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List of works by Manuel Perucho

A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines

scientific article published on 01 December 1997

A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis

scientific article

A comprehensive custom panel design for routine hereditary cancer testing: preserving control, improving diagnostics and revealing a complex variation landscape

scientific article

A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells

scientific article

A novel long non-coding RNA from NBL2 pericentromeric macrosatellite forms a perinucleolar aggregate structure in colon cancer.

scientific article published in June 2018

Activation of a human c-K-ras oncogene

scientific article

Alleles with short CAG and GGN repeats in the androgen receptor gene are associated with benign endometrial cancer

scientific article

Amplotyping of microdissected, methanol-fixed lung carcinoma by arbitrarily primed polymerase chain reaction

scientific article published on 01 January 2000

An evaluation of two activated clotting time monitors during cardiac surgery

scientific article

An improved method for the preparation of undegraded polysomes and active messenger RNA from immature chicken erythrocytes

scientific article published in October 1979

Analysis of Somatic DNA Methylation Alterations of Genes Encoding Cell Surface Metallopeptidases in Colorectal Cancer.

scientific article published in January 2018

Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers

scientific article published on August 2005

Analysis of genetic variability and mapping of point mutations in influenza virus by the RNase A mismatch cleavage method

scientific article

Array-based identification of common DNA methylation alterations in ulcerative colitis

scientific article published on 6 December 2011

Assessment of genomic damage in colorectal cancer by DNA fingerprinting: prognostic applications

scientific article published on 01 October 1997

Cancer genomics and molecular diagnosis--The Nineteenth International Symposium of Sapporo Cancer Seminar

scientific article published in November 1999

Cancer of the microsatellite mutator phenotype.

scientific article published on November 1996

Characterization of genetic variation and 3'-azido-3'-deoxythymidine- resistance mutations of human immunodeficiency virus by the RNase A mismatch cleavage method

scientific article published on May 1991

Characterization of the human c-K-ras gene promoter

scientific article

Chromatin structure of the promoter region of the human c-K-ras gene

scientific article

Chromosomal assignment of human DNA fingerprint sequences by simultaneous hybridization to arbitrarily primed PCR products from human/rodent monochromosome cell hybrids

scientific article published in May 1996

Chromosome 7q allelic losses in pancreatic carcinoma.

scientific article published on August 1996

Clinical characteristics of synchronous colorectal cancers in Japan

scientific article published on 24 October 2016

Clinical implications of microsatellite instability in colorectal cancers

scientific article published on 01 January 1996

Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer

scientific article published on July 1994

Comparative genomic hybridization and amplotyping by arbitrarily primed PCR in stage A B-CLL

scientific article published on 01 October 2001

Correspondence re: C.R. Boland et al., A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in c

article

DNA demethylation in normal colon tissue predicts predisposition to multiple cancers

scientific article

DNA fingerprinting techniques for the analysis of genetic and epigenetic alterations in colorectal cancer

scientific article published on 17 September 2010

DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability

scientific article

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability

scientific article published on May 1994

Defects in replication fidelity of simple repeated sequences reveal a new mutator mechanism for oncogenesis

scientific article

Design of a selectable reporter for the detection of mutations in mammalian simple repeat sequences

scientific article published on May 1995

Detection of DNA Abnormalities by Arbitrarily Primed PCR Fingerprinting: Allelic Losses in Chromosome 10q in Lung Cancers

scientific article published on 01 October 1998

Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas.

scientific article published on February 1990

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

scientific article published on May 1987

Detection of microsatellite instability in cancers by arbitrarily primed-PCR fingerprinting using a fluorescently labeled primer (FAP-PCR)

scientific article published on 01 September 1996

Development of a rat cell line containing stably integrated copies of a lambda/lacI shuttle vector

scientific article published on April 1995

Diagnostic detection of mutant ras genes in minor cell populations

scientific article published on January 1995

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

scientific article

Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells

scientific article published on March 1999

Double strand break repair components are frequent targets of microsatellite instability in endometrial cancer

article

Down-regulation of epidermal growth factor receptor by selective expansion of a 5'-end regulatory dinucleotide repeat in colon cancer with microsatellite instability

scientific article

Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.

scientific article

Emerging roles of macrosatellite repeats in genome organization and disease development.

scientific article

Enrichment of histone H5-synthesizing polysomes by indirect immunoadsorption. Purification of H5 mRNA

scientific article published in Journal of Biological Chemistry

Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer.

scientific article

Epithelioid gastrointestinal stromal tumor with PDGFRA activating mutation and immunoreactivity

scientific article

Expression of intact Ki-ras p21 protein in Escherichia coli.

scientific article

Expression of the Kirsten ras viral and human proteins in Escherichia coli

scientific article published on February 1987

Fingerprinting of DNA and RNA by arbitrarily primed polymerase chain reaction: applications in cancer research

scientific article

First Barcelona Conference on Epigenetics and Cancer

scientific article published on 10 January 2014

Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype

scientific article published on June 1999

Frameshift mutations in Fas, Apaf-1 and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype

scientific article published on 01 February 2000

Frameshift mutator mutations

scientific article published in Nature

Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype

scientific article

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors

scientific article

Frequent Chromosome 8q Gains in Human Small Cell Lung Carcinoma Detected by Arbitrarily Primed-PCR Genomic Fingerprinting

article

Frequent alterations in gene expression in colon tumor cells of the microsatellite mutator phenotype

article

Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.

scientific article published in September 2000

Frequent somatic demethylation of RAPGEF1/C3G intronic sequences in gastrointestinal and gynecological cancer

article

Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype.

