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List of works by Steve Horvath

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

scientific article

A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores

scientific article published on January 2017

A mammalian methylation array for profiling methylation levels at conserved sequences

scientific article published on 10 February 2022

A meta-analysis of genome-wide association studies of epigenetic age acceleration

scientific article published on 18 November 2019

A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease

scientific article

A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study

scientific article published on 31 December 2018

A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models

scientific article published on 23 July 2011

ARDD 2020: from aging mechanisms to interventions

scientific article published on 30 December 2020

Accelerated epigenetic aging in Down syndrome

scientific article

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome.

scientific article

An anatomically comprehensive atlas of the adult human brain transcriptome

scientific article (publication date: 20 September 2012)

An epigenetic biomarker of aging for lifespan and healthspan

scientific article published on 18 April 2018

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

scientific article

An epigenetic clock for gestational age at birth based on blood methylation data

scientific article

An epigenetic predictor of death captures multi-modal measures of brain health

scientific article published on 03 December 2019

An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy

scientific article

An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association

scientific article

Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease

scientific article published on 06 March 2020

Analysis of the Na,K-ATPase α- and β-subunit expression profiles of bladder cancer using tissue microarrays

article

Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo

scientific article

Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer.

scientific article published in December 2004

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

scientific article

Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats

correction of a scholarly article

Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

scientific article published in Nature

Biomarkers for early and late stage chronic allograft nephropathy by proteogenomic profiling of peripheral blood

scientific article

Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status.

scientific article

Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy

scientific article (publication date: February 2003)

Clinicopathologic and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma

scientific article published on 01 June 2005

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

scientific article published on 29 May 2021

Cluster and propensity based approximation of a network

scientific article (publication date: 14 March 2013)

Comparison of co-expression measures: mutual information, correlation, and model based indices

scientific article

Conservation and evolution of gene coexpression networks in human and chimpanzee brains

scholarly article

Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study

Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma

scientific article

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

scientific article published on 30 November 2017

DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age.

scientific article

DNA methylation age of blood predicts all-cause mortality in later life

scientific article

DNA methylation age of human tissues and cell types

scientific article

DNA methylation as a tool to explore ageing in wild roe deer populations

scientific article published in 2021

DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging

scientific article published in 2023

DNA methylation signatures in Blood DNA of Hutchinson-Gilford Progeria syndrome

scientific article published on 19 January 2022

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

scientific article published on 12 December 2016

DNA methylation study of Huntington's disease and motor progression in patients and in animal models

scientific article published on 10 September 2020

DNA methylation-based measures of biological age: meta-analysis predicting time to death

scientific article

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

scientific article

Detecting network modules in fMRI time series: a weighted network analysis approach

scientific article

Development of Epigenetic Clocks for Key Ruminant Species

scientific article published on 30 December 2021

Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples

scientific article

Development of epigenetic clocks for New Zealand livestock

scientific article published on 2 July 2021

Differential expression of anterior gradient gene AGR2 in prostate cancer

scientific article

Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors

scientific article

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

scientific article

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

scientific article

Eigengene networks for studying the relationships between co-expression modules

scientific article

Elevated MED28 expression predicts poor outcome in women with breast cancer

scientific article

Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks

scientific article published on 30 October 2008

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning

scientific article

Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

scientific article

Epigenetic clock and methylation studies in vervet monkeys

scientific article published on 30 September 2021

Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging

scientific article published on 02 April 2021

Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids

scientific article published on 17 December 2021

Epigenetic mutation load is weakly correlated with epigenetic age acceleration

scientific article published on 29 September 2020

Epigenetic predictor of age

scientific article

Epigenetic predictors of maximum lifespan and other life history traits in mammals

scientific article published on 18 May 2021

Epithelial membrane protein-2 expression is an early predictor of endometrial cancer development

scientific article

Erratum to: DNA methylation age of human tissues and cell types

scientific article

Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets

scientific article published on 31 March 2017

Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer

scientific article

Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence

scientific article published in October 2007

Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression

scientific article

Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival.

scientific article

Expression of transcription factor Yin Yang 1 in prostate cancer

scientific article

Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics

scientific article

Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score

scientific article

Functional Modules Distinguish Human Induced Pluripotent Stem Cells from Embryonic Stem Cells ⬇️

scientific article published on June 20, 2011

Functional organization of the transcriptome in human brain

scientific article published on 12 October 2008

Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks

scientific article

Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age

scientific article

Gene expression profiling identifies molecular subtypes of gliomas

scientific article

Gene expression profiling of gliomas strongly predicts survival

scientific article published in September 2004

Gene network interconnectedness and the generalized topological overlap measure

scientific article published on 24 January 2007

Gene networks associated with conditional fear in mice identified using a systems genetics approach

scientific article

Genes and pathways underlying regional and cell type changes in Alzheimer's disease

scientific article published on 25 May 2013

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

scientific article

Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling

scientific article published on 31 March 2009

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

scientific article

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

scientific article

Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder

scientific article

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

scientific article published on 5 December 2016

Geometric interpretation of gene coexpression network analysis

scientific article

Glycerol kinase deficiency alters expression of genes involved in lipid metabolism, carbohydrate metabolism, and insulin signaling

scientific article

Hibernation slows epigenetic ageing in yellow-bellied marmots

scientific article published on 07 March 2022

High expression of AGR2 in lung cancer is predictive of poor survival

scientific article

Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome

scientific article

Higher levels of GATA3 predict better survival in women with breast cancer

scientific article

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

scientific article published on 12 June 2019

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

scientific article

Identification of molecular subtypes of glioblastoma by gene expression profiling

scientific article published in April 2003

Identification of schizophrenia-associated loci by combining DNA methylation and gene expression data from whole blood

scientific article

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.

