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List of works by Rachael Natrajan

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

scientific article published on 23 February 2012

APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer

scientific article

Abstract 3917: EMSY amplification and overexpression is not associated with defective homologous recombination and does not predict sensitivity to cisplatin or PARP inhibitors

article by Paul Wilkerson et al published 15 April 2011 in Cancer Research

Abstract 4829: Massively parallel RNA sequencing analysis of micropapillary carcinomas of the breast

article by Rachael Natrajan et al published 15 April 2011 in Cancer Research

Abstract 4987: Identification of novel genes and pathways involved in resistance to HER2-targeting agents in breast cancer

article

Abstract 5076: Integrative genomic and transcriptomic analysis of metaplastic carcinomas of the breast

article by Alan G. Mackay et al published 15 April 2012 in Cancer Research

Abstract PD05-08: Genomic characterisation of invasive breast cancers with heterogeneous HER2 gene amplification

article

Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers

scientific article

Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors

scientific article

An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer.

scientific article

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

scientific article published on 18 August 2009

An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer

scientific article published on 10 June 2013

Analysis by array CGH of genomic changes associated with the progression or relapse of Wilms' tumour

scientific article published on 01 January 2007

Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse

scientific article published on 01 September 2006

Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA.

scientific article

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

scientific article published on September 2010

Blastemal expression of type I insulin-like growth factor receptor in Wilms' tumors is driven by increased copy number and correlates with relapse

scientific article

Breast cancer heterogeneity: parallel evolution or conscious uncoupling?

scientific article published on 28 May 2015

Breast cancer molecular profiling with single sample predictors: a retrospective analysis

scientific article

CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification

scientific article published on 7 April 2009

Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

scientific article

Chromogenic and fluorescent in situ hybridization in breast cancer

scientific article

Comparative proteomic assessment of matrisome enrichment methodologies

scientific article (publication date: November 2016)

Complex landscapes of somatic rearrangement in human breast cancer genomes

scientific article

Complex patterns of chromosome 9 alterations including the p16INK4a locus in Wilms tumours

scientific article published on 16 March 2007

Corrigendum: metastatic breast carcinomas display genomic and transcriptomic heterogeneity

scientific article published on 01 April 2015

Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study

scientific article

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

scientific article

DNA amplifications in breast cancer: genotypic-phenotypic correlations

scientific article published on June 2010

Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH

scientific article published on 01 June 2007

Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer

scientific article published on 9 September 2010

Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer

article

Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors

scientific article (publication date: 25 October 2016)

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.

scientific article published in April 2018

ESR1 gene amplification in breast cancer: a common phenomenon?

scientific article published in July 2008

Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers ⬇️

scientific article

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer.

scientific article published on 13 November 2017

FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo

scientific article

FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

scientific article

From integrative genomics to therapeutic targets

scientific article

Functional characterization of EMSY gene amplification in human cancers

scientific article published on 7 July 2011

Functional characterization of the 19q12 amplicon in grade III breast cancers

scientific article

Functional viability profiles of breast cancer

scientific article

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

scientific article published on 20 November 2011

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity

scientific article

Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines

scientific article

Genomic analysis reveals the molecular heterogeneity of ovarian clear cell carcinomas

scientific article published on 01 March 2011

Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast

scientific article published on 7 May 2010

Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast

scientific article published on 01 August 2008

Genomic and mutational profiling of ductal carcinomas in situ and matched adjacent invasive breast cancers reveals intra-tumour genetic heterogeneity and clonal selection

scientific article published on 21 March 2012

Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast

scientific article published in December 2017

Genomic landscape of adenoid cystic carcinoma of the breast

scientific article

Genomic profiling of histological special types of breast cancer

scientific article published on 27 October 2013

Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology

scientific article published on 21 April 2011

Getting it right: designing microarray (and not 'microawry') comparative genomic hybridization studies for cancer research

scientific article published on 11 June 2007

HG-09INFANTILE GLIOBLASTOMA WITH SARCOMATOUS HISTOLOGY DRIVEN BY ETV6:NTRK3 FUSIONS ARE SENSITIVE TO TRK INHIBITION BY PHA-848125.

