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List of works by Sadayoshi Itō

'Lead pipe'-like stiff aorta with grossly widened pulse pressure in burned-out Takayasu arteritis

scientific article published on 28 March 2017

(Pro)renin receptor is involved in mesangial fibrosis and matrix expansion.

scientific article published on 8 January 2018

18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status

scientific article published on 01 June 2019

18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism

scientific article

A 29-year-old Woman with Recurrent Pregnancy-induced Hypertension Based on Vascular Compression of the Medulla Oblongata

scientific article published on 17 April 2019

A Case of IgG4-related Tubulointerstitial Nephritis Complicated Nephrotic Syndrome ⬇️

scientific article published on March 10, 2012

A Catastrophic Case of Idiopathic Cholesterol Crystal Embolism with Multiple Lethal Complications: A Labyrinth Underneath the Diagnosis of Skin Ulcers in Chronic Kidney Disease Patients

scientific article published on 01 February 2019

A Message From the New Editorial Team at the American Journal of Hypertension

scientific article

A case of aldosterone-producing adrenocortical adenoma associated with a probable post-operative adrenal crisis: histopathological analyses of the adrenal gland.

scientific article published in August 2003

A case of bilateral aldosterone-producing adenomas differentiated by segmental adrenal venous sampling for bilateral adrenal sparing surgery

scientific article published on 5 November 2015

A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide

scientific article (publication date: June 2003)

A decline in glomerular filtration rate rather than renal arterial stenotic lesions, per se, predicts cardiovascular-renal events in type 2 diabetic patients.

scientific article

A functional (pro)renin receptor is expressed in human lymphocytes and monocytes.

scientific article published on 10 December 2014

A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS).

scientific article published on 14 November 2012

A multicenter trial of mizoribine compared with placebo in children with frequently relapsing nephrotic syndrome

scientific article published on 01 July 2000

A novel Sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats.

scientific article published on 24 July 2008

A novel and sensitive assay for heme oxygenase activity

scientific article published on 29 July 2015

A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial

scientific article

A novel clinical biomarker for myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis

scientific article published on 14 June 2010

A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-α and TGF-β1 pathways

scientific article

A novel regulatory role of gp49B on dendritic cells in T-cell priming

scientific article published on 01 September 2008

ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration

scientific article published on 15 April 2019

Acarbose lowers serum triglyceride and postprandial chylomicron levels in type 2 diabetes.

scientific article

Achieving LDL-C target levels less than 70 mg/dL may provide extra cardiovascular protection in high-risk patients: exploratory analysis of the Standard Versus Intensive Statin Therapy for Patients With Hypercholesterolemia and Diabetic Retinopathy S

scientific article published on 06 December 2018

Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells

scientific article published on 8 February 2018

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

scientific journal article

Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic CYP3A4 Inhibition by Clarithromycin Plus Voriconazole

scientific article published on July 2017

Adrenomedullin and its receptor complexes in remnant kidneys of rats with renal mass ablation: decreased expression of calcitonin receptor-like receptor and receptor-activity modifying protein-3

scientific article published on 01 November 2001

Adult onset Fanconi syndrome: extensive tubulo-interstitial lesions and glomerulopathy in the early stage of Chinese herbs nephropathy.

scientific article published in September 2004

Albuminuria indicates the pressure-associated injury of juxtamedullary nephrons and cerebral strain vessels in spontaneously hypertensive stroke-prone rats

scientific article published on 23 August 2012

Aldosterone suppression on contralateral adrenal during adrenal vein sampling does not predict blood pressure response after adrenalectomy

scientific article published on 13 August 2014

Aldosterone-Producing Adenomas: Genotypes and Phenotypes.

scientific article

Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals

scientific article published on 12 May 2017

Aldosterone-producing adenoma accompanied with renal artery stenosis

scientific article published on 01 July 2006

Aliskiren reduces albuminuria and oxidative stress, and elevates glomerular filtration rates in Japanese patients with advanced diabetic nephropathy

scientific article published on 16 December 2010

All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta

scientific article

All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling

scientific article published on 14 December 2006

Alpha-oxoaldehydes in haemodialysis solution

scientific article published on 15 March 2007

Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD.

scientific article published on 18 December 2014

Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis

scientific article

Altered sympathetic and vagal modulations of the cardiovascular system in patients with pheochromocytoma: their relations to orthostatic hypotension

scientific article published on 01 June 1999

An immortalized cell line derived from renal erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts

scientific article published on 02 August 2019

An in vitro approach to the study of macula densa-mediated glomerular hemodynamics

scientific article published on 01 December 1990

Angiographic index for angioplasty-treatable atheromatous renal artery stenosis

scientific article published in May 2008

Angiotensin II Type 1 Receptor Blockers Reduce Urinary Angiotensinogen Excretion and the Levels of Urinary Markers of Oxidative Stress and Inflammation in Patients with Type 2 Diabetic Nephropathy

scientific article published on 23 June 2009

Angiotensin II action in isolated microperfused rabbit afferent arterioles is modulated by flow

scientific article published in February 1996

Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.

scientific article published on 12 December 2013

Angiotensin II type 1 receptor blockers reduce urinary oxidative stress markers in hypertensive diabetic nephropathy

scientific article published on 27 February 2006

Aortic Blood Flow Reversal Determines Renal Function: Potential Explanation for Renal Dysfunction Caused by Aortic Stiffening in Hypertension

scientific article published on 27 April 2015

Aortic stiffness determines diastolic blood flow reversal in the descending thoracic aorta: potential implication for retrograde embolic stroke in hypertension

scientific article published on 24 June 2013

Apparent Diffusion Coefficient in the Resolution of Renal Ischemia after Angioplasty on Diffusion-weighted Imaging: A Case of Renal Artery Stenosis Caused by Progressive Thrombosis in Residual Chronic Aortic Dissection

scientific article published on 17 January 2020

Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia

scientific article published in February 2004

Assessment of competence of predialysis chronic kidney disease stage 5 patients to make treatment decisions: preliminary report

scientific article

Association Between Home Blood Pressure and Body Composition by Bioimpedance Monitoring in Patients Undergoing Peritoneal Dialysis

scientific article published in January 2015

Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.