scientific article

GCAT|Genomes for life: a prospective cohort study of the genomes of Catalonia.

scientific article published on 27 March 2018

Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features

scientific article published on June 1999

Gastrointestinal cancer of the microsatellite mutator phenotype pathway

scientific article

Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability

scientific article published on 01 April 2001

Genetic and epigenetic modification of MLH1.

scientific article published on September 2000

Genetic and physical linkage of exogenous sequences in transformed cells

scientific article

Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas.

scientific article published on July 1993

Genetics supersedes epigenetics in colon cancer phenotype

article

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

scientific article

Genomic profiling in advanced stage non-small-cell lung cancer patients with platinum-based chemotherapy identifies germline variants with prognostic value in SMYD2

scientific article published on 01 March 2018

Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype

scientific article published on 01 July 2001

Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage

scientific article

Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation

scientific article published on 18 April 2016

High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability.

scientific article

Histone H5 messenger RNA is polyadenylated

scientific article published in Nature

Human-tumor-derived cell lines contain common and different transforming genes

scientific article

Hypersensitivity of tumor cell lines with microsatellite instability to DNA double strand break producing chemotherapeutic agent bleomycin

scientific article published on July 2004

Identification of novel deletion regions on chromosome arms 2q and 6p in breast carcinomas by amplotype analysis

scientific article

Identification of the mammalian DNA-binding protein P8 as glyceraldehyde-3-phosphate dehydrogenase

scientific article published on December 1977

Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers

scientific article published on May 1999

Inhibitory effect of interferon on the genetic and oncogenic transformation by viral and cellular genes.

scientific article published on April 1985

Initial characterization of a potential transcriptional enhancer for the human c-K-ras gene

scientific article published in April 1988

International conference on the healthy effect of virgin olive oil.

scientific article

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction

scientific article

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

scientific article

Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line

scientific article

Isolation of the chicken thymidine kinase gene by plasmid rescue.

scientific article

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

scientific article

Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women

article

Linkage and expression of foreign DNA in cultured animal cells

scientific article

Low mutation incidence in polymorphic noncoding short mononucleotide repeats in gastrointestinal cancer of the microsatellite mutator phenotype pathway

scientific article published in April 2002

MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells

scientific article published on 14 October 2016

Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies

scientific article

Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability

scientific article

Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans

scientific article published on February 2015

Methylation-Sensitive Amplification Length Polymorphism (MS-AFLP) Microarrays for Epigenetic Analysis of Human Genomes.

scientific article published in January 2018

Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer

scientific article

Microsatellite instability predicts clinical outcome in radiation-treated endometrioid endometrial cancer.

scientific article published on January 2010

Microsatellite instability: the mutator that mutates the other mutator

scientific article published in June 1996

Moderate amplifications of the c-myc gene correlate with molecular and clinicopathological parameters in colorectal cancer

scientific article

Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting

scientific article

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

scientific article

Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort

article

Mutational activation of the c-K-ras gene in human pancreatic carcinoma.

scientific article published on March 1990

Mutational dynamics in human tumors confirm the neutral intrinsic instability of the mitochondrial D-loop poly-cytidine repeat

scientific article published on August 2006

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

scientific article published on September 2000

Mutations in the p53 suppressor gene do not correlate with C-k-ras oncogene mutations in colorectal-cancer

article

Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells

scientific article

Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates

scientific article

Notl-Msell methylation-sensitive amplied fragment length polymorhism for DNA methylation analysis of human cancers

scientific article published on June 2001

Nucleic acid fingerprinting by PCR-based methods: applications to problems in aging and mutagenesis

scientific article

Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes

scientific article published on July 1986

Oncogenic Ki-ras but not oncogenic Ha-ras blocks integrin beta1-chain maturation in colon epithelial cells

scientific article published on December 1997

Preferential loss of a polymorphic RIZ allele in human hepatocellular carcinoma.

scientific article published on March 2001

Preservation of fertility in patients with cancer (Review)

scientific article published on 14 March 2019

Prognostic significance of apoptosis regulators in breast cancer.

scientific article

Quantification of unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples

scientific article published on 07 February 2016

Ras oncogene mutations in thyroid tumors: polymerase chain reaction-restriction-fragment-length polymorphism analysis from paraffin-embedded tissues.

scientific article published in March 1996

Requirement of RIZ1 for cancer prevention by methyl-balanced diet

scientific article

Second German-Catalan workshop on epigenetics & cancer

scientific article published on 7 April 2015

Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer

scientific article published on 30 April 2015

Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer

scientific article published in March 1998

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype

scientific article

Somatic mutation of the β2-microglobulin gene associates with unfavorable prognosis in gastrointestinal cancer of the microsatellite mutator phenotype

article

Somatic mutations in mitochondrial DNA do not associate with nuclear microsatellite instability in gastrointestinal cancer

scientific article published on 01 December 2000

Study of the interaction of glyceraldehyde-3-phosphate dehydrogenase with DNA.

scientific article

Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface

scientific article

The genomic damage estimated by arbitrarily primed PCR DNA fingerprinting is useful for the prognosis of gastric cancer

article

The microsatellite mutator phenotype of colon cancer cells is often recessive

scientific article published on December 1995

The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer

article

The somatic replication of DNA methylation

scientific article

Three human transforming genes are related to the viral ras oncogenes

scientific article published on April 1983

Transformation of mammalian cells with an amplifiable dominant-acting gene

scientific article

Tumor size is an independent risk predictor for metachronous colorectal cancer

scientific article published on 21 February 2016

Tumors with microsatellite instability: many mutations, targets and paradoxes ⬇️

scientific article published on April 17, 2003

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

scientific article

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