List of works - Takahiko Akiyama

A novel approach to 2-arylated quinolines: electrocyclization of alkynyl imines via vinylidene complexes

scientific article published on 01 February 2004

Asymmetric transfer hydrogenation of ketimines by indoline as recyclable hydrogen donor

scientific article published on 25 September 2014

B(C6F5)3-Catalyzed Hydrodesulfurization Using Hydrosilanes--Metal-Free Reduction of Sulfides.

scientific article

Benzothiazoline: versatile hydrogen donor for organocatalytic transfer hydrogenation.

scientific article

Benzothiazolines as radical transfer reagents: hydroalkylation and hydroacylation of alkenes by radical generation under photoirradiation conditions

scientific article published on 01 September 2019

Brønsted acid-catalyzed Nazarov cyclization of pyrrole derivatives accelerated by microwave irradiation.

scientific article published on 3 May 2009

C-C coupling reactions of superstrong CF3 groups with C(sp2)-H bonds: reactivity and synthetic utility of zero-valent niobium catalyst

scientific article published on 01 February 2008

Catalytic trifluoromethylation of iodoarenes by use of 2-trifluoromethylated benzimidazoline as trifluoromethylating reagent

scientific article published on 30 September 2020

Chiral Brønsted acid catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones: short access to optically active 2- and 3-substituted indole derivatives

scientific article published on 28 September 2010

Chiral Brønsted acid catalyzed enantioselective Mannich-type reaction

scientific article published on 04 May 2007

Chiral Brønsted acid catalyzed enantioselective aza-Diels-Alder reaction of Brassard's diene with imines

scientific article published on 01 July 2006

Chiral Brønsted acid catalyzed enantioselective hydrophosphonylation of imines: asymmetric synthesis of alpha-amino phosphonates

scientific article published on 01 June 2005

Chiral Brønsted acid-catalyzed inverse electron-demand aza Diels-Alder reaction

scientific article published on 01 October 2006

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

scientific article published on 11 May 2018

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach

scientific article published on 23 June 2015

Chiral Phosphoric Acid Catalyzed Kinetic Resolution of Indolines Based on a Self-Redox Reaction

scientific article published on 28 January 2016

Chiral copper(II) phosphate catalyzed enantioselective synthesis of isochromene derivatives by sequential intramolecular cyclization and asymmetric transfer hydrogenation of o-alkynylacetophenones

scientific article

Chiral phosphoric acid catalyzed desymmetrization of meso-1,3-diones: asymmetric synthesis of chiral cyclohexenones

scientific article published on 01 January 2009

Chiral phosphoric acid catalyzed enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes: cooperative effect of 3 A molecular sieves

scientific article published on 01 January 2008

Chiral phosphoric acid catalyzed enantioselective synthesis of β-amino-α,α-difluoro carbonyl compounds

scientific article published on 10 March 2011

Chiral phosphoric acid catalyzed enantioselective transfer deuteration of ketimines by use of benzothiazoline as a deuterium donor: synthesis of optically active deuterated amines

scientific article published on 22 June 2012

Chiral phosphoric acid catalyzed oxidative kinetic resolution of cyclic secondary amine derivatives including tetrahydroquinolines by hydrogen transfer to imines.

scientific article published in October 2015

Chiral phosphoric acid catalyzed transfer hydrogenation: facile synthetic access to highly optically active trifluoromethylated amines

scientific article published on 11 July 2011

Chiral phosphoric acid-catalyzed oxidative kinetic resolution of indolines based on transfer hydrogenation to imines.

scientific article published on 25 July 2013

Chiral phosphoric-acid-catalyzed transfer hydrogenation of ethyl ketimine derivatives by using benzothiazoline

scientific article published on 06 May 2014

Concise route to 3-arylisoquinoline skeleton by Lewis acid catalyzed C(sp3)-H bond functionalization and its application to formal synthesis of (±)-tetrahydropalmatine

scientific article published on 05 March 2012

Cu(I)-catalyzed enantioselective [2 + 2] cycloaddition of 1-methoxyallenylsilane with alpha-imino ester: chiral synthesis of alpha,beta-unsaturated acylsilanes.

