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List of works by René H. Medema

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

scientific article published in April 2016

A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases

scientific article

A growing role for Aurora A in chromosome instability.

scientific article published in August 2014

A new role for Cdks in the DNA damage response.

scientific article published in August 2010

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

scientific article

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

scientific article

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

scientific article published on 9 January 2017

ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.

scientific article published on 12 June 2017

Ablation of the spindle assembly checkpoint by a compound targeting Mps1.

scientific article published on September 2005

Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain

scientific article

Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP.

scientific article published on March 2005

Activation of nuclear factor-kappa B signalling promotes cellular senescence

scientific article published on 17 January 2011

Activation of overexpressed receptors for insulin and epidermal growth factor interferes in mitogenic signaling without affecting the activation of p21ras

scientific article published on June 1994

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

scientific article

Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the S/G2 transition

scientific article published on 27 February 2014

Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning

scientific article

Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation.

scientific article published on 29 June 2016

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. ⬇️

scientific article published on January 2011

Aurora-A and hBora join the game of Polo.

scientific article published on June 2009

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised

scientific article published in February 2018

Balanced activity of three mitotic motors is required for bipolar spindle assembly and chromosome segregation

scientific article published on 7 August 2014

Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry

scientific article

Boosting and suppressing mitotic phosphorylation ⬇️

scientific article published on September 28, 2011

Bora and Aurora-A continue to activate Plk1 in mitosis

scientific article published on 11 December 2013

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

scientific article published on 08 March 2016

CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes

scientific article published on March 1999

CLIP-170 facilitates the formation of kinetochore-microtubule attachments

scientific article

Cancer Core Europe: a consortium to address the cancer care-cancer research continuum challenge

scientific article published on 25 September 2014

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

scientific article

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

scientific article published on November 2002

Cell death by mitotic catastrophe: a molecular definition

scientific article

Cell fate in the Hand of Plk4

scientific article published on 01 October 2007

Checking out the G(2)/M transition.

scientific article published in May 2001

Checkpoint control and cancer.

scientific article published on 03 October 2011

Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer

scientific article

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

scientific article (publication date: 2008)

Chromosome misalignments induce spindle-positioning defects.

scientific article

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

scientific article published on September 2011

Chromosomes trapped in micronuclei are liable to segregation errors

scientific article published in 2018

Claspin: timing the cell cycle arrest when the genome is damaged

scientific article published on 15 December 2006

Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening

scientific article

Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response.

scientific article published on 23 April 2013

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

scientific article

Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.

scientific article published on April 2001

Cyclin D3 Regulates Proliferation and Apoptosis of Leukemic T Cell Lines

scientific article published in Journal of Biological Chemistry

Cyclin G-associated kinase promotes microtubule outgrowth from chromosomes during spindle assembly

scientific article

Cytosolic FoxO1: alive and killing

article

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

scientific article

Delaying mitotic exit downregulates FLIP expression and strongly sensitizes tumor cells to TRAIL.

scientific article published on 3 February 2014

Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1.

scientific article published on 25 January 2012

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

scientific article published on March 2005

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

scientific article

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

scientific article published on 15 January 2012

Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation.

scientific article published on 8 February 2018

Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence

scientific article published in 2022

Dynein at the nuclear envelope

scientific article

Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.

scientific article

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

scientific article published on 23 October 2009

Enter the nucleus to exit the cycle

scientific article

Entosis: aneuploidy by invasion ⬇️

scientific article published on March 1, 2011

Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways

scientific article published on December 1993

Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors

scientific article published on March 1993

Exploiting the Compromised Spindle Assembly Checkpoint Function of Tumor Cells: Dawn on the Horizon?

scientific article published on 16 January 2006

Expression of p21 (Waf1/Cip1) in head and neck cancer in relation to proliferation, differentiation, p53 status and cyclin D1 expression ⬇️

scientific article published on 01 September 1998

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

scientific article (publication date: 5 October 2000)

FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance

scientific article

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

scientific article published on 21 October 2013

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

scientific article

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

scientific article

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

scientific article (publication date: 19 September 2002)

Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.

scientific article published on 24 September 2007

FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner

scientific article

FoxM1 is required for execution of the mitotic programme and chromosome stability

scientific article

FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis

scientific article

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

scientific article published in Nature Communications

FoxM1: at the crossroads of ageing and cancer

scientific article published on 30 August 2006

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

scientific article (publication date: 12 December 2003)

Function and regulation of dynein in mitotic chromosome segregation

scientific article published on 29 May 2014

GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion

scientific article

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

scientific article published on 6 May 2013

Genetic instability: tipping the balance ⬇️

scientific article published on December 17, 2012

Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1.

scientific article published on 12 May 2015

Genomic Stability: Boosting Cohesion Corrects CIN

scientific article published on 01 June 2014

Getting in and out of mitosis with Polo-like kinase-1.

scientific article

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome

scientific article published on 21 September 2016

Greatwall in control of recovery ⬇️

scientific article published on November 1, 2010

Growth suppression by p16ink4 requires functional retinoblastoma protein

scientific article

H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression

scientific article published on 4 February 2002

HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets

scientific article

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement

scholarly article

Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.

scientific article

Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora.

scientific article published on 10 October 2016

Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

scientific article published on 20 August 2001

Inhibition of cell proliferation by lithium is associated with interference in cdc2 activation

scientific article published on August 1999

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

scientific article published in Journal of Biological Chemistry

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

scientific article published on 7 July 2015

Insulin stimulation of gene expression mediated by p21ras activation.

scientific article published on May 1991

Insulin-induced p21ras activation does not require protein kinase C, but a protein sensitive to phenylarsine oxide.

scientific article published on November 1991

Interaction between the p21ras GTPase activating protein and the insulin receptor ⬇️

scientific article published on November 25, 1992

Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy

scientific article

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

scientific article published on March 1994

Kif15 cooperates with eg5 to promote bipolar spindle assembly

scientific article

Killing a zombie: a full deletion of the BUB1 gene in HAP1 cells

scientific article published on 22 October 2019

Life in the (Pluripotent) Fast Lane: Cdk1 Preserves the Epigenome to Maintain Pluripotency

scientific article published on 01 May 2020

Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF.

scientific article published on 18 May 2010

Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly

scientific article published on 24 July 2011

Mechanisms of centrosome separation and bipolar spindle assembly

scientific article published on December 2010

Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids

scientific article published on 01 September 2011

Mitogen requirement for cell cycle progression in the absence of pocket protein activity

scientific article published on 01 December 2005

Mitosis as an anti-cancer target ⬇️

scientific article published on February 21, 2011

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

scientific article published on May 2004

Molecular basis underlying resistance to Mps1/TTK inhibitors.

scientific article published on 14 September 2015

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

scientific article

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

scientific article

Mps1 promotes rapid centromere accumulation of Aurora B.

scientific article

Mutations in LRRC50 predispose zebrafish and humans to seminomas

scientific article

Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

scientific article

Negative growth regulation of SK-N-MC cells by bFGF defines a growth factor-sensitive point in G2.

scientific article

No Way Out for Tumor Cells

scientific article published on 01 October 2009

Novel functions of FoxM1: from molecular mechanisms to cancer therapy

scientific article published on 5 March 2013

Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation

scientific article

Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation

scientific article

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance

scientific article

Optimizing RNA interference for application in mammalian cells

scientific article published on June 2004

P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development

scientific article published on January 2009

PHF6 promotes non-homologous end joining and G2 checkpoint recovery

scientific article published on 29 November 2019

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance.

scientific article

Persistent repair intermediates induce senescence

scientific article published in Nature Communications

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts

scientific article

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.

