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List of works by Roberto Docampo

1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase

scientific article

5-Diphosphoinositol Pentakisphosphate (5-IP) Regulates Phosphate Release from Acidocalcisomes and Yeast Vacuoles

scientific article published in Journal of Biological Chemistry

A 43-nucleotide U-rich element in 3'-untranslated region of large number of Trypanosoma cruzi transcripts is important for mRNA abundance in intracellular amastigotes

scientific article

A Riboswitch-based Inducible Gene Expression System for Trypanosoma brucei.

scientific article published on 19 December 2017

A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis

scientific article

A contractile vacuole complex is involved in osmoregulation in Trypanosoma cruzi

scientific article

A novel role of Rab11 in trafficking GPI-anchored trans-sialidase to the plasma membrane of Trypanosoma cruzi

scientific article

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

scientific article

Acidocalcisome-Mitochondrion Membrane Contact Sites in Trypanosoma brucei.

scientific article published on 22 March 2018

Acidocalcisomes ⬇️

scientific article (publication date: August 2011)

Acidocalcisomes - conserved from bacteria to man.

scientific article

Acidocalcisomes and the contractile vacuole complex are involved in osmoregulation in Trypanosoma cruzi

scientific article

Acidocalcisomes as calcium- and polyphosphate-storage compartments during embryogenesis of the insect Rhodnius prolixus Stahl

scientific article

Acidocalcisomes of eukaryotes.

scientific article published on 25 April 2016

Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii.

scientific article

Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes

scientific article

Adaptor Protein-3 (AP-3) Complex Mediates the Biogenesis of Acidocalcisomes and Is Essential for Growth and Virulence of Trypanosoma brucei ⬇️

scientific article published on August 31, 2011

Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP<sub>7</sub> )-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages

scientific article published on 22 December 2020

An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi

scientific article

Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites.

scientific article published on 4 January 2017

Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii.

scientific article published on 27 April 2015

Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase

scientific article published on 17 February 2012

CRISPR/Cas9-Induced Disruption of Paraflagellar Rod Protein 1 and 2 Genes in Trypanosoma cruzi Reveals Their Role in Flagellar Attachment

scientific article published on 21 July 2015

CRISPR/Cas9-mediated endogenous C-terminal Tagging of Trypanosoma cruzi Genes Reveals the Acidocalcisome Localization of the Inositol 1,4,5-Trisphosphate Receptor.

scientific article published on 28 October 2016

Ca2+ Regulation of Trypanosoma brucei Phosphoinositide Phospholipase C.

scientific article published on 13 March 2015

Ca<sup>2+</sup> entry at the plasma membrane and uptake by acidic stores is regulated by the activity of the V-H<sup>+</sup> -ATPase in Toxoplasma gondii

scientific article published on 19 April 2021

Calcium regulation in protozoan parasites

scientific article

Calcium signaling in trypanosomatid parasites

scientific article

Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP

scientific article

Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of

scientific article published in Journal of Biological Chemistry

Catching protein polyphosphorylation in the act

scientific article published on 01 February 2020

Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi

scientific article

Current chemotherapy of human African trypanosomiasis

scientific article

Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi

scientific article

Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

scientific article

Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents

scientific article published on 18 September 2013

Detection of Weakly Expressed Trypanosoma cruzi Membrane Proteins Using High-Performance Probes

scientific article published on 30 March 2018

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi

scientific article

Different Sensitivity of Control and MICU1- and MICU2-Ablated <i>Trypanosoma cruzi</i> Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors

scientific article published on 07 December 2020

Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes

scientific article

Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote

scientific article published on August 2003

Further insights of selenium-containing analogues of WC-9 against Trypanosoma cruzi

scientific article published on 19 February 2019

Genetic tool development in marine protists: emerging model organisms for experimental cell biology

scientific article published on 06 April 2020

Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes.

scientific article

Hyperosmotic stress induces aquaporin-dependent cell shrinkage, polyphosphate synthesis, amino acid accumulation, and global gene expression changes in Trypanosoma cruzi.

scientific article published on 28 October 2011

Identification of contractile vacuole proteins in Trypanosoma cruzi

scientific article (publication date: 2011)

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei

scientific article

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

scientific article

Inorganic polyphosphate interacts with nucleolar and glycosomal proteins in trypanosomatids

scientific article published on 18 October 2018

Inositolphosphoceramide Metabolism in Trypanosoma cruzi as Compared with other Trypanosomatids ⬇️

scientific article published on February 21, 2011

Intracellular calcium channels in protozoa

scientific article

Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in Leishmania major

scientific article published on 01 July 2020

Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth

scientific article

Localization and developmental regulation of a dispersed gene family 1 protein in Trypanosoma cruzi

scientific article

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi

scientific article published on 07 May 2019

Membrane Proteins in Trypanosomatids Involved in Ca2+ Homeostasis and Signaling.