scientific article

Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome

scientific article

Integrating genetic and network analysis to characterize genes related to mouse weight

scientific article published on 5 July 2006

Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism

scientific article published on November 2013

Is human blood a good surrogate for brain tissue in transcriptional studies? ⬇️

scientific article published on October 20, 2010

Is my network module preserved and reproducible?

scientific article

Ki67, gelsolin and PTEN expression in sarcomatoid renal tumors

scientific article

Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes

scientific article

Long-term maturation of human cortical organoids matches key early postnatal transitions

scientific article published on 22 February 2021

Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer

scientific article published on April 2003

Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome

scientific article published in December 2016

Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells

scientific article published in January 2008

Menopause accelerates biological aging

scientific article

Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy

scientific article published in 2021

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice.

scientific article published on 11 January 2018

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

scientific article

Multivariate variance-components analysis of longitudinal blood pressure measurements from the Framingham Heart Study

scientific article

Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

scientific article (publication date: April 2003)

Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer ⬇️

scientific article published on February 17, 2012

Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma

scientific article

Network methods for describing sample relationships in genomic datasets: application to Huntington’s disease ⬇️

scientific article published on June 12, 2012

Network organization of the huntingtin proteomic interactome in mammalian brain

scientific article

Neuropathological and transcriptomic characteristics of the aged brain.

scientific article

Neurosphere formation is an independent predictor of clinical outcome in malignant glioma

scientific article

Persistent accelerated epigenetic ageing in a longitudinal cohort of vertically infected HIV-positive adolescents

scientific article published in June 2023

Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies

scientific article published on 5 November 2015

Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer

scientific article

Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma

scientific article published in June 2004

Prostate cancer cell phenotypes based on AGR2 and CD10 expression

scientific article published on 25 January 2013

Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer

scientific article published in March 2004

Prostate stem cell antigen is overexpressed in prostate cancer metastases

scientific article (publication date: April 2005)

Protein expression based multimarker analysis of breast cancer samples

scientific article

Random generalized linear model: a highly accurate and interpretable ensemble predictor

scientific article

Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation

scientific article published on 01 May 2019

Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2.

scientific article published in May 2007

Reprogramming to recover youthful epigenetic information and restore vision

scientific article published on 02 December 2020

Resting-state quantitative electroencephalography reveals increased neurophysiologic connectivity in depression

scientific article

Reversal of epigenetic aging and immunosenescent trends in humans

scientific article published on 08 September 2019

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.

scientific article

Statistical methods for analyzing tissue microarray data

scientific article published in August 2004

Strategies for aggregating gene expression data: the collapseRows R function

scientific article

Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease

scientific article (publication date: 13 February 2013)

Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity

scientific article published on 20 December 2005

Text-mining applied to autoimmune disease research: the Sjögren's syndrome knowledge base

scientific article

The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients

scientific article published on 12 June 2020

The cerebellum ages slowly according to the epigenetic clock

scientific article

The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort.

scientific article published on 15 January 2017

The organization of the transcriptional network in specific neuronal classes.

scientific article published on 28 July 2009

Tissue microarray analysis of cytoskeletal actin-associated biomarkers gelsolin and E-cadherin in urothelial carcinoma

scientific article published in September 2002

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

scientific article (publication date: 25 May 2011)

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

scientific article published in 2020

Trefoil factor 3 is overexpressed in human prostate cancer

scientific article

Tumor classification by tissue microarray profiling: random forest clustering applied to renal cell carcinoma

scientific article

Understanding network concepts in modules

scientific article

Unsupervised Learning With Random Forest Predictors

Using epigenetic clocks to investigate changes in the age structure of critically endangered Māui dolphins

scientific article published on 28 September 2023

Using genetic markers to orient the edges in quantitative trait networks: the NEO software

scientific article

Using protein expressions to predict survival in clear cell renal carcinoma

scientific article

Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma

scientific article published in May 2005

Variations in DNA elucidate molecular networks that cause disease

scientific article

WGCNA: an R package for weighted correlation network analysis

scientific article

Weighted gene co-expression network analysis identifies biomarkers in glycerol kinase deficient mice.

scientific article published on 27 May 2009

When is hub gene selection better than standard meta-analysis?

scientific article published in 2013

p53 is an independent predictor of tumor recurrence and progression after nephrectomy in patients with localized renal cell carcinoma.

scientific article published in March 2005

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