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List of works by John D. Helmann

A Central Role for Magnesium Homeostasis during Adaptation to Osmotic Stress

scientific article published on 15 February 2022

A complex thiolate switch regulates the Bacillus subtilis organic peroxide sensor OhrR.

scholarly article

A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism

scientific article

A metabolic checkpoint protein GlmR is important for diverting carbon into peptidoglycan biosynthesis in Bacillus subtilis

scientific article published on 24 September 2018

A mutation of the RNA polymerase β' subunit (rpoC) confers cephalosporin resistance in Bacillus subtilis.

scientific article published on 15 October 2012

A novel DNA modification by sulphur

scientific article published on September 2005

A peroxide-induced zinc uptake system plays an important role in protection against oxidative stress in Bacillus subtilis.

scientific article

A previously unidentified sigma factor and two accessory proteins regulate oxalate decarboxylase expression in Bacillus subtilis

scientific article published on 28 June 2008

A promoter melting region in the primary sigma factor of Bacillus subtilis. Identification of functionally important aromatic amino acids

scientific article published on February 1994

A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

scientific article published on 08 September 2020

A two-subunit bacterial sigma-factor activates transcription in Bacillus subtilis

scientific article

A σD-dependent antisense transcript modulates expression of the cyclic-di-AMP hydrolase GdpP in Bacillus subtilis.

scientific article

A σW-dependent stress response in Bacillus subtilis that reduces membrane fluidity

scientific article

Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter

scientific article

Alternative sigma factors and the regulation of flagellar gene expression ⬇️

scientific article published on December 1, 1991

An antibiotic-inducible cell wall-associated protein that protects Bacillus subtilis from autolysis

scientific article published on 4 May 2007

Analysis of the role of Bacillus subtilis σ(M) in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

scientific article published on 4 January 2012

Anti-sigma factors

scientific article

Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis

scientific article published on August 2004

Antibiotics that inhibit cell wall biosynthesis induce expression of the Bacillus subtilis sigma(W) and sigma(M) regulons

scientific article

Assessing the impact of denitrifier-produced nitric oxide on other bacteria.

scientific article

Bacillithiol is a major buffer of the labile zinc pool in Bacillus subtilis

scientific article published on 7 October 2014

Bacillithiol is an antioxidant thiol produced in Bacilli ⬇️

scientific article

Bacillithiol, a new player in bacterial redox homeostasis

scientific article

Bacillus subtilis CPx-type ATPases: characterization of Cd, Zn, Co and Cu efflux systems

scientific article

Bacillus subtilis FolE is sustained by the ZagA zinc metallochaperone and the alarmone ZTP under conditions of zinc deficiency

scientific article published on 11 June 2019

Bacillus subtilis Fur Is a Transcriptional Activator for the PerR-Repressed pfeT Gene, Encoding an Iron Efflux Pump

scientific article published on 26 March 2020

Bacillus subtilis Fur represses one of two paralogous haem-degrading monooxygenases.

scientific article

Bacillus subtilis MntR coordinates the transcriptional regulation of manganese uptake and efflux systems

scientific article published on 17 October 2016

Bacillus subtilis MrgA is a Dps(PexB) homologue: evidence for metalloregulation of an oxidative-stress gene

scientific article published on 01 October 1995

Bacillus subtilis PgcA moonlights as a phosphoglucosamine mutase in support of peptidoglycan synthesis

scientific article published on 07 October 2019

Bacillus subtilis TerC Family Proteins Help Prevent Manganese Intoxication

scientific article published on 02 January 2020

Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors ⬇️

scientific article published on July 1, 1998

Bacillus subtilis extracytoplasmic function (ECF) sigma factors and defense of the cell envelope

scientific article published on 19 February 2016

Bacillus subtilis paraquat resistance is directed by sigmaM, an extracytoplasmic function sigma factor, and is conferred by YqjL and BcrC.

scientific article published on May 2005

Bacillus subtilis σ(V) confers lysozyme resistance by activation of two cell wall modification pathways, peptidoglycan O-acetylation and D-alanylation of teichoic acids

scientific article published on 16 September 2011

Biochemical characterization of the structural Zn2+ site in the Bacillus subtilis peroxide sensor PerR

scientific article published on 08 June 2006

Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli

scientific article

Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon

scientific article

Characterization of the Fur regulon in Pseudomonas syringae pv. tomato DC3000

scientific article

Contributions of Zur-controlled ribosomal proteins to growth under zinc starvation conditions

scientific article

Conversion of Bacillus subtilis OhrR from a 1-Cys to a 2-Cys peroxide sensor.

