selective alterations in responsiveness of guanylate cyclase to activation by nitroso compounds during enzyme purification ⬇️

scientific article published on 01 April 1981

Sensing endoplasmic reticulum stress by protein kinase RNA‐like endoplasmic reticulum kinase promotes adaptive mitochondrial DNA biogenesis and cell survival via heme oxygenase‐1/carbon monoxide activity ⬇️

scientific article published on 05 March 2012

Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene

scientific article

Shear stress-induced release of nitric oxide from endothelial cells grown on beads

scientific article published in February 1991

Signal transduction mechanisms involving nitric oxide

scientific article published on February 1991

Small Molecule Signaling Agents: The Integrated Chemistry and Biochemistry of Nitrogen Oxides, Oxides of Carbon, Dioxygen, Hydrogen Sulfide, and Their Derived Species ⬇️

scientific article published on February 9, 2012

Sp1 transcription factor expression is regulated by estrogen-related receptor alpha1.

scientific article

Stimulation of mammalian adenylate cyclase activity with guanosine 5'-tetraphosphate and other guanine nucleotides

scientific article published on June 15, 1978

Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate

scientific article published on 01 January 1974

Studies of hypoxemic/reoxygenation injury: with aortic clamping. XIII. Interaction between oxygen tension and cardioplegic composition in limiting nitric oxide production and oxidant damage

scientific article

Studies of hypoxemic/reoxygenation injury: without aortic clamping. V. Role of the L-arginine-nitric oxide pathway: the nitric oxide paradox

scientific article published on October 1995

Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension

scientific article

The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio

scientific article published on April 2007

The Link Between Erectile and Cardiovascular Health: The Canary in the Coal Mine ⬇️

scientific article published on May 31, 2011

The cloned neurotensin receptor mediates cyclic GMP formation when coexpressed with nitric oxide synthase cDNA.

scientific article published on July 1994

The effects of amrinone on human platelet aggregation: evidence that amrinone does not act through a cyclic nucleotide mechanism in platelet rich plasma

scientific article published on 01 May 1985

The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats

scientific article published on 05 May 2007

The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation

scientific article

The presence of antagonistically acting alpha and beta adrenergic receptors in the mouse spleen ⬇️

scientific article published in March 1968

The protective effect of tetrahydrobiopterin on the nitric oxide-mediated inhibition of purified nitric oxide synthase

scientific article published on 01 January 1995

The requriement of sympathetic innervation for the active transport of norepinephrine by the heart

scientific article published in January 1968

The role of oxidative stress in adult critical care

scientific article

The unique role of nitric oxide as a signaling molecule in the cardiovascular system

scientific article published on 01 September 2000

Therapeutic angiogenesis in diabetic apolipoprotein E-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention

scientific article

Therapeutic approaches in vascular repair induced by adult bone marrow cells and circulating progenitor endothelial cells

scientific article

Therapeutic dose of nebivolol, a nitric oxide-releasing beta-blocker, reduces atherosclerosis in cholesterol-fed rabbits

scientific article published on 4 April 2008

Therapeutic effects of autologous bone marrow cells and metabolic intervention in the ischemic hindlimb of spontaneously hypertensive rats involve reduced cell senescence and CXCR4/Akt/eNOS pathways

scientific article

Therapeutic effects of concurrent autologous bone marrow cell infusion and metabolic intervention in ischemia-induced angiogenesis in the hypercholesterolemic mouse hindlimb

scientific article

Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia.

scientific article

Up-regulation of endothelial nitric oxide synthase through beta(2)-adrenergic receptor--the role of a beta-blocker with NO-releasing action

scientific article

Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide

scientific article published in July 1990

Vasodilator actions of several N-nitroso compounds ⬇️

scientific article published on January 1, 1982

Wei Lun Visiting Professorial Lecture: Nitric oxide in the regulation of vascular function: an historical overview.

scientific article

l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits

scientific article

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