scientific article

High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform

scientific article

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

scientific article published on 08 August 2019

Identification and Validation of Driver Kinases from Next-Generation Sequencing Data

scientific article published on January 2017

Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma

scientific article

Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines

scientific article

Immunophenotypic and genomic characterization of papillary carcinomas of the breast

scientific article published on 09 December 2011

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Influence of whole arm loss of chromosome 16q on gene expression patterns in oestrogen receptor-positive, invasive breast cancer

scientific article published on 27 June 2011

Integrated functional, gene expression and genomic analysis for the identification of cancer targets

scientific article

Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast

scientific article published on 26 June 2014

Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies

scientific article published on 21 January 2013

Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

scientific article

Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

scientific article published on 22 May 2015

Is acinic cell carcinoma a variant of secretory carcinoma? A FISH study using ETV6'split apart' probes

scientific article published on 6 May 2008

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

scientific article published on 2 March 2016

Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR

scientific article published on 20 November 2019

Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?

scientific article published in April 2009

Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.

scientific article

Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected]. .

scientific article published on 21 November 2014

Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement

scientific article

Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis

scientific article

Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma

scientific article published on December 2009

Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components.

scientific article published in July 2009

Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas

scientific article

Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis

scientific article

Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in wilms tumor

article

Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type

scientific article published on November 2010

Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney

scientific article

Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations

scientific article published on 12 February 2013

Next-generation sequencing applied to molecular diagnostics

scientific article published on 01 May 2011

Non-existence of caveolin-1 gene mutations in human breast cancer

scientific article published on 11 September 2011

Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers.

scientific article published on 16 April 2018

P1-06-22: Identification of Biomarkers in Breast Cancer for Prediction of Response to PARP Inhibitor Olaparib

article by A Daemen et al published 15 December 2011 in Cancer Research

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study

scientific article published on 11 June 2010

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

scientific article published on 17 March 2009

PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors

scientific article published on October 2010

Preclinical evaluation of PARP inhibition as a treatment for endometrioid endometrial carcinomas

article by K. J. Dedes et al published 20 May 2010 in Journal of Clinical Oncology

Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer

scientific article published on 17 December 2016

Prognostic classification of relapsing favorable histology Wilms tumor using cDNA microarray expression profiling and support vector machines

scientific article published in September 2004

Real-time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study

scientific article published on 22 December 2019

Resistance to therapy caused by intragenic deletion in BRCA2

scientific article

Risk Stratification and Intrinsic Subtype Classification of Breast Cancer: a Multi-Parameter Test to Rule Them All?

scientific article published on 29 April 2016

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms

scientific article published on 20 March 2015

SF3B1 mutations constitute a novel therapeutic target in breast cancer

scientific article

SWATH mass spectrometry as a tool for quantitative profiling of the matrisome

scientific article published on 28 February 2018

Splicing dysregulation as a driver of breast cancer

scholarly article by Abigail Read & Rachael Natrajan published 1 September 2018 in Endocrine-related cancer

Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer.

scientific article published on 17 August 2016

The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas

scientific article published on 2 February 2017

The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer

scientific article published on 11 June 2018

The genomic profile of HER2-amplified breast cancers: the influence of ER status

scientific article

The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type

scientific article

The status of epidermal growth factor receptor in borderline ovarian tumours.

scientific article published on 08 February 2016

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model

scientific article published on 11 August 2016

Tiling path genomic profiling of grade 3 invasive ductal breast cancers

scientific article published on 24 March 2009

Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas

scientific article published in September 2010

Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.

scientific article

Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization

scientific article

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures.

scientific article published on 26 December 2016

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

scientific article published on 12 November 2010

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