scientific article published on 13 February 2014

Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice

scientific article published on 17 May 2009

Autoinduction of tumor necrosis factor-alpha in FRTL-5 rat thyroid cells.

scientific article published on October 2005

Autonomously functioning thyroid nodule associated with thyrotoxic periodic paralysis

scientific article published on 17 January 2008

Awareness about and educational intervention for chronic kidney disease in the general population: from a survey of participants at the CKD educational lecture in Miyagi prefecture

scientific article published in January 2014

Beneficial role of tolvaptan in the control of body fluids without reductions in residual renal function in patients undergoing peritoneal dialysis

scientific article published in January 2013

Better Healing of the Exit Site with Negative-Pressure Wound Therapy

scientific article published on 01 November 2018

Bilateral calcified renal artery aneurysms in a patient with von Recklinghausen's disease

scientific article published on 01 May 2005

Biological effects of electrolyzed water in hemodialysis.

scientific article published on 3 April 2009

Biphasic vasodilator action of troglitazone on the renal microcirculation.

scientific article published in February 2002

Blockade of angiotensin II type-1 receptor increases salt sensitivity in Sprague-Dawley rats.

scientific article published in May 2009

Blood purification therapies in methotrexate-induced acute kidney injury: four case reports

CKD Clinical Practice Guidebook. The essence of treatment for CKD patients

scientific article published on 01 June 2009

COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.

scholarly article

Calibration and evaluation of routine methods by serum certified reference material for aldosterone measurement in blood

scientific article published on 2 September 2016

Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model.

scientific article published on 22 November 2017

Carbonated soft drinks and carbonyl stress burden

scientific article published in December 2009

Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats

scientific article published on 31 January 2013

Cardiac infarcts increase sodium transporter transcripts (rBSC1) in the thick ascending limb of Henle

scientific article published on 01 May 2000

Cardiorenal connection in chronic kidney disease ⬇️

scientific article published on November 1, 2011

Cardiorenal syndrome: an evolutionary point of view

scientific article published on 02 July 2012

Carotid Flow Augmentation, Arterial Aging, and Cerebral White Matter Hyperintensities

scientific article published on 01 December 2018

Case of rhabdomyolysis induced by the approved daily dose of a traditional Chinese medicine

scientific article published in January 2008

Cellular and Genetic Causes of Idiopathic Hyperaldosteronism

scientific article published on 01 October 2018

Central diastolic pressure decay mediates the relationship between aortic stiffness and myocardial viability: potential implications for aortosclerosis-induced myocardial ischemia

scientific article published on 13 June 2017

Central pulse pressure and aortic stiffness determine renal hemodynamics: pathophysiological implication for microalbuminuria in hypertension

scientific article published on 03 October 2011

Central pulse pressure links microalbuminuria with plasma B-type natriuretic peptide elevation: causal implication for cardiorenal syndrome in hypertension

scientific article

Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies

scientific article published on 08 January 2019

Changes in clinical features and long-term prognosis in patients with pheochromocytoma

scientific article published on 01 January 2000

Changes in prostacyclin, thromboxane A2 and F2-isoprostanes, and influence of eicosapentaenoic acid and antiplatelet agents in patients with hypertension and hyperlipidemia

scientific article published on 01 October 1999

Characteristic effects of methylglyoxal and its degraded product formate on viability of human histiocytes: a possible detoxification pathway of methylglyoxal

scientific article published on 21 March 2011

Characteristics of blood pressure measured at home in the morning and in the evening: the Ohasama study

scientific article published on 01 July 1999

Characteristics of the antibodies of two patients who developed daytime hyperglycemia and morning hypoglycemia because of insulin antibodies.

scientific article published on 27 March 2009

Characterization of Mouse Retinoid X Receptor (RXR)-β Gene Promoter: Negative Regulation by Tumor Necrosis Factor (TNF)-α ⬇️

scientific article published on June 1, 1998

Characterization of a mouse cortical collecting duct cell line.

scientific article published on June 1991

Characterization of the organic cation transporter SLC22A16: a doxorubicin importer

scientific article

Clinical outcome of renal artery stenting for hypertension and chronic kidney disease up to 12 months in the J-RAS Study – prospective, single-arm, multicenter clinical study.

scientific article

Clinical significance of urinary interleukin-6 in children with reflux nephropathy.

scientific article

Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy.

scientific article published on 9 June 2016

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

scientific article published on 01 February 2020

Combination therapy for hypertension in patients with CKD: a subanalysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events trial

article published in 2013

Combination therapy for hypertension in the elderly: a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial

article

Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial

scientific article

Combination therapy with renin-angiotensin system inhibitors and the calcium channel blocker azelnidipine decreases plasma inflammatory markers and urinary oxidative stress markers in patients with diabetic nephropathy.

scientific article

Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial

scientific article

Comparison of blood pressure values-self-measured at home, measured at an unattended office, and measured at a conventional attended office

scientific article published on 21 June 2019

Comparison of olmesartan combined with a calcium channel blocker or a diuretic in elderly hypertensive patients (COLM Study): safety and tolerability.

scientific article

Comparisons of amino acids, body constituents and antioxidative response between long-time HD and normal HD.