scientific article

Cu(I)-catalyzed enantioselective [3 + 2] cycloaddition reaction of 1-alkylallenylsilane with alpha-imino ester: asymmetric synthesis of dehydroproline derivatives

scientific article published on 01 March 2005

Diastereoselective Synthesis of CF3-Substituted Spiroisochromans by [1,5]-Hydride Shift/Cyclization/Intramolecular Friedel-Crafts Reaction Sequence

scientific article published on 18 March 2019

Double C(sp3)-H bond functionalization mediated by sequential hydride shift/cyclization process: diastereoselective construction of polyheterocycles

scientific article published on 03 March 2014

Dynamic Kinetic Resolution Approach for the Asymmetric Synthesis of Tetrahydrobenzodiazepines Using Transfer Hydrogenation by Chiral Phosphoric Acid

scientific article published on 06 May 2016

Enantiodivergent Atroposelective Synthesis of Chiral Biaryls by Asymmetric Transfer Hydrogenation: Chiral Phosphoric Acid Catalyzed Dynamic Kinetic Resolution

scientific article published on 5 August 2016

Enantioselective Dehydroxyhydrogenation of 3-Indolylmethanols by the Combined Use of Benzothiazoline and Chiral Phosphoric Acid: Construction of a Tertiary Carbon Center

scientific article published on 27 February 2020

Enantioselective Friedel-Crafts Alkylation Reaction of Heteroarenes with N-Unprotected Trifluoromethyl Ketimines by Means of Chiral Phosphoric Acid

scientific article published on 27 March 2019

Enantioselective Friedel-Crafts alkylation of indoles, pyrroles, and furans with trifluoropyruvate catalyzed by chiral phosphoric acid

scientific article published in March 2010

Enantioselective Friedel-Crafts alkylation reaction of indoles with alpha,beta-unsaturated acyl phosphonates catalyzed by chiral phosphoric acid

scientific article published on 16 March 2010

Enantioselective Mannich-type reaction catalyzed by a chiral Brønsted acid

scientific article published in March 2004

Enantioselective Robinson-type annulation reaction catalyzed by chiral phosphoric acids.

scientific article published in January 2009

Enantioselective aza-Darzens reaction catalyzed by a chiral phosphoric acid

scientific article published on 01 June 2009

Enantioselective organocatalytic reductive amination of aliphatic ketones by benzothiazoline as hydrogen donor

scientific article published on 02 April 2012

Enantioselective synthesis of fused heterocycles with contiguous stereogenic centers by chiral phosphoric acid catalyzed symmetry breaking

scientific article published on 21 September 2015

Enantioselective synthesis of multisubstituted biaryl skeleton by chiral phosphoric acid catalyzed desymmetrization/kinetic resolution sequence.

scientific article

Enzymatic resolution of racemic 1,2:5,6-di-O-cyclohexylidene and 1,2:3,4-di-O-cyclohexylidene-myo-inositol

scientific article published on 01 August 1993

Expedient synthesis of N-fused indoles: a C-F activation and C-H insertion approach

scientific article published on 01 January 2009

Expeditious construction of a carbobicyclic skeleton via sp3-C-H functionalization: hydride shift from an aliphatic tertiary position in an internal redox process

scientific article published on 09 February 2011

Expeditious synthesis of 1-aminoindane derivatives achieved by [1,4]-hydride shift mediated C(sp3)-H bond functionalization

scientific article published on 01 April 2014

Expeditious synthesis of benzopyrans via Lewis acid-catalyzed C-H functionalization: remarkable enhancement of reactivity by an ortho substituent

scientific article published in April 2010

Highly diastereoselective synthesis of tricyclic fused-pyrans by sequential hydride shift mediated double C(sp3)-H bond functionalization.

scientific article published on 25 June 2018

Low-valent niobium-catalyzed reduction of alpha,alpha,alpha-trifluorotoluenes

scientific article published on 13 March 2007

Low-valent niobium-mediated double activation of C-F/C-H bonds: fluorene synthesis from o-arylated alpha,alpha,alpha-trifluorotoluene derivatives

scientific article published in February 2006

Mechanism of oil-in-water emulsification using a water-soluble amphiphilic polymer and lipophilic surfactant

scientific article published on 03 April 2006

Niobium(v)-catalyzed defluorinative triallylation of α,α,α-trifluorotoluene derivatives by triple C-F bond activation.

scientific article

Novel thermal reaction of Fischer carbene complexes with imines: synthesis of beta-methoxy allylic amine derivatives

scientific article published on 01 October 2002

Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control

scientific article published on 02 April 2020

Remarkable Differences in Reactivity between Benzothiazoline and Hantzsch Ester as a Hydrogen Donor in Chiral Phosphoric Acid Catalyzed Asymmetric Reductive Amination of Ketones.

