List of works - Michael Schnekenburger

4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

scientific article published on 5 November 2015

5-aza-2'-deoxycytidine-mediated c-myc Down-regulation triggers telomere-dependent senescence by regulating human telomerase reverse transcriptase in chronic myeloid leukemia

scientific article

An introduction to the molecular mechanisms of apoptosis

scientific article published on December 2003

Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases

scientific article published on 27 September 2013

Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin

scientific article

Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines proliferation and NF-κB regulation.

scientific article published on 6 April 2014

COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells

scientific article published on 24 June 2011

Chemopreventive and therapeutic effects of curcumin

scientific article

Chromatin-modifying agents in anti-cancer therapy

scientific article published on 22 May 2012

Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation

scientific article (publication date: October 2007)

Conference Scene: Omic technologies in human disease: extending the network of epigenetic control

scientific article published in October 2011

Curcumin stability and its effect on glutathione S-transferase P1-1 mRNA expression in K562 cells

scientific article published in December 2004

Curcumin-induced cell death in two leukemia cell lines: K562 and Jurkat

scientific article published in December 2003

DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs

scientific article published on 18 January 2012

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

scientific article published on 19 March 2016

Dual induction of mitochondrial apoptosis and senescence in chronic myelogenous leukemia by myrtucommulone A.

scientific article

Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition

scientific article

Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments

scientific article published on 25 August 2015

Epigenetic modulators from "The Big Blue": a treasure to fight against cancer

scientific article published on 22 June 2014

Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells

scientific article published on April 2013

Epigenetics Offer New Horizons for Colorectal Cancer Prevention

scientific article

Epigenomics of leukemia: from mechanisms to therapeutic applications

scientific article

Expression of glutathione S-transferase P1-1 in differentiating K562: role of GATA-1.

scientific article published in November 2003

Expression of glutathione S-transferase P1-1 in leukemic cells is regulated by inducible AP-1 binding

scientific article published in December 2004

Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs.

scientific article published on 24 March 2009

HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation

scientific article published on 20 July 2007

HDAC6-an Emerging Target Against Chronic Myeloid Leukemia?

scientific article published on 29 January 2020

Histone deacetylase 6 in health and disease

scientific article

Histone deacetylase modulators provided by Mother Nature

scientific article

Increased glutathione S-transferase P1-1 expression by mRNA stabilization in hemin-induced differentiation of K562 cells

scientific article

Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition

scientific article published in October 2003

Long term low-dose arsenic exposure induces loss of DNA methylation

scientific article published on 10 November 2006

MicroRNAs in cancer management and their modulation by dietary agents

scientific article published on 09 February 2012

Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer

scientific article

Natural chalcones as dual inhibitors of HDACs and NF-κB.

scientific article published on 15 June 2012

Natural compounds as inflammation inhibitors.

scientific article

Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic Readers, Writers and Erasers as Therapeutic Targets

scientific article published on 01 January 2016

Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines

scientific article published on 28 June 2014

Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms as Therapeutic Targets?

scientific article published on 01 January 2016

Plant-derived epigenetic modulators for cancer treatment and prevention

scientific article published on April 2014

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity

scientific article

Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum

scientific article

Regulation of epigenetic traits of the glutathione S-transferase P1 gene: from detoxification toward cancer prevention and diagnosis

scientific article

Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells

scientific article published on April 2004

Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors

scientific article published on 16 January 2008

Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines

scientific article published on 29 March 2011

Role of Histone Acetylation in Cell Cycle Regulation

scientific article published on 25 August 2015

Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells

scientific article published on 15 January 2014

Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription.

scientific article

Sustained exposure to the DNA demethylating agent, 2'-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

scientific article published on 31 October 2010

Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(), 6(), 1'(), 6'(), 11(), 17()-Fistularin-3 and Bcl-2 Inhibitor Venetoclax

scientific article published on 19 December 2018

Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia

scientific article published on 07 February 2020

The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation

scientific article

The DNA hypomethylating agent, 5-aza-2'-deoxycytidine, enhances tumor cell invasion through a transcription-dependent modulation of MMP-1 expression in human fibrosarcoma cells.