scientific article published in October 2016

Concurrent analogous organ damage in the brain, eyes, and kidneys in malignant hypertension: reversible encephalopathy, serous retinal detachment, and proteinuria

scientific article published on 27 July 2020

Concurrent isolated IgG2-positive membranous nephropathy and malignant B-cell lymphoma

scientific article published on 15 May 2018

Conformational change in transfer RNA is an early indicator of acute cellular damage

scientific article

Controversies on obesity and CKD

scientific article published on 09 February 2010

Cost-Effectiveness Analysis of the Diagnosis and Treatment of Primary Aldosteronism in Japan

scientific article published on 25 August 2015

Crucial roles of Brn1 in distal tubule formation and function in mouse kidney

scientific journal article

Cutting balloon angioplasty of resistant renal artery stenosis caused by fibromuscular dysplasia.

scientific article published in May 2005

Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus

scientific article published on 12 July 2005

Design and baseline characteristics of an observational study in Japanese patients with hypertension: Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH).

scientific article published in September 2007

Design and rationale of Japanese evaluation between Formula of Azelnidipine and amlodipine add on olmesartan to Get antialbuminuric effect study (J-FLAG) : evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic

scientific article published on 01 August 2011

Detection of Segmental Renal Ischemia by Diffusion-Weighted Magnetic Resonance Imaging: Clinical Utility for Diagnosis of Renovascular Hypertension

scientific article published on 11 September 2015

Detection of mRNA for alpha-3 chain of type IV collagen in the glomerular epithelium, and the effect of perfused elastase on its expression

scientific article published on 01 December 2002

Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study.

scientific article published on 30 October 2009

Development of sensitive derivatization method for aldosterone in liquid chromatography-electrospray ionization tandem mass spectrometry of corticosteroids.

scientific article published on 22 May 2008

Development of subclinical hyperthyroidism due to Graves' disease in a hypothyroid woman who had undergone hemithyroidectomy for adenomatous goiter and radiotherapy for nasopharyngeal cancer

scientific article published on 20 October 2006

Diabetes mellitus as a cause or comorbidity of chronic kidney disease and its outcomes: the Gonryo study

scientific article

Diagnosis of aldosterone producing adenomas

scientific article

Dialyzable uremic solutes contribute to enhanced oxidation of serum albumin in regular hemodialysis patients

scientific article published on 25 April 2007

Difference in urinary LTE4 and 11-dehydro-TXB2 excretion in asthmatic patients

scientific article published on 01 October 2000

Different clinical outcomes for cardiovascular events and mortality in chronic kidney disease according to underlying renal disease: the Gonryo study

scientific article published on 17 June 2010

Different expression of 11β-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas

scientific article

Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes

scientific journal article

Differential upregulation of rat Na-K-Cl cotransporter, rBSC1, mRNA in the thick ascending limb of Henle in different pathological conditions

scientific article published on 01 September 1998

Difficult-to-control hypertension due to bilateral aldosterone-producing adrenocortical microadenomas associated with a cortisol-producing adrenal macroadenoma

scientific article

Dilation of renal artery stenosis after administration of losartan

scientific article published in October 2007

Discrepancy between screening blood pressure and ambulatory blood pressure: a community-based study in Ohasama

scientific article published in June 1998

Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity

scientific article published on 31 October 2017

Diuretic usage for protection against end-organ damage in liver cirrhosis and heart failure.

scientific article published on 17 March 2016

Does rosuvastatin offer therapeutic potential in autoimmune thyroiditis in nonobese diabetic mice?

scientific article published on 20 November 2008

Double-Blind Randomized Phase 3 Study Comparing Esaxerenone (CS-3150) and Eplerenone in Patients With Essential Hypertension (ESAX-HTN Study)

scientific article published on 02 December 2019

Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers

scientific article published on 25 November 2019

Dual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney disease

scientific article published on 23 March 2020

Dynamic multidetector CT and non-contrast-enhanced MR for right adrenal vein imaging: comparison with catheter venography in adrenal venous sampling

scientific article published on 25 June 2015

Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats

scientific article published on 9 February 2012

Effect of Behavior Modification on Outcome in Early- to Moderate-Stage Chronic Kidney Disease: A Cluster-Randomized Trial

scientific article

Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis

scientific article published on 29 July 2019

Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients

scientific article published on 26 November 2013

Effect of adrenocorticotropic hormone stimulation during adrenal vein sampling in primary aldosteronism

scientific article published on 13 February 2012

Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study

scientific article published on 29 November 2012

Effect of the Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, on Nocturnal Hypertension: A Post Hoc Analysis of the ESAX-HTN Study

scientific article published on 09 November 2020

Effects of PPARγ agonists against vascular and renal dysfunction

scientific article published on June 2012

Effects of PPARγ on hypertension, atherosclerosis, and chronic kidney disease

scientific article published on 28 September 2010

Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression.

scientific article published on 29 December 2015

Effects of a benidipine-based combination therapy on the risk of stroke according to stroke subtype: the COPE trial

scientific article published on 29 August 2013

Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice

scientific article published on 24 October 2007

Effects of blood pressure on renal and cardiovascular outcomes in Asian patients with type 2 diabetes and overt nephropathy: a post hoc analysis (ORIENT-blood pressure).

scientific article published on 6 July 2015

Effects of dual blockade of the renin-angiotensin system on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy and hypertension in the ORIENT: a post-hoc analysis (ORIENT-Hypertension).

scientific article published on 12 September 2013

Effects of exercise training on nitric oxide synthase in the kidney of spontaneously hypertensive rats ⬇️

scientific article published on 01 February 2013

Effects of green tea polyphenols on iodide-induced autoimmune thyroiditis in nonobese diabetic mice

scientific article

Effects of interleukin-6 blockade on the development of autoimmune thyroiditis in nonobese diabetic mice

scientific article published in March 2009

Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene

scientific journal article

Effects of monotherapy of temocapril or candesartan with dose increments or combination therapy with both drugs on the suppression of diabetic nephropathy.

scientific article published in April 2007

Effects of nifedipine on renal vascular responses to vasoactive agents in rabbits

scientific article published on 01 January 1984

Effects of nifedipine on the renal vascular responses and blood pressure responses to norepinephrine and angiotensin II in the anesthetized rabbit.