scientific article published on 27 June 2008

Coordinate regulation of Bacillus subtilis peroxide stress genes by hydrogen peroxide and metal ions

scientific article

Crystal Structure of Peroxide Stress Regulator from Streptococcus pyogenes Provides Functional Insights into the Mechanism of Oxidative Stress Sensing

scientific article

DNA-binding and oligomerization studies of the manganese(II) metalloregulatory protein MntR from Bacillus subtilis

scientific article

DNA-binding properties of the Bacillus subtilis and Aeribacillus pallidus AC6 σ(D) proteins.

scientific article published on 19 November 2010

DNA-melting at the Bacillus subtilis flagellin promoter nucleates near -10 and expands unidirectionally

scientific article

Deciphering the essentiality and function of the anti-σM factors in Bacillus subtilis

scientific article published on 13 March 2019

Defining the Bacillus subtilis sigma(W) regulon: a comparative analysis of promoter consensus search, run-off transcription/macroarray analysis (ROMA), and transcriptional profiling approaches

scientific article published on 01 February 2002

Derepression of the Bacillus subtilis PerR peroxide stress response leads to iron deficiency

scientific article published on 22 December 2011

Direct stimulus perception and transcription activation by a membrane-bound DNA binding protein

scientific article published on 7 July 2009

Direct substitution and assisted dissociation pathways for turning off transcription by a MerR-family metalloregulator

scientific article

Don't let sleeping dogmas lie: new views of peptidoglycan synthesis and its regulation

scientific article published on 4 October 2017

Dysregulation of Magnesium Transport Protects Bacillus subtilis against Manganese and Cobalt Intoxication

scientific article published on 11 March 2020

Editorial: An Inaugural Series of Thematic MicroReviews from the BLAST Meeting

scientific article published on 01 January 2017

Elemental economy: microbial strategies for optimizing growth in the face of nutrient limitation

scientific article

Expression, abundance, and RNA polymerase binding properties of the delta factor of Bacillus subtilis

scientific article published on 01 May 1999

Extracytoplasmic function sigma factors regulate expression of the Bacillus subtilis yabE gene via a cis-acting antisense RNA.

scientific article published in December 2008

Extracytoplasmic function sigma factors with overlapping promoter specificity regulate sublancin production in Bacillus subtilis

scientific article published on 22 May 2009

Ferrous iron efflux systems in bacteria

scientific article

Fluoro-phenyl-styrene-sulfonamide, a novel inhibitor of σB activity, prevents the activation of σB by environmental and energy stresses in Bacillus subtilis

scientific article published on 22 March 2013

Functional analysis of the Bacillus subtilis Zur regulon.

scientific article

Functional specialization within the Fur family of metalloregulators

scientific article published on 10 January 2007

Genetic analysis of factors affecting susceptibility of Bacillus subtilis to daptomycin

scientific article published on 21 January 2009

Genetic and physiological responses of Bacillus subtilis to metal ion stress

scientific article published in July 2005

Genome-Wide Characterization of the Fur Regulatory Network Reveals a Link between Catechol Degradation and Bacillibactin Metabolism in Bacillus subtilis

scientific article published on 30 October 2018

Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).

scientific article published on 23 December 2008

Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon

scientific article

Global transcriptional response of Bacillus subtilis to heat shock

scientific article

Glutamate dehydrogenase affects resistance to cell wall antibiotics in Bacillus subtilis

scientific article published on 16 December 2011

Group A streptococcus AdcR regulon participates in bacterial defense against host-mediated zinc sequestration and contributes to virulence

scientific article published on 11 May 2020

Identification of Bacillus subtilis sigma-dependent genes that provide intrinsic resistance to antimicrobial compounds produced by Bacilli

scientific journal article

Identification of Novel Spx Regulatory Pathways in Bacillus subtilis Uncovers a Close Relationship between the CtsR and Spx Regulons

scientific article published on 10 June 2019

Identification of altered function alleles that affect Bacillus subtilis PerR metal ion selectivity.

scientific article

Identification of target promoters for the Bacillus subtilis extracytoplasmic function sigma factor, sigma W

scientific article published on 01 January 1999

Identification of target promoters for the Bacillus subtilis sigma X factor using a consensus-directed search

scientific article published in May 1998

Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter

scientific article published on March 2000

In vitro mutagenesis of Bacillus subtilis by using a modified Tn7 transposon with an outward-facing inducible promoter

scientific article published on 11 April 2008

Induction of the Spx regulon by cell wall stress reveals novel regulatory mechanisms in Bacillus subtilis.