scientific article published on 16 November 2015

Selective activation of enantiotopic C(sp3)-hydrogen by means of chiral phosphoric acid: asymmetric synthesis of tetrahydroquinoline derivatives

scientific article published on 05 April 2011

Stronger Brønsted Acids: Recent Progress

scientific article published on 16 July 2015

Stronger Brønsted acids

scientific article published on 06 November 2007

Synthesis of nitrogen-containing compounds using chromium Fischer carbene complexes

scientific article published on 01 January 2007

Synthesis of pyrroles: reaction of chromium N-alkylaminocarbene complexes with alpha,beta-unsaturated aldehydes

scientific article published on 26 April 2006

The asymmetric [3 + 2] cycloaddition reaction of chiral alkenyl Fischer carbene complexes with imines: synthesis of optically pure 2,5-disubstituted-3-pyrrolidinones

scientific article published on 01 July 2001

γ-Silylboronates in the chiral Brønsted acid-catalysed allylboration of aldehydes

scientific article published on 01 March 2015

List of works by Takahiko Akiyama

A novel approach to 2-arylated quinolines: electrocyclization of alkynyl imines via vinylidene complexes

Asymmetric transfer hydrogenation of ketimines by indoline as recyclable hydrogen donor

B(C6F5)3-Catalyzed Hydrodesulfurization Using Hydrosilanes--Metal-Free Reduction of Sulfides.

Benzothiazoline: versatile hydrogen donor for organocatalytic transfer hydrogenation.

Benzothiazolines as radical transfer reagents: hydroalkylation and hydroacylation of alkenes by radical generation under photoirradiation conditions

Brønsted acid-catalyzed Nazarov cyclization of pyrrole derivatives accelerated by microwave irradiation.

C-C coupling reactions of superstrong CF3 groups with C(sp2)-H bonds: reactivity and synthetic utility of zero-valent niobium catalyst

Catalytic trifluoromethylation of iodoarenes by use of 2-trifluoromethylated benzimidazoline as trifluoromethylating reagent

Chiral Brønsted acid catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones: short access to optically active 2- and 3-substituted indole derivatives

Chiral Brønsted acid catalyzed enantioselective Mannich-type reaction

Chiral Brønsted acid catalyzed enantioselective aza-Diels-Alder reaction of Brassard's diene with imines

Chiral Brønsted acid catalyzed enantioselective hydrophosphonylation of imines: asymmetric synthesis of alpha-amino phosphonates

Chiral Brønsted acid-catalyzed inverse electron-demand aza Diels-Alder reaction

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach

Chiral Phosphoric Acid Catalyzed Kinetic Resolution of Indolines Based on a Self-Redox Reaction

Chiral copper(II) phosphate catalyzed enantioselective synthesis of isochromene derivatives by sequential intramolecular cyclization and asymmetric transfer hydrogenation of o-alkynylacetophenones

Chiral phosphoric acid catalyzed desymmetrization of meso-1,3-diones: asymmetric synthesis of chiral cyclohexenones

Chiral phosphoric acid catalyzed enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes: cooperative effect of 3 A molecular sieves

Chiral phosphoric acid catalyzed enantioselective synthesis of β-amino-α,α-difluoro carbonyl compounds

Chiral phosphoric acid catalyzed enantioselective transfer deuteration of ketimines by use of benzothiazoline as a deuterium donor: synthesis of optically active deuterated amines

Chiral phosphoric acid catalyzed oxidative kinetic resolution of cyclic secondary amine derivatives including tetrahydroquinolines by hydrogen transfer to imines.

Chiral phosphoric acid catalyzed transfer hydrogenation: facile synthetic access to highly optically active trifluoromethylated amines

Chiral phosphoric acid-catalyzed oxidative kinetic resolution of indolines based on transfer hydrogenation to imines.

Chiral phosphoric-acid-catalyzed transfer hydrogenation of ethyl ketimine derivatives by using benzothiazoline

Concise route to 3-arylisoquinoline skeleton by Lewis acid catalyzed C(sp3)-H bond functionalization and its application to formal synthesis of (±)-tetrahydropalmatine

Cu(I)-catalyzed enantioselective [2 + 2] cycloaddition of 1-methoxyallenylsilane with alpha-imino ester: chiral synthesis of alpha,beta-unsaturated acylsilanes.

Cu(I)-catalyzed enantioselective [3 + 2] cycloaddition reaction of 1-alkylallenylsilane with alpha-imino ester: asymmetric synthesis of dehydroproline derivatives

Diastereoselective Synthesis of CF3-Substituted Spiroisochromans by [1,5]-Hydride Shift/Cyclization/Intramolecular Friedel-Crafts Reaction Sequence

Double C(sp3)-H bond functionalization mediated by sequential hydride shift/cyclization process: diastereoselective construction of polyheterocycles

Dynamic Kinetic Resolution Approach for the Asymmetric Synthesis of Tetrahydrobenzodiazepines Using Transfer Hydrogenation by Chiral Phosphoric Acid

Enantiodivergent Atroposelective Synthesis of Chiral Biaryls by Asymmetric Transfer Hydrogenation: Chiral Phosphoric Acid Catalyzed Dynamic Kinetic Resolution

Enantioselective Dehydroxyhydrogenation of 3-Indolylmethanols by the Combined Use of Benzothiazoline and Chiral Phosphoric Acid: Construction of a Tertiary Carbon Center

Enantioselective Friedel-Crafts Alkylation Reaction of Heteroarenes with N-Unprotected Trifluoromethyl Ketimines by Means of Chiral Phosphoric Acid

Enantioselective Friedel-Crafts alkylation of indoles, pyrroles, and furans with trifluoropyruvate catalyzed by chiral phosphoric acid

Enantioselective Friedel-Crafts alkylation reaction of indoles with alpha,beta-unsaturated acyl phosphonates catalyzed by chiral phosphoric acid

Enantioselective Mannich-type reaction catalyzed by a chiral Brønsted acid

Enantioselective Robinson-type annulation reaction catalyzed by chiral phosphoric acids.

Enantioselective aza-Darzens reaction catalyzed by a chiral phosphoric acid

Enantioselective organocatalytic reductive amination of aliphatic ketones by benzothiazoline as hydrogen donor

Enantioselective synthesis of fused heterocycles with contiguous stereogenic centers by chiral phosphoric acid catalyzed symmetry breaking

Enantioselective synthesis of multisubstituted biaryl skeleton by chiral phosphoric acid catalyzed desymmetrization/kinetic resolution sequence.

Enzymatic resolution of racemic 1,2:5,6-di-O-cyclohexylidene and 1,2:3,4-di-O-cyclohexylidene-myo-inositol

Expedient synthesis of N-fused indoles: a C-F activation and C-H insertion approach

Expeditious construction of a carbobicyclic skeleton via sp3-C-H functionalization: hydride shift from an aliphatic tertiary position in an internal redox process

Expeditious synthesis of 1-aminoindane derivatives achieved by [1,4]-hydride shift mediated C(sp3)-H bond functionalization

Expeditious synthesis of benzopyrans via Lewis acid-catalyzed C-H functionalization: remarkable enhancement of reactivity by an ortho substituent

Highly diastereoselective synthesis of tricyclic fused-pyrans by sequential hydride shift mediated double C(sp3)-H bond functionalization.

Low-valent niobium-catalyzed reduction of alpha,alpha,alpha-trifluorotoluenes

Low-valent niobium-mediated double activation of C-F/C-H bonds: fluorene synthesis from o-arylated alpha,alpha,alpha-trifluorotoluene derivatives

Mechanism of oil-in-water emulsification using a water-soluble amphiphilic polymer and lipophilic surfactant

Niobium(v)-catalyzed defluorinative triallylation of α,α,α-trifluorotoluene derivatives by triple C-F bond activation.

Novel thermal reaction of Fischer carbene complexes with imines: synthesis of beta-methoxy allylic amine derivatives

Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control

Remarkable Differences in Reactivity between Benzothiazoline and Hantzsch Ester as a Hydrogen Donor in Chiral Phosphoric Acid Catalyzed Asymmetric Reductive Amination of Ketones.

Selective activation of enantiotopic C(sp3)-hydrogen by means of chiral phosphoric acid: asymmetric synthesis of tetrahydroquinoline derivatives

Stronger Brønsted Acids: Recent Progress

Stronger Brønsted acids

Synthesis of nitrogen-containing compounds using chromium Fischer carbene complexes

Synthesis of pyrroles: reaction of chromium N-alkylaminocarbene complexes with alpha,beta-unsaturated aldehydes

The asymmetric [3 + 2] cycloaddition reaction of chiral alkenyl Fischer carbene complexes with imines: synthesis of optically pure 2,5-disubstituted-3-pyrrolidinones

γ-Silylboronates in the chiral Brønsted acid-catalysed allylboration of aldehydes