scientific article

Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study.

scientific article published on 13 October 2011

Effects of perinatal exposure to low doses of cadmium or methylmercury on thyroid hormone metabolism in metallothionein-deficient mouse neonates

scientific article published on 22 August 2006

Effects of renal perfusion pressure on renal medullary hydrogen peroxide and nitric oxide production

scientific article

Effects of sodium-glucose cotransporter 2 inhibitors on hypoglycaemia in brittle diabetic patients with decreased endogenous insulin secretion

scientific article published on 01 December 2018

Effects of surgical treatment for acromegaly on knee MRI structural features

scientific article published on 13 July 2018

Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice.

scientific article published on 10 May 2011

Effects of the Great East Japan Earthquake and huge tsunami on glycaemic control and blood pressure in patients with diabetes mellitus

scientific article published on 13 April 2012

Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition

scientific article published on 05 March 2020

Efficacy and Biocompatibility of Neutral Icodextrin Peritoneal Dialysis Fluid

scientific article published in January 2016

Efficacy and Safety of Esaxerenone (CS-3150) for the Treatment of Type 2 Diabetes with Microalbuminuria: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial

scientific article published on 27 June 2019

Efficacy and Safety of Imarikiren in Patients with Type 2 Diabetes and Microalbuminuria: A Randomized, Controlled Trial

scientific article published on 12 February 2019

Efficacy and safety of aliskiren in Japanese hypertensive patients with renal dysfunction.

scientific article published on 20 November 2009

Efficacy and safety of dosage-escalation of low-dosage esaxerenone added to a RAS inhibitor in hypertensive patients with type 2 diabetes and albuminuria: a single-arm, open-label study

scientific article published on 25 June 2019

Efficacy and safety of esaxerenone (CS-3150) for the treatment of essential hypertension: a phase 2 randomized, placebo-controlled, double-blind study

scientific article published on 21 May 2019

Efficacy and safety of esaxerenone (CS-3150), a newly available nonsteroidal mineralocorticoid receptor blocker, in hypertensive patients with primary aldosteronism

scientific article published on 16 November 2020

Efficacy and safety of long-term losartan therapy demonstrated by a prospective observational study in Japanese patients with hypertension: The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study

scientific article

Eicosapentaenoic acid improves glycemic control in elderly bedridden patients with type 2 diabetes.

scientific article published in January 2013

Elevated plasma concentration of IP-10 in patients with type 2 diabetes mellitus

scientific article published in January 2005

Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy

scientific article published on 01 October 2004

Elucidation of the etiology and characteristics of pink urine in young healthy subjects.

scientific article published on 5 December 2014

Endogenous hydrogen peroxide up-regulates the expression of nitric oxide synthase in the kidney of SHR ⬇️

scientific article published on 01 June 2011

Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part I: General mechanisms: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and The Japanese So

scientific article published on 7 November 2017

Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II: Role in disease conditions: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and the Ja

scientific article published on 14 November 2017

Endothelium-derived nitric oxide modulates vascular action of aldosterone in renal arteriole

scientific article published on 22 December 2003

Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole.

scientific article

Erratum to: Impact of hemoglobin levels on renal and non-renal clinical outcomes differs by chronic kidney disease stages: the Gonryo study

scientific article published on 01 December 2017

Erythrocyte zinc concentration as an indicator to distinguish painless thyroiditis-associated transient hypothyroidism from permanent hypothyroidism

scientific article published on 15 October 2010

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

scientific article published on 8 June 2015

Esaxerenone (CS-3150) in Patients with Type 2 Diabetes and Microalbuminuria (ESAX-DN): Phase 3 Randomized Controlled Clinical Trial

scientific article published on 25 November 2020

Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease

scientific article published on 28 March 2007

Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach

scientific article published on 8 April 2017

Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.

scientific article

Exonic mutations in the SLC12A3 gene cause exon skipping and premature termination in Gitelman syndrome

scientific article

Experimental autoimmune thyroiditis in human parvovirus B19 transgenic mice

scientific article published on 21 February 2011

Experimental autoimmune thyroiditis in nonobese diabetic mice lacking interferon regulatory factor-1

scientific article published on 01 November 2004

Expression of (pro)renin receptor and its upregulation by high salt intake in the rat nephron

scientific article published on 31 December 2014

Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic adrenal tissues.

scientific article published on 6 May 2008

Expression of adrenomedullin2/intermedin in human brain, heart, and kidney

scientific article

Expression of cytochrome P-450 4 enzymes in the kidney and liver: regulation by PPAR and species-difference between rat and human

scientific article published on 22 March 2006

Expression of peptide YY in human brain and pituitary tissues

scientific article published on 26 July 2008

Expression of peroxisome proliferator-activated receptor isoform proteins in the rat kidney.

scientific article published in June 2004

Fabry's disease discovered with chance urinary mulberry cells: a case report.

scientific article

Factors affecting the difference between screening and home blood pressure measurements: the Ohasama Study

scientific article published on 01 January 2001

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial

scientific article published on 01 September 2018

Focal Segmental Glomerulosclerosis Associated with Chronic Progressive External Ophthalmoplegia and Mitochondrial DNA A3243G Mutation

scientific article published on 30 November 2017

Genome-wide association study identifies new loci for albuminuria in the Japanese population

scientific article published on 10 April 2020

Glomerular Injury Is Exacerbated in Lupus-Prone MRL/lpr Mice Treated with a Protease-Activated Receptor 2 Antagonist

scientific article published on 01 October 2019

Glomerular prostaglandins modulate vascular reactivity of the downstream efferent arterioles.

scientific article

Glucose and Insulin Response to Peritoneal Dialysis Fluid in Diabetic and Nondiabetic Peritoneal Dialysis Patients.

