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List of works by Zora Modrusan

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

scientific article published on 06 September 2016

A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

scientific article published on 19 January 2017

A comprehensive transcriptional portrait of human cancer cell lines

scientific article published on 08 December 2014

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

scientific article published on March 2017

A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target.

scientific article

A hierarchy of self-renewing tumor-initiating cell types in glioblastoma

scientific article published in April 2010

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation

scientific article published on June 2013

A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis

scientific article

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

scientific article

Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy ⬇️

scientific article published on November 22, 2011

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

scientific article published on 10 March 2009

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.

scientific article published on September 2008

Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model

scientific article published in 2013

Building proteomic tool boxes to monitor MHC class I and class II peptides

scientific article published on 8 December 2016

CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma

scientific article published on March 2011

CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.

scientific article

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells ⬇️

scientific article published on May 19, 2011

Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis.

scientific article published in October 2010

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation.

scientific article

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

scientific article published on 2 September 2012

Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India

scientific article published on 13 February 2018

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

scientific article published on 29 February 2016

Corrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

scientific article published on 25 May 2017

Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity

scientific article

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

scientific article published on 19 February 2013

DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer

scientific article published on 19 January 2012

Death Receptors DR6 and TROY Regulate Brain Vascular Development ⬇️

scientific article published on February 14, 2012

Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus

scientific article

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

scientific article published in 2011

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

scientific journal article

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models

scientific article published in January 2018

Diverse modes of genomic alteration in hepatocellular carcinoma

scientific article

Diverse somatic mutation patterns and pathway alterations in human cancers

scientific article (publication date: 12 August 2010)

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

scientific article published on December 2005

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

scientific article published on 24 October 2011

Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers

scientific article

Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis

scientific article published on 11 December 2006

Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer

scientific article

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways

scientific article published on 27 December 2010

Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer

scientific article

Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse

scientific journal article

Global gene expression of methicillin-resistant Staphylococcus aureus USA300 during human and mouse infection

scientific article published on 28 November 2013

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes ⬇️

scientific article published on November 16, 2010

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

scientific article

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

scientific article

Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer.

scientific article

Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages

scientific article published on 02 July 2013

Host-derived fatty acids activate type VII secretion in Staphylococcus aureus

scientific article published on 2 October 2017

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells.

scientific article published on 5 September 2013

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells.

scientific article published on 14 March 2015

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

scientific article

Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies.

scientific article published on 17 May 2013

Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma

scientific article

Identification of Mutant K-Ras-dependent Phenotypes Using a Panel of Isogenic Cell Lines ⬇️

scientific article published on November 27, 2012

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

scientific article published on 8 May 2014

Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control

scientific article

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

scientific article (publication date: March 2008)

Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion

scientific article

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

scientific article published on 4 December 2017

Loss of the tumor suppressor BAP1 causes myeloid transformation

scientific article published on 09 August 2012

Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model

scientific article

Massively parallel nanowell-based single-cell gene expression profiling

scientific article

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

scientific journal article

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

scientific journal article

Oncogenic ERBB3 mutations in human cancers

scientific article

Oncogenic activating mutations are associated with local copy gain

scientific article

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment

scientific article

PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors

scientific article

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.

scientific article

Recurrent R-spondin fusions in colon cancer ⬇️

scientific article published on August 30, 2012

Regulation of ERK3/MAPK6 expression by BRAF.

scientific article

Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4.

scientific article

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types

scientific article published on 31 March 2017

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance ⬇️

scientific article published on January 15, 2011

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

scientific article

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1.

scientific article published on 20 October 2013

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

scientific article published on 17 November 2014

Stem cell plasticity enables hair regeneration following Lgr5+ cell loss

scientific article

TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer

scientific journal article

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

scientific article published on 01 February 2007

The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification

The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.

scientific article published on 20 January 2012

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

scientific article

Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

scientific article published on 17 August 2017

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.

scientific article

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain

article published in the Proceedings of the National Academy of Sciences of the United States of America

Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses

scientific article published on 21 April 2016

miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer

scientific article

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

scientific article published on 24 November 2015

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