scientific article published on 22 December 2017

Intracellular Zn(II) Intoxication Leads to Dysregulation of the PerR Regulon Resulting in Heme Toxicity in Bacillus subtilis

scientific article

Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence.

scientific article published on 27 March 2017

Lack of formylated methionyl-tRNA has pleiotropic effects on Bacillus subtilis

scientific article published on 15 December 2016

LiaRS-dependent gene expression is embedded in transition state regulation in Bacillus subtilis

scientific article published on 01 August 2007

Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins

scientific article published on 01 March 2000

Manganese impairs the QoxABCD terminal oxidase leading to respiration‐associated toxicity

scientific article published in 2021

Measuring metals with RNA.

scientific article published on September 2007

Metal homeostasis and resistance in bacteria

scientific article published on 27 March 2017

Metal ion homeostasis in Bacillus subtilis

scientific article

Metal-induced structural organization and stabilization of the metalloregulatory protein MntR.

scientific article

Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol-dependent and independent pathways

scientific article published on 07 January 2014

Modulation of extracytoplasmic function (ECF) sigma factor promoter selectivity by spacer region sequence

scientific article published on 23 October 2017

Molecular logic of the Zur-regulated zinc deprivation response in Bacillus subtilis

scientific article published on 26 August 2016

Molecular scribes in the spotlight: Methods for illuminating Bacterial and Archaeal transcription.

scientific article published on 17 July 2015

Mutational analysis of active site residues essential for sensing of organic hydroperoxides by Bacillus subtilis OhrR.

scientific article

Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the sigma(X) and sigma(W) factors in Bacillus subtilis

scientific article

Mutations in sigma factor that affect the temperature dependence of transcription from a promoter, but not from a mismatch bubble in double-stranded DNA.

scientific article published on September 1994

Mutations of the Bacillus subtilis YidC1 (SpoIIIJ) insertase alleviate stress associated with σM-dependent membrane protein overproduction

scientific article published on 18 October 2019

New dimensions at Molecular Microbiology: 3D graphics and the Wiley Online Library ⬇️

scientific article published on May 12, 2011

OhrR is a repressor of ohrA, a key organic hydroperoxide resistance determinant in Bacillus subtilis

scientific article

Open complex formation by Escherichia coli RNA polymerase: the mechanism of polymerase-induced strand separation of double helical DNA

scientific article

Origins of metal ion selectivity in the DtxR/MntR family of metalloregulators

scientific article

Origins of specificity and cross-talk in metal ion sensing by Bacillus subtilis Fur

scientific article

Oxidant-dependent switching between reversible and sacrificial oxidation pathways for Bacillus subtilis OhrR.

scientific article

Oxidation of a single active site suffices for the functional inactivation of the dimeric Bacillus subtilis OhrR repressor in vitro.

scientific article published on 07 January 2009

OxyR: a molecular code for redox sensing?

scientific article

Pathway of promoter melting by Bacillus subtilis RNA polymerase at a stable RNA promoter: effects of temperature, delta protein, and sigma factor mutations.

scientific article published on July 1995

Peroxide stress elicits adaptive changes in bacterial metal ion homeostasis

scientific article

PfeT, a P1B4 -type ATPase, effluxes ferrous iron and protects Bacillus subtilis against iron intoxication

scientific article published on 11 August 2015

Phenotypic and transcriptomic characterization of Bacillus subtilis mutants with grossly altered membrane composition

scientific article published on 26 September 2008

Protein-nucleic acid interactions during open complex formation investigated by systematic alteration of the protein and DNA binding partners

scientific article

Purification of Bacillus subtilis RNA polymerase and associated factors.

scientific article

RNA polymerase sigma factor determines start-site selection but is not required for upstream promoter element activation on heteroduplex (bubble) templates

scientific article published on May 1997

RNA polymerase: a nexus of gene regulation

scientific article published on January 2009

ROMA: an in vitro approach to defining target genes for transcription regulators

scientific article published on 21 October 2008

RaoN, a small RNA encoded within Salmonella pathogenicity island-11, confers resistance to macrophage-induced stress

scientific article published on 08 May 2013

Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence

scientific article

Recognition of DNA by three ferric uptake regulator (Fur) homologs in Bacillus subtilis.