scientific article published in January 2015

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

scientific article published on 23 April 2019

HPRT-related hyperuricemia with a novel p.V35M mutation in HPRT1 presenting familial juvenile gout

scientific article published on 03 March 2020

Heavy chain deposition disease: an overview.

scientific article published on 08 May 2013

Hemodynamic index of atheromatous renal artery stenosis for angioplasty.

scientific article published on 04 March 2009

Hepatic dysfunction and thrombocytopenia induced by excess sFlt1 in mice lacking endothelial nitric oxide synthase

scientific article published on 8 January 2018

Hepatocyte growth factor stimulates nitric oxide production through endothelial nitric oxide synthase activation by the phosphoinositide 3-kinase/Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells.

scientific article published in November 2004

High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study

scientific article published on 02 August 2018

High glucose augments angiotensin II action by inhibiting NO synthesis in in vitro microperfused rabbit afferent arterioles

scientific article published on 01 September 1995

High glucose level and angiotensin II type 1 receptor stimulation synergistically amplify oxidative stress in renal mesangial cells

scientific article published on 26 March 2019

High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells

scientific article published on 29 August 2017

High-normal blood pressure is associated with microalbuminuria in the general population: the Watari study

scientific article published on 28 July 2011

High-normal diastolic blood pressure is a risk for development of microalbuminuria in the general population: the Watari study

scientific article

Histological Characterization of Aldosterone-producing Adrenocortical Adenomas with Different Somatic Mutations

scientific article published on 01 March 2020

Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism

scientific article published in April 2017

Home blood pressure measurement has a stronger predictive power for mortality than does screening blood pressure measurement: a population-based observation in Ohasama, Japan.

scientific article

Hydrochlorothiazide ameliorates polyuria caused by tolvaptan treatment of polycystic kidney disease in PCK rats

scientific article published on 13 November 2018

Hypertension and COVID-19

scientific article published on 06 April 2020

Hypocalcemia in a patient with severe hypertension and surgically induced relative hypoparathyroidism

scientific article published on 11 May 2008

Identification and characterization of novel rat and human gonad-specific organic anion transporters

scientific journal article

Identification of a novel Reg family gene, Reg IIIdelta, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region.

scientific article

Identification of senescence-associated genes and their networks under oxidative stress by the analysis of Bach1.

scientific article

Identification of the stages of diabetic nephropathy at which angiotensin II receptor blockers most effectively suppress albuminuria.

scientific article published on 17 June 2013

Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.

scientific article published on 25 November 2015

Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 labeling index is a predictor for recurrence of adrenocortical carcinomas.

scientific article published on 10 January 2008

Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle

scientific article (publication date: July 2003)

Immunolocalization of urotensin II and its receptor in human adrenal tumors and attached non-neoplastic adrenal tissues.

scientific article published on 4 July 2007

Immunoreactive orexin-A in human plasma

scientific article published on 01 January 2001

Impact of Small Renal Ischemia in Hypertension Development: Renovascular Hypertension Caused by Small Branch Artery Stenosis

scientific article

Impact of blood pressure control on cardiovascular events in 26,512 Japanese hypertensive patients: the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study, a prospective nationwide observational study

scientific article published in March 2008

Impact of hemoglobin levels on renal and non-renal clinical outcomes differs by chronic kidney disease stages: the Gonryo study

scientific article published on 30 October 2015

Impact of lower body mass index on risk of all-cause mortality and infection-related death in Japanese chronic kidney disease patients

scientific article published on 30 June 2020

Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan.

scientific article

Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques

scientific article published on 28 December 2017

In vitro study of the juxtaglomerular apparatus and its implications in the chronic kidney disease.

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Increase of sodium delivery stimulates the mitochondrial respiratory chain H2O2 production in rat renal medullary thick ascending limb

scientific article published on 5 October 2011

Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure

scientific article published on 01 December 2000

Increased plasma urotensin II levels in patients with diabetes mellitus

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Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy: the Gonryo study.

scientific article published on 28 July 2011

Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3.

scientific article

Induction of PPAR gamma mRNA and protein expression by rosiglitazone in chronic cyclosporine nephropathy in the rat.

scientific article published in April 2007

Influence of renal function and demographic data on intrarenal Doppler ultrasonography

scientific article published on 27 August 2019

Inherited, not acquired, Gitelman syndrome in a patient with Sjögren's syndrome: importance of genetic testing to distinguish the two forms

scientific article

Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats.

scientific article

Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study.

scientific article published on 6 April 2018

Intra-adrenal Aldosterone Secretion: Segmental Adrenal Venous Sampling for Localization

scientific article published on 06 July 2015

Intrathyroidal persistence of human parvovirus B19 DNA in a patient with Hashimoto's thyroiditis.

scientific article

Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17.

scientific article published on 17 November 2015

Is renal antiaging possible? ⬇️

scientific article published on September 23, 2010

Is there a role for segmental adrenal venous sampling and adrenal sparing surgery in patients with primary aldosteronism?

scientific article published on 20 July 2015

Ischemia/reperfusion of unilateral kidney exaggerates aging-induced damage to the heart and contralateral kidney

scientific article published on 03 July 2014

Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism.

scientific article published in January 2013

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

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JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension-the JSH Asahikawa declaration

scientific article published on 08 April 2019

JSH Statement: Kyoto declaration on hypertension research in Asia

scientific article published on 07 January 2019

Kidney and hypertension

scientific article published in January 2009

Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study

scientific article published on 29 March 2007

Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney

scientific article published on 22 May 2020

Kidney function, blood pressure and proteinuria were associated with pregnancy outcomes of pregnant women with chronic kidney disease: a single-center, retrospective study in the Asian population

scientific article published on 11 March 2020

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

scientific article published in June 2001

Lack of endothelial nitric oxide synthase accelerates ectopic calcification in uremic mice fed an adenine and high phosphorus diet

scientific article published on 04 November 2020

Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report

scientific article published on 01 November 2019

Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water

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Levels of 8-oxo-dGsn and 8-oxo-Gsn in random urine are consistent with 24 h urine in healthy subjects and patients with renal disease.