scientific article published on 21 May 2007

Polo-box domains confer target specificity to the Polo-like kinase family

scientific article

Polo-like kinase 1 inhibitors and their potential role in anticancer therapy, with a focus on NSCLC.

scientific article published on October 2011

Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1

scientific article published in 2009

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

scientific article

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

scientific article published on September 2004

Polo-like kinase-1 is a target of the DNA damage checkpoint

scientific article published on 01 September 2000

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

scientific article

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

scientific article published on 21 June 2004

Polo-like kinases: a team in control of the division

scientific article (publication date: April 2006)

Positivity of the proliferation marker Ki-67 in noncycling cells

scientific article published in July 1998

Protein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines

scientific article published on 16 July 2001

Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation.

scientific article published on 03 August 2011

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

scientific article

RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment.

scientific article

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment

scientific article published on 15 August 2016

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

scientific article published on January 1993

Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1.

scientific article published on 9 April 2010

Regulation of localization and activity of the microtubule depolymerase MCAK

scientific article

Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation.

scientific article published on July 1992

Relaying the checkpoint signal from kinetochore to APC/C.

scientific article published in January 2009

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

article

Restarting the cell cycle when the checkpoint comes to a halt

scientific article

SUMO targets the APC/C to regulate transition from metaphase to anaphase.

scientific article published on 16 March 2018

Several Noncontiguous Domains of CDK4 Are Involved in Binding to the P16 Tumor Suppressor Protein ⬇️

scientific article published on August 19, 1998

Shared and separate functions of polo-like kinases and aurora kinases in cancer

scientific article

Spatial Separation of Plk1 Phosphorylation and Activity

scientific article

Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines

scientific article

Stress mixes chromosomes

scientific article published in Nature

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence

scientific article

Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown

scientific article

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

scientific article

Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody

scientific article

Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis

scientific article

Switching Polo-like kinase-1 on and off in time and space

scientific article

Systematic dissection of dynein regulators in mitosis

scientific article published on April 2013

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

scientific article published on 29 September 2017

Targeting the Mitotic Checkpoint to Kill Tumor Cells ⬇️

scientific article published on December 17, 2010

The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit

scientific article (publication date: 23 August 2010)

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

scientific article

The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment

scientific article published on 29 October 2012

The X factor: skewing X inactivation towards cancer

scientific article published on June 2007

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

scientific article

The case for Survivin as mitotic regulator

scientific article published on 7 September 2006

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

scientific article published on May 2004

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions

scientific article published on 15 August 2007

The chromosomal passenger complex: guiding Aurora-B through mitosis

scientific article published on 12 June 2006

The chromosome shuffle

scientific article published on 01 September 2008

The core spliceosome as target and effector of non-canonical ATM signalling.

scientific article

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

scientific article

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

scientific article (publication date: 15 May 2002)

The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis

scientific article

The role of p21ras in receptor tyrosine kinase signaling

scientific article

The role of ras proteins in insulin signal transduction

scientific article

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle

scientific article published on 20 January 2015

The survivin/Aurora B complex: its role in coordinating tension and attachment

scientific article published on November 2003

Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest

scientific article published on March 2016

Transcriptional regulation underlying recovery from a DNA damage-induced arrest.

scientific article published on July 2010

Transient activation of p53 in G2 phase is sufficient to induce senescence.

scientific article

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

scientific article published on December 1991

USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response

scientific article

UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway

scientific article published on 27 February 2013

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.

scientific article

Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident

scientific article published in December 1998

Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres

scientific article

Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein

scientific article published on 27 February 2014

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

scientific article

Unexpected gene activation following CRISPR-Cas9-mediated genome editing

scientific article published on 20 December 2021

Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

scientific article

WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy

scientific article published on 19 September 2013

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

scientific article published on August 2011

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. ⬇️

scientific article

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition

scientific article

p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

scientific article published on 01 January 1998

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

scientific article published in June 2017

pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F

scientific article

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