scientific article

Redox Sensing by Fe2+ in Bacterial Fur Family Metalloregulators

scientific article

Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis

scientific article

Regulation of LiaRS-dependent gene expression in bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system

scientific article

Regulation of inducible peroxide stress responses

scientific article

Regulation of the Bacillus subtilis bcrC bacitracin resistance gene by two extracytoplasmic function sigma factors.

scientific article

Regulation of the Bacillus subtilis extracytoplasmic function protein sigma(Y) and its target promoters

scientific article published on August 2003

Regulation of the Bacillus subtilis fur and perR genes by PerR: not all members of the PerR regulon are peroxide inducible

scientific article

Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function sigma factors

scientific article

Response of Bacillus subtilis to nitric oxide and the nitrosating agent sodium nitroprusside

scientific article

Restoration of motility to an Escherichia coli fliA flagellar mutant by a Bacillus subtilis sigma factor

scientific article published on June 1992

Roles of the A and C Sites in the Manganese-Specific Activation of MntR ⬇️

scientific article published on January 17, 2013

S-cysteinylation is a general mechanism for thiol protection of Bacillus subtilis proteins after oxidative stress

scientific article published on 04 July 2007

Sensing nickel. NikRs with two pockets

scientific article published on 01 October 2002

Sequential binding and sensing of Zn(II) by Bacillus subtilis Zur.

scientific article published on 5 August 2011

Sequential induction of Fur-regulated genes in response to iron limitation in Bacillus subtilis

scientific article published on 13 November 2017

Sigma Factors in Gene Expression

article

Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.

scientific article

Stabilization of Bacillus subtilis Spx under cell wall stress requires the anti-adaptor protein YirB

scientific article published on 12 July 2018

Structural analysis of the Bacillus subtilis delta factor: a protein polyanion which displaces RNA from RNA polymerase.

scientific article

Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.

scientific article published on March 2006

Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family

scientific article

Structure of the manganese-bound manganese transport regulator of Bacillus subtilis

scientific article

Substrate induction of siderophore transport in Bacillus subtilis mediated by a novel one-component regulator

scientific article published on 28 August 2007

The -10 region is a key promoter specificity determinant for the Bacillus subtilis extracytoplasmic-function sigma factors sigma(X) and sigma(W)

scientific article

The A. tumefaciens transcriptional activator OccR causes a bend at a target promoter, which is partially relaxed by a plant tumor metabolite

scientific article

The Bacillus subtilis GntR family repressor YtrA responds to cell wall antibiotics

scientific article

The Bacillus subtilis extracytoplasmic-function sigmaX factor regulates modification of the cell envelope and resistance to cationic antimicrobial peptides.

scientific article published on February 2004

The Bacillus subtilis flagellar regulatory protein sigma D: overproduction, domain analysis and DNA-binding properties

scientific article published on 01 June 1995

The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins

scientific article

The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses

scientific article

The FsrA sRNA and FbpB protein mediate the iron-dependent induction of the Bacillus subtilis lutABC iron-sulfur-containing oxidases

scientific article

The MerR metalloregulatory protein binds mercuric ion as a tricoordinate, metal-bridged dimer

scientific article

The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative

scientific article

The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation

scientific article published in Nature

The Role of Bacillithiol in Gram-Positive Firmicutes

scientific article published on 16 March 2017

The YvrI alternative sigma factor is essential for acid stress induction of oxalate decarboxylase in Bacillus subtilis

scientific article published on December 2008

The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state.

scientific article

The delta subunit of Bacillus subtilis RNA polymerase. An allosteric effector of the initiation and core-recycling phases of transcription

scientific article published on May 1994

The global transcriptional response of Bacillus subtilis to manganese involves the MntR, Fur, TnrA and sigmaB regulons.

scientific article

The global transcriptional response of Bacillus subtilis to peroxide stress is coordinated by three transcription factors

scientific article

The sigma70 family of sigma factors

scientific article

The yydFGHIJ operon of Bacillus subtilis encodes a peptide that induces the LiaRS two-component system

scientific article

Thiol-based redox switches and gene regulation

scientific article

Transcription activation by the siderophore sensor Btr is mediated by ligand-dependent stimulation of promoter clearance

scientific article published on 30 December 2011

Transcriptional switching by the MerR protein: activation and repression mutants implicate distinct DNA and mercury(II) binding domains

scientific article

Transcriptomic and phenotypic characterization of a Bacillus subtilis strain without extracytoplasmic function σ factors.

scientific article

Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB

scientific article

sigma factor mutations affecting the sequence-selective interaction of RNA polymerase with -10 region single-stranded DNA

scientific article published on July 1997

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