scientific article

Localization of aldosterone-producing adrenocortical adenomas: significance of adrenal venous sampling

scientific article published in November 2007

Long-term assessment of intrarenal blood flow with Doppler ultrasonography for hypertensive patients after percutaneous transluminal renal angioplasty

scientific article published on 31 May 2019

Long-term phase 3 study of esaxerenone as mono or combination therapy with other antihypertensive drugs in patients with essential hypertension

scientific article published on 25 September 2019

Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats.

scientific article published on 8 September 2011

Low frequency of cervicocranial artery involvement in Japanese with renal artery fibromuscular dysplasia compared with that of Caucasians

scientific article published on 20 April 2018

Low-energy extracorporeal shock wave ameliorates ischemic acute kidney injury in rats

scientific article published on 07 January 2019

Lower urinary pH is useful for predicting renovascular disorder onset in patients with diabetes

scientific article published on 30 June 2015

Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells

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MAGI-1a functions as a scaffolding protein for the distal renal tubular basolateral K+ channels

scientific journal article

MDM2: a novel mineralocorticoid-responsive gene involved in aldosterone-induced human vascular structural remodeling.

scientific article published on August 2006

Macula densa control of renin release and glomerular hemodynamics.

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Masked hypertension determined by self-measured blood pressure at home and chronic kidney disease in the Japanese general population: the Ohasama study.

scientific article published in December 2008

Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism.

scientific article

Mesangial proliferative glomerulonephritis with aldosterone-producing adenoma

scientific article published on 28 June 2007

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

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Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model

scientific article published on 22 June 2011

Metabolomic profiling of uremic solutes in CKD patients.

scientific article published on 8 July 2010

Metabolomics of a mouse model of preeclampsia induced by overexpressing soluble fms-like tyrosine kinase 1

scientific article published on 21 May 2020

Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells.

scientific article published in January 2010

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.

scientific article

Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure

scientific article published on 19 July 2010

Methylmercury inhibition of type II 5'-deiodinase activity resulting in a decrease in growth hormone production in GH3 cells.

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Methylmercury inhibits type II 5'-deiodinase activity in NB41A3 neuroblastoma cells

scientific article published on 2 September 2005

Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes: a post-hoc analysis of The Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (IN

scientific article published in April 2008

Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.

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Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases.

scientific article published on January 2015

Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage

scientific article published on 25 November 2015

Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan

scientific article published in December 2007

Molecular characterization of human and rat organic anion transporter OATP-D

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Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate

scientific article published in September 2000

Molecular mechanisms and therapeutic strategies of chronic renal injury: physiological role of angiotensin II-induced oxidative stress in renal medulla.

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Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis

scientific article published in January 2016

Nephrotic syndrome associated with hypocomplementaemic urticarial vasculitis syndrome: successful treatment with cyclosporin A

scientific article published on 01 July 1999

Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide

scientific article published on 07 February 2019

Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure

scientific article published on 07 December 2016

Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia

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Nifedipine controlled-release 40 mg b.i.d. in Japanese patients with essential hypertension who responded insufficiently to nifedipine controlled-release 40 mg q.d.: a phase III, randomized, double-blind and parallel-group study

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Nongenomic vascular action of aldosterone in the glomerular microcirculation

scientific article published in September 2003

Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study

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Novel trial for the treatment of steroid dependency in minimal change disease: combined therapy of camostat mesilate and glycyrrhizin

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Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.

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Office and ambulatory pulse pressure--association with clinical characteristics and cardiovascular risk factors in normoalbuminuric patients with type 2 diabetes (ROADMAP study).

scientific article published on 9 December 2010

Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes

article by Hermann Haller et al published 10 March 2011 in The New England Journal of Medicine

Olmesartan reducing incidence of endstage renal disease in diabetic nephropathy trial (ORIENT): rationale and study design

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Orexin-A in the human brain and tumor tissues of ganglioneuroblastoma and neuroblastoma

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PDZ binding motif-dependent localization of K+ channel on the basolateral side in distal tubules.

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PDZ-binding and di-hydrophobic motifs regulate distribution of Kir4.1 channels in renal cells.

scientific article published on 20 July 2005

PPARγ agonist beyond glucose lowering effect.

scientific article published on 02 March 2011

Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma

scientific article published on 06 May 2014

Pathology of glomerular lipidosis.

scientific article published on 16 October 2013

Pathophysiological and molecular mechanisms involved in renal congestion in a novel rat model

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Periodontitis-associated septic pulmonary embolism caused by Actinomyces species identified by anaerobic culture of bronchoalveolar lavage fluid: a case report

scientific article published in December 2015

Peritoneal clearance and transport of methylglyoxal

scientific article published on 19 November 2010

Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production

scientific article published on 19 January 2011

Phenotypic change of glomerular podocytes in primary focal segmental glomerulosclerosis: developmental paradigm?

scientific article published in January 2002

Physiologic variance of corticotropin affects diagnosis in adrenal vein sampling.

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Pigment epithelium-derived factor as a new predictor of mortality among chronic kidney disease patients treated with hemodialysis.

scientific article published on 11 March 2013

Plasma BNP levels in the treatment of type 2 diabetes with pioglitazone.

scientific article published in August 2003

Plasma alpha-oxoaldehyde levels in diabetic and nondiabetic chronic kidney disease patients.

scientific article published on 12 June 2008

Plasma renin activity revealed renal artery stenosis concealed by aneurysms

scientific article published on 01 March 2005

Plasticity of renal erythropoietin-producing cells governs fibrosis.

scientific article published on 5 July 2013

Polymorphonuclear leukocyte injury by methylglyoxal and hydrogen peroxide: a possible pathological role for enhanced oxidative stress in chronic kidney disease

scientific article published on 28 April 2008

Possible cause of recurrent renal artery stenosis

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Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.

scientific article published on 13 September 2017

Posterior reversible encephalopathy syndrome treated with renin-angiotensin system blockade.

scientific article published on 6 June 2015

Postpartum recurrence of Graves' hyperthyroidism can be prevented by the continuation of antithyroid drugs during pregnancy.

scientific article published in October 2002

Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene

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Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate

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Predictors of decreasing glomerular filtration rate and prevalence of chronic kidney disease after treatment of primary aldosteronism: renal outcome of 213 cases

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Predictors of undiagnosed renal artery stenosis among Japanese patients with risk factors of atherosclerosis

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Presence of kisspeptin-like immunoreactivity in human adrenal glands and adrenal tumors

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scientific article published on 28 June 2007

Preventing microalbuminuria in patients with diabetes: rationale and design of the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study

scientific article published in February 2006

Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension ⬇️

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Prevention of microalbuminuria in patients with type 2 diabetes and hypertension

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Prevention of transition from incipient to overt nephropathy with telmisartan in patients with type 2 diabetes

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Primary aldosteronism: A Japanese perspective

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Progress in the Management of Primary Aldosteronism

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Prominent hyperplasia of renin-producing juxtaglomerular apparatus after chronic and complete blockade of the renin-angiotensin system in adult IgA nephropathy

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Protease-activated receptor 2 contributes to placental development and fetal growth in mice

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Protease-activated receptor 2 exacerbates adenine-induced renal tubulointerstitial injury in mice.

scientific article published on 23 December 2016

Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity

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Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury

Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases

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Pulse pressure amplification, arterial stiffness, and peripheral wave reflection determine pulsatile flow waveform of the femoral artery

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Questionnaire survey on the prescription of renal replacement therapy for acute phase patients on maintenance dialysis who developed cerebrovascular disease

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Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide

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Rapid Screening of Primary Aldosteronism by a Novel Chemiluminescent Immunoassay

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Rat kidney thromboxane synthase: cDNA cloning and gene expression regulation in hydronephrotic kidney

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Ratio of diastolic to systolic blood pressure represents renal resistive index

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Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients.

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Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice

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Reduced albuminuria with sarpogrelate is accompanied by a decrease in monocyte chemoattractant protein-1 levels in type 2 diabetes

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Reduction and residual proteinuria are therapeutic targets in type 2 diabetes with overt nephropathy: a post hoc analysis (ORIENT-proteinuria).

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Reduction of serum antioxidative capacity during hemodialysis

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Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria: effect of angiotensin II blockade

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Regulation of cytochrome P-450 4A activity by peroxisome proliferator-activated receptors in the rat kidney

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Relapse of Graves' disease in a patient with pheochromocytoma.

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Relationship between low blood pressure and renal/cardiovascular outcomes in Japanese patients with chronic kidney disease under nephrologist care: the Gonryo study

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Relationship of ocular microcirculation, measured by laser speckle flowgraphy, and silent brain infarction in primary aldosteronism

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Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism.

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Renal artery dissection after angiographic evaluation of lower extremities

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Renal statistical map for positron emission tomography with [O-15] water

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Renal tubule-specific transcription and chromosomal localization of rat thiazide-sensitive Na-Cl cotransporter gene

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Renin release from microdissected superficial, midcortical, and juxtamedullary afferent arterioles in rabbits.

scientific article published in September 1990

Reno-protective effects of oral alkalizing agents in chronic kidney disease with aciduria: protocol for a randomized cohort study

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Renovascular hypertension associated with JAK2 V617F positive myeloproliferative neoplasms treated with angioplasty: 2 cases and literature review.

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Response to COVID-19 and ACEI/ARB: NOT ASSOCIATED?

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Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells

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Role of Chronic Use of Tolvaptan in Patients with Heart Failure Undergoing Peritoneal Dialysis

scientific article published in January 2016

Role of androgens in the renal production of 20-hydroxyeicosatetraenoic acid in spontaneously hypertensive rats

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Role of neuronal nitric oxide synthase in the macula densa.

scientific article published in November 2001

Role of renal eicosanoids in the control of intraglomerular and systemic blood pressure during development of hypertension

scientific article published in January 2004

Role of renal medullary oxidative and/or carbonyl stress in salt-sensitive hypertension and diabetes.

scientific article published on January 2012

Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation.

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Role of urotensin II in patients on dialysis

scientific article published on 01 September 2001

Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats.

scientific article published in August 2005

SAT-058 Histopathological Analysis of Kidneys and Adrenal Glands in the Same Primary Aldosteronism (PA) Patients: Exploring the Mechanisms of Aldosterone Specific Renal Injuries

scientific article published on 30 April 2019

SAT-068 A Precise Prevalence Of Genotypes And Histological Subtypes Of Consecutive JapanesePA CasesUndergoing Surgery From 2012 To 2017.

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SAT-079 Renal Protective Effects Of Topiroxostat And Febuxostat In Hypertensives With Hyperuricemia

SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation

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SUN-496 A Perioperative Risk For Exacerbation of Hypercalcemia in Primary Hyperparathyroidism.

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Safety and efficacy of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with hypertension and renal dysfunction.

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Selection of patients for angioplasty for treatment of atherosclerotic renovascular disease: predicting responsive patients

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Selective embolization therapy for intrarenal artery stenosis causing renovascular hypertension: Efficacy and follow-up renal imaging

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Serious Hypocalcemia After Withdrawal of Vitamin D Analog in Bedridden Nonagenarians with Previous Thyroidectomy: A Report of Two Cases

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Significance of early phenotypic change of glomerular podocytes detected by Pax2 in primary focal segmental glomerulosclerosis

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Single-center Outcome of Laparoscopic Unilateral Adrenalectomy for Patients With Primary Aldosteronism: Lateralizing Disease Using Results of Adrenal Venous Sampling ⬇️

scientific article published on February 18, 2011

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes

scientific article published on 01 February 2011

Some mechanical aspects of arterial aging: physiological overview based on pulse wave analysis.