scientific article published on 19 June 2018

Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi

scientific article published in 2021

Mitochondrial calcium transport in trypanosomes

scientific article

Molecular and Electrophysiological Characterization of a Novel Cation Channel of Trypanosoma cruzi ⬇️

scientific article published on June 7, 2012

Molecular parasitology in the 21st Century ⬇️

scientific article published on January 1, 2011

NUDIX hydrolases with inorganic polyphosphate exo- and endopolyphosphatase activities in the glycosome, cytosol and nucleus of

scientific article published on 17 May 2019

New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.

scientific article

New insights into roles of acidocalcisomes and contractile vacuole complex in osmoregulation in protists

scientific article

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

scientific article published on May 2015

Phosphonium lipocations as antiparasitic agents ⬇️

scientific article published on February 23, 2012

Polyphosphate and its diverse functions in host cells and pathogens

scientific article (publication date: 2013)

Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes

scientific article published on 3 July 2012

Polyphosphate modulates blood coagulation and fibrinolysis.

scientific article

Proteomic analysis of acidocalcisomes of Trypanosoma brucei uncovers their role in phosphate metabolism, cation homeostasis, and calcium signaling

scientific article

Proteomic analysis of the acidocalcisome, an organelle conserved from bacteria to human cells

scientific article

Publisher Correction: Genetic tool development in marine protists: emerging model organisms for experimental cell biology

scientific article published on 15 April 2020

Pyrophosphate Stimulates the Phosphate-Sodium Symporter of Acidocalcisomes and Vacuoles

scientific article published on 03 April 2019

Rab11 regulates trafficking of trans-sialidase to the plasma membrane through the contractile vacuole complex of Trypanosoma cruzi

scientific article

Rab32 is essential for maintaining functional acidocalcisomes, and for growth and infectivity of Trypanosoma cruzi

scientific article

Risedronate metal complexes potentially active against Chagas disease.

scientific article

SQ109, a new drug lead for Chagas disease

scientific article

Signaling pathways involved in environmental sensing in Trypanosoma cruzi

scientific article published on 09 October 2020

Specific chemotherapy of Chagas disease: controversies and advances ⬇️

scientific article published on November 1, 2003

Squalene synthase as a target for Chagas disease therapeutics

scientific article

Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase

scientific article published on 10 December 2007

Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.

scientific article

Target of rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei

scientific article

TbVps41 regulates trafficking of endocytic but not biosynthetic cargo to lysosomes of bloodstream forms of Trypanosoma brucei

scientific article published on 01 June 2021

TcPho91 is a contractile vacuole phosphate sodium symporter that regulates phosphate and polyphosphate metabolism in Trypanosoma cruzi

scientific article

The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions

scientific article published on 02 November 2021

The Inositol Pyrophosphate Biosynthetic Pathway of <i>Trypanosoma cruzi</i>

scientific article published on 07 January 2021

The Mitochondrial Ca Uniporter Complex (MCUC) of Trypanosoma brucei Is a Hetero-oligomer That Contains Novel Subunits Essential for Ca Uptake

scientific article published in 2018

The Mitochondrial Calcium Uniporter Interacts with Subunit c of the ATP Synthase of Trypanosomes and Humans

scientific article published on 17 March 2020

The Role of Acidocalcisomes in the Stress Response of Trypanosoma cruzi ⬇️

scientific article published on January 1, 2011

The acidocalcisome inositol-1,4,5-trisphosphate receptor of Trypanosoma brucei is stimulated by luminal polyphosphate hydrolysis products

scientific article published on 28 May 2019

The acidocalcisome vacuolar transporter chaperone 4 catalyzes the synthesis of polyphosphate in insect-stages of Trypanosoma brucei and T. cruzi

scientific article published on 03 January 2014

The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes

scientific article published on 9 August 2017

The interplay between folding-facilitating mechanisms in Trypanosoma cruzi endoplasmic reticulum.

scientific article published on 27 June 2003

The origin and evolution of the acidocalcisome and its interactions with other organelles

scientific article

The role of acidocalcisomes in parasitic protists

scientific article

The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants

scientific article

Trypanosoma cruzi H+-ATPase 1 (TcHA1) and 2 (TcHA2) genes complement yeast mutants defective in H+ pumps and encode plasma membrane P-type H+-ATPases with different enzymatic properties

scientific article

Trypanosomes and the solution to a 50-year mitochondrial calcium mystery

scientific article

Volutin granules of Eimeria parasites are acidic compartments and have physiological and structural characteristics similar to acidocalcisomes

scientific article

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