scientific article published on 4 September 2013

The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition

scientific article

Transcriptional and post-transcriptional regulation of glutathione S-transferase P1 expression during butyric acid-induced differentiation of K562 cells

scientific article

Transcriptional regulation of glutathione S-transferase P1-1 in human leukemia

scientific article

Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1.

scientific article published on 18 October 2008

Tumor necrosis factor alpha inhibits aclacinomycin A-induced erythroid differentiation of K562 cells via GATA-1.

scientific article published on 7 November 2005

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

scientific article published on 21 September 2010

Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway

scientific article

Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks

scientific article published on 21 September 2014

List of works by Michael Schnekenburger

4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

5-aza-2'-deoxycytidine-mediated c-myc Down-regulation triggers telomere-dependent senescence by regulating human telomerase reverse transcriptase in chronic myeloid leukemia

An introduction to the molecular mechanisms of apoptosis

Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases

Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin

Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines proliferation and NF-κB regulation.

COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells

Chemopreventive and therapeutic effects of curcumin

Chromatin-modifying agents in anti-cancer therapy

Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation

Conference Scene: Omic technologies in human disease: extending the network of epigenetic control

Curcumin stability and its effect on glutathione S-transferase P1-1 mRNA expression in K562 cells

Curcumin-induced cell death in two leukemia cell lines: K562 and Jurkat

DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

Dual induction of mitochondrial apoptosis and senescence in chronic myelogenous leukemia by myrtucommulone A.

Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition

Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments

Epigenetic modulators from "The Big Blue": a treasure to fight against cancer

Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells

Epigenetics Offer New Horizons for Colorectal Cancer Prevention

Epigenomics of leukemia: from mechanisms to therapeutic applications

Expression of glutathione S-transferase P1-1 in differentiating K562: role of GATA-1.

Expression of glutathione S-transferase P1-1 in leukemic cells is regulated by inducible AP-1 binding

Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs.

HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation

HDAC6-an Emerging Target Against Chronic Myeloid Leukemia?

Histone deacetylase 6 in health and disease

Histone deacetylase modulators provided by Mother Nature

Increased glutathione S-transferase P1-1 expression by mRNA stabilization in hemin-induced differentiation of K562 cells

Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition

Long term low-dose arsenic exposure induces loss of DNA methylation

MicroRNAs in cancer management and their modulation by dietary agents

Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer

Natural chalcones as dual inhibitors of HDACs and NF-κB.

Natural compounds as inflammation inhibitors.

Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic Readers, Writers and Erasers as Therapeutic Targets

Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines

Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms as Therapeutic Targets?

Plant-derived epigenetic modulators for cancer treatment and prevention

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity

Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum

Regulation of epigenetic traits of the glutathione S-transferase P1 gene: from detoxification toward cancer prevention and diagnosis

Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells

Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors

Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines

Role of Histone Acetylation in Cell Cycle Regulation

Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells

Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription.

Sustained exposure to the DNA demethylating agent, 2'-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(), 6(), 1'(), 6'(), 11(), 17()-Fistularin-3 and Bcl-2 Inhibitor Venetoclax

Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia

The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation

The DNA hypomethylating agent, 5-aza-2'-deoxycytidine, enhances tumor cell invasion through a transcription-dependent modulation of MMP-1 expression in human fibrosarcoma cells.

The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition

Transcriptional and post-transcriptional regulation of glutathione S-transferase P1 expression during butyric acid-induced differentiation of K562 cells

Transcriptional regulation of glutathione S-transferase P1-1 in human leukemia

Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1.

Tumor necrosis factor alpha inhibits aclacinomycin A-induced erythroid differentiation of K562 cells via GATA-1.

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway

Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks