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List of works by Bradly Wouters

"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways

scientific article published on July 2006

18S is an appropriate housekeeping gene for in vitro hypoxia experiments.

scientific article published on 20 July 2010

A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy

scientific article published on 01 November 1999

A simple but highly effective approach to evaluate the prognostic performance of gene expression signatures

scientific article (publication date: 2011)

A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients

scientific article

A β-galactosidase probe for the detection of cellular senescence by mass cytometry

scientific article published on 01 August 2017

AMPK regulates metabolism and survival in response to ionizing radiation

scientific article published on 27 June 2011

Activating transcription factor 4 is translationally regulated by hypoxic stress

scientific article published on September 2004

Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.

scientific article published on 23 February 2018

An Engineered Paper‐Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype

scientific article published in 2022

An association between the radiation-induced arrest of G2-phase cells and low-dose hyper-radiosensitivity: a plausible underlying mechanism?

scientific article published in July 2003

Antiproton radiotherapy.

scientific article published on 26 December 2007

Apoptosis, p53, and tumor cell sensitivity to anticancer agents

scientific article

Apoptosis: mediator or mode of cell killing by anticancer agents?

scientific article

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma

scientific article

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

scientific article

Binding of cetuximab to the EGFRvIII deletion mutant and its biological consequences in malignant glioma cells

scientific article

CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration.

scientific article

Cancer classification using the Immunoscore: a worldwide task force

scientific article

Cancer therapy and tumor physiology

scientific article published on 01 January 1998

Cell Death Identification in Anticancer Therapy-Letter

scientific article published on 18 August 2015

Cell cycle progression and radiation survival following prolonged hypoxia and re-oxygenation.

scientific article published in March 2001

Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity

scientific article

Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy

scientific article

Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance

scientific article published in January 2008

Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin

scientific article published on June 1999

Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage

scientific article published in November 2003

Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study

scientific article published in 2022

Comments on hyperbaric oxygen and carbogen/nicotinamide with fractionated radiation

scientific article published on 01 November 1997

Control of the hypoxic response through regulation of mRNA translation.

scientific article

Cytotoxic effect of RB 6145 in human tumour cell lines: dependence on hypoxia, extra- and intracellular pH and drug uptake

scientific article

DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma

scientific article published on 13 July 2016

Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment

scientific article

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

scientific article published on 12 June 2011

Development and evaluation of a cetuximab-based imaging probe to target EGFR and EGFRvIII.

scientific article published on 24 May 2007

Development of TRACER: tissue roll for analysis of cellular environment and response.

scientific article

Development of a flexible and potent hypoxia-inducible promoter for tumor-targeted gene expression in attenuated Salmonella

scientific article published on 28 September 2006

Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability

scientific article published on 12 March 2010

Disparity between in vivo EGFR expression and 89Zr-labeled cetuximab uptake assessed with PET.

scientific article

Dose- and time-dependent changes in gene expression in human glioma cells after low radiation doses

scientific article

Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects

scientific article published on 9 June 2016

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

scientific article published on 15 June 2011

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

scientific article published on 8 September 2005

Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy

scientific article published on 3 February 2015

Effects of radiotherapy and chemotherapy on angiogenesis and leukocyte infiltration in rectal cancer

scientific article published on 01 November 2006

Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression

scientific article published on 20 February 2007

Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies

scientific article published in 2021

Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma

scientific article published on 23 August 2018

Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance

scientific article published on 23 May 2007

Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity

scientific article published on 28 March 2007

Frontiers in molecular radiation biology/oncology

scientific article published on 17 October 2011

Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide

scientific article published on 12 April 2019

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone

article

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

scientific article

Hypoxia and Predicting Radiation Response

scientific article published on 15 May 2015

Hypoxia and metastasis in an orthotopic cervix cancer xenograft model

scientific article published on 12 July 2013

Hypoxia and regulation of messenger RNA translation

scientific article published on January 2007

Hypoxia as a target for combined modality treatments.

scientific article

Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T

scientific article published on 29 June 2011

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.

scientific article published on 26 October 2016

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

scientific article

Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells

scientific article

Hypoxia signaling and the metastatic phenotype

scientific article published on January 2014

Hypoxia signalling through mTOR and the unfolded protein response in cancer

scientific article published on 10 October 2008

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

scientific article

Hypoxia, Androgen Deprivation and Systemic Metastases in Prostate Cancer (In Response to “Antivascular Effects of Neoadjuvant Androgen Deprivation for Prostate Cancer: An In Vivo Human Study Using Susceptibility and Relaxitivity Dynamic MRI”: In

scientific article published on 01 March 2012

Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis

scientific article published in April 2008

Hypoxia-activated prodrugs: paths forward in the era of personalised medicine.

scientific article published on 12 April 2016

Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response

scientific article published on 29 June 2009

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

scientific article published on April 2004

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

scientific article

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

scientific article published on 17 September 2013

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.

scientific article

Hypoxic cell sensitization: low-dose intrinsic radiosensitivity is predictive for etanidazole efficacy in a panel of human tumour cell lines

scientific article published on December 1996

Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer.

scientific article published on 11 February 2011

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

scientific article published on 21 August 2015

Identification of hypoxic cells using an organotellurium tag compatible with mass cytometry

scientific article published on 4 September 2014

Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy (18)Fluorodeoxyglucose-PET-CT scan

scientific article

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

scientific article published on 16 July 2009

Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors

scientific article published on 14 May 2007

Impact of supervised gene signatures of early hypoxia on patient survival

scientific article published on 25 May 2007

Increased therapeutic ratio by 18FDG-PET CT planning in patients with clinical CT stage N2-N3M0 non-small-cell lung cancer: a modeling study

scientific article published in March 2005

Independent and functional validation of a multi-tumour-type proliferation signature

scientific article

Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance

scientific article published in March 2009

Integrating RAS status into prognostic signatures for adenocarcinomas of the lung

scientific article published on 21 January 2015

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

scientific article published on 24 January 2019

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

scientific article published in The Lancet

Intra-voxel heterogeneity influences the dose prescription for dose-painting with radiotherapy: a modelling study

scientific article published on 17 March 2009

In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model

scientific article published on 14 September 2016

Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution

scientific article published in October 2016

Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism.

scientific article

Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells.

scientific article published on March 2004

Low-dose hypersensitivity and increased radioresistance in a panel of human tumor cell lines with different radiosensitivity

scientific article published in October 1996

Low-dose radiation sensitivity and induced radioresistance to cell killing in HT-29 cells is distinct from the "adaptive response" and cannot be explained by a subpopulation of sensitive cells.

scientific article published on November 1997

Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations

scientific article published on 12 June 2006

MATE2 Expression Is Associated with Cancer Cell Response to Metformin

scientific article

MK3 modulation affects BMI1-dependent and independent cell cycle check-points

scientific article published on 8 April 2015

Maximal neutropenia during chemotherapy and radiotherapy is significantly associated with the development of acute radiation-induced dysphagia in lung cancer patients

article

Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay

scientific article published on August 1996

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

scientific article

Mitochondrial dysfunction after aerobic exposure to the hypoxic cytotoxin tirapazamine

scientific article

Modulation of cell death in the tumor microenvironment

scientific article

Molecular and translational radiation biology/oncology: what's up?

scientific article published on 01 June 2011

Molecular radiation biology/oncology at its best: cutting edge research presented at the 13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology

scientific article published in September 2013

Molecular targeting of hypoxia in radiotherapy

scientific article

Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer

scientific article published on 08 September 2020

NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data

scientific article

Neuroendocrine carcinoma in a patient with Birt-Hogg-Dubé syndrome

scientific article published on 14 September 2010

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia

scientific article published on 3 July 2013

Non-invasive 19F MR spectroscopy of 5-fluorocytosine to 5-fluorouracil conversion by recombinant Salmonella in tumours.

scientific article

ONECUT2 is a driver of neuroendocrine prostate cancer

scientific article published in Nature Communications

Oncology Scan—How Radiation Effects on Cells in the Stromal Microenvironment Influence Tumor Development, Proliferation, and Recovery ⬇️

scientific article published on July 15, 2013

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

scientific article published on 7 March 2013

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

scientific article published on 20 June 2016

Pantoprazole Affecting Docetaxel Resistance Pathways via Autophagy (PANDORA): Phase II Trial of High Dose Pantoprazole (Autophagy Inhibitor) with Docetaxel in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

scientific article published on 05 April 2019

Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies

scientific article published on 22 August 2006

Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.

scientific article published on 24 May 2007

Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients

scientific article published in September 2004

Poorer outcome in stromal HIF-2 alpha- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis

scientific article published on 19 August 2008

Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours ⬇️

scientific article published on February 2014

Potential and limitations of bacterial-mediated cancer therapy

scientific article published on May 2007

Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress

article

Proteomics: methodologies and applications in oncology

scientific article published on April 2008

Quantifying hypoxia in human cancers using static PET imaging

scientific article published on 25 October 2016

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

scientific article

Radiation Dose Prescription for Non–Small-Cell Lung Cancer According to Normal Tissue Dose Constraints: An In Silico Clinical Trial

scientific article published on 06 February 2008

Radiobiological intercomparison of the 160 MeV and 230 MeV proton therapy beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital

scientific article

Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia

scientific article published on 17 May 2007

Regulation of PCNA polyubiquitination in human cells

scientific article

Regulation of autophagy through multiple independent hypoxic signaling pathways.

scientific article published on May 2009

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

scientific article

Regulatory functions of ubiquitin in diverse DNA damage responses

scientific article published on March 2011

Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo

scientific article published on 3 October 2006

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response

scientific article published on 18 October 2013

Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.

scientific article

Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: possible role for thrombosis

scientific article published on 11 December 2006

Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types

scientific article published on 4 November 2008

Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia

scientific article published on 17 February 2009

Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer

scientific article published on 19 July 2019

Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas.

scientific article

Substructure in the cell survival response at low radiation dose: effect of different subpopulations

scientific article published on 01 June 1997

Substructure in the radiation survival response at low dose in cells of human tumor cell lines

scientific article published on October 1996

Substructure in the radiation survival response at low dose: asynchronous and partially synchronized V79-WNRE cells

scientific article published on November 1993

Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase

scientific article

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

scientific article published on April 2009

Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy

scientific article published on 10 June 2017

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

scientific article published on 29 March 2019

Targeting hypoxia tolerance in cancer

scientific article published on February 2004

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

scientific article

TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry

scientific article published on 10 April 2019

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels

scientific article published on 10 August 2009

The Future of Radiobiology.

scientific article published on 3 November 2017

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

scientific article published on 9 July 2013

The biological effectiveness of antiproton irradiation.

scientific article published on 27 October 2006

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

scientific article published on 16 July 2009

The hypoxic proteome is influenced by gene-specific changes in mRNA translation

scientific article published on August 2005

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer

scientific article published on 16 February 2018

The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency

scientific article published in March 2008

The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer

scientific article published on 20 February 2012

The response of a human tumor cell line to low radiation doses: evidence of enhanced sensitivity.

scientific article published on April 1994

The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia

scientific article published on October 2013

The survival of asynchronous V79 cells at low radiation doses: modeling the response of mixed cell populations

scientific article published on 01 April 1994

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

scientific article published on 28 April 2014

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

scientific article

The use of a comprehensive tumour xenograft dataset to validate gene signatures relevant for radiation response.

scientific article published on 15 July 2009

Time Between the First Day of Chemotherapy and the Last Day of Chest Radiation Is the Most Important Predictor of Survival in Limited-Disease Small-Cell Lung Cancer

scientific article published on 01 March 2006

Tirapazamine: a new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer

scientific article published on 01 January 1999

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

scientific article

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

scientific article

Translational control is a major contributor to hypoxia induced gene expression

scientific article published on 28 June 2011

Translational control of gene expression during hypoxia

scientific article published on July 2006

Tumor-specific gene delivery using genetically engineered bacteria

scientific article

Two phases of disulfide bond formation have differing requirements for oxygen.

scientific article

Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity.

scientific article

hMMS2 serves a redundant role in human PCNA polyubiquitination

scientific article

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