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Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor

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Spironolactone further reduces urinary albumin excretion and plasma B-type natriuretic peptide levels in hypertensive type II diabetes treated with angiotensin-converting enzyme inhibitor

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Stabilization of postprandial blood glucose fluctuations by addition of glucagon like polypeptide-analog administration to intensive insulin therapy

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Stage of chronic kidney disease is an outcome-predicting factor of angioplasty for atheromatous renal artery stenosis

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Steroid resistance in prolonged type I membranoproliferative glomerulonephritis and accelerated disease remission after steroid withdrawal.

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Stimulatory effects of low-dose 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor fluvastatin on hepatocyte growth factor-induced angiogenesis: involvement of p38 mitogen-activated protein kinase.

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Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk.

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Strict angiotensin blockade prevents the augmentation of intrarenal angiotensin II and podocyte abnormalities in type 2 diabetic rats with microalbuminuria.

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Structure and Transcriptional Function of the 5′-Flanking Region of Rat Thromboxane Receptor Gene ⬇️

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Study profile of The Tohoku Medical Megabank Community-Based Cohort Study

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Successful treatment of severe hypertension with the combination of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker.

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Surgical outcomes of laparoscopic adrenalectomy for patients with Cushing’s and subclinical Cushing’s syndrome: a single center experience ⬇️

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Systemic hemodynamic atherothrombotic syndrome (SHATS) - Coupling vascular disease and blood pressure variability: Proposed concept from pulse of Asia

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Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study

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The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides

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The Influence of One‐Year Treatment by Angiotensin Converting Enzyme Inhibitor on Baroreflex Sensitivity and Flow‐Mediated Vasodilation of the Brachial Artery in Essential Hypertension—Comparison with Calcium Channel Blockers ⬇️

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The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)

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The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014)

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The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

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The Japanese Society of Hypertension-Digest of plan for the future

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The Kidney Disease: improving Global Outcomes website: comparison of guidelines as a tool for harmonization

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The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease.

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The Reduction in Urinary Glutamate Excretion Is Responsible for Lowering Urinary pH in Pink Urine Syndrome

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The Sendai declaration for the eradication of kidney disease

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The Tohoku Medical Megabank Project: Design and Mission

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The effect of aldosterone on adiposity - The role of glucose absorption in the small intestine

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The glucagon-like peptide-1 analog liraglutide suppresses ghrelin and controls diabetes in a patient with Prader-Willi syndrome

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The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease

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The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

The importance of home blood pressure measurement for preventing stroke and cardiovascular disease in hypertensive patients: a sub-analysis of the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study, a pros

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The involvement of advanced glycation endproducts (AGEs) in renal injury of diabetic glomerulosclerosis: association with phenotypic change in renal cells and infiltration of immune cells

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The kidney and hypertension

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The mechanisms underlying altered vascular resistance of glomerular afferent and efferent arterioles in diabetic nephropathy.

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The organic anion transporter (OATP) family.

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The redox state of albumin and serious cardiovascular incidence in hemodialysis patients.

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The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion.

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The relationship between the renal reabsorption of cysteine and the lowered urinary pH in diabetics

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The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation.

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The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice

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The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration rise

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Therapeutic advantage of angiotensin converting enzyme inhibitors in chronic glomerulonephritis

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Three Cases of Gitelman's Syndrome Possibly Caused by Different Mutations in the Thiazide-Sensitive Na-Cl Cotransporter ⬇️

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Thyroid hormone transporters: recent advances.

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Thyroid metastasis of pulmonary adenocarcinoma

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To stimulate or not to stimulate: is adrenocorticotrophic hormone testing necessary, or not?

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Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.

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Transcription suppression of peroxisome proliferator-activated receptor gamma2 gene expression by tumor necrosis factor alpha via an inhibition of CCAAT/ enhancer-binding protein delta during the early stage of adipocyte differentiation.

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Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells

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Transcription suppression of thromboxane receptor gene expression by retinoids in vascular smooth muscle cells

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Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease.

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Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1

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Transcriptional suppression of rat angiotensin AT1a receptor gene expression by interferon-gamma in vascular smooth muscle cells.

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Translational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen

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Treatment of Refractory Hypertension with Timely Angioplasty in Total Renal Artery Occlusion with Atrophic Kidney

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Treatment of fibromuscular dysplasia

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Urinary angiotensinogen excretion is associated with blood pressure in obese young adults

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Urinary angiotensinogen excretion level is associated with elevated blood pressure in the normotensive general population

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Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan-influence of umami (L-glutamate) on saltiness and palatability of low-salt solutions

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Vasodilation mediated by angiotensin II type 2 receptor is impaired in afferent arterioles of young spontaneously hypertensive rats

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[Renin-angiotensin system]

scientific article published on 01 January 2007

[Reninoma]

scientific article published on 01 March 2005

[Role of angiotensin II on renal medullary circulation]

scientific article published on 01 January 2010

[The 39th scientific meeting: perspectives of internal medicine; the cutting edge of treatment of medical disorders encountered in clinical practice: 3. Approach to chronic kidney disease]

scientific article published on 01 March 2012

[The 41st Scientific Meeting: perspectives of internal medicine ; lessons from the disaster of the Great East Japan earthquake; 1. Preface]

scientific article published on 01 March 2014

[Therapy of hypertension associated with organ damage]

scientific article published on 01 August 2006

[Thiazide-induced hypercalcemic nephropathy in a patient with secondary hypoparathyroidism]

scientific article published on 